CN103301760B - A kind of dissolve the method for rotundin, rotundin solution and application thereof - Google Patents
A kind of dissolve the method for rotundin, rotundin solution and application thereof Download PDFInfo
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- CN103301760B CN103301760B CN201310245353.3A CN201310245353A CN103301760B CN 103301760 B CN103301760 B CN 103301760B CN 201310245353 A CN201310245353 A CN 201310245353A CN 103301760 B CN103301760 B CN 103301760B
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- rotundin
- phosphoric acid
- water
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- drugs
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/36—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring
- A24B15/38—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances containing a heterocyclic ring having only nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Abstract
The present invention provides a kind of and dissolves the method for rotundin, rotundin solution and application thereof.The method is characterized in that addition phosphoric acid in the suspension of the water of rotundin, make the rotundin of suspension be dissolved.The limpid flaxen rotundin solution dissolved with water and phosphoric acid is sprayed on tobacco shred by the present invention uniformly, or mix homogeneously with other raw materials and to make Foods or drinks, so give drug abstainer use to be both happy to accept for drug abstainer, phosphoric acid adds for food simultaneously, more meet health health for producing medicated cigarette and other edible products, meet country's regulation to food safety and sanitation.
Description
Technical field
The invention belongs to food and medicine field, relate to a kind of dissolving the method for rotundin, rotundin solution and application thereof.
Background technology
Along with the day by day intensification of this social problem of taking drugs, people prevent medicine and the preparation that addict relapses after developing various treating narcotic addiction and treating narcotic addiction.Rotundin (l-tetrahydropalmatinel-THP, or rotundine, also referred to as rotundine), is dopamine (DA) receptor blocking agent, oral administration or after intramuscular injection except having analgesic activity, also there is stable effect, the loaded state-promulgated pharmacopoeia of this medicine.Since 2005, having had scholar's research to find, l-THP can block the differentiating effect of morphine, the behavior anchor effect of energy antagonism amfetamine.Show that it can reduce or suppress the formation of the psychic dependence of m orphine and Capillary zone electropheresis.Referring to " Xuzhou Medical College's journal " the 2nd phase in 2002 and " Chinese Journal of Drug Dependence " the 1st phase 27-29 page in 2005.But rotundin is white powder, as being made into powder, then producing a large amount of dust, both contaminated environment also can produce pneumosilicosis, and the waste of production cost height is big.
Although research finds that rotundin can reduce or suppress the formation of the psychic dependence of m orphine and Capillary zone electropheresis, the rotundin used in prior art is typically all makes white powder or graininess by rotundin, and then make white tablet, but these white article are easily addict and bring the illusion to white drugs, both life-time service it had been unfavorable for, it is also difficult to reach the effect of thorough treating narcotic addiction.Especially in suppressing addict that drugs are craved for heart addiction, needs can not be met far away.
Observing statistics according to clinical data, the addict of 90% takes drugs at first and is made by what medicated cigarette started, and lifelong smoking addiction, and every day, medicated cigarette was not from hands mouth, and especially they are during giving up drugs and the treating narcotic addiction later stage, suck medicated cigarette amount every day and increase.If rotundin is made solution, uniformly being sprayed onto on tobacco shred and then make medicated cigarette, or make solution and be then mixed and made into food with other raw materials, beverage etc. is the goods of drug abstainer acceptable form, so be conducive to drug abstainer life-time service, and respond well.But, rotundin is water insoluble, it is slightly soluble in ethanol, it is only soluble in dilute sulfuric acid, if be dissolved in sulphuric acid prepare into solution be necessary for transport, store a certain amount of sulphuric acid, it produces preparation process and transportation all contains bigger potential safety hazard, uses sulphuric acid to dissolve rotundin simultaneously and does not also meet food safety, is not suitable for food industry.
Therefore, develop a kind of method dissolving rotundin, and then make the big Gospel that treating narcotic addiction goods are drug abuse, drug abstainer, utilize the solution of preparation after dissolving also can prepare other edible or medical function product.
Summary of the invention
Demand according to above-mentioned field and deficiency, the present invention provides a kind of and dissolves the method for rotundin, rotundin solution and application thereof, and the rotundin solution dissolved by the inventive method can be used for preparing medicated cigarette, beverage or food.
Technical scheme is as follows:
A kind of method dissolving rotundin, it is characterised in that add phosphoric acid in the suspension of the water of rotundin, make the rotundin of suspension be dissolved.
Preferably, described phosphoric acid is edible phosphoric acid.
Described phosphoric acid is the food grade phosphoric acid of liquid, and the proportioning of described water, rotundin and phosphoric acid is: water 100ml: rotundin 1～25g: phosphoric acid 5～30ml.
In said method, it is preferred that described water is the warm water of 45～80 DEG C, described phosphoric acid is the food grade phosphoric acid of liquid, and the proportioning of described warm water, rotundin and phosphoric acid is: warm water 100ml: rotundin 1～40g: phosphoric acid 5～30ml.
Above-mentioned method, comprises the steps:
(1) at lucifuge, normal temperature environment lower-weighing rotundin；
(2) in light protected environment, the rotundin that step (1) weighs is added to the water stirring, is simultaneously introduced phosphoric acid, continue stirring, make limpid, yellow solution.
A kind of rotundin solution, it is characterised in that this solution comprises water, rotundin and phosphoric acid.
Preferably, described phosphoric acid is edible phosphoric acid.
Described phosphoric acid is the food grade phosphoric acid of liquid, and the proportioning of described water, rotundin and phosphoric acid is: water 100ml: rotundin 1～25g: phosphoric acid 5～30ml.
Preferably, described phosphoric acid is the food grade phosphoric acid of liquid, the warm water of 45～80 DEG C of described water, and each composition proportion of described liquid is: warm water 100ml: rotundin 1～40g: phosphoric acid 5～30ml.
A kind of medicated cigarette that can suppress addict that drugs are craved for heart addiction, it is characterised in that described medicated cigarette contains above-mentioned rotundin solution；During preparation, by the spray solution made containing rotundin, water, phosphoric acid to tobacco shred.
A kind of beverage that can suppress addict that drugs are craved for heart addiction, it is characterised in that containing above-mentioned rotundin solution.
A kind of food that can suppress addict that drugs are craved for heart addiction, it is characterised in that containing above-mentioned rotundin solution.
Beneficial effects of the present invention:
Inventor's water and phosphoric acid dissolve rotundin makes solution, and then be made to suppress addict's medicated cigarette craving for heart addiction to drugs as effective ingredient using this solution, addict can be met and suck the psychological goal of medicated cigarette, the effect suppressing drugs heart addiction can be played again, smoker is made both to be ready to suck, inhibit again the hope consumed illegal drugs unconsciously, make health, nerve improve simultaneously, this makes convalescent patient's confidence be strengthened, it is thus possible to suppress heart addiction better.After rotundin is sucked with tobacco shred mixing ignition by inventor, it is possible to effectively addiction and heroinomania, alleviate addict, in the stopping narcotic taking phase, drugs are craved for desire.And inventor also demonstrates this point really by numerous embodiments and contrast test.Meanwhile, rotundin is made other goods as effective ingredient and is served corresponding effect too by inventor.Other goods such as food is owing to being necessity for life every day, and beverage mouthfeel with great difficulty for well-established greatly, therefore wherein contains rotundin, and every day eats, and also can play with the akin inhibitory action of medicated cigarette.
Inventor is patent to find out rotundin is made solution, uniformly it is sprayed onto on tobacco shred and then makes medicated cigarette, or make solution and be then mixed and made into food with other raw materials, beverages etc. are the goods of drug abstainer acceptable form, so be conducive to drug abstainer life-time service, and respond well.But, as it was previously stated, prior art does not have safely, eat, be easy to store and transport rotundin, therefore rotundin is made solution in R&D process and is encountered a difficult problem by inventor.Inventor through exploratory development many times, uses one or more of the multiple alcohol such as ethanol, propanol, propylene glycol, butanol, butanediol, amylalcohol, pentanediol to dissolve rotundin effect not satisfactory.
Finally inventor have found that；Appropriate water coordinates a certain amount of phosphoric acid, rotundin fully can be dissolved into uniform, limpid, yellow solution, and then this solution can be sprayed on tobacco shred uniformly, or mix homogeneously with other raw materials and to make Foods or drinks, so give drug abstainer use to be both happy to accept for drug abstainer, food grade phosphoric acid or analytical pure phosphoric acid can be used for food interpolation simultaneously, are used for producing medicated cigarette and more meet health health with other edible products, meet country's regulation to food safety and sanitation.
Meanwhile, the present inventor finds in research process, and rotundin is also had a significant impact by water temperature, and the warm water of 45～80 DEG C can improve the dissolubility of rotundin significantly.In research process, inventor uses the common drinking water of 100ml to coordinate 5～30ml phosphoric acid, it is possible to the amount dissolving rotundin is up to 25g；And use 100ml, the warm water of 45～80 DEG C coordinates 5～30ml phosphoric acid, the amount of rotundin can be dissolved up to 40g, if warm water and 5～30ml phosphoric acid dissolving rotundin more than 40g with 100ml will have rotundin Precipitation, be unfavorable for subsequent use；Simultaneously, consider the application of reality, because the present invention dissolves tetrahydropalmatine is mainly used for preparation medicated cigarette, Foods or drinks, if the phosphoric acid of the warm water of 100ml Yu more than 30ml is used in conjunction with each other, rotundin dissolubility in water can be greatly improved, but this will cause solution peracid (acidity is excessive), mouthfeel is not good on the one hand, the solution of peracid will corrode tobacco shred and other compositions of food, beverage on the other hand, and the rotundin that therefore peracid solutions is dissolved is not suitable for doing medicated cigarette, drink and food.
The present invention adds phosphoric acid in the suspension of the water of rotundin, owing in the phosphoric acid of the liquid added, the content of phosphoric acid is of a relatively high, the rotundin being suspended in water can be made fully to dissolve, if being dissolved in by rotundin in the phosphorus aqueous acid prepared in advance, then rotundin can not be made fully to dissolve because the content of phosphoric acid in phosphate aqueous solution is not enough.
The inventive method also has following effect；Pollution-free without dust, without potential safety hazard, technique is simple, and low production cost, easy to use, existing equipment and technology can produce in a large number, meet state food safe and sanitary standard.
Detailed description of the invention
Thering is provided following embodiment is to be further appreciated by the present invention better; it is not limited to described preferred forms; present disclosure and protection domain are not construed as limiting; anyone under the enlightenment of the present invention or any and present invention feature of the present invention Yu other prior aries being combined and drawing same or like like product, all fall within protection scope of the present invention.
Reagent source of the present invention and specification list are as follows:
Rotundin is purchased approach and obtains, purchased from Guanghan, Sichuan self-sufficient and strategically located region Industrial Co., Ltd., 0838-5913889；
Phosphoric acid is food grade phosphoric acid, and the approach that is purchased obtains, and is purchased from the honest Chemical Co., Ltd. in Shanghai；Credit rating: high-class product color/outward appearance: colourless liquid；Manufacturer/place of production: Wengfu group；Purposes rank: food stage；The content of phosphoric acid >=: 85%.The phosphoric acid of the present invention can also be commercially available analytical pure phosphoric acid.
Water used in the embodiment of the present invention is common drinking water.
In the present invention, rotundin used is also referred to as rotundine or rotundine, at pharmaceutical field, generally rotundin is directly called tetrahydropalmatine, if needing to use dextrorotation tetrahydropalmatine, those of ordinary skill in the art can directly claim dextrorotation tetrahydropalmatine.Refer to 2005 " Pharmacopoea Chinensis ".
Analytical pure (AR, red label) (seconds): main constituent content is significantly high, purity is higher, interference impurity is very low, it is adaptable to Industrial Analysis and chemical experiment；For the purity of concrete material, different requirements for pharmaceuticals is different, and concrete medicine has the purity range determined.Analytical pure etc. are the purity grades of reagent, as the difference of a kind of content and the purity of reagent.Reagent is often bottle packaging, is generally 500g/ bottle, and the mass content of the phosphoric acid of AR level is: >=85% (molten water).
Food grade phosphoric acid refers to that sanitary grade aspect is edible phosphoric acid, and the material of food stage can use as the additive of food, and the food grade phosphoric acid in the present invention can use as food additive.Content >=85% of phosphoric acid in normal food level phosphoric acid on market, uses the food grade phosphoric acid that the honest Chemical Co., Ltd. in Shanghai sells in the present invention.
Embodiment 1.
Under lucifuge, normal temperature environment, fine weighing rotundin 25g, account for the 35.71 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 30ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 25mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 2.
Under lucifuge, normal temperature environment, fine weighing rotundin 20g, account for the 28.57 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 8ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 20mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 3.
Under lucifuge, normal temperature environment, fine weighing rotundin 15g, account for the 21.43 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 10ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 15mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 4.
Under lucifuge, normal temperature environment, fine weighing rotundin 12g, account for the 17.14 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 5ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 12mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 5.
Under lucifuge, normal temperature environment, fine weighing rotundin 22g, account for the 31.43 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 13ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 22mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 6.
Under lucifuge, normal temperature environment, fine weighing rotundin 25g, account for the 35.71 ‰ of tobacco shred weight, it is slowly added to 100ml water uniform stirring, it is slowly added 5ml phosphoric acid, continue uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 25mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 7.
Under lucifuge, normal temperature environment, fine weighing rotundin 40g, account for the 57.14 ‰ of tobacco shred weight, it is slowly added to 100ml, the warm water uniform stirring of 69 DEG C, is slowly added 20ml phosphoric acid, continues uniform stirring, uniform, limpid, weak yellow liquid occurs, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 40mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 8.
Under lucifuge, normal temperature environment, fine weighing rotundin 30g, account for the 42.86 ‰ of tobacco shred weight, it is slowly added to 100ml, the warm water uniform stirring of 80 DEG C, it is slowly added 28ml phosphoric acid, continues uniform stirring and occur to uniform, limpid, weak yellow liquid, this liquid is uniformly sprayed onto dry for standby on tobacco shred.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 30mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the medicated cigarette craving for heart addiction, prevention of relapse that can suppress addict to drugs.
Embodiment 9.
Under lucifuge, normal temperature environment, fine weighing rotundin 15g, account for the 21.43 ‰ of tobacco shred weight, it is slowly added to 100ml, the warm water uniform stirring of 70 DEG C, it is slowly added 15ml phosphoric acid, continues uniform stirring and occur to uniform, bright, weak yellow liquid, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 15mg.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the present invention and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.
Embodiment 10.
Prepare the present invention according to the method identical with described in embodiment 8 and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.Simply in every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 35mg, wherein rotundin accounts for the 50 ‰ of tobacco shred weight.Preparing each amount of substance in the present embodiment process is: rotundin 35g, tobacco shred 700g, and the amount of warm water and phosphoric acid is respectively as follows: 100ml, 30ml, and the temperature of warm water is 65 DEG C.
Embodiment 11.
Prepare the present invention according to the method identical with described in embodiment 8 and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.Simply in every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 25mg, wherein rotundin accounts for the 35.71 ‰ of tobacco shred weight.Preparing each amount of substance in the present embodiment process is: rotundin 25g, tobacco shred 700g, and the amount of warm water and phosphoric acid is respectively as follows: 100ml, 18ml, and the temperature of warm water is 76 DEG C.
Embodiment 12.
Prepare the present invention according to the method identical with described in embodiment 8 and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.Simply in every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 20mg, wherein rotundin accounts for the 28.57 ‰ of tobacco shred weight.Preparing each amount of substance in the present embodiment process is: rotundin 20g, tobacco shred 700g, and the amount of warm water and phosphoric acid is respectively as follows: 100ml, 15ml, and the temperature of warm water is 53 DEG C.
Embodiment 13.
Prepare the present invention according to the method identical with described in embodiment 8 and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.Simply in every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 15mg, wherein rotundin accounts for the 21.43 ‰ of tobacco shred weight.Preparing each amount of substance in the present embodiment process is: rotundin 15g, tobacco shred 700g, and the amount of warm water and phosphoric acid is respectively as follows: 100ml, 15ml, and the temperature of warm water is 48 DEG C.
Embodiment 14.
Prepare the present invention according to the method identical with described in embodiment 8 and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.Simply in every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 10mg, wherein rotundin accounts for the 14.29 ‰ of tobacco shred weight.Preparing each amount of substance in the present embodiment process is: rotundin 10g, tobacco shred 700g, and the amount of warm water and phosphoric acid is respectively as follows: 100ml, 8ml, and the temperature of warm water is 45 DEG C.
Embodiment 15.
Under lucifuge, normal temperature environment, fine weighing rotundin 50g, it is slowly added to 300ml, the warm water uniform stirring of 65 DEG C, it is slowly added 45ml phosphoric acid, continues uniform stirring and occur to uniform, bright, weak yellow liquid, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 50mg, wherein rotundin accounts for the 71.43 ‰ of tobacco shred weight.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the present invention and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.
Embodiment 16.
Under lucifuge, normal temperature environment, fine weighing rotundin 40g, it is slowly added to 200ml, the warm water uniform stirring of 47 DEG C, it is slowly added 30ml phosphoric acid, continues uniform stirring and occur to uniform, bright, weak yellow liquid, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 40mg, wherein rotundin accounts for the 57.14 ‰ of tobacco shred weight.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the present invention and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.
Embodiment 17.
Under lucifuge, normal temperature environment, fine weighing rotundin 10g, it is slowly added to 100ml, the warm water uniform stirring of 63 DEG C, it is slowly added 14ml phosphoric acid, continues uniform stirring and occur to uniform, bright, weak yellow liquid, this liquid is uniformly sprayed onto dry for standby on the tobacco shred of 700g.In every medicated cigarette, tobacco shred, rotundin consumption respectively 700mg, 10mg, wherein rotundin accounts for the 14.29 ‰ of tobacco shred weight.The tobacco shred that will thus obtain, rolls according to preparation method conventional in medicated cigarette field, packs, can obtain the present invention and can suppress addict's medicated cigarette craving for heart addiction, prevention of relapse to drugs.
Embodiment 18.
Under lucifuge, normal temperature environment, fine weighing rotundin 30g, it is slowly added to 100ml, the warm water uniform stirring of 55 DEG C, it is slowly added 29ml phosphoric acid, continue uniform stirring uniformly, liquid bright, flaxen, then its raw material adding chewing gum with preparation is mixed homogeneously, can obtain, according to the conventional method production preparing chewing gum, the chewing gum craving for heart addiction, prevention of relapse that addict can be suppressed to drugs.The drug dose of the present invention is: every piece of chewing gum 1.5g, containing 30mg rotundin.
Embodiment 19～21.
The chewing gum of the present invention is prepared according to the method identical with embodiment 17.Simply the consumption of medicine is: every piece of chewing gum 1.5g, respectively containing 5mg, 10mg and 20mg rotundin.Each embodiment each amount of substance in preparation process is: rotundin is 5g respectively, 10g, 20g, warm water 100ml, phosphatase 11 5ml, and the temperature of warm water is 56 DEG C.
Embodiment 22.
Under lucifuge, normal temperature environment, fine weighing rotundin 30g, it is slowly added to 200ml warm water uniform stirring, it is slowly added 25ml phosphoric acid, continue uniform stirring uniformly, liquid bright, flaxen, then it is mixed homogeneously with the raw material preparing confection, produce, according to the conventional method preparing confection, the confection craving for heart addiction, enhancing immunity, prevention of relapse that can obtain can suppressing addict to drugs.The consumption of its Chinese medicine is: every piece of candy 1.5g, containing 30mg rotundin.In embodiment of the present invention preparation process, the temperature of warm water is 59 DEG C.
Embodiment 23～25.
The confection containing rotundin is prepared according to the method identical with embodiment 22.Simply the consumption of its Chinese medicine is: every piece of candy 1.5g, respectively containing 5mg, 10mg or 20mg rotundin.Preparing each amount of substance in each embodiment process is: rotundin is 5g respectively, 10g, 20g；Warm water 100ml, phosphatase 11 5ml, the temperature of warm water is 64 DEG C.
Embodiment 26.
Under lucifuge, normal temperature environment, fine weighing rotundin 30g, it is slowly added to 200ml, the warm water uniform stirring of 54 DEG C, it is slowly added 30ml phosphoric acid, continue uniform stirring uniformly, liquid bright, flaxen, then this liquid is joined in the raw material preparing soft drink and disperses mix homogeneously, that makes the present invention according to a conventional method can suppress addict's soft drink craving for heart addiction, prevention of relapse to drugs.Wherein every 250ml soft drink is containing rotundin 30mg.
Embodiment 27～29.
Make the present invention according to the method identical with embodiment 26 and can suppress addict's soft drink craving for heart addiction, prevention of relapse to drugs.Wherein respectively containing 5mg, 10mg, 20mg rotundin in every 250ml soft drink.Each embodiment each amount of substance in preparation process is: rotundin is 5g respectively, 10g, 20g；Warm water 100ml, phosphatase 11 5ml, the temperature of warm water is 61 DEG C.
Embodiment 30.
Under lucifuge, normal temperature environment, fine weighing rotundin 15g, it is slowly added to 100ml, the warm water uniform stirring of 50 DEG C, it is slowly added 12ml phosphoric acid, continue uniform stirring uniformly, liquid bright, flaxen, then this liquid is joined in the raw material preparing nutrition oral administration and disperses mix homogeneously, that makes the present invention according to a conventional method can suppress addict's nutrition oral administration craving for heart addiction, prevention of relapse to drugs.Wherein every 50ml nutrition oral administration is containing 15mg rotundin.
Embodiment 31～33.
Addict's nutrition oral administration craving for heart addiction, prevention of relapse to drugs can be suppressed according to what the method identical with embodiment 30 prepared the present invention.Simply drug dose is respectively containing 5mg, 10mg or 15mg rotundin in every 50ml oral liquid.Each embodiment consumption of each material in preparation process is: rotundin is 5g respectively, 10g, 15g；Warm water 100ml, phosphatase 11 3ml, the temperature of warm water is 60 DEG C.
Experimental example 1.
The goods prepared according to each embodiment method are provided freely to community's drug abstainer use, carry out laboratory observation.Drug abstainer at least uses the goods that this method of 6 deals prepares every day, is obtained with clinical effectiveness within 30 days, and for the drug abstainer that every staggering amount amount is big, medicated cigarette of the present invention is without producing any untoward reaction.
Experimenter uses the effect data of various embodiments of the present invention goods and prior art goods to compare in Table 1.Wherein, X1 is common cigarette group.
Table 1 inventive article and prior art goods are to the inhibitory action contrast of addict's heart addiction and protracted symptom in community's stopping narcotic taking
* *: compare p < 0.001 with common cigarette group；###: with suck before compare p < 0.001.
As shown above, compared with common cigarette group, the goods of the addiction and heroinomania of the present invention can be obviously improved the protracted abstinence symptom (psa) after junkie detoxification, cold sweat as uncomfortable in sporadic limbs pain, sporadic, insomnia and anxiety etc., and drugs are craved for heart addiction by convalescence after can significantly alleviating its detoxification.Thus illustrate, use series of steps such as dissolving rotundin new method that finally prepared goods can effectively suppress the drug abstainer heart addiction that drugs are craved for by convalescence after treating narcotic addiction.
This experimental example is only to using the goods containing rotundin in embodiments of the invention to test.It should be understood that other goods containing rotundin of the present invention also have similar effect.
The following is inventor in the process preparing each embodiment product, the dissolving information slip of rotundin
The dissolving information slip of rotundin in table 2 various embodiments of the present invention
From table 2 it can be seen that the common drinking water of 100ml coordinates 5～30ml phosphoric acid, it is possible to the amount dissolving rotundin is up to 25g；And using 100ml, the warm water of 45～80 DEG C coordinates 5～30ml phosphoric acid, it is possible to dissolve the amount of rotundin up to 40g.It is shown that rotundin dissolubility in water is also had a significant impact by water temperature, the warm water of 45～80 DEG C can improve the dissolubility of rotundin significantly, makes the meltage amount of rotundin up to 40g.Describe the present invention above by embodiment and experimental example, be only presently preferred embodiments of the present invention, not the present invention is done any pro forma restriction.Although the present invention is with preferred embodiment openly as above, but not any mode limits the present invention.It should be understood that, for the person of ordinary skill of the art, under the premise of the spirit and essence that not necessarily depart from the present invention, all utilize technology contents disclosed above to make a little to change or modify, should be regarded as the Equivalent embodiments of equivalent variations, in every case it is without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and modification that above example is made by the technical spirit of the present invention, all still falls within the scope of technical solution of the present invention.
Claims (8)
1. the method dissolving rotundin, it is characterized in that, the suspension of the water of rotundin adds phosphoric acid, the rotundin making suspension is dissolved, described phosphoric acid is edible phosphoric acid, described rotundin aqueous solution for prepare addict can be suppressed drugs crave for heart addiction, prevention of relapse goods；
Described phosphoric acid is the food grade phosphoric acid of liquid, and the proportioning of described water, rotundin and phosphoric acid is: water 100ml: rotundin 1～25g: phosphoric acid 5～30ml.
2. the method dissolving rotundin, it is characterized in that, the suspension of the water of rotundin adds phosphoric acid, the rotundin making suspension is dissolved, described phosphoric acid is edible phosphoric acid, described rotundin aqueous solution for prepare addict can be suppressed drugs crave for heart addiction, prevention of relapse goods；
Described water is the warm water of 45～80 DEG C；The proportioning of described warm water, rotundin and phosphoric acid is: warm water 100ml: rotundin 1～40g: phosphoric acid 5～30ml.
3. method according to claim 1 and 2, comprises the steps:
(1) at lucifuge, normal temperature environment lower-weighing rotundin；
(2) in light protected environment, the rotundin that step (1) weighs is added to the water stirring, is simultaneously introduced phosphoric acid, continue stirring, make limpid, yellow solution.
4. a rotundin solution, it is characterized in that, this solution comprises water, rotundin and phosphoric acid, and described phosphoric acid is edible phosphoric acid, described rotundin aqueous solution for prepare addict can be suppressed drugs crave for heart addiction, prevention of relapse goods；
During preparation, the suspension of the water of rotundin adds phosphoric acid, the rotundin making suspension is molten, described phosphoric acid is the food grade phosphoric acid of liquid, and the proportioning of described water, rotundin and phosphoric acid is: water 100ml: rotundin 1～25g: phosphoric acid 5～30ml.
5. a rotundin solution, it is characterized in that, this solution comprises water, rotundin and phosphoric acid, and described phosphoric acid is edible phosphoric acid, described rotundin aqueous solution for prepare addict can be suppressed drugs crave for heart addiction, prevention of relapse goods；
During preparation, the suspension of the water of rotundin adds phosphoric acid, the rotundin making suspension is dissolved, and described water is the warm water of 45～80 DEG C, and each composition proportion of described liquid is: warm water 100ml: rotundin 1～40g: phosphoric acid 5～30ml.
6. one kind can be suppressed the medicated cigarette that heart addiction craved for by drugs by addict, it is characterised in that containing the rotundin solution described in claim 4 or 5；During preparation, by the spray solution made containing rotundin, water, phosphoric acid to tobacco shred.
7. one kind can be suppressed the beverage that heart addiction craved for by drugs by addict, it is characterised in that containing the rotundin solution described in claim 4 or 5.
8. one kind can be suppressed the food that heart addiction craved for by drugs by addict, it is characterised in that containing the rotundin solution described in claim 4 or 5.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310245353.3A CN103301760B (en) | 2013-06-19 | 2013-06-19 | A kind of dissolve the method for rotundin, rotundin solution and application thereof |
| PCT/CN2014/080288 WO2014202012A1 (en) | 2013-06-19 | 2014-06-19 | L-tetrahydropalmatine dissolving method, l-tetrahydropalmatine solution and use thereof |
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| CN201310245353.3A CN103301760B (en) | 2013-06-19 | 2013-06-19 | A kind of dissolve the method for rotundin, rotundin solution and application thereof |
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| WO (1) | WO2014202012A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103284322B (en) * | 2013-04-02 | 2016-07-06 | 徐志强 | A kind of medicated cigarette and other goods and preparation method thereof that can suppress addict that drugs are craved for heart addiction |
| CN103301760B (en) * | 2013-06-19 | 2016-07-06 | 徐志强 | A kind of dissolve the method for rotundin, rotundin solution and application thereof |
| CN104698141B (en) * | 2015-03-25 | 2016-05-04 | 川渝中烟工业有限责任公司 | The analogue means of gum base type tobacco product oral cavity stripping |
| CN109077352A (en) * | 2018-07-06 | 2018-12-25 | 贵阳世纪珠玑科技有限公司 | A kind of addiction and heroinomania product |
| CN112076153A (en) * | 2020-09-30 | 2020-12-15 | 苏州克劳丽化妆品有限公司 | Rotundine solution and method for dissolving rotundine |
| CN113397163A (en) * | 2021-06-30 | 2021-09-17 | 魏道珍 | Product containing tetrahydropalmatine and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358463A (en) * | 2000-12-11 | 2002-07-17 | 广州世纪珠玑实业发展有限公司 | Cigarette for preventing drug retaking after giving up and method for making same |
| JP2008136471A (en) * | 2006-12-04 | 2008-06-19 | Tsuurin Osada | Schizandrae fructus health food |
| CN103040766A (en) * | 2013-01-10 | 2013-04-17 | 罗诚 | Drug composition containing pamidronate disodium compound |
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| CN103301760B (en) * | 2013-06-19 | 2016-07-06 | 徐志强 | A kind of dissolve the method for rotundin, rotundin solution and application thereof |
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1358463A (en) * | 2000-12-11 | 2002-07-17 | 广州世纪珠玑实业发展有限公司 | Cigarette for preventing drug retaking after giving up and method for making same |
| JP2008136471A (en) * | 2006-12-04 | 2008-06-19 | Tsuurin Osada | Schizandrae fructus health food |
| CN103040766A (en) * | 2013-01-10 | 2013-04-17 | 罗诚 | Drug composition containing pamidronate disodium compound |
Non-Patent Citations (1)
| Title |
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| 罗通定鼻腔喷雾剂的研究;刘长瑜;《中国优秀硕士学位论文全文数据库 医药卫生科技辑》;20090215;第12页 * |
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| CN103301760A (en) | 2013-09-18 |
| WO2014202012A1 (en) | 2014-12-24 |
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