CN112618597A - Diabetes and blood sugar reducing capsule and preparation method thereof - Google Patents
Diabetes and blood sugar reducing capsule and preparation method thereof Download PDFInfo
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- CN112618597A CN112618597A CN202011267665.0A CN202011267665A CN112618597A CN 112618597 A CN112618597 A CN 112618597A CN 202011267665 A CN202011267665 A CN 202011267665A CN 112618597 A CN112618597 A CN 112618597A
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- corn starch
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to the technical field of traditional Chinese medicine capsules and preparation methods thereof, and discloses a thirst-quenching and blood sugar-reducing capsule which comprises guava leaves and auxiliary materials, wherein the auxiliary materials comprise corn starch, magnesium stearate and hollow capsules, and the guava leaves account for 25-35 parts; 8-12 parts of corn starch; 4-6 parts of magnesium stearate; 20-30 parts of hollow capsules. The invention has the advantages of less traditional Chinese medicines and low cost by adopting the guava leaves, the corn starch, the magnesium stearate and the hollow capsules, and the manufacturing engineering is not complicated by the working procedures of extraction, calculation of the corn starch amount, granulation, sieving of whole granules, total mixing, filling, packaging and the like, thereby being more suitable for popularization.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a thirst quenching and blood sugar reducing capsule and a preparation method thereof.
Background
Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by a defect in insulin secretion or an impaired biological action, or both. The hyperglycemia of diabetes patients is easy to cause chronic damage and dysfunction of various tissues, particularly eyes, kidneys, hearts, blood vessels and nerves.
The clinical manifestations of diabetics are polyphagia, polydipsia, polyuria and emaciation. Diabetes patients are easy to have water shortage due to polyuria. In summer, the external temperature is high, the human body is easy to sweat, and in addition, the diabetes patients are polyuria, so that the water shortage of the patients is more easily caused. Diabetes patients lack water to easily cause blood concentration and increase blood viscosity, and if water is not supplemented in time, the patients are easily aggravated, and in order to solve the problem, the diabetes blood sugar reducing capsule appears.
The existing diabetes and blood sugar reducing capsules are mainly prepared from a plurality of traditional Chinese medicines, so that the cost is high, and the preparation process is complicated, so that further improvement is needed.
Disclosure of Invention
Technical problem to be solved
In order to solve the problems in the prior art, the invention provides a thirst quenching and blood sugar reducing capsule and a preparation method thereof.
(II) technical scheme
In order to achieve the purpose, the invention adopts the main technical scheme that:
a thirst quenching and blood sugar reducing capsule comprises guava leaves and auxiliary materials, wherein the auxiliary materials comprise corn starch, magnesium stearate and hollow capsules, and the guava leaves account for 25-35 parts; 8-12 parts of corn starch; 4-6 parts of magnesium stearate; 20-30 parts of hollow capsules.
In a further embodiment, the guava leaves, corn starch and magnesium stearate are all filled inside the empty capsule.
In a further embodiment, the guava leaves and the corn starch are both granular.
A preparation method of a diabetes and blood sugar reducing capsule comprises the following steps,
s1, extracting: selecting a proper amount of guava leaves, adding the guava leaves into an extraction tank, adding 18 times of water, boiling the water, extracting the solution twice, extracting for 2 hours each time, discharging liquid medicine after extraction is finished, filtering, combining the filtrates obtained by two-time extraction, concentrating the filtrate into clear paste with the relative density of 1.25(80 ℃), then placing and cooling the clear paste, adding 4 times of ethanol, stirring uniformly, standing for 24 hours, filtering again, recovering the ethanol in the filtrate, concentrating the filtrate into clear paste with the relative density of 1.15(80 ℃), putting the clear paste into a clean barrel, weighing and recording, then sticking a material label, injecting the name, specification, weight, date, operator and the like, then warehousing and storing the clear paste under the condition of 2-8 ℃;
s2, calculating the corn starch quantity: calculating the addition of corn starch according to the weight of the extract and the solid content of the extract, wherein the corn starch content is theoretical yield-extract weight multiplied by the solid content of the extract, and then weighing and selecting a proper amount of corn starch;
s3, granulating: placing the corn starch prepared in the step S2 into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying the clear paste prepared in the step S1, granulating, keeping the drying temperature of the material between 50-85 ℃, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the moisture within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;
s4, finishing and sieving: crushing and granulating the granules prepared in the step S3 by a crusher with a screen with the aperture of 0.8mm (20 meshes);
s5, total mixing: adding magnesium stearate accounting for 1% of the total amount of the granules into the granules prepared in the step S4, mixing for at least 15 minutes by using a mixing device, sampling the granules after mixing is finished, and carrying out granule intermediate inspection;
s6, filling: selecting a proper amount of hollow capsules with green capsule caps and white capsule bodies, adjusting the loading of the particles prepared in the step S5 according to 0.3g of the loading of each particle, firstly carrying out trial loading, carrying out capsule intermediate inspection on the capsules prepared after the trial loading to be qualified, starting formal filling, checking the loading at any time in the filling process, strictly controlling the loading difference, and polishing after the filling is finished;
s7, packaging: and packaging the capsules prepared in the S6 by using a packaging machine to prepare the diabetes and blood sugar reducing capsules.
(III) advantageous effects
The invention provides a thirst-quenching and blood sugar-reducing capsule and a preparation method thereof. The method has the following beneficial effects:
the thirst quenching and blood sugar reducing capsule is prepared from guava leaves, corn starch, magnesium stearate and hollow capsules, and has the advantages of few traditional Chinese medicines, low cost and simple preparation process, so the thirst quenching and blood sugar reducing capsule is more suitable for popularization.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A thirst quenching and blood sugar reducing capsule comprises guava leaves and auxiliary materials, wherein the auxiliary materials comprise corn starch, magnesium stearate and empty capsules, the guava leaves and the corn starch are both granular, and the guava leaves account for 25 parts; 8 parts of corn starch; 4 parts of magnesium stearate; 20 parts of hollow capsules, and the guava leaves, the corn starch and the magnesium stearate are all filled in the hollow capsules.
A preparation method of a diabetes and blood sugar reducing capsule comprises the following steps,
s1, extracting: selecting 25 parts of guava leaves, adding the guava leaves into an extraction tank, adding 18 times of water, boiling the water, extracting the solution twice, extracting for 2 hours each time, discharging liquid medicine after extraction is finished, filtering, combining the filtrates obtained by two times of extraction, concentrating the filtrate into clear paste with the relative density of 1.25(80 ℃), then placing and cooling, adding 4 times of ethanol, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol in the filtrate, concentrating the filtrate into clear paste with the relative density of 1.15(80 ℃), putting the clear paste into a clean barrel, weighing and recording, then sticking a material label, injecting the name, specification, weight, date, operator and the like, then warehousing and storing the clear paste under the condition of 2-8 ℃;
s2, calculating the corn starch quantity: calculating the addition of corn starch according to the weight of the extract and the solid content of the extract, wherein the corn starch content is theoretical yield-extract weight multiplied by the solid content of the extract, and then weighing and selecting a proper amount of corn starch;
s3, granulating: placing the corn starch prepared in the step S2 into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying the clear paste prepared in the step S1, granulating, keeping the drying temperature of the material between 50-85 ℃, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the moisture within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;
s4, finishing and sieving: crushing and granulating the granules prepared in the step S3 by a crusher with a screen with the aperture of 0.8mm (20 meshes);
s5, total mixing: adding magnesium stearate accounting for 1% of the total amount of the granules into the granules prepared in the step S4, mixing for at least 15 minutes by using a mixing device, sampling the granules after mixing is finished, and carrying out granule intermediate inspection;
s6, filling: selecting a proper amount of hollow capsules with green capsule caps and white capsule bodies, adjusting the loading of the particles prepared in the step S5 according to 0.3g of the loading of each particle, firstly carrying out trial loading, carrying out capsule intermediate inspection on the capsules prepared after the trial loading to be qualified, starting formal filling, checking the loading at any time in the filling process, strictly controlling the loading difference, and polishing after the filling is finished;
s7, packaging: and packaging the capsules prepared in the S6 by using a packaging machine to prepare the diabetes and blood sugar reducing capsules.
Example 2
A thirst quenching and blood sugar reducing capsule comprises guava leaves and auxiliary materials, wherein the auxiliary materials comprise corn starch, magnesium stearate and empty capsules, the guava leaves and the corn starch are both granular, and the guava leaves account for 35 parts; 12 parts of corn starch; 6 parts of magnesium stearate; 30 parts of hollow capsules, and the guava leaves, the corn starch and the magnesium stearate are all filled in the hollow capsules.
A preparation method of a diabetes and blood sugar reducing capsule comprises the following steps,
s1, extracting: selecting 35 parts of guava leaves, adding the guava leaves into an extraction tank, adding 18 times of water, boiling the water, extracting the solution twice, extracting for 2 hours each time, discharging liquid medicine after extraction is finished, filtering, combining the filtrates obtained by two times of extraction, concentrating the filtrate into clear paste with the relative density of 1.25(80 ℃), then placing and cooling, adding 4 times of ethanol, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol in the filtrate, concentrating the filtrate into clear paste with the relative density of 1.15(80 ℃), putting the clear paste into a clean barrel, weighing and recording, then sticking a material label, injecting the name, specification, weight, date, operator and the like, then warehousing and storing the clear paste under the condition of 2-8 ℃;
s2, calculating the corn starch quantity: calculating the addition of corn starch according to the weight of the extract and the solid content of the extract, wherein the corn starch content is theoretical yield-extract weight multiplied by the solid content of the extract, and then weighing and selecting a proper amount of corn starch;
s3, granulating: placing the corn starch prepared in the step S2 into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying the clear paste prepared in the step S1, granulating, keeping the drying temperature of the material between 50-85 ℃, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the moisture within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;
s4, finishing and sieving: crushing and granulating the granules prepared in the step S3 by a crusher with a screen with the aperture of 0.8mm (20 meshes);
s5, total mixing: adding magnesium stearate accounting for 1% of the total amount of the granules into the granules prepared in the step S4, mixing for at least 15 minutes by using a mixing device, sampling the granules after mixing is finished, and carrying out granule intermediate inspection;
s6, filling: selecting a proper amount of hollow capsules with green capsule caps and white capsule bodies, adjusting the loading of the particles prepared in the step S5 according to 0.3g of the loading of each particle, firstly carrying out trial loading, carrying out capsule intermediate inspection on the capsules prepared after the trial loading to be qualified, starting formal filling, checking the loading at any time in the filling process, strictly controlling the loading difference, and polishing after the filling is finished;
s7, packaging: and packaging the capsules prepared in the S6 by using a packaging machine to prepare the diabetes and blood sugar reducing capsules.
Example 3
A thirst quenching and blood sugar reducing capsule comprises guava leaves and auxiliary materials, wherein the auxiliary materials comprise corn starch, magnesium stearate and empty capsules, the guava leaves and the corn starch are both granular, and the guava leaves account for 30 parts; 10 parts of corn starch; 5 parts of magnesium stearate; 25 parts of hollow capsules, wherein the guava leaves, the corn starch and the magnesium stearate are all filled in the hollow capsules.
A preparation method of a diabetes and blood sugar reducing capsule comprises the following steps,
s1, extracting: selecting 30 parts of guava leaves, adding the guava leaves into an extraction tank, adding 18 times of water, boiling the water, extracting the solution twice, extracting for 2 hours each time, discharging liquid medicine after extraction is finished, filtering, combining the filtrates obtained by two-time extraction, concentrating the filtrate into clear paste with the relative density of 1.25(80 ℃), then placing and cooling, adding 4 times of ethanol, stirring uniformly, standing for 24 hours, filtering, recovering the ethanol in the filtrate, concentrating the filtrate into clear paste with the relative density of 1.15(80 ℃), putting the clear paste into a clean barrel, weighing and recording, then sticking a material label, injecting the name, specification, weight, date, operator and the like, then warehousing and storing the clear paste under the condition of 2-8 ℃;
s2, calculating the corn starch quantity: calculating the addition of corn starch according to the weight of the extract and the solid content of the extract, wherein the corn starch content is theoretical yield-extract weight multiplied by the solid content of the extract, and then weighing and selecting a proper amount of corn starch;
s3, granulating: placing the corn starch prepared in the step S2 into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying the clear paste prepared in the step S1, granulating, keeping the drying temperature of the material between 50-85 ℃, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the moisture within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;
s4, finishing and sieving: crushing and granulating the granules prepared in the step S3 by a crusher with a screen with the aperture of 0.8mm (20 meshes);
s5, total mixing: adding magnesium stearate accounting for 1% of the total amount of the granules into the granules prepared in the step S4, mixing for at least 15 minutes by using a mixing device, sampling the granules after mixing is finished, and carrying out granule intermediate inspection;
s6, filling: selecting a proper amount of hollow capsules with green capsule caps and white capsule bodies, adjusting the loading of the particles prepared in the step S5 according to 0.3g of the loading of each particle, firstly carrying out trial loading, carrying out capsule intermediate inspection on the capsules prepared after the trial loading to be qualified, starting formal filling, checking the loading at any time in the filling process, strictly controlling the loading difference, and polishing after the filling is finished;
s7, packaging: and packaging the capsules prepared in the S6 by using a packaging machine to prepare the diabetes and blood sugar reducing capsules.
In conclusion, the thirst-quenching and blood sugar-reducing capsule is prepared from guava leaves, corn starch, magnesium stearate and hollow capsules, and has the advantages of few traditional Chinese medicines, low cost and simple preparation process, so the thirst-quenching and blood sugar-reducing capsule is more suitable for popularization.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising a reference structure" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. A thirst quenching and sugar reducing capsule comprises guava leaves and auxiliary materials, and is characterized in that: the auxiliary materials comprise corn starch, magnesium stearate and empty capsules, and 25-35 parts of guava leaves are added; 8-12 parts of corn starch; 4-6 parts of magnesium stearate; 20-30 parts of hollow capsules.
2. The thirst quenching and blood sugar reducing capsule according to claim 1, wherein: the guava leaves, the corn starch and the magnesium stearate are all filled in the hollow capsule.
3. The thirst quenching and blood sugar reducing capsule according to claim 1, wherein: the guava leaves and the corn starch are both granular.
4. The method for preparing a diabetes and blood sugar reducing capsule according to any one of claims 1-2, wherein the method comprises the following steps: comprises the following steps of (a) carrying out,
s1, extracting: selecting a proper amount of guava leaves, adding the guava leaves into an extraction tank, adding 18 times of water, boiling the water, extracting the solution twice, extracting for 2 hours each time, discharging liquid medicine after extraction is finished, filtering, combining the filtrates obtained by two-time extraction, concentrating the filtrate into clear paste with the relative density of 1.25(80 ℃), then placing and cooling the clear paste, adding 4 times of ethanol, stirring uniformly, standing for 24 hours, filtering again, recovering the ethanol in the filtrate, concentrating the filtrate into clear paste with the relative density of 1.15(80 ℃), putting the clear paste into a clean barrel, weighing and recording, then sticking a material label, injecting the name, specification, weight, date, operator and the like, then warehousing and storing the clear paste under the condition of 2-8 ℃;
s2, calculating the corn starch quantity: calculating the addition of corn starch according to the weight of the extract and the solid content of the extract, wherein the corn starch content = theoretical yield-extract weight multiplied by extract solid content, and then weighing and selecting a proper amount of corn starch;
s3, granulating: placing the corn starch prepared in the step S2 into a hopper of a boiling granulation dryer, preheating for 5-15 minutes, spraying the clear paste prepared in the step S1, granulating, keeping the drying temperature of the material between 50-85 ℃, continuously drying the granules for 20-30 minutes after the clear paste is sprayed, controlling the moisture within 6%, taking out of the pot, sampling, and carrying out granule intermediate inspection;
s4, finishing and sieving: crushing and granulating the granules prepared in the step S3 by a crusher with a screen with the aperture of 0.8mm (20 meshes);
s5, total mixing: adding magnesium stearate accounting for 1% of the total amount of the granules into the granules prepared in the step S4, mixing for at least 15 minutes by using a mixing device, sampling the granules after mixing is finished, and carrying out granule intermediate inspection;
s6, filling: selecting a proper amount of hollow capsules with green capsule caps and white capsule bodies, adjusting the loading of the particles prepared in the step S5 according to 0.3g of the loading of each particle, firstly carrying out trial loading, carrying out capsule intermediate inspection on the capsules prepared after the trial loading to be qualified, starting formal filling, checking the loading at any time in the filling process, strictly controlling the loading difference, and polishing after the filling is finished;
s7, packaging: and packaging the capsules prepared in the S6 by using a packaging machine to prepare the diabetes and blood sugar reducing capsules.
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| CN202011267665.0A CN112618597A (en) | 2020-11-13 | 2020-11-13 | Diabetes and blood sugar reducing capsule and preparation method thereof |
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| CN202011267665.0A CN112618597A (en) | 2020-11-13 | 2020-11-13 | Diabetes and blood sugar reducing capsule and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081998A (en) * | 2021-04-16 | 2021-07-09 | 湖北龙辅药业有限公司 | Chlorzoxazone capsule and preparation method thereof |
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2020
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113081998A (en) * | 2021-04-16 | 2021-07-09 | 湖北龙辅药业有限公司 | Chlorzoxazone capsule and preparation method thereof |
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Application publication date: 20210409 |