CN112586372A

CN112586372A - Mouse metabolism cage

Info

Publication number: CN112586372A
Application number: CN202011561992.7A
Authority: CN
Inventors: 孙佳; 黄晓忠; 黄慧雅; 牛超; 叶炜剑; 郭世坤; 林孝坤
Original assignee: Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University
Current assignee: Second Affiliated Hospital and Yuying Childrens Hospital of Wenzhou Medical University
Priority date: 2020-12-25
Filing date: 2020-12-25
Publication date: 2021-04-02

Abstract

The invention discloses a mouse metabolism cage which adopts the technical scheme that the mouse metabolism cage comprises a first test tube for collecting urine, a first valve port is arranged, a second test tube for collecting excrement is detachably connected with a second guide tube, the second valve port is arranged, and a timer and a control device for controlling the opening and closing of the first guide tube and the second guide tube are further arranged on a bottom frame. The invention has the following beneficial effects: after the experiment reaches the preset time, the timer sends a signal to the driving device, so that the first valve plate is used for inserting the first valve port to seal the first conduit, the second valve plate is used for inserting the second valve port to seal the second conduit, and metabolites metabolized by the mouse are prevented from being mixed in outside the experiment time, so that the accuracy of the experiment is ensured, the collection of the metabolites metabolized by the mouse within the limited time can be automatically completed, the manual monitoring and operation are not needed, and the experiment efficiency is improved.

Description

Mouse metabolism cage

Technical Field

The invention relates to an animal metabolism cage, in particular to a mouse metabolism cage.

Background

An animal metabolism cage is a medical scientific research instrument used in the field of clinical medicine, and is mainly used for metabolism detection of small animals. The metabolism cage collects the excrement and urine naturally discharged by the experimental animal by a method of directly collecting urine quantity by using an excrement-urine separation device, and is a specially designed sealed breeding cage for collecting various excreta of the experimental animal. General experiment can go on in the time of injecing, for example 24 hours mouse metabolism detects, needs the laboratory technician to carry out the experiment in the experimental time to avoid the experiment to produce the error, but the laboratory technician undertakes heavy experimental task, can not monitor always, can waste the manual work like this, is unfavorable for raising the efficiency.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide the mouse metabolism cage which can automatically collect mouse metabolites within a limited time without manual monitoring, so that the experiment efficiency is improved.

In order to achieve the purpose, the invention provides the following technical scheme: a mouse metabolism cage comprises a chassis, a cage body for breeding mice is installed on the chassis, the bottom of the cage body is a screen plate, a collecting tank is connected below the screen plate, a separating plate for separating urine and excrement is arranged in the collecting tank, a first outlet for discharging the urine is arranged at the bottom of the collecting tank, a first conduit for leading out the urine is connected to the first outlet, a second outlet for discharging the excrement is arranged on the side surface of the collecting tank, a second conduit for leading out the excrement is connected to the second outlet, a first test tube for collecting the urine is detachably connected to the first conduit, a first valve port is arranged at the first conduit, a second test tube for collecting the excrement is detachably connected to the second conduit, a second valve port is arranged at the second conduit, a timer and a control device for controlling the opening and closing of the first conduit and the second conduit are further installed on the chassis, the control device comprises a driving device, the timer is electrically connected with the driving device, a telescopic rod is arranged on the driving device, a connecting plate is connected onto the telescopic rod, a first valve plate and a second valve plate are connected onto the connecting plate, the first valve plate is used for being inserted into the first valve port to seal the first guide pipe, and the second valve plate is used for being inserted into the second valve port to seal the second guide pipe.

The invention is further configured to: the inner wall of the collecting tank is provided with a sensor used for sensing urine and excrement, the sensor is electrically connected with the driving device, when the sensor senses that the urine or the excrement enters the collecting tank, the driving device drives the telescopic rod to move, the first valve plate is driven to be drawn out from the first valve port, the first guide pipe is opened, and the second valve plate is driven to be drawn out from the second valve port, so that the second guide pipe is opened.

The invention is further configured to: still install vibration isolation device on the chassis, vibration isolation device is including the motor, the motor is provided with the output shaft, the output shaft stretches into in the collecting vat, and be connected with the cam, the cam supports and leans on the bottom surface of separator plate, the separator plate slope sets up, and the lower extreme rotates to be connected on the inner wall of collecting vat, the motor is connected with the sensor electricity, when the sensor senses urine or excrement and urine and gets into the collecting vat, the motor starts, make the cam rotate, with the vibration separator plate, with urine and excrement and urine separation, and guide excrement and urine gets into in the second pipe.

The invention is further configured to: be provided with the blotter on the bottom surface of separator plate, the blotter is provided with the spacing groove, and the spacing groove is used for supplying the cam to insert to it is spacing with the cam.

The invention is further configured to: the first valve port is matched with the first valve plate, a first rubber pad for cleaning the top surface of the first valve plate is arranged above the inner side of the first valve port, the second valve port is matched with the second valve plate, and a second rubber pad for cleaning the top surface of the second valve plate is arranged above the inner side of the second valve port.

The invention is further configured to: still be provided with in the second test tube and strain a section of thick bamboo, the nozzle department of straining a section of thick bamboo is provided with and keeps off the ring, keeps off the ring and is used for placing on the top surface of second test tube to it is unsettled at the test tube to make to strain a section of thick bamboo, and the bottom of straining a section of thick bamboo and the bottom of test tube are provided with the clearance, and the clearance is used for holding the excrement after filtering.

The invention is further configured to: the collecting groove is funnel-shaped.

The invention is further configured to: the cage body is provided with a water supply tank and a feed trough, the water supply tank is connected with a control valve, and the control valve is electrically connected with a timer.

In conclusion, the invention has the following beneficial effects: the experimenter puts the mouse into the cage body, and sets the experiment time through the timer. During the set experimental time, urine and feces metabolized by the mice are separated by the separation plate and pass into the first test tube and the second test tube, respectively. After the experiment reaches the preset time, the timer sends a signal to drive arrangement, control drive arrangement drives the telescopic link and stretches out, make first valve plate be used for inserting first valve port, with closed first pipe, the second valve plate is used for inserting the second valve port, with closed second pipe, the metabolite of mouse metabolism play sneaks into outside the avoidance experiment time, with the accuracy of guaranteeing the experiment, and can accomplish the collection of mouse metabolite in the limited time voluntarily, need not artifical control and operation, thereby improve experimental efficiency.

Drawings

FIG. 1 is a schematic perspective view of a mouse metabolic cage;

FIG. 2 is an enlarged view A of FIG. 1;

FIG. 3 is an enlarged view B of FIG. 1;

fig. 4 is an enlarged view of C of fig. 1.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and examples. In which like parts are designated by like reference numerals. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "bottom" and "top," "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.

Referring to fig. 1-4, a mouse metabolism cage comprises a base frame 1, a cage body 2 for breeding mice is mounted on the base frame 1, a net plate 21 is arranged at the bottom of the cage body 2, a collecting tank 3 is connected below the net plate 21, a separating plate 31 for separating urine and feces is arranged in the collecting tank 3, a first outlet 32 for discharging urine is arranged at the bottom, the first outlet 32 is connected with a first conduit 321 for leading out urine, a second outlet 33 for discharging feces is arranged on the side surface of the collecting tank 3, the second outlet 33 is connected with a second conduit 331 for leading out feces, the first conduit 321 is detachably connected with a first test tube 322 for collecting urine and is provided with a first valve port 323, the second conduit 331 is detachably connected with a second test tube 332 for collecting feces and is provided with a second valve port 333, a timer 11 and a control device 4 for controlling the opening and closing of the first conduit 321 and the second conduit 331 are further mounted on the base frame 1, the control device 4 comprises a driving device 41, the timer 11 is electrically connected with the driving device 41, an expansion link 42 is arranged on the driving device 41, a connecting plate 43 is connected on the expansion link 42, a first valve plate 44 and a second valve plate 45 are connected on the connecting plate 43, the first valve plate 44 is inserted into the first valve port 323 to close the first conduit 321, and the second valve plate 45 is inserted into the second valve port 333 to close the second conduit 331.

Through the scheme, the experimenter puts the mouse into the cage body 2, and sets experiment time through the timer 11. Urine and feces metabolized by the mice are separated by the separation plate 31 and pass into the first test tube 322 and the second test tube 332, respectively, during the set experimental time. After the experiment reaches the preset time, the timer 11 sends a signal to the driving device 41, and the driving device 41 is controlled to drive the telescopic rod 42 to extend out, so that the first valve plate 44 is inserted into the first valve port 323 to seal the first conduit 321, and the second valve plate 45 is inserted into the second valve port 333 to seal the second conduit 331, so that metabolites metabolized by the mouse are prevented from being mixed outside the experiment time, the accuracy of the experiment is ensured, the collection of the metabolites metabolized by the mouse within the limited time can be automatically completed, the manual monitoring and operation are not needed, and the experiment efficiency is improved.

As a modified embodiment, a sensor 34 for sensing urine and feces is disposed on the inner wall of the collecting tank 3, the sensor 34 is electrically connected to the driving device 41, and when the sensor 34 senses that urine or feces enters the collecting tank 3, the driving device 41 drives the telescopic rod 42 to move, so as to draw the first valve plate 44 out of the first valve port 323, so as to open the first conduit 321, and to draw the second valve plate 45 out of the second valve port 333, so as to open the second conduit 331.

Through above-mentioned scheme, in the experimental time, when sensor 34 did not sense the mouse and had metabolism out urine and excrement and urine, first pipe 321 and second pipe 331 all are in the closed condition to avoid the evaporation of water in excrement and urine or the urine, ensure the integrality of data, ensure to accomplish the experiment accurately. When the sensor 34 senses that the mouse metabolizes urine and feces, the sensor 34 sends a signal to control the driving device 41 to drive the telescopic rod 42 to move, drive the first valve plate 44 to be drawn out from the first valve port 323 to open the first conduit 321, and drive the second valve plate 45 to be drawn out from the second valve port 333 to open the second conduit 331, and after the metabolites are collected, rapidly close the first conduit 321 and the second conduit 331, so that the metabolites can be collected as much as possible, and the accuracy of the experiment can be guaranteed.

As a modified specific embodiment, a vibration separation device 5 is further installed on the chassis 1, the vibration separation device 5 includes a motor 51, the motor 51 is provided with an output shaft 52, the output shaft 52 extends into the collecting tank 3 and is connected with a cam 53, the cam 53 abuts against the bottom surface of the separation plate 31, the separation plate 31 is obliquely arranged, and the lower end of the separation plate is rotatably connected to the inner wall of the collecting tank 3, the motor 51 is electrically connected with a sensor, when the sensor 34 senses that urine or feces enters the collecting tank 3, the motor 51 is started to rotate the cam 53 to vibrate the separation plate 31 to separate the urine from the feces, and the feces are guided into the second conduit 331.

Through above-mentioned scheme, when sensor 34 sensed that urine or excrement and urine got into collecting vat 3, motor 51 started, drive output shaft 52 and rotate for cam 53 rotates thereupon, with vibration separation plate 31, the vibration is favorable to can complete the separation as far as possible with urine and excrement and urine, and can shake excrement and urine, guide excrement and urine along the separator 311 entering second pipe 331 of slope in, in order to accelerate the speed of separation, and make excrement and urine just can get into in second pipe 331 as early as possible, in order to reduce the time that excrement and urine exposes outside, in order to improve the precision of experiment.

As a modified embodiment, a cushion pad 54 is provided on the bottom surface of the separation plate 31, and the cushion pad 54 is provided with a limiting groove 541, and the limiting groove 541 is used for the cam 53 to be inserted to limit the cam 53.

Through the above scheme, the cushion pad 54 is made of elastic material to avoid too severe vibration, and the cam 53 is limited through the limiting groove 541, and the connection between the cam and the cam is maintained to ensure that the separation plate 31 can be vibrated smoothly and continuously.

As a modified embodiment, the first valve port 323 is matched with the first valve plate 44, a first rubber pad 324 for cleaning the top surface of the first valve plate 44 is arranged above the inner side of the first valve port 323, the second valve port 333 is matched with the second valve plate 45, and a second rubber pad 334 for cleaning the top surface of the second valve plate 45 is arranged above the inner side of the second valve port 333.

Through the scheme, in the back and forth movement process of the first valve plate 44, the first rubber pad 324 abuts against the top surface of the first valve plate 44 to clean the top surface of the first valve plate 44, so that urine is prevented from remaining on the first valve plate 44, and the first valve plate 44 is ensured to move smoothly. During the back and forth movement of the second valve plate 45, the second rubber pad 334 abuts against the top surface of the second valve plate 45, cleaning the top surface of the second valve plate 45 to avoid remaining on the top surface of the second valve plate, respectively, and ensuring that the second valve plate 45 can move smoothly.

As a modified embodiment, the second test tube 332 is further provided with a filter cartridge 6, a stop ring 61 is arranged at the mouth of the filter cartridge 6, the stop ring 61 is used for being placed on the top surface of the second test tube 332 so as to suspend the filter cartridge 6 in the test tube, a gap 62 is arranged between the bottom of the filter cartridge 6 and the bottom of the test tube, and the gap 62 is used for accommodating filtered excrement.

By the above solution, the filter cartridge 6 can contain the feces and filter the excess liquid or other excrement contained in the gap 62 to avoid the feces from being contaminated and ensure that the feces can be kept intact.

As a modified embodiment, the collection trough 3 is funnel-shaped.

Through above-mentioned scheme, leak hopper-shaped be convenient for collect the excrement as far as possible, improve the efficiency of collecting.

In a modified embodiment, the cage body 2 is provided with a water supply tank 22 and a feed tank 23, the water supply tank 22 is connected with a control valve 24, and the control valve 24 is electrically connected with the timer 11.

Through the above scheme, the interval of water feeding is set through the timer 11, thereby ensuring that sufficient water can be supplied through the water supply tank 22. And the mice are fed through the trough 23 to simulate the normal living conditions of the mice as much as possible.

The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. The utility model provides a mouse metabolism cage, is including chassis (1), install on chassis (1) and be used for breeding the cage body (2) of mouse, characterized by: the bottom of the cage body (2) is provided with a screen plate (21), a collecting tank (3) is connected below the screen plate, a separating plate (31) for separating urine and excrement is arranged in the collecting tank (3), a first outlet (32) for discharging the urine is arranged at the bottom of the collecting tank, a first conduit (321) for guiding out the urine is connected to the first outlet (32), a second outlet (33) for discharging the excrement is arranged on the side surface of the collecting tank (3), a second conduit (331) for guiding out the excrement is connected to the second outlet (33), a first test tube (322) for collecting the urine is detachably connected to the first conduit (321), a first valve port (323) is arranged, a second test tube (332) for collecting the excrement is detachably connected to the second conduit (331), a second valve port (333) is arranged, a timer (11) and a controller for controlling the first conduit (321) and the second conduit (331) are further arranged on the chassis (1) ) The control device (4) comprises a driving device (41), the timer (11) is electrically connected with the driving device (41), an expansion rod (42) is arranged on the driving device (41), a connecting plate (43) is connected onto the expansion rod (42), a first valve plate (44) and a second valve plate (45) are connected onto the connecting plate (43), the first valve plate (44) is used for being inserted into a first valve port (323) to seal a first guide pipe (321), and the second valve plate (45) is used for being inserted into a second valve port (333) to seal a second guide pipe (331).

2. The mouse metabolic cage of claim 1, wherein: the inner wall of the collecting tank (3) is provided with a sensor (34) for sensing urine and excrement, the sensor (34) is electrically connected with a driving device (41), when the sensor (34) senses that the urine or the excrement enters the collecting tank (3), the driving device (41) drives the telescopic rod (42) to move, the first valve plate (44) is driven to be drawn out from the first valve port (323) to open the first conduit (321), and the second valve plate (45) is driven to be drawn out from the second valve port (333) to open the second conduit (331).

3. The mouse metabolic cage of claim 2, wherein: still install vibration isolation device (5) on chassis (1), vibration isolation device (5) are including motor (51), motor (51) are provided with output shaft (52), output shaft (52) stretch into in collecting vat (3) to be connected with cam (53), cam (53) support and lean on the bottom surface of separation plate (31), separation plate (31) slope sets up, and the lower extreme rotates and connects on the inner wall of collecting vat (3), motor (51) are connected with sensor (34) electricity, and when sensor (34) sensed urine or excrement and urine and got into collecting vat (3), motor (51) started for cam (53) rotate to vibration separation plate (31), with urine and excrement and urine separation to guide excrement and urine to get into in second pipe (331).

4. The mouse metabolic cage of claim 3, wherein: a buffer pad (54) is arranged on the bottom surface of the separating plate (31), a limiting groove (541) is formed in the buffer pad (54), and the limiting groove (541) is used for inserting the cam (53) so as to limit the cam (53).

5. The mouse metabolic cage of claim 4, wherein: the first valve port (323) is matched with the first valve plate (44), a first rubber pad (324) used for cleaning the top surface of the first valve plate (44) is arranged above the inner side of the first valve port (323), the second valve port (333) is matched with the second valve plate (45), and a second rubber pad (334) used for cleaning the top surface of the second valve plate (45) is arranged above the inner side of the second valve port (333).

6. The mouse metabolic cage of claim 5, wherein: a filter cylinder (6) is further arranged in the second test tube (332), a blocking ring (61) is arranged at the opening of the filter cylinder (6), the blocking ring (61) is placed on the top surface of the second test tube (332) so that the filter cylinder (6) is suspended in the test tube, a gap (62) is formed between the bottom of the filter cylinder (6) and the bottom of the test tube, and the gap (62) is used for accommodating filtered excrement.

7. The mouse metabolic cage of claim 6, wherein: the collecting groove (3) is funnel-shaped.

8. The mouse metabolic cage according to any one of claims 1-7, wherein: the cage body (2) is provided with a water supply tank (22) and a feed tank (23), the water supply tank (22) is connected with a control valve (24), and the control valve (24) is electrically connected with a timer (11).