CN1126473C - Product containing tetiahydriopalmatime for curing opium-addiction and heroinomania and method for production thereof - Google Patents
Product containing tetiahydriopalmatime for curing opium-addiction and heroinomania and method for production thereof Download PDFInfo
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- CN1126473C CN1126473C CN01802359A CN01802359A CN1126473C CN 1126473 C CN1126473 C CN 1126473C CN 01802359 A CN01802359 A CN 01802359A CN 01802359 A CN01802359 A CN 01802359A CN 1126473 C CN1126473 C CN 1126473C
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- Prior art keywords
- addiction
- tetiahydriopalmatimefor
- cigarette
- heroinomania
- curing opium
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- 206010013663 drug dependence Diseases 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title description 3
- 208000004224 Opium Dependence Diseases 0.000 title 1
- 235000019504 cigarettes Nutrition 0.000 claims abstract description 67
- 206010012335 Dependence Diseases 0.000 claims abstract description 61
- 239000003814 drug Substances 0.000 claims abstract description 49
- 238000002360 preparation method Methods 0.000 claims abstract description 32
- 235000013305 food Nutrition 0.000 claims abstract description 28
- 239000000725 suspension Substances 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 21
- 235000013361 beverage Nutrition 0.000 claims abstract description 19
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 239000002253 acid Substances 0.000 claims abstract description 10
- 239000003021 water soluble solvent Substances 0.000 claims abstract description 8
- 239000008896 Opium Substances 0.000 claims description 91
- 229960001027 opium Drugs 0.000 claims description 91
- 241000208125 Nicotiana Species 0.000 claims description 36
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 10
- 235000015218 chewing gum Nutrition 0.000 claims description 9
- 229940112822 chewing gum Drugs 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- 235000009508 confectionery Nutrition 0.000 claims description 7
- 235000014214 soft drink Nutrition 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 4
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 4
- 235000016709 nutrition Nutrition 0.000 claims description 3
- 230000035764 nutrition Effects 0.000 claims description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 claims description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 44
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract description 14
- 239000002994 raw material Substances 0.000 abstract description 8
- 229960005181 morphine Drugs 0.000 abstract description 7
- 208000024891 symptom Diseases 0.000 abstract description 7
- 238000007796 conventional method Methods 0.000 abstract description 6
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 238000001784 detoxification Methods 0.000 description 9
- 239000000243 solution Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- 208000019901 Anxiety disease Diseases 0.000 description 3
- 206010052804 Drug tolerance Diseases 0.000 description 3
- 230000036506 anxiety Effects 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000026781 habituation Effects 0.000 description 3
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 3
- 229960003086 naltrexone Drugs 0.000 description 3
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 2
- 206010009866 Cold sweat Diseases 0.000 description 2
- 230000000680 avirulence Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229960001797 methadone Drugs 0.000 description 2
- 230000036407 pain Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000004799 sedative–hypnotic effect Effects 0.000 description 2
- 239000003390 Chinese drug Substances 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 241001539473 Euphoria Species 0.000 description 1
- 206010015535 Euphoric mood Diseases 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacture Of Tobacco Products (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Confectionery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to a product for preventing the relapse of drug addition, which contains tetiahydriopalmatime, and a preparation method thereof. The product of the present invention can relieve abstinence symptoms of morphine drugs and inhibit internal addiction to drugs. The present invention has the advantages of no toxicity, no addiction, no drug dependence, convenient use, reasonable price and simple preparation process. The product of the present invention comprises cigarettes, food and beverages, and the usage amount of the tetiahydriopalmatime ranges between 3/1000 and 50/1000. The preparation method of the product of the present invention comprises the steps that tetiahydriopalmatime is prepared into fine powder at normal temperature in an environment without light, and then, the fine powder is uniformly mixed with raw materials of the product so as to obtain the product of the present invention; or the fine powder is mixed with an acid water soluble solvent so as to obtain a suspension solution, the suspension solution is mixed with the raw materials of the product, and then, a mixture of the suspension solution and the raw materials is prepared into the product of the present invention by means of a conventional method.
Description
Invention field
The present invention relates to tetiahydriopalmatimefor for curing opium at the application of addiction and heroinomania and the goods and preparation method thereof that contain the addiction and heroinomania of tetiahydriopalmatimefor for curing opium, the invention still further relates to cigarette of containing tetiahydriopalmatimefor for curing opium, drink and food of a kind of addiction and heroinomania and preparation method thereof, particularly a kind ofly can alleviate the drugs such as morphine withrawal symptom and suppress cigarette of containing tetiahydriopalmatimefor for curing opium, drink and food to the addiction and heroinomania of drugs heart addiction and preparation method thereof.
Background technology
At present, internationally recognized drug rehabilitation is divided into detoxification and pre-two stages of preventing suction again.International and domesticly still do not have desirable method and a technology in the pre-preventing suction again stage, cause probability that drug abstainer reverts to take drugs 100% nearly.International and domestic scholar recommends to use methadone and naltrexone to be used for pre-preventing suction again, but methadone medicine as an alternative belongs to similar have habituation and dependent analgesia arcotic with drugs such as morphine, finally can only allow drug abstainer take all the life, this is actually a kind of drug and replaces another kind of drug, and need every day and take one glass, implement very difficulty.Naltrexone is as the antagonist of drugs such as morphine, can eliminate the floaty euphoria that drugs such as morphine brings, and produce a series of discomforts when drug abstainer is reverted to take drugs, but need take for a long time could be effectively for naltrexone, and to regularly carry out urine examination measuring and calculating consumption, drug abstainer is difficult to persist.Referring to " Chinese drug-dependent magazine " the 3rd, 4 phases in 1998,1999 the 1st, 2,3,4 phases, 2000 1,2,3 phases.
Goal of the invention
One object of the present invention is existingly to be used to prevent the weak point of medicine that drug abstainer is reverted to take drugs or preparation and a kind of cigarette of containing tetiahydriopalmatimefor for curing opium, drink and food of addiction and heroinomania are provided in order to overcome, the cigarette of containing tetiahydriopalmatimefor for curing opium of addiction and heroinomania of the present invention, drink and food can be alleviated the drugs such as morphine withrawal symptom and suppress drugs heart addiction, avirulence, habituation not, do not form pharmacological dependence, easy to use, cost is reasonable, and manufacturing process is simple.
Another object of the present invention is to provide the cigarette of containing tetiahydriopalmatimefor for curing opium of aforesaid addiction and heroinomania, the preparation method of drink and food.
Summary of the invention
The invention provides a kind of cigarette of addiction and heroinomania, it is characterized in that: described cigarette is contained tetiahydriopalmatimefor for curing opium.
The present invention also provides a kind of preparation method of cigarette of addiction and heroinomania, comprising: with tetiahydriopalmatimefor for curing opium at the fine powder of making under lucifuge, the normal temperature more than 100 orders; Under the lucifuge condition, fine powder is added the acid water soluble solvent and make suspension, evenly be sprayed at the aqueous suspension of resulting tetiahydriopalmatimefor for curing opium on the pipe tobacco; The pipe tobacco cigarette preparation method routinely that will contain tetiahydriopalmatimefor for curing opium rolls, packs.
The present invention also provides a kind of food of addiction and heroinomania, it is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described food.
The present invention also provides a kind of beverage of addiction and heroinomania, it is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described beverage.
The detailed description of invention
Along with day by day seriously changing of this social concern of taking drugs, people prevent medicine and the preparation that drug abstainer is reverted to take drugs after developing various drug rehabilitations and drug rehabilitation.Tetiahydriopalmatimefor for curing opium is a kind of common drug of record in " Pharmacopoea Chinensis ".After tetiahydriopalmatimefor for curing opium oral administration or the intramuscular injection, has sedative-hypnotic effect.The present inventor finds that through a large amount of screenings and experiment to various medicines tetiahydriopalmatimefor for curing opium except having sedative-hypnotic effect, also has the withrawal symptom of alleviating drugs such as morphine, suppresses the effect that drug abstainer was thirsted for the psychology of drugs in the detoxification later stage.Especially after tetiahydriopalmatimefor for curing opium and pipe tobacco mixing ignition are sucked, drug rehabilitation, heart-addiction prevented effect are more obvious.We know that smoking is very close with the relation of taking drugs, and majority still can not abandon sucking cigarette behind the drug abstainer narcotics abstinence, and smoking occupies extremely important status psychologically the drug addict.Tetiahydriopalmatimefor for curing opium is made cigarette as active component offer drug abstainer, drug abstainer is sucked the medicine of pre-preventing suction again in conscious or automatic smoking process, finally reach the purpose of pre-preventing suction again drugs, drug abstainer is taken like a shot and can be used for a long time, the active component avirulence of the cigarette of this addiction and heroinomania, non-habituation, can not form pharmacological dependence, manufacturing process is simple, reasonable price.
Based on above-mentioned discovery, the invention provides a kind of cigarette of addiction and heroinomania, it is characterized in that: described cigarette is contained tetiahydriopalmatimefor for curing opium.
According to the cigarette of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption counts 6.25 ‰-50 ‰ by the pipe tobacco gross weight.
According to the cigarette of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption is preferably 12.5 ‰-43.75 ‰ by the pipe tobacco gross weight.
According to the cigarette of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption is preferably 18.75 ‰-37.5 ‰ by the pipe tobacco gross weight.
According to the cigarette of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption is preferably 25 ‰-31.25 ‰ by the pipe tobacco gross weight.
The present invention also provides the preparation method of the cigarette of aforesaid addiction and heroinomania, comprising:
(1) with tetiahydriopalmatimefor for curing opium at the fine powder of making under lucifuge, the normal temperature more than 100 orders;
(2) under the lucifuge condition, described fine powder is added the acid water soluble solvent and make suspension, evenly be sprayed at suspension on the pipe tobacco and mix;
(3) the cigarette cut tobacco cigarette preparation method routinely who step (2) is obtained rolls, packs.
According to the inventive method, wherein said acid water soluble solvent is the mixture of at least a alcohol in water and the C2-C5 alcohol, and the acid that wherein contains is sulfuric acid or hydrochloric acid.
According to the inventive method, the alcohol in the wherein said acid water soluble solvent is ethanol, propyl alcohol, propane diols, butanols, butanediol, amylalcohol, pentanediol or its mixture.
Based on above-mentioned discovery, the present invention also provides a kind of food of addiction and heroinomania, it is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described food.
According to the food of addiction and heroinomania of the present invention, wherein said food can be various food, preferably is convenient to often edible food, for example biscuit, candy or chewing gum.
According to the food of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption counts 3 ‰-25 ‰ by the gross weight of food.
The present invention also provides a kind of beverage of addiction and heroinomania, it is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described beverage.
According to the beverage of addiction and heroinomania of the present invention, wherein said tetiahydriopalmatimefor for curing opium consumption counts 3 ‰-25 ‰ by the gross weight of beverage.
Beverage according to addiction and heroinomania of the present invention is characterized in that: described beverage can be various soft drinks or nutrition oral administration.
The preparation method of the food of the addiction and heroinomania that contains tetiahydriopalmatimefor for curing opium of the present invention is the preparation method of conventional food, just tetiahydriopalmatimefor for curing opium is ground to form granularity greater than 100 purpose fine powders under lucifuge, normal temperature, raw material with preparation food mixes then, again with its conventional method food prepared therefrom according to preparation food, for example candy or chewing gum.
The preparation method of the beverage of the addiction and heroinomania that contains tetiahydriopalmatimefor for curing opium of the present invention is, earlier with tetiahydriopalmatimefor for curing opium at the fine powder of making under lucifuge, the normal temperature more than 100 orders; Under the lucifuge condition, described fine powder is added the acid water soluble solvent by aforesaid method and make suspension, suspension is scattered in the beverage gets final product again.
Implement best mode of the present invention
The present invention is described further with the test example below in conjunction with non-limiting embodiment.
Embodiment 1
Tetiahydriopalmatimefor for curing opium ground under lucifuge, 25 ℃ of conditions make 120 order fine powders, acidity (sulfuric acid) solution mixing system with itself and water and propane diols gets suspension then.Under the lucifuge condition, evenly be sprayed at prepared suspension on the pipe tobacco and mix.In every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 30 milligrams.The pipe tobacco that obtains is thus rolled, is packaged to be the cigarette of addiction and heroinomania of the present invention according to preparation method conventional in the cigarette field.
Embodiment 2
Tetiahydriopalmatimefor for curing opium ground under lucifuge, 25 ℃ of conditions make 100 order fine powders, acidity (sulfuric acid) solution mixing system with itself and water and butanediol gets suspension then.Under the lucifuge condition, evenly be sprayed at prepared suspension on the pipe tobacco and mix.In every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 15 milligrams.The pipe tobacco that obtains is thus rolled, is packaged to be the cigarette of addiction and heroinomania of the present invention according to preparation method conventional in the cigarette field.
Embodiment 3
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 1, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 40 milligrams.
Embodiment 4
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 2, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 35 milligrams.
Embodiment 5
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 2, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 25 milligrams.
Embodiment 6
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 1, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 20 milligrams.
Embodiment 7
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 1, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 10 milligrams.
Embodiment 8
According to the cigarette for preparing addiction and heroinomania of the present invention with the described identical method of embodiment 2, be in every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 5 milligrams.
Embodiment 9
Tetiahydriopalmatimefor for curing opium ground under lucifuge, 25 ℃ of conditions make 140 order fine powders, acidity (hydrochloric acid) solution mixing system with itself and water and propyl alcohol gets its suspension then.Under the lucifuge condition, evenly be sprayed at prepared suspension on the pipe tobacco and mix.In every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 3 milligrams.The pipe tobacco that obtains is thus rolled, is packaged to be the cigarette of addiction and heroinomania of the present invention according to preparation method conventional in the cigarette field.
Embodiment 10
Tetiahydriopalmatimefor for curing opium ground under lucifuge, 25 ℃ of conditions make 150 order fine powders, acidity (hydrochloric acid) solution mixing system with itself and water and propane diols gets its suspension then.。Under the lucifuge condition, evenly be sprayed at prepared suspension on the pipe tobacco and mix.In every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 50 milligrams.The pipe tobacco that obtains is thus rolled, is packaged to be the cigarette of addiction and heroinomania of the present invention according to method conventional in the cigarette field.
Embodiment 11
Tetiahydriopalmatimefor for curing opium ground under lucifuge, 25 ℃ of conditions make 150 order fine powders, acidity (sulfuric acid) solution mixing system with itself and water and butanediol gets its suspension then.。Under the lucifuge condition, evenly be sprayed at prepared suspension on the pipe tobacco and mix.In every cigarette, the consumption of pipe tobacco and tetiahydriopalmatimefor for curing opium is respectively 800 milligrams and 10 milligrams.The pipe tobacco that obtains is thus rolled, is packaged to be the cigarette of addiction and heroinomania of the present invention according to preparation method conventional in the cigarette field.
Embodiment 12
Tetiahydriopalmatimefor for curing opium is ground to form 120 purpose fine powders, then its raw material with the preparation chewing gum is mixed, make the chewing gum that contains tetiahydriopalmatimefor for curing opium according to a conventional method.The consumption of tetiahydriopalmatimefor for curing opium is that every chewing gum contains the 0.25mg tetiahydriopalmatimefor for curing opium.
Embodiment 13-15
The chewing gum that contains tetiahydriopalmatimefor for curing opium according to the method preparation identical with embodiment 12.Just the consumption of tetiahydriopalmatimefor for curing opium is that every chewing gum contains 1mg respectively, 10mg and 20mg tetiahydriopalmatimefor for curing opium.
Embodiment 16
Tetiahydriopalmatimefor for curing opium is ground to form 120 purpose fine powders, then its raw material with the preparation candy is mixed, make the candy that contains tetiahydriopalmatimefor for curing opium according to a conventional method.The consumption of tetiahydriopalmatimefor for curing opium is that every piece of candy contains the 0.25mg tetiahydriopalmatimefor for curing opium.
Embodiment 17-19
The chewing gum that contains tetiahydriopalmatimefor for curing opium according to the method preparation identical with embodiment 16.Just the consumption of tetiahydriopalmatimefor for curing opium is that every piece of candy contains 1mg respectively, 10mg and 20mg tetiahydriopalmatimefor for curing opium.
Embodiment 20
Tetiahydriopalmatimefor for curing opium is ground to form 120 purpose fine powders, then it is made suspension according to embodiment 1 described method, again prepared suspension is joined and also disperse in the raw material for preparing soft drink to mix, make the soft drink that contains tetiahydriopalmatimefor for curing opium according to a conventional method.The consumption of tetiahydriopalmatimefor for curing opium is that per 240 milliliters of soft drinks contain the 0.25mg tetiahydriopalmatimefor for curing opium.
Embodiment 21-23
The beverage that contains tetiahydriopalmatimefor for curing opium according to the method preparation identical with embodiment 20.Just the consumption of tetiahydriopalmatimefor for curing opium is that per 240 milliliters of soft drinks contain 1mg respectively, 10mg and 20mg tetiahydriopalmatimefor for curing opium.
Embodiment 24
Tetiahydriopalmatimefor for curing opium is ground to form 120 purpose fine powders, then it is made suspension according to embodiment 1 described method, again prepared suspension is joined and also disperse in the raw material for preparing nutrition oral administration to mix, make the soft drink that contains tetiahydriopalmatimefor for curing opium according to a conventional method.The consumption of tetiahydriopalmatimefor for curing opium is that every oral liquid contains the 0.25mg tetiahydriopalmatimefor for curing opium.
Embodiment 25-27
The beverage that contains tetiahydriopalmatimefor for curing opium according to the method preparation identical with embodiment 24.Just the consumption of tetiahydriopalmatimefor for curing opium is that every oral liquid contains 1mg respectively, 10mg and 20mg tetiahydriopalmatimefor for curing opium.
The test example
The cigarette of the addiction and heroinomania that makes is according to the method described above offered the drug addict suck, drug abstainer is sucked the cigarette of 3 addiction and heroinomanias every day at least and just can be taken effect; For the big drug abstainer of smoking capacity every day, the present invention can not produce any bad reaction yet.
In clinical trial, the inventor uses observation group of the present invention with 30 drug abstainers after as detoxification, and other 30 are only used the drug abstainer of conventional cigarette to organize in contrast, prolong and check withrawal symptom relatively.The result is as follows:
Prolong and check withrawal symptom observation group (%) control group (%)
Sporadic limbs pain discomfort 4.06 ± 0.95 8.0 ± 0.87 in 30 days after the detoxification
Sporadic cold sweat 2.03 ± 0.8 8.38 ± 1.09 in 30 days after the detoxification
60 days anxiety percentage 5.35 ± 1.43 28.96 ± 4.39 after the detoxification
Heart addiction percentage 9.9 ± 2.32 38.23 ± 4.96 after the detoxification
Wherein anxiety percentage and heart addiction percentage obtain with the visual analogue scale experimental technique.
As above shown in the table, compare with control group, the cigarette of addiction and heroinomania of the present invention can obviously be improved the various withrawal symptoms after drug addict's detoxification, as sporadic limbs pain discomfort, sporadic cold sweat etc., and can significantly alleviate mood anxiety degree and heart addiction after its detoxification.
Test example of the present invention only uses the cigarette of containing tetiahydriopalmatimefor for curing opium of the present invention to test.It should be understood that other goods that contain tetiahydriopalmatimefor for curing opium of the present invention, for example the Food ﹠ Drink of tetiahydriopalmatimefor for curing opium have similar effects.
More than by embodiment and the test example describe the present invention.It should be understood that for the person of ordinary skill of the art, under the prerequisite that does not depart from spirit of the present invention and essence, can carry out various modifications and variations the present invention.
Claims (15)
1, a kind of cigarette of addiction and heroinomania is characterized in that: described cigarette is contained tetiahydriopalmatimefor for curing opium.
2, the cigarette of addiction and heroinomania according to claim 1 is characterized in that: the consumption of tetiahydriopalmatimefor for curing opium counts 6.25 ‰-50 ‰ by the pipe tobacco gross weight in the described cigarette.
3, the cigarette of addiction and heroinomania according to claim 2 is characterized in that: the consumption of tetiahydriopalmatimefor for curing opium counts 12.5 ‰-43.75 ‰ by the pipe tobacco gross weight in the described cigarette.
4, the cigarette of addiction and heroinomania according to claim 3 is characterized in that: the consumption of the tetiahydriopalmatimefor for curing opium in the described cigarette counts 18.75 ‰-37.5 ‰ by the pipe tobacco gross weight.
5, the cigarette of addiction and heroinomania according to claim 4 is characterized in that: the consumption of the tetiahydriopalmatimefor for curing opium in the described cigarette counts 25 ‰-31.25 ‰ by the pipe tobacco gross weight.
6, a kind of preparation method of cigarette of addiction and heroinomania comprises:
(1) with the tetiahydriopalmatimefor for curing opium of active component at the fine powder of making under lucifuge, the normal temperature more than 100 orders;
(2) under the lucifuge condition, described fine powder is added the acid water soluble solvent and make suspension, evenly be sprayed at suspension on the pipe tobacco and mix;
(3) the cigarette cut tobacco cigarette preparation method routinely who step (2) is obtained rolls, packs.
7, method as claimed in claim 6, wherein said acid water soluble solvent are the mixture of at least a alcohol in water and the C2-C5 alcohol, and the acid that wherein contains is sulfuric acid or hydrochloric acid.
8, method as claimed in claim 7, wherein said alcohol are ethanol, propyl alcohol, propane diols, butanols, butanediol, amylalcohol, pentanediol or its mixture.
9, a kind of food of addiction and heroinomania is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described food.
10, the food of addiction and heroinomania as claimed in claim 9, wherein said food are candy or chewing gum.
11, as the food of claim 9 or 10 described addiction and heroinomanias, wherein said tetiahydriopalmatimefor for curing opium consumption counts 3 ‰-25 ‰ by the gross weight of food.
12, a kind of beverage of addiction and heroinomania is characterized in that: contain tetiahydriopalmatimefor for curing opium in the described beverage.
13, the beverage of addiction and heroinomania as claimed in claim 12, wherein said tetiahydriopalmatimefor for curing opium consumption counts 3 ‰-25 ‰ by the gross weight of beverage.
14, as the beverage of claim 12 or 13 described addiction and heroinomanias, wherein said beverage is soft drink or nutrition oral administration.
15, the application of tetiahydriopalmatimefor for curing opium in the medicine goods of preparation addiction and heroinomania.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00134010A CN1112136C (en) | 2000-12-11 | 2000-12-11 | Cigarette for preventing drug retaking after giving up and method for making same |
| CN00134010.7 | 2000-12-11 | ||
| PCT/CN2001/001615 WO2002047495A1 (en) | 2000-12-11 | 2001-12-11 | A product containing tetiahydiopalmatime for curing opium-addiction and heroinomania and the method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1392777A CN1392777A (en) | 2003-01-22 |
| CN1126473C true CN1126473C (en) | 2003-11-05 |
Family
ID=4595963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00134010A Expired - Fee Related CN1112136C (en) | 2000-12-11 | 2000-12-11 | Cigarette for preventing drug retaking after giving up and method for making same |
| CN01802359A Expired - Lifetime CN1126473C (en) | 2000-12-11 | 2001-12-11 | Product containing tetiahydriopalmatime for curing opium-addiction and heroinomania and method for production thereof |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00134010A Expired - Fee Related CN1112136C (en) | 2000-12-11 | 2000-12-11 | Cigarette for preventing drug retaking after giving up and method for making same |
Country Status (4)
| Country | Link |
|---|---|
| CN (2) | CN1112136C (en) |
| AU (1) | AU2002215818A1 (en) |
| HK (1) | HK1048234B (en) |
| WO (1) | WO2002047495A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284322B (en) * | 2013-04-02 | 2016-07-06 | 徐志强 | A kind of medicated cigarette and other goods and preparation method thereof that can suppress addict that drugs are craved for heart addiction |
| CN103301760B (en) * | 2013-06-19 | 2016-07-06 | 徐志强 | A kind of dissolve the method for rotundin, rotundin solution and application thereof |
| CN104839375A (en) * | 2015-06-10 | 2015-08-19 | 贵阳世纪珠玑科技有限公司 | Tea leaves for preventing relapse after drug rehabilitation and preparation method thereof |
| CN108208925A (en) * | 2016-12-09 | 2018-06-29 | 金朝晖 | Anti-additive medicament containing anti-additive medicament sucks device, cigarette filter and cigarette |
| CN109077352A (en) * | 2018-07-06 | 2018-12-25 | 贵阳世纪珠玑科技有限公司 | A kind of addiction and heroinomania product |
| CN113397163A (en) * | 2021-06-30 | 2021-09-17 | 魏道珍 | Product containing tetrahydropalmatine and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1112425A (en) * | 1994-05-21 | 1995-11-29 | 曹均才 | Stephania japonica drug-witd rawal cigarette |
| CN1072490C (en) * | 1996-08-21 | 2001-10-10 | 卢和川 | Powder for giving up smoking |
-
2000
- 2000-12-11 CN CN00134010A patent/CN1112136C/en not_active Expired - Fee Related
-
2001
- 2001-12-11 CN CN01802359A patent/CN1126473C/en not_active Expired - Lifetime
- 2001-12-11 WO PCT/CN2001/001615 patent/WO2002047495A1/en not_active Application Discontinuation
- 2001-12-11 AU AU2002215818A patent/AU2002215818A1/en not_active Abandoned
-
2002
- 2002-12-27 HK HK02109364.7A patent/HK1048234B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1112136C (en) | 2003-06-25 |
| WO2002047495A1 (en) | 2002-06-20 |
| CN1358463A (en) | 2002-07-17 |
| HK1048234A1 (en) | 2003-03-28 |
| AU2002215818A1 (en) | 2002-06-24 |
| CN1392777A (en) | 2003-01-22 |
| HK1048234B (en) | 2004-08-13 |
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