CN112649410A - Light source lens barrel device for multi-wave long-time resolution fluorescence measuring device - Google Patents
Light source lens barrel device for multi-wave long-time resolution fluorescence measuring device Download PDFInfo
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- CN112649410A CN112649410A CN202011564865.2A CN202011564865A CN112649410A CN 112649410 A CN112649410 A CN 112649410A CN 202011564865 A CN202011564865 A CN 202011564865A CN 112649410 A CN112649410 A CN 112649410A
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- xenon lamp
- light
- light source
- path
- lens barrel
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- 229910052724 xenon Inorganic materials 0.000 claims description 50
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 50
- 230000003287 optical effect Effects 0.000 claims description 46
- 210000004907 gland Anatomy 0.000 claims description 8
- 125000006850 spacer group Chemical group 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 abstract description 15
- 238000000338 in vitro Methods 0.000 abstract description 2
- 238000003018 immunoassay Methods 0.000 description 13
- 239000000370 acceptor Substances 0.000 description 11
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 6
- 238000002877 time resolved fluorescence resonance energy transfer Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 229910052761 rare earth metal Inorganic materials 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007885 magnetic separation Methods 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- NLMDJJTUQPXZFG-UHFFFAOYSA-N 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane Chemical compound C1COCCOCCNCCOCCOCCN1 NLMDJJTUQPXZFG-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002739 cryptand Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000009149 molecular binding Effects 0.000 description 1
- 230000001443 photoexcitation Effects 0.000 description 1
- 239000013636 protein dimer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000002910 rare earth metals Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
Abstract
The invention discloses a light source lens barrel device for a multi-wave long-time resolution fluorescence measuring device, which belongs to the field of medical optics application in IVD (in vitro diagnostic) medical instrument technology.
Description
Technical Field
The invention belongs to the field of medical optical application in IVD (in vitro diagnostic) medical instrument technology, and particularly relates to a light source lens barrel device for a multi-wave long-time resolution fluorescence measuring device.
Background
For more than half a century, the mainstream immunoassay technology is radio immunoassay, enzyme-linked immunoassay, chemiluminescence immunoassay and the like, wherein the radio immunoassay is used in a small amount at present due to the problem of radioactivity, the enzyme-linked immunoassay is gradually replaced due to long detection time, and the chemiluminescence immunoassay is the mainstream immunoassay technology at present. In the field of instant detection such as emergency treatment and the like, chemiluminescence is difficult to widely apply due to complex technology and high cost, and the demands promote instant detection type immunoassay technologies such as colloidal gold immunoassay, fluorescence chromatography immunoassay, colloidal turbidimetric immunoassay and the like. The chemiluminescence immunoassay technology is born in the seventies of the last century, the main technology adopted is magnetic particle chemiluminescence, the core hypothesis is that the separation of specific immune complexes and biological matrixes can be realized certainly through magnetic separation, but in clinical practical application, due to the diversity of clinical specimens, cases of magnetic separation failure cannot be avoided, such as 'jump value' phenomenon caused by nonspecific adsorption due to fibrin adhesion, false positive caused by heterophilic antibodies and the like. Half of the failures are due to magnetic cleaning failures for the instrument itself. Therefore, the cleaning-free immunoassay technology is a research hotspot for nearly two-thirty years, siemens, beckmann and other companies have related technology reserves, a series of high-flux immunoassay systems are provided by Beijing Koimei corporation of domestic enterprises based on the Siemens patent light-activated chemiluminescence technology, and the clinical application of cleaning-free detection is realized for the first time.
The time-resolved fluorescence resonance energy transfer immunoassay (TR-FRET) technology was originally developed by a supramolecular rare earth cryptand ether probe discovered by German Bolames (brahms) company based on Jean-Marie Lehn, Nobel chemical prize-winning France, and overcomes the influence of abnormal alignment accuracy of samples such as hemolysis, hyperlipidemia, jaundice and the like in homogeneous detection. Compared with other immunoassay technologies, the technology has many advantages, does not need a solid phase carrier and a solid phase probe, and has the advantages of good precision and accuracy, simple operation, easy automation and miniaturization and the like.
The core of the time-resolved fluorescence resonance energy transfer method is that two fluorescence molecules are called donor and acceptor respectively, wherein the donor can absorb exciting light and emit fluorescence, and the fluorescence can also be transmitted to the acceptor in a fluorescence resonance energy transfer mode and emitted by the acceptor. Specifically, a chelate label of a rare earth element having a cryptic structure is used as a fluorescence donor, and a short-lived fluorescent molecule having a good spectral overlap with the fluorescence donor is used as a fluorescence acceptor, and Fluorescence Resonance Energy Transfer (FRET) occurs between the donor and the acceptor (second fluorescent label) of the cryptic compound of a rare earth element. In fluorescence resonance energy transfer, the lifetime of the acceptor emitted fluorescence approaches that of the donor. Because the donor fluorescence decay period is long, the donor induces the acceptor to emit fluorescence for a long time, and the fluorescence generated after the acceptor is excited can last for a long time, so that the self-scattered fluorescence with short lifetime can be distinguished through time resolution, and the FRET signal can be easily distinguished from the background of the fluorescence with short lifetime.
The fluorescent donor and acceptor can be covalently linked to different partner molecules, e.g., protein dimers, complementary strands of DNA, antigens and antibodies, ligands and acceptors, and the like. Conventional FRET fluorescent compounds are susceptible to interference from background fluorescence of the sample (serum, plasma, buffers, proteins, chemicals and cell lysates). The lifetime of this background fluorescence is extremely short (10)-9On the order of seconds) it is easy to remove this interference by a time-resolved method. The time-resolved fluorescence resonance energy transfer (TR-FRET) technique combines the FRET technique and the time-resolved fluorescence measurement, and removes the extremely short-lived background fluorescence. After transient photoexcitation, the non-specific short-lived emission drops to zero after a delay of 50-150 microseconds. Whereas TR-FRET fluorophores emit long-lived fluorescence that participates in the FRET process. Thus, long-lived acceptor emission represents the energy transfer upon molecular binding.
Aiming at the time resolution energy transfer technology, an optical incident lens barrel with good light shading performance and high integration level is needed, most of the existing optical lens barrels are split structures and are mainly used for laboratory research, and the optical lens barrels are not suitable for being used by a multi-wave long-time resolution fluorescence measuring device.
Disclosure of Invention
The invention aims to provide a light source lens barrel device for a multi-wave long-time resolution fluorescence measuring device.
The technical solution for realizing the purpose of the invention is as follows:
a light source lens barrel device for a multi-wave long-time resolution fluorescence measuring device is characterized by comprising a xenon lamp light source component and a light path component which are connected; the optical path component comprises an optical path mirror sleeve and an optical element arranged in the optical path mirror sleeve; the optical path mirror sleeve is integrally formed, and a stepped structure is arranged in the optical path mirror sleeve and used for fixing the optical element.
Compared with the prior art, the invention has the following remarkable advantages:
the invention adopts an integrated light-entering optical path mirror sleeve structure, greatly improves the light shading performance of the optical path, integrates an optical element in the light-entering optical path mirror sleeve, has simple and compact structure and good stability, and can be directly applied to a corresponding detection device as a light-entering optical path component.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is an exploded view of a xenon lamp light source assembly and a xenon lamp gland.
Fig. 3 is an exploded view of the optical path entry component.
Fig. 4 is a cross-sectional view of the integral assembly of the present invention.
Detailed Description
The invention is further described with reference to the following figures and embodiments.
With reference to fig. 1, the light source lens barrel device for the multi-wavelength time-resolved fluorescence measuring device of the present invention is composed of a xenon lamp light source assembly 1, a xenon lamp gland 2, and a light inlet path assembly 3, wherein the light inlet path assembly 3 is a main body of the light source lens barrel device, and the xenon lamp assembly 1 is fixed on the light inlet path assembly 3 through thread matching by the xenon lamp gland 2 and the light inlet path lens sleeve 301, so as to form the light source lens barrel device for the multi-wavelength time-resolved fluorescence measuring device.
With reference to fig. 2, the xenon lamp assembly 1 includes a xenon lamp socket 101, a xenon lamp base 102 and a xenon lamp adjusting pad 103, the xenon lamp base 102 is inserted into the xenon lamp socket 101 to form a xenon lamp light source, and the xenon lamp light source is provided under the condition of power supply of a high-voltage power supply;
the xenon lamp adjusting pad 103 and the light-entering road mirror sleeve 301 are sleeved on the excircle of the xenon lamp holder 101, a circle of flange is arranged on the excircle of the xenon lamp holder 101, a plurality of xenon lamp adjusting pads 103 are arranged between the flange and the end face of the light-entering road mirror sleeve 301, and the distance from the xenon lamp light source to the optical element of the light-entering road component 3 is adjusted by adjusting the number of the xenon lamp adjusting pads 103.
Threads are processed on the inner side of the xenon lamp gland 2, and the xenon lamp component 1 is fixed on the light inlet path component 3 through matching with the external threads on the light inlet path mirror sleeve 301; and a reticulate pattern knurl is processed on the outer side of the xenon lamp gland 2, so that slipping during rotary installation and disassembly is prevented.
With reference to fig. 3, the light path entering component 3 includes a light path entering mirror sleeve 301, a lens cap 302, a collimating lens 303, a light path entering spacer 304, a pressing ring 305, and a light path entering filter 306; the optical lens sleeve 301 is a machined cylindrical part, is different from a split structure of a common optical lens barrel, is integrally formed, and has a stepped structure inside for fixing an optical element. The collimating lens 303 is mounted in the lens cap 302 and is mounted in the optical path mirror sleeve 301 together with the lens cap, the optical path spacer 304 is also mounted in the optical path mirror sleeve 301 after the collimating lens 303 is mounted in the optical path mirror sleeve 301, and is used for positioning the position of the collimating lens 303 and spacing the collimating lens 303 and the optical path filter 306, and the optical path filter 306 is mounted in the optical path mirror sleeve 301 and then axially positioned by the pressing ring 305 through thread fit, and locks elements in the optical path mirror sleeve 301.
With reference to fig. 1-4, the xenon lamp holder 102 is inserted into the xenon lamp holder 101 to form a xenon lamp light source, the light source is provided under the condition of power supply of a high-voltage power supply, the xenon lamp light source and the light-entering path component are fixed together by the xenon lamp gland 2 and the light-entering path mirror sleeve 301 through thread matching, and the distance from the xenon lamp light source to the optical element is adjusted by adjusting the number of the xenon lamp adjusting pads 103 arranged in front of and behind the fixing flange of the xenon lamp holder 102; the collimating lens 303 is mounted in the lens cap 302 and is mounted in the light-entering lens sleeve 301 together with the lens cap, the light-entering optical path spacer sleeve 304 is also mounted in the light-entering lens sleeve 301 after the collimating lens 303 is mounted in the light-entering lens sleeve 301 to determine the position of the collimating lens 303, then is mounted in the optical path optical filter 306, the components are locked by the pressing ring 305, the light emitted by the xenon lamp light source is collimated by the collimating lens 303 and then is filtered by the optical path optical filter 306, and a light source with fixed wavelength can be provided for the multi-wavelength time-resolved fluorescence measuring device.
Claims (10)
1. A light source lens barrel device for a multi-wave long-time resolution fluorescence measuring device is characterized by comprising a xenon lamp light source component (1) and a light path entering component (3) which are connected; the light inlet path component (3) comprises a light inlet path mirror sleeve (301) and an optical element arranged in the light inlet path mirror sleeve (301); the optical path mirror sleeve (301) is integrally formed, and a stepped structure is arranged in the optical path mirror sleeve and used for fixing an optical element.
2. The light source lens barrel device for the multiwave long-time resolution fluorescence measuring device according to claim 1, wherein the optical elements comprise a collimating lens (303), a light path filter (306); the light inlet optical filter (306) is arranged in the light inlet optical mirror sleeve (301) together; an optical path spacer bush (304) is arranged between the collimating lens (303) and the optical path filter (306); and a pressing ring (305) is connected in the light path lens sleeve (301) and is used for axially positioning the light path filter (306).
3. The light source lens barrel device for the multiwave long-time resolution fluorescence measuring device according to claim 2, wherein the pressing ring (305) is screwed with the light path lens sleeve (301).
4. The light source lens barrel device for the multi-wave long-time resolution fluorescence measuring device according to claim 1, wherein the xenon lamp component (1) is fixed on the light inlet path component (3) through a screw thread fit by a xenon lamp gland (2) and a light inlet path lens sleeve (301).
5. The light source lens barrel device for the multi-wave long-time resolution fluorescence measuring device according to claim 4, wherein a knurled pattern is processed on the outer side of the xenon lamp gland (2).
6. The light source lens barrel device for the multi-wave long-time resolution fluorescence measuring device according to claim 1, wherein the xenon lamp component (1) comprises a xenon lamp holder (101), a xenon lamp cap (102); the xenon lamp holder (102) is inserted into the xenon lamp holder (101) to form a xenon lamp light source.
7. The light source lens barrel device for the multiwave long-time resolution fluorescence measuring device according to claim 1, wherein the distance between the xenon lamp assembly (1) and the optical element of the light incoming path assembly (3) is adjustable.
8. The light source lens barrel device for the multiwave long-time resolution fluorescence measuring device according to claim 7, wherein a plurality of xenon lamp adjusting pads (103) are arranged between the optical elements of the xenon lamp component (1) and the light inlet path component (3).
9. The light source lens barrel device for the multi-wave long-time resolution fluorescence measuring device according to claim 8, wherein a circle of flange is arranged on the excircle of the xenon lamp holder (101), the xenon lamp adjusting pad (103) and the light inlet road mirror sleeve (301) are sleeved on the excircle of the xenon lamp holder (101), and the xenon lamp adjusting pad (103) is arranged between the flange and the end face of the light inlet road mirror sleeve (301).
10. The light source lens barrel device for the multiwave long-time resolution fluorescence measuring device according to claim 1, wherein the light path lens sleeve (301) is a cylindrical structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011564865.2A CN112649410A (en) | 2020-12-25 | 2020-12-25 | Light source lens barrel device for multi-wave long-time resolution fluorescence measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011564865.2A CN112649410A (en) | 2020-12-25 | 2020-12-25 | Light source lens barrel device for multi-wave long-time resolution fluorescence measuring device |
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| CN112649410A true CN112649410A (en) | 2021-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011564865.2A Pending CN112649410A (en) | 2020-12-25 | 2020-12-25 | Light source lens barrel device for multi-wave long-time resolution fluorescence measuring device |
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| CN (1) | CN112649410A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115931808A (en) * | 2023-02-09 | 2023-04-07 | 北京鹏宇昌亚环保科技有限公司 | Totally-enclosed light path device of mercury detector |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192350A (en) * | 1997-03-02 | 1998-09-09 | 邢刚 | Optical system for mastotic diagnostic instrument |
| CN102444792A (en) * | 2010-10-06 | 2012-05-09 | 鸿富锦精密工业（深圳）有限公司 | LED (light emitting diode) illumination device |
| CN102840528A (en) * | 2011-08-26 | 2012-12-26 | 南通突优科技创业有限公司 | Automotive xenon lamp capable of being subjected to manual focusing |
| CN203337549U (en) * | 2013-06-28 | 2013-12-11 | 陕西师范大学 | Optical assembly suitable for fluorescence detection of micro-trace explosives |
| CN205316183U (en) * | 2015-10-26 | 2016-06-15 | 惠州市西顿工业发展有限公司 | Spot lamp |
| CN206862893U (en) * | 2017-04-24 | 2018-01-09 | 中国石油兰州石油化工公司研究院 | A kind of optical path component for controlling Ultraluminescence bandwidth |
| CN207408729U (en) * | 2017-08-08 | 2018-05-25 | 上海孚起机电科技有限公司 | A kind of projection arrangement for guiding production station manipulation |
| CN110174352A (en) * | 2019-04-12 | 2019-08-27 | 吉林亚泰中科医疗器械工程技术研究院股份有限公司 | A kind of homogeneous phase time discrimination light path detecting device on multi-function microplate reader |
-
2020
- 2020-12-25 CN CN202011564865.2A patent/CN112649410A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1192350A (en) * | 1997-03-02 | 1998-09-09 | 邢刚 | Optical system for mastotic diagnostic instrument |
| CN102444792A (en) * | 2010-10-06 | 2012-05-09 | 鸿富锦精密工业（深圳）有限公司 | LED (light emitting diode) illumination device |
| CN102840528A (en) * | 2011-08-26 | 2012-12-26 | 南通突优科技创业有限公司 | Automotive xenon lamp capable of being subjected to manual focusing |
| CN203337549U (en) * | 2013-06-28 | 2013-12-11 | 陕西师范大学 | Optical assembly suitable for fluorescence detection of micro-trace explosives |
| CN205316183U (en) * | 2015-10-26 | 2016-06-15 | 惠州市西顿工业发展有限公司 | Spot lamp |
| CN206862893U (en) * | 2017-04-24 | 2018-01-09 | 中国石油兰州石油化工公司研究院 | A kind of optical path component for controlling Ultraluminescence bandwidth |
| CN207408729U (en) * | 2017-08-08 | 2018-05-25 | 上海孚起机电科技有限公司 | A kind of projection arrangement for guiding production station manipulation |
| CN110174352A (en) * | 2019-04-12 | 2019-08-27 | 吉林亚泰中科医疗器械工程技术研究院股份有限公司 | A kind of homogeneous phase time discrimination light path detecting device on multi-function microplate reader |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115931808A (en) * | 2023-02-09 | 2023-04-07 | 北京鹏宇昌亚环保科技有限公司 | Totally-enclosed light path device of mercury detector |
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Application publication date: 20210413 |
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