CN112648736A - A pot-type freeze thawing system for freezing of bio-pharmaceuticals material, unfreeze - Google Patents
A pot-type freeze thawing system for freezing of bio-pharmaceuticals material, unfreeze Download PDFInfo
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- CN112648736A CN112648736A CN202011619145.1A CN202011619145A CN112648736A CN 112648736 A CN112648736 A CN 112648736A CN 202011619145 A CN202011619145 A CN 202011619145A CN 112648736 A CN112648736 A CN 112648736A
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- freezing
- thawing
- heat conduction
- conduction oil
- tank
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24H—FLUID HEATERS, e.g. WATER OR AIR HEATERS, HAVING HEAT-GENERATING MEANS, e.g. HEAT PUMPS, IN GENERAL
- F24H7/00—Storage heaters, i.e. heaters in which the energy is stored as heat in masses for subsequent release
- F24H7/02—Storage heaters, i.e. heaters in which the energy is stored as heat in masses for subsequent release the released heat being conveyed to a transfer fluid
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24H—FLUID HEATERS, e.g. WATER OR AIR HEATERS, HAVING HEAT-GENERATING MEANS, e.g. HEAT PUMPS, IN GENERAL
- F24H9/00—Details
- F24H9/18—Arrangement or mounting of grates or heating means
- F24H9/1809—Arrangement or mounting of grates or heating means for water heaters
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24H—FLUID HEATERS, e.g. WATER OR AIR HEATERS, HAVING HEAT-GENERATING MEANS, e.g. HEAT PUMPS, IN GENERAL
- F24H9/00—Details
- F24H9/20—Arrangement or mounting of control or safety devices
- F24H9/2007—Arrangement or mounting of control or safety devices for water heaters
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- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses a tank-type freezing and thawing system for freezing and thawing biopharmaceutical materials, which is characterized by comprising a control system, a freezing and thawing unit, a freezing and thawing tank, power equipment and a feed liquid circulating pipeline; the freeze-thaw tank comprises a tank body; an end cap for sealing the can body; a first pipeline for material flow, wherein a feed inlet and a discharge outlet at two ends of the first pipeline are respectively exposed out of the tank body, and the feed inlet and the discharge outlet are communicated with a feed liquid circulation pipeline; the heat conduction oil inlet and the heat conduction oil outlet at two ends of the heat conduction oil coil are respectively exposed out of the tank body, and are respectively communicated with the freeze thawing unit through an inlet pipe and a return pipe; a section of concentric pipe is arranged in the heat-conducting oil coil pipe and sleeved outside the first pipeline; and a heat conduction oil port of the jacket is communicated with the heat conduction oil coil through a second pipeline. Compared with the traditional freezing and thawing device, the invention can realize efficient and uniform freezing and thawing operation.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical production mechanical equipment or medical instruments, relates to biological material processing equipment (such as freezing, unfreezing and the like), and particularly relates to a tank type freezing and thawing system for freezing and unfreezing biological pharmaceutical materials.
Background
At present, most of domestic biological pharmaceutical companies and scientific research institutions adopt traditional low-temperature refrigerators, low-temperature cold stores and the like to freeze biological pharmaceutical materials; the biological medicine material is still unfrozen at room temperature in a water bath kettle and the like. The container filled with the biopharmaceutical material is placed under a low-temperature refrigerator or a low-temperature cold storage for freezing, low-temperature air is obtained by accelerating the heat exchange between the air and a refrigerant in the refrigerator or the cold storage, and the aim of rapidly freezing a working area is fulfilled by a low-temperature air forced convection blowing mode; thawing, directly taking out from low temperature refrigerator or cold storage, and slowly thawing in room temperature or water bath.
The low-temperature refrigerator, the low-temperature cold storage or the room temperature and water bath kettle and the like used at present have the following defects:
1. due to the structural limitation of a freezing working space and the limitation of an air freezing and thawing working principle, the environmental temperature difference at different spatial positions in the working space is serious; during the freezing and thawing process of the biopharmaceutical material, different sub-packaging materials of the same batch of material are in different freezing and thawing states in the freezing and thawing process due to different freezing working space positions and different peripheral temperatures, so that the whole freezing and thawing process is inconsistent and the process is uncontrollable.
2. In the freezing and unfreezing process, a freezing working space is fixed and unchanged, and the environmental temperature difference at different spatial positions in the working space is serious; the relationship between the phase transition temperature of the biopharmaceutical material and the temperature change of the surrounding environment cannot be accurately determined along with the change of the quantity of the biopharmaceutical material, so that the process amplification control cannot be carried out.
3. The relationship between the phase change temperature of the biopharmaceutical material and the temperature change of the surrounding environment cannot be accurately determined, the process record of a temperature curve is not available, and the quality of the product cannot be ensured.
4. Because different sub-packaging materials of the same batch of materials are in different freezing and unfreezing states in the freezing and unfreezing processes, the whole freezing and unfreezing processes are not uniformly carried out, the whole synchronous processing cannot be ensured in the processing process of the biological pharmaceutical materials, and the condition that the quality of the same batch of biological pharmaceutical materials is not uniform is further caused, so that the quality evaluation is influenced, and the quality guarantee period of the whole effective activity is shorter.
Disclosure of Invention
The invention aims to solve the problems that: the tank-type freezing and thawing system for freezing and thawing the biopharmaceutical material is provided to solve the problem of nonuniform material temperature in the freezing and thawing process and ensure that the biopharmaceutical material meets the production specification requirements in the freezing and thawing process.
In order to solve the problems, the invention adopts the following technical scheme:
a can-type freeze-thaw system for freezing and thawing biopharmaceutical materials, comprising:
a control system;
the freezing and thawing unit is controlled by a control system and is used for controlling the temperature of the heat-conducting oil;
the freeze thawing tank is used for exchanging heat between the heat conduction oil and the materials;
the power equipment (controlled by the control system) and the feed liquid circulating pipeline are used for enabling the materials in the freezing and thawing tank to circularly flow;
the electrical cabinet is used for mounting and protecting electrical components;
the freeze-thaw tank includes:
a tank body;
an end cap for sealing the can body;
a first pipeline for material flow, wherein a feed inlet and a discharge outlet at two ends of the first pipeline are respectively exposed out of the tank body, and the feed inlet and the discharge outlet are communicated with a feed liquid circulation pipeline;
the heat conduction oil inlet and the heat conduction oil outlet at two ends of the heat conduction oil coil are respectively exposed out of the tank body, and are respectively communicated with the freeze thawing unit through an inlet pipe and a return pipe; a section of concentric pipe is arranged in the heat-conducting oil coil pipe and sleeved outside the first pipeline;
and a heat conduction oil port of the jacket is communicated with the heat conduction oil coil through a second pipeline.
Preferably, the outer side of the tank body is provided with an insulating layer.
Preferably, the end cap is secured by a locking device.
Preferably, the freeze-thaw tank further comprises a sight glass for viewing the interior of the tank body.
Preferably, the freeze-thaw tank further comprises a temperature probe for measuring the temperature of the material in the tank.
Preferably, the freeze-thaw tank further comprises a drain interface for draining the tank body.
Preferably, the outer side of the tank body is provided with a handle, the top of the tank body is provided with a lifting lug, and the bottom of the tank body is provided with a support caster.
Preferably, the end cover is provided with at least one of a cleaning water interface for cleaning the tank body, a sterilization medium interface for sterilizing the tank body, a pressure gauge interface, a safety valve interface and a standby interface.
Preferably, the heat conducting oil coils are uniformly distributed in the tank body.
Compared with the prior art, the invention has the following beneficial effects:
1. the freeze-thaw tank of the tank type freeze-thaw system bears heat conduction oil through the jacket and the coil pipes in the tank, and the biological pharmaceutical material is frozen or thawed inside and outside at the same time, so that the efficiency is higher compared with the single-surface refrigeration or heating in the modes of a traditional refrigerator, a cold storage, a room temperature, a water bath and the like;
2. according to the freeze-thaw tank of the tank-type freeze-thaw system, the coils are uniformly distributed in the horizontal and longitudinal three-dimensional space, so that the temperature of the biopharmaceutical material in the whole tank body is more uniform;
3. the biopharmaceutical materials in the freezing and thawing tank of the tank-type freezing and thawing system can flow under the action of external force, and compared with the traditional static refrigeration or heating condition, the biopharmaceutical materials in the freezing and thawing tank can be effectively mixed, so that the temperature of the biopharmaceutical materials in the tank is more uniform; meanwhile, by means of the mixing of the biological pharmaceutical materials, cold or heat can permeate into any corner in the tank more quickly, and the freezing or thawing efficiency is higher.
4. The biopharmaceutical material in the freezing and thawing tank of the tank-type freezing and thawing system can flow under the action of external force, the outer side of the flow pipe in the tank is provided with the concentric pipe, and hot oil is conducted in the concentric pipe, so that the flowing biopharmaceutical material is always kept in close contact with the heat-conducting oil in the flowing process, the effective transmission and absorption of cold and heat are facilitated, and the freezing or thawing efficiency is higher.
Drawings
FIG. 1 is a schematic structural diagram of a can-type freeze thawing system provided by the present invention;
fig. 2 is a schematic diagram of the construction of a freeze-thaw tank.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings.
Examples
As shown in fig. 1, there is provided a freeze/thaw system of a can type for freezing and thawing biopharmaceutical materials, comprising:
the freezing and thawing unit 2 is used for controlling the temperature of the heat-conducting oil;
the freeze thawing tank 5 is used for exchanging heat between the heat conduction oil and the materials;
the power equipment 7 and the feed liquid circulating pipeline 6 are used for enabling materials in the freezing and thawing tank 5 to flow circularly;
the control system 1 is used for controlling all electronic components, including a freeze thawing unit 2, a power device 7, a temperature probe 5-2 and the like;
and the electrical cabinet 8 is used for mounting and protecting electrical components.
As shown in fig. 2, the freezing and thawing tank 5 includes:
5-14 parts of a tank body;
the end cover 5-5 is used for sealing the tank body, and the end cover 5-5 is fixed through a locking device 5-7; the end covers 5-5 are provided with a cleaning water interface for cleaning the tank body, a sterilization medium interface for sterilizing the tank body, a pressure gauge interface, a safety valve interface and a standby interface;
a first pipeline 5-15 for material flow, wherein a feed inlet 5-3 and a discharge outlet 5-17 at two ends of the first pipeline 5-15 are respectively exposed out of the tank body 5-14, and the feed inlet 5-3 and the discharge outlet 5-17 are communicated with the feed liquid circulation pipeline 6 to realize the flow of materials;
a jacket 5-11 for adjusting the temperature of the tank body;
the heat conduction oil coil pipes 5-11 are used for bearing heat conduction oil, and the heat conduction oil coil pipes 5-11 are uniformly distributed in the tank bodies 5-14; one end of the heat-conducting oil coil pipe 5-11 is a heat-conducting oil outlet 5-8, the other end is connected with a heat-conducting oil port of the jacket 5-11 through a pipeline II 5-6, the other heat-conducting oil port of the jacket 5-11 is connected with a heat-conducting oil inlet 5-16, the heat-conducting oil inlet 5-16 and the heat-conducting oil outlet 5-8 are respectively exposed out of the tank body 5-14, and the heat-conducting oil inlet 5-16 and the heat-conducting oil outlet 5-8 are respectively communicated with the freezing and thawing unit 2 through the inlet pipe 3 and the return pipe 4, so that indirect freezing and thawing of materials in; a section of concentric pipe 5-1 is arranged in the heat conducting oil coil pipe 5-11 and is sleeved outside the first pipeline 5-15;
a sight glass 5-4 for observing the inside of the tank body;
a temperature probe 5-2 for measuring the temperature of the materials in the tank 5-14;
and the drainage interface 5-18 for draining the tank body is positioned at the bottom of the tank body 5-14.
And 5-12 heat-insulating layers are arranged on the outer sides of the tank bodies 5-14.
The outer side of the tank body 5-14 is also provided with a handle 5-10, the top is provided with a lifting lug 5-9, and the bottom is provided with a support caster 5-19.
The working process of the equipment is as follows:
the freeze thawing unit 2 and the power equipment 7 are opened through the control system 1, namely a heat conduction oil circulation loop and a material circulation loop are started;
the heat-conducting oil enters the bottoms of the jackets 5-13 of the freeze-thawing tank 5 through heat-conducting oil inlets 5-16 and heat-conducting oil ports at the bottoms of the jackets 5-13, flows out of the heat-conducting oil ports at the tops of the jackets 5-13, enters the heat-conducting oil coil pipes 5-11 in the tank bodies 5-14 of the freeze-thawing tank 5 through the pipelines 5-6, and returns to the freeze-thawing unit 2 through heat-conducting oil outlets 5-8.
The material (biological pharmacy material) enters the material liquid circulation pipeline 6 through the discharge port 5-17 under the action of the power device 7, passes through the power device 7, and then returns to the freezing and thawing tank 5 from the feed port 5-3.
The biological pharmaceutical material is frozen or thawed in the freezing and thawing tank 5 under the influence of the heat conducting oil in the heat conducting oil coil pipes 5-11 and the jackets 5-13. Meanwhile, the biopharmaceutical materials are cooled or heated by the heat conduction oil in the concentric tube 5-1 through the first pipeline 5-15 in the circulation process.
The temperature probe 5-2 in the freezing and thawing tank 5 monitors the temperature of the biopharmaceutical material in real time and feeds back the temperature to the control system 1 for judging the start and stop of refrigeration or heating.
The biological products in the whole freezing and thawing tank 5 can uniformly and efficiently receive cold or heat in the whole freezing or thawing process, and can realize efficient freezing and thawing.
Claims (9)
1. A can-type freeze-thaw system for freezing and thawing biopharmaceutical materials, comprising:
a control system (1);
the freezing and thawing unit (2) is used for controlling the temperature of the heat-conducting oil;
the freezing and thawing tank (5) is used for exchanging heat between the heat conduction oil and the materials;
the power equipment (7) and the feed liquid circulating pipeline (6) are used for enabling the materials in the freezing and thawing tank (5) to circularly flow;
the freeze-thaw tank (5) includes:
a tank body (5-14);
an end cap (5-5) for sealing the can body;
a first pipeline (5-15) for material flow, wherein the feed inlet (5-3) and the discharge outlet (5-17) at two ends of the first pipeline (5-15) are respectively exposed out of the tank body (5-14), and the feed inlet (5-3) and the discharge outlet (5-17) are communicated with the material liquid circulation pipeline (6);
the heat conduction oil cooling system comprises heat conduction oil coils (5-11) for bearing heat conduction oil, wherein heat conduction oil inlets (5-16) and heat conduction oil outlets (5-8) at two ends of the heat conduction oil coils (5-11) are respectively exposed out of a tank body (5-14), and the heat conduction oil inlets (5-16) and the heat conduction oil outlets (5-8) are respectively communicated with a freeze thawing unit (2) through an inlet pipe (3) and a return pipe (4); a section of concentric pipe (5-1) is arranged in the heat conducting oil coil pipe (5-11) and is sleeved outside the first pipeline (5-15);
and a heat conducting oil port of the jacket (5-11) is communicated with the heat conducting oil coil (5-11) through a second pipeline (5-6).
2. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said cans (5-14) are provided with insulation (5-12) on the outside.
3. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said end caps (5-5) are secured by locking means (5-7).
4. The can-type freezing and thawing system for freezing and thawing of biopharmaceutical materials of claim 1, wherein said freezing and thawing can (5) further comprises a sight glass (5-4) for viewing the interior of the can body.
5. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said freezing and thawing can (5) further comprises a temperature probe (5-2) for determining the temperature of the material in the can body (5-14).
6. The can-type freezing and thawing system for freezing and thawing of biopharmaceutical materials of claim 1, wherein said freezing and thawing can (5) further comprises a drain interface (5-18) for draining the can body.
7. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said cans (5-14) are provided with handles (5-10) on the outside, lifting lugs (5-9) on the top and support casters (5-19) on the bottom.
8. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said end caps (5-5) are provided with at least one of a cleaning water port for cleaning the can, a sterilization medium port for sterilizing the can, a pressure gauge port, a safety valve port, and a standby port.
9. The can-type freezing and thawing system for freezing and thawing biopharmaceutical materials of claim 1, wherein said thermally conductive oil coils (5-11) are evenly distributed within said cans (5-14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011619145.1A CN112648736A (en) | 2020-12-30 | 2020-12-30 | A pot-type freeze thawing system for freezing of bio-pharmaceuticals material, unfreeze |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011619145.1A CN112648736A (en) | 2020-12-30 | 2020-12-30 | A pot-type freeze thawing system for freezing of bio-pharmaceuticals material, unfreeze |
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| Publication Number | Publication Date |
|---|---|
| CN112648736A true CN112648736A (en) | 2021-04-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202011619145.1A Pending CN112648736A (en) | 2020-12-30 | 2020-12-30 | A pot-type freeze thawing system for freezing of bio-pharmaceuticals material, unfreeze |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114152015A (en) * | 2021-11-25 | 2022-03-08 | 南通恒信达冷冻设备有限公司 | Liquid nitrogen freeze thawing machine |
-
2020
- 2020-12-30 CN CN202011619145.1A patent/CN112648736A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114152015A (en) * | 2021-11-25 | 2022-03-08 | 南通恒信达冷冻设备有限公司 | Liquid nitrogen freeze thawing machine |
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