CN112638426B - 基于芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 - Google Patents
基于芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 Download PDFInfo
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- CN112638426B CN112638426B CN201980056464.5A CN201980056464A CN112638426B CN 112638426 B CN112638426 B CN 112638426B CN 201980056464 A CN201980056464 A CN 201980056464A CN 112638426 B CN112638426 B CN 112638426B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018111065440 | 2018-09-21 | ||
| CN201811106544 | 2018-09-21 | ||
| PCT/CN2019/106418 WO2020057543A1 (fr) | 2018-09-21 | 2019-09-18 | Lieur à base d'aryle nitro, conjugué anticorps-médicament contenant un lieur et utilisation de lieur |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112638426A CN112638426A (zh) | 2021-04-09 |
| CN112638426B true CN112638426B (zh) | 2023-06-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980056464.5A Active CN112638426B (zh) | 2018-09-21 | 2019-09-18 | 基于芳硝基的连接子、含连接子的抗体偶联药物及连接子的用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112638426B (fr) |
| WO (1) | WO2020057543A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115215780B (zh) * | 2022-04-22 | 2023-08-08 | 上海格苓凯生物科技有限公司 | 一种利用n,n-二琥珀酰亚胺基碳酸酯制备异双功能交联剂smcc的方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018002902A1 (fr) * | 2016-07-01 | 2018-01-04 | Glaxosmithkline Intellectual Property (No.2) Limited | Conjugués anticorps-médicament et procédés thérapeutiques utilisant ceux-ci |
| CN107995912A (zh) * | 2015-03-27 | 2018-05-04 | 里珍纳龙药品有限公司 | 美登素类衍生物、其偶联物和使用方法 |
| WO2018095422A1 (fr) * | 2016-11-25 | 2018-05-31 | 上海青润医药科技有限公司 | Lieur d'amide maléique di-substitué pour conjugaison anticorps-médicament, son procédé de préparation et son utilisation |
| CN108452318A (zh) * | 2017-02-17 | 2018-08-28 | 浙江特瑞思药业股份有限公司 | 靶向cd20的抗体偶联药物及其制备方法和用途 |
| CN108452319A (zh) * | 2017-02-20 | 2018-08-28 | 浙江特瑞思药业股份有限公司 | 靶向cd20的抗体偶联药物制剂 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011106639A1 (fr) * | 2010-02-25 | 2011-09-01 | Purdue Research Foundation | Conjugués ligand de liaison à un antigène de membrane spécifique à la prostate (psma) lieur et procédés d'utilisation associés |
-
2019
- 2019-09-18 WO PCT/CN2019/106418 patent/WO2020057543A1/fr active Application Filing
- 2019-09-18 CN CN201980056464.5A patent/CN112638426B/zh active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107995912A (zh) * | 2015-03-27 | 2018-05-04 | 里珍纳龙药品有限公司 | 美登素类衍生物、其偶联物和使用方法 |
| WO2018002902A1 (fr) * | 2016-07-01 | 2018-01-04 | Glaxosmithkline Intellectual Property (No.2) Limited | Conjugués anticorps-médicament et procédés thérapeutiques utilisant ceux-ci |
| WO2018095422A1 (fr) * | 2016-11-25 | 2018-05-31 | 上海青润医药科技有限公司 | Lieur d'amide maléique di-substitué pour conjugaison anticorps-médicament, son procédé de préparation et son utilisation |
| CN108452318A (zh) * | 2017-02-17 | 2018-08-28 | 浙江特瑞思药业股份有限公司 | 靶向cd20的抗体偶联药物及其制备方法和用途 |
| CN108452319A (zh) * | 2017-02-20 | 2018-08-28 | 浙江特瑞思药业股份有限公司 | 靶向cd20的抗体偶联药物制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112638426A (zh) | 2021-04-09 |
| WO2020057543A1 (fr) | 2020-03-26 |
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