CN112656846A - Ointment for treating cervical spondylotic radiculopathy and preparation method thereof - Google Patents
Ointment for treating cervical spondylotic radiculopathy and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an ointment for treating cervical spondylotic radiculopathy and a preparation method thereof: crushing notoginseng to prepare powder, extracting the powder by using an ethanol solution to obtain a notoginsenoside extracting solution, and then performing macroporous resin treatment on the extracting solution to obtain notoginsenoside powder after vacuum freezing the filtrate; extracting volatile oil from notopterygium root and clematis root, and performing inclusion by using beta-cyclodextrin to obtain a volatile oil inclusion compound; decocting radix Puerariae and radix Paeoniae alba with water, concentrating the filtrate, and precipitating with ethanol to obtain fluid extract; extracting rhizoma Ligustici Chuanxiong and rhizoma corydalis with ethanol under reflux, recovering ethanol from the extractive solution, and concentrating into fluid extract; mixing the two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate to obtain Chinese medicinal extract; mixing the Chinese medicinal extract with vaseline, stearic acid, Colophonium, glycerol, potassium hydroxide, and azone, and making ointment. The obtained ointment has low skin irritation, high quality stability, and good permeability and absorption rate.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an ointment for treating nerve-root type cervical spondylosis and a preparation method thereof.
Background
The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.
The incidence rate of the cervical spondylotic radiculopathy is 50-60%, and the middle-aged and the elderly are common, and clinically, patients with the cervical spondylotic radiculopathy have cervical discomfort and limited movement of upper limbs or numb fingers. Cervical spondylotic radiculopathy is a condition in which the nerve roots of the spinal nerve on one or both sides are stimulated or pressed, resulting in dysfunction of movement, pain, numbness, etc. of the neck, shoulder, back and upper arm. The symptoms of radiculocervical spondylosis have obvious root symptoms, and the numbness, pain symptoms and range of the symptoms are consistent with the area dominated by cervical and spinal nerves, which seriously cause muscle weakness and even atrophy. This stimulation or compression is primarily caused by the following aspects: protrusion or prolapse of nucleus pulposus is serious, hyperosteogeny of the posterior facet joint is light, bony spur of the uncinate vertebra joint is formed slightly, loosening and displacement of the midvertebral body joint, the uncinate vertebra joint and the posterior facet joint are mild, and traumatic arthritis is caused.
There are many ways of treating cervical spondylotic radiculopathy, including the currently available granules, tablets and capsules for cervicodynia. The cervicodynia granules, the cervicodynia tablets and the cervicodynia capsules are all oral traditional Chinese medicine compound preparations for treating nerve-root type cervical spondylosis, have the effects of promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain, have satisfactory curative effects in clinical treatment, and have the effects of promoting blood circulation to remove blood stasis and regulating qi to alleviate pain by comprising pseudo-ginseng, ligusticum wallichii, rhizoma corydalis, notopterygium root, radix paeoniae alba, radix clematidis and radix puerariae.
However, the dosage form taken orally through the digestive tract often causes gastrointestinal side effects of patients, so that the medicine taking population is limited, and the phenomenon that the original dosage entering the blood circulation is reduced due to the first pass effect of the liver when the medicine is taken through the digestive tract is caused. The defects caused by gastrointestinal absorption can be solved through transdermal absorption, but the problems of large skin irritation, low permeability and low absorption rate and the like exist in the transdermal absorption. In the prior art, a technical scheme for preparing a prescription for treating cervical spondylotic radiculopathy into an ointment preparation does not exist.
Disclosure of Invention
In order to solve the technical problems in the prior art, the invention aims to provide an ointment for treating the cervical spondylotic radiculopathy and a preparation method thereof.
Specifically, the technical scheme of the invention is as follows:
in a first aspect of the present invention, there is provided an ointment for treating cervical spondylotic radiculopathy, which is prepared by the following steps:
crushing notoginseng to prepare powder, extracting by using an ethanol solution to obtain a notoginsenoside extracting solution, and then performing macroporous resin, and performing vacuum freezing on the filtrate to obtain notoginsenoside powder;
extracting volatile oil from notopterygium root and clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin to obtain a volatile oil inclusion compound;
decocting radix Puerariae and radix Paeoniae alba with water, concentrating the filtrate, and precipitating with ethanol to obtain fluid extract;
extracting rhizoma Ligustici Chuanxiong and rhizoma corydalis with ethanol under reflux, recovering ethanol from the extractive solution, and concentrating into fluid extract;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate;
mixing the above obtained extract with vaseline, stearic acid, Colophonium, glycerol, potassium hydroxide, and azone, sterilizing with ultraviolet, and packaging.
In a second aspect of the present invention, there is provided a use of the ointment for the treatment of cervical spondylotic radiculopathy of the first aspect in combination with a cervical pain granule for the treatment of cervical radiculopathy.
The specific embodiment of the invention has the following beneficial effects:
compared with the method for preparing the ointment by directly processing the pseudo-ginseng into the micro powder, the method for preparing the ointment by crushing the pseudo-ginseng and extracting the effective components of the pseudo-ginseng has the advantages that the effective components of the pseudo-ginseng can be more effectively applied, the quality stability of the ointment can be enhanced, and the phenomenon of oil-water separation of the ointment is not easy to occur;
according to the embodiment of the invention, the active ingredients in the ointment can be quickly absorbed by skin and the onset time of the ointment is shortened by the compatibility of the traditional Chinese medicine ingredients and the corresponding matrix and the regulation and control of the dosage ratio between the traditional Chinese medicine ingredients and the matrix; moreover, the components of the invention are matched with each other, so that the stimulation of the cream on the skin of a patient when the cream is directly coated on the skin can be effectively avoided, and no anaphylactic reaction exists.
The ointment for treating cervical vertebra pain of nerve root type prepared in the embodiment of the invention has the advantages of high permeability and high absorption rate, the product does not stimulate organs such as digestive tract, has less side effects, and has better effect by being taken orally and externally in combination with the cervical pain granules.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
The ointment is a semisolid external preparation which is easily coated on skin, mucosa or wound surface by adding the medicine into a proper substrate. The ointment mainly comprises a medicament and a matrix. The base is not only an excipient of the ointment, but it also has an important effect on both the release and absorption of the drug.
In one embodiment of the present invention, an ointment for treating cervical spondylotic radiculopathy is provided, which is prepared by the following steps:
crushing notoginseng to prepare powder, extracting by using an ethanol solution to obtain a notoginsenoside extracting solution, and then performing macroporous resin, and performing vacuum freezing on the filtrate to obtain notoginsenoside powder;
extracting volatile oil from notopterygium root and clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin to obtain a volatile oil inclusion compound;
decocting radix Puerariae and radix Paeoniae alba with water, concentrating the filtrate, and precipitating with ethanol to obtain fluid extract;
extracting rhizoma Ligustici Chuanxiong and rhizoma corydalis with ethanol under reflux, recovering ethanol from the extractive solution, and concentrating into fluid extract;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate to obtain Chinese medicinal extract;
mixing the Chinese medicinal extract with vaseline, stearic acid, Colophonium, glycerol, potassium hydroxide, and azone, sterilizing with ultraviolet, and packaging into small canister to obtain ointment for treating cervical spondylotic radiculopathy.
Preferably, the mass ratio of the pseudo-ginseng, the ligusticum wallichii, the corydalis tuber, the notopterygium root, the white paeony root, the clematis root and the kudzu-vine root is 30-40: 75-90: 55-70: 100: 95: 100: 95;
preferably, the mass ratio of the pseudo-ginseng, the ligusticum wallichii, the corydalis tuber, the notopterygium root, the white paeony root, the clematis root and the kudzu-vine root is 35-38: 80-85: 60-65: 100: 95: 100: 95;
preferably, pulverizing Notoginseng radix with a wall breaking machine, sieving with 20 mesh sieve, extracting with 75% ethanol solution, filtering, mixing filtrates, recovering ethanol under reduced pressure, adding water, passing through macroporous resin, washing with water until the effluent is colorless, eluting with 50% ethanol, and vacuum freezing the filtrate to obtain notoginsenoside powder;
preferably, decocting radix Puerariae and radix Paeoniae alba with water twice, the first time for 2 hr and the second time for 1 hr, mixing the filtrate with the above two water solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain fluid extract with relative density of 1.25-1.30 at 50 deg.C;
preferably, reflux-extracting rhizoma Ligustici Chuanxiong and rhizoma corydalis with ethanol, discarding residue, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25-1.30 at 50 deg.C;
preferably, the following components account for the total mass of the ointment in percentage by mass: 10-15% of stearic acid, 4-8% of glycerol, 2-4% of azone, 0.5-1.5% of rosin, 0.1-1.5% of potassium hydroxide and 1-3% of vaseline;
more preferably, the stearic acid accounts for 12% of the total mass of the ointment, the glycerol is 6%, the azone is 3%, the rosin is 1%, the potassium hydroxide is 1%, and the vaseline is 2%;
preferably, vaseline, stearic acid, rosin and azone are heated and melted to prepare a uniform oil phase, glycerol, potassium hydroxide and water are mixed to prepare a uniform water phase, and the uniform water phase is added into the oil phase after being heated to 80 ℃ to prepare ointment matrix;
then the temperature of the ointment matrix is reduced to below 60 ℃, and the traditional Chinese medicine extract is added into the matrix and stirred and mixed evenly.
In experiments, the applicant finds that the effective components in the pseudo-ginseng can be more effectively applied and the quality stability of the ointment can be enhanced compared with the method of directly processing the pseudo-ginseng into the micro powder to prepare the ointment, because the effective components in the pseudo-ginseng are poorly dissolved in the ointment, and the particles in the form of the micro powder of the pseudo-ginseng can damage the stability of the ointment, so that the ointment is easy to have the phenomenon of oil-water separation.
According to the ointment, the active ingredients in the ointment can be quickly absorbed by skin and the onset time of the ointment is shortened by the compatibility of the traditional Chinese medicine ingredients and the corresponding matrix and the regulation and control of the dosage ratio of the traditional Chinese medicine ingredients to the matrix; moreover, the components of the invention are matched with each other, so that the stimulation of the cream on the skin of a patient when the cream is directly coated on the skin can be effectively avoided, and no anaphylactic reaction exists.
The invention will be further explained and illustrated with reference to the following examples.
Example 1
An ointment for treating cervical spondylotic radiculopathy is prepared by the following steps:
crushing 350g of pseudo-ginseng by using a wall breaking machine, sieving the crushed pseudo-ginseng with a 20-mesh sieve, extracting the crushed pseudo-ginseng for 2 hours by using 75% ethanol solution, filtering and combining the filtrate, recovering ethanol under reduced pressure, adding water, passing through macroporous resin, washing the macroporous resin with water until effluent is colorless, eluting the macroporous resin with 50% ethanol, and freezing the filtrate in vacuum at the temperature of-20 ℃ and the pressure of 0.1MPa to obtain pseudo-ginseng saponin powder;
extracting volatile oil from 1000g of notopterygium root and 1000g of clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin, wherein the dosage ratio of the volatile oil to the beta-cyclodextrin is 1 mL: 2.1g, obtaining a volatile oil inclusion compound;
decocting 950g of radix Puerariae and 950g of radix Paeoniae alba with water twice, the first time for 2 hr and the second time for 1 hr, mixing the filtrate with the above two water solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
extracting rhizoma Ligustici Chuanxiong 800g and rhizoma corydalis 600g with ethanol under reflux for 2 hr, discarding residue, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate to obtain Chinese medicinal extract;
weighing vaseline, stearic acid, rosin and azone according to a certain proportion, heating and melting to prepare a uniform oil phase, mixing glycerol, potassium hydroxide and 3 times of water to prepare a uniform water phase, heating to 80 ℃, adding the uniform water phase into the oil phase, and preparing into ointment matrix;
and cooling the ointment matrix to below 60 deg.C, adding the Chinese medicinal extract into the matrix, stirring, mixing, sterilizing with ultraviolet, and packaging in small canister to obtain ointment for treating cervical spondylotic radiculopathy.
Example 2
An ointment for treating cervical spondylotic radiculopathy is prepared by the following steps:
pulverizing 380g of Notoginseng radix with a wall breaking machine, sieving with a 20 mesh sieve, extracting with 75% ethanol solution for 2h, filtering, mixing filtrates, recovering ethanol under reduced pressure, adding water, passing through macroporous resin, washing with water until the effluent is colorless, eluting with 50% ethanol, and vacuum freezing the filtrate at-20 deg.C under 0.1MPa to obtain notoginsenoside powder;
extracting volatile oil from 1000g of notopterygium root and 1000g of clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin, wherein the dosage ratio of the volatile oil to the beta-cyclodextrin is 1 mL: 2.1g, obtaining a volatile oil inclusion compound;
decocting 950g of radix Puerariae and 950g of radix Paeoniae alba with water twice, the first time for 2 hr and the second time for 1 hr, mixing the filtrate with the above two water solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
extracting 850g of rhizoma Ligustici Chuanxiong and 650g of rhizoma corydalis with ethanol under reflux for 2h, discarding residue, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate;
weighing vaseline, stearic acid, rosin and azone according to a certain proportion, heating and melting to prepare a uniform oil phase, mixing glycerol, potassium hydroxide and 3 times of water to prepare a uniform water phase, heating to 80 ℃, adding the uniform water phase into the oil phase, and preparing into ointment matrix;
and cooling the ointment matrix to below 60 deg.C, adding the Chinese medicinal extract into the matrix, stirring, mixing, sterilizing with ultraviolet, and packaging in small canister to obtain ointment for treating cervical spondylotic radiculopathy.
Example 3
An ointment for treating cervical spondylotic radiculopathy is prepared by the following steps:
pulverizing 370g of Notoginseng radix with a wall breaking machine, sieving with a 20 mesh sieve, extracting with 75% ethanol solution for 2h, filtering, mixing filtrates, recovering ethanol under reduced pressure, adding water, passing through macroporous resin, washing with water until the effluent is colorless, eluting with 50% ethanol, and vacuum freezing the filtrate at-20 deg.C under 0.1MPa to obtain notoginsenoside powder;
extracting volatile oil from 1000g of notopterygium root and 1000g of clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin, wherein the dosage ratio of the volatile oil to the beta-cyclodextrin is 1 mL: 2.1g, obtaining a volatile oil inclusion compound;
decocting 950g of radix Puerariae and 950g of radix Paeoniae alba with water twice, the first time for 2 hr and the second time for 1 hr, mixing the filtrate with the above two water solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
extracting 830g rhizoma Ligustici Chuanxiong and 630g rhizoma corydalis with ethanol under reflux for 2 hr, discarding residue, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate;
weighing vaseline, stearic acid, rosin and azone according to a certain proportion, heating and melting to prepare a uniform oil phase, mixing glycerol, potassium hydroxide and 3 times of water to prepare a uniform water phase, heating to 80 ℃, adding the uniform water phase into the oil phase, and preparing into ointment matrix;
and cooling the ointment matrix to below 60 deg.C, adding the Chinese medicinal extract into the matrix, stirring, mixing, sterilizing with ultraviolet, and packaging in small canister to obtain ointment for treating cervical spondylotic radiculopathy.
Comparative example 1
An ointment for treating cervical spondylotic radiculopathy is prepared by the following steps:
350g of pseudo-ginseng is crushed to 200 meshes to form pseudo-ginseng micro powder;
extracting volatile oil from 1000g of notopterygium root and 1000g of clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin, wherein the dosage ratio of the volatile oil to the beta-cyclodextrin is 1 mL: 2.1g, obtaining a volatile oil inclusion compound;
decocting 950g of radix Puerariae and 950g of radix Paeoniae alba with water twice, the first time for 2 hr and the second time for 1 hr, mixing the filtrate with the above two water solutions, concentrating, precipitating with ethanol, recovering ethanol, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
extracting rhizoma Ligustici Chuanxiong 800g and rhizoma corydalis 600g with ethanol under reflux for 2 hr, discarding residue, recovering ethanol from the extractive solution, and concentrating to obtain fluid extract with relative density of 1.25 at 50 deg.C;
mixing the above two fluid extracts, adding Notoginseng radix micropowder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate;
weighing vaseline, stearic acid and azone according to a certain proportion, heating and melting to prepare a uniform oil phase, mixing glycerol, potassium hydroxide and 3 times of water to prepare a uniform water phase, heating to 80 ℃, adding the uniform water phase into the oil phase, and preparing into ointment matrix;
and cooling the ointment matrix to below 60 deg.C, adding the Chinese medicinal extract into the matrix, stirring, mixing, sterilizing with ultraviolet, and packaging in small canister to obtain ointment for treating cervical spondylotic radiculopathy.
Test for stability of quality
The ointment for treating the cervical spondylotic radiculopathy prepared in example 1 was divided into 2 equal parts, 1 part of the ointment was placed in an environment of 60 ℃ for 12 hours, and 1 part of the ointment was placed in an environment of-5 ℃ for 24 hours, and observation was carried out, and no oil-water separation phenomenon occurred in 2 samples, so that the ointment for treating the cervical spondylotic radiculopathy prepared in example 1 of the present invention was found to have good quality stability.
The test conditions are as follows: temperature 60 ℃, test time: 12h, the test results are shown in the following table:
table 1:
the test conditions are as follows: temperature-5 ℃, test time: 24h, the test results are shown in the following table:
table 2:
the ointment for treating the cervical spondylotic radiculopathy prepared in the comparative example 1 is divided into 2 equal parts, 1 part of the ointment is placed in an environment at 60 ℃ for 12 hours, 1 part of the ointment is placed in an environment at-5 ℃ for 24 hours, and observation is carried out, so that the oil-water separation phenomenon occurs in 9 hours for the sample in the environment at 60 ℃, and the oil-water separation phenomenon occurs in 18 hours for the sample in the environment at-5 ℃, and the quality stability of the ointment for treating the cervical spondylotic radiculopathy prepared in the comparative example 1 is poor.
The test conditions are as follows: temperature 60 ℃, test time: 12h, the test results are shown in the following table:
table 3:
the test conditions are as follows: temperature-5 ℃, test time: 24h, the test results are shown in the following table:
table 4:
skin sensitization test
SD rats and 5 male and female rats are selected respectively, the ointment for treating the nerve-root cervical spondylosis prepared in the example 1 is coated on the skin surfaces of the rats after hair removal, the administration dose is 1g/kg, and no abnormality is observed on the skin surfaces of 10 rats, which indicates that the ointment prepared by the invention has no sensitization effect and the sensitization reaction is 0 grade;
skin irritation test
Selecting Chinese white rabbits with the weight of 2kg and 5 male and female rabbits respectively, removing hairs of the elbow skin of the white rabbits, smearing the ointment prepared in the embodiment 1, wiping off the residual ointment on the skin after 12 hours, observing whether skin irritation occurs or not, observing that the skin at the position of smearing is soft and ruddy, and no abnormality is found in pathological and histological examination, thereby indicating that the ointment has no irritation to the skin.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An ointment for treating cervical spondylotic radiculopathy is characterized in that the preparation method of the ointment for treating cervical radiculopathy is as follows:
crushing notoginseng to prepare powder, extracting by using an ethanol solution to obtain a notoginsenoside extracting solution, and then performing macroporous resin, and performing vacuum freezing on the filtrate to obtain notoginsenoside powder;
extracting volatile oil from notopterygium root and clematis root, and then performing inclusion on the volatile oil by using beta-cyclodextrin to obtain a volatile oil inclusion compound;
decocting radix Puerariae and radix Paeoniae alba with water, concentrating the filtrate, and precipitating with ethanol to obtain fluid extract;
extracting rhizoma Ligustici Chuanxiong and rhizoma corydalis with ethanol under reflux, recovering ethanol from the extractive solution, and concentrating into fluid extract;
mixing the above two fluid extracts, adding notoginsenoside powder, mixing, drying, pulverizing into fine powder, and adding the volatile oil clathrate to obtain Chinese medicinal extract;
mixing the Chinese medicinal extract with vaseline, stearic acid, Colophonium, glycerol, potassium hydroxide, and azone, and making into ointment for treating cervical spondylotic radiculopathy.
2. The ointment for treating cervical spondylotic radiculopathy according to claim 1, wherein the mass ratio of notoginseng, chuanxiong rhizome, corydalis tuber, notopterygium root, white peony root, clematis root and kudzuvine root is 30-40: 75-90: 55-70: 100: 95: 100: 95.
3. the ointment for treating cervical spondylotic radiculopathy according to claim 2, wherein the mass ratio of notoginseng, chuanxiong rhizome, corydalis tuber, notopterygium root, white peony root, clematis root and kudzuvine root is 35-38: 80-85: 60-65: 100: 95: 100: 95.
4. the ointment for treating cervical spondylotic radiculopathy according to claim 1, which comprises the following components in percentage by mass: 10-15% of stearic acid, 4-8% of glycerol, 2-4% of azone, 0.5-1.5% of rosin, 0.1-1.5% of potassium hydroxide and 1-3% of vaseline.
5. The ointment for treating cervical spondylotic radiculopathy according to claim 1, which comprises the following components in percentage by mass: 12% of stearic acid, 6% of glycerol, 3% of azone, 1% of rosin, 1% of potassium hydroxide and 2% of vaseline.
6. The ointment for treating cervical spondylotic radiculopathy according to claim 1, wherein notoginseng is pulverized by a wall breaking machine, and passed through a 20-mesh sieve, and then extracted with 75% ethanol solution, the filtrates are combined by filtration, the ethanol is recovered under reduced pressure, water is added to pass through macroporous resin, the eluate is washed with water until it is colorless, and then eluted with 50% ethanol, and the filtrate is frozen under vacuum to obtain notoginsenoside powder.
7. The ointment for treating cervical spondylotic radiculopathy according to claim 1, wherein pueraria root and paeonia lactiflora pall are decocted with water twice, the first time lasts for 2 hours, the second time lasts for 1 hour, the filtrate is combined with the two aqueous solutions, concentrated and precipitated with ethanol, the ethanol is recovered, and the concentrated solution becomes the clear paste with the relative density of 1.25-1.30 at 50 ℃.
8. The ointment for treating cervical spondylotic radiculopathy according to claim 1, wherein ligusticum wallichii and corydalis tuber are extracted by ethanol under reflux, the residue is discarded, the ethanol is recovered from the extract, and the extract is concentrated into clear paste with the relative density of 1.25-1.30 at 50 ℃.
9. The ointment for treating cervical spondylotic radiculopathy according to claim 1, wherein vaseline, stearic acid, rosin and azone are melted by heating to form a homogeneous oil phase, glycerol, potassium hydroxide and water are mixed to form a homogeneous water phase, and the homogeneous water phase is heated to 80 ℃ and then added to the oil phase to form the ointment base.
10. The ointment for treating cervical spondylotic radiculopathy of claim 9, wherein the ointment base is cooled to below 60 ℃ and then the extract of Chinese traditional medicine is added to the base and mixed well by stirring.
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| CN202110126930.1A CN112656846A (en) | 2021-01-29 | 2021-01-29 | Ointment for treating cervical spondylotic radiculopathy and preparation method thereof |
| PCT/CN2021/098699 WO2022160548A1 (en) | 2021-01-29 | 2021-06-07 | Ointment for treating cervical spondylotic radiculopathy and preparation method therefor |
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| WO2022160548A1 (en) * | 2021-01-29 | 2022-08-04 | 山东明仁福瑞达制药股份有限公司 | Ointment for treating cervical spondylotic radiculopathy and preparation method therefor |
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| CN115010618B (en) * | 2022-08-08 | 2022-11-01 | 江西省科学院应用化学研究所 | Separation and purification method of aureoyl amide alcohol ester capable of reducing uric acid and application thereof |
| CN115944677B (en) * | 2023-03-15 | 2023-05-26 | 赛灵药业科技集团股份有限公司北京分公司 | Pseudo-ginseng pain-relieving paste with stable active ingredients and preparation method thereof |
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| CN104887771A (en) * | 2014-03-06 | 2015-09-09 | 山东明仁福瑞达制药股份有限公司 | Medicinal preparation for treating nerve-root cervical spondylopathy, and preparation method and quality detection method thereof |
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| CN1228071C (en) * | 2003-03-24 | 2005-11-23 | 于少华 | Medicament for treating cervical spondylosis and its preparation method |
| CN111888395A (en) * | 2020-07-28 | 2020-11-06 | 山东明仁福瑞达制药股份有限公司 | Pharmaceutical composition, preparation method thereof and application thereof in scapulohumeral periarthritis treatment |
| CN111789887A (en) * | 2020-07-29 | 2020-10-20 | 山东明仁福瑞达制药股份有限公司 | Chinese herbal medicine health foot bath powder for improving osteoarticular diseases and preparation method thereof |
| CN111888396B (en) * | 2020-08-06 | 2022-06-07 | 山东明仁福瑞达制药股份有限公司 | Pharmaceutical composition for treating cervical spondylosis and preparation method and application thereof |
| CN112656846A (en) * | 2021-01-29 | 2021-04-16 | 山东明仁福瑞达制药股份有限公司 | Ointment for treating cervical spondylotic radiculopathy and preparation method thereof |
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| CN104887771A (en) * | 2014-03-06 | 2015-09-09 | 山东明仁福瑞达制药股份有限公司 | Medicinal preparation for treating nerve-root cervical spondylopathy, and preparation method and quality detection method thereof |
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