CN112569203A - Preparation method of animal gelatin capsule shell - Google Patents
Preparation method of animal gelatin capsule shell Download PDFInfo
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- CN112569203A CN112569203A CN202011409786.4A CN202011409786A CN112569203A CN 112569203 A CN112569203 A CN 112569203A CN 202011409786 A CN202011409786 A CN 202011409786A CN 112569203 A CN112569203 A CN 112569203A
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- animal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
Abstract
The invention relates to the technical field of medicine processing, in particular to a preparation method of an animal gelatin capsule shell. The method comprises the operation steps of dissolving gelatin and animal collagen respectively, mixing the prepared solution uniformly, stirring in water bath, ultrasonic and vacuum degassing, keeping at constant temperature, dipping in glue for solidification, drying at constant temperature, pulling out shells and cutting, ozone sterilization and the like. The design of the invention can improve the solubility, the uniformity and the viscosity of the gelatin solution, thereby improving the taste and the quality of the finished capsule shell product, and simultaneously can be molded and used for different purposes on the premise of keeping the active ingredients of the collagen, strengthening the respective effects of the gelatin and the animal collagen, and further improving the medicinal value and the nutritional effect of the capsule medicament.
Description
Technical Field
The invention relates to the technical field of medicine processing, in particular to a preparation method of an animal gelatin capsule shell.
Background
The capsule shell is made from edible medicinal gelatin through fine treatment and auxiliary materials. The edible gelatin is beneficial to the digestion of food, and the animal collagen has the functions of enhancing memory and human immunity. If the animal collagen is applied to the preparation process of the capsule shell, the medicinal value and the nutritional effect of the capsule medicine can be improved. At present, a plurality of methods for preparing edible gelatin and animal collagen exist, but at present, no report is found on a method for rapidly preparing a capsule shell by combining the edible gelatin and the animal collagen.
Disclosure of Invention
The invention aims to provide a method for preparing an animal gelatin capsule shell, which aims to solve the problems in the background technology and comprises the following steps:
s1, respectively carrying out dissolving operation on gelatin and animal collagen;
s2, setting the preheating temperature of the reaction tank to 60 ℃, mixing the dissolved gelatin and the collagen according to the ratio of 8:2 after the temperature is reached, and simultaneously adding a plasticizer and a surfactant according to mass percentage to fully and uniformly mix various materials;
s3, placing the uniformly mixed glue solution prepared in the step into a water bath kettle at the constant temperature of 40-70 ℃ and stirring until a wall material solution flowing uniformly is formed;
s4, carrying out ultrasonic degassing on the wall material solution, and then placing the wall material solution under vacuum pressure until the solution becomes clear and transparent to form a uniform shell material;
s5, transferring the degassed shell material into a preheated holding tank, setting the temperature to be 60 ℃ and the time to be 4 hours for later encapsulation;
s6, carrying out glue dipping, cooling and solidifying operations through the mold rod of the capsule grinding tool;
s7, transferring the solidified capsules into a constant-temperature dryer, setting the drying temperature to be 40-60 ℃ and the drying time to be 45 min;
s8, pulling out the blastocyst after the blastocyst is remoistened, cutting the blastocyst according to the required proportion size, and combining the cut capsule body and the cut capsule cap to obtain a finished capsule shell product;
s9, sterilizing the hollow capsule prepared in the above steps by adopting an ozone sterilization method, wherein the ozone pressure is set to be 0.2MPa, and the sterilization time is set to be 1-10 min.
As a further improvement of the present technical solution, in S1, the process of dissolving gelatin and animal collagen comprises the following steps:
s1.1, mixing gelatin, glycerol, sorbitol and water at a ratio of 40:12:12:15:33 at room temperature, placing the mixed solution in a heating tank, setting the temperature to be 70 ℃, vacuumizing, and heating and stirring for 30min until a gel block is molten;
s1.2, mixing the animal collagen with water at room temperature according to a ratio of 1:1, heating to 64 ℃ in vacuum, and stirring for 42min until the animal collagen is melted.
As a further improvement of the technical scheme, in S1.2, the animal collagen is collagen peptide with the relative molecular mass less than 2 KD.
As a further improvement of the technical scheme, in the S1.2, when the selected animal collagen is fish skin collagen, the dissolving condition is set to be vacuum heating to 55 ℃ and stirring for 30 min.
As a further improvement of the technical scheme, in the S1.2, when the selected animal collagen is pig skin or donkey skin collagen, the dissolving condition is set to vacuum heating to 64 ℃, and stirring for 42 min.
In a further improvement of the present invention, in S2, the mass fraction of the plasticizer is 0.1% to 30%, and the mass fraction of the surfactant is 0.1% to 30%.
As a further improvement of the technical scheme, in the S4, in the ultrasonic degassing process, the ultrasonic frequency is set to be 20 kHz-120 kHz, and the vacuum pressure is set to be 0.08-0.09 MPa.
As a further improvement of the present technical solution, in S6, the flow of the glue dipping and cooling solidification operation includes the following steps:
s6.1, immersing the die rod of the capsule grinding tool into mustard oil for sufficient lubrication, so that the surface of the die rod is uniformly covered with a layer of mustard oil;
s6.2, immersing the lubricated mould rod of the capsule grinding tool into the glue solution for about 5-20S, slowly lifting the mould, and turning over for 3-7 times to uniformly distribute the glue solution on the surface of the mould;
and S6.3, quickly extending the part, covered with the glue solution, of the die rod of the grinding tool into purified cold water for cooling and solidification.
Compared with the prior art, the invention has the beneficial effects that: in the preparation method of the animal gelatin capsule shell, firstly, the solubility, the uniformity and the viscosity of the gelatin solution can be improved by changing the components and the proportion of the gelatin solution, so that the taste and the quality of the finished capsule shell are improved, meanwhile, the animal collagen and the edible gelatin are reasonably proportioned, the gelatin can be molded and used for different purposes on the premise of retaining the active ingredients of the collagen, the respective effects of the gelatin and the animal collagen are strengthened, and the medicinal value and the nutritional effect of the capsule medicine are improved.
Drawings
FIG. 1 is an overall flow chart of the present invention;
FIG. 2 is an overall flow diagram of the present invention;
FIG. 3 is a flow chart of the method for dissolving gelatin and animal collagen according to the present invention;
FIG. 4 is a flow chart of the dipping and coagulation method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
As shown in fig. 1 to 4, the present embodiment aims to provide a method for preparing an animal gelatin capsule shell, comprising the following steps:
s1, respectively carrying out dissolving operation on gelatin and animal collagen;
s2, setting the preheating temperature of the reaction tank to 60 ℃, mixing the dissolved gelatin and the collagen according to the ratio of 8:2 after the temperature is reached, and simultaneously adding a plasticizer and a surfactant according to mass percentage to fully and uniformly mix various materials;
s3, placing the uniformly mixed glue solution prepared in the step into a water bath kettle at the constant temperature of 40-70 ℃ and stirring until a wall material solution flowing uniformly is formed;
s4, carrying out ultrasonic degassing on the wall material solution, and then placing the wall material solution under vacuum pressure until the solution becomes clear and transparent to form a uniform shell material;
s5, transferring the degassed shell material into a preheated holding tank, setting the temperature to be 60 ℃ and the time to be 4 hours for later encapsulation;
s6, carrying out glue dipping, cooling and solidifying operations through the mold rod of the capsule grinding tool;
s7, transferring the solidified capsules into a constant-temperature dryer, setting the drying temperature to be 40-60 ℃ and the drying time to be 45 min;
s8, pulling out the blastocyst after the blastocyst is remoistened, cutting the blastocyst according to the required proportion size, and combining the cut capsule body and the cut capsule cap to obtain a finished capsule shell product;
s9, sterilizing the hollow capsule prepared in the above steps by adopting an ozone sterilization method, wherein the ozone pressure is set to be 0.2MPa, and the sterilization time is set to be 1-10 min.
In this embodiment, in S1, the process of dissolving gelatin and animal collagen includes the following steps:
s1.1, mixing gelatin, glycerol, sorbitol and water at a ratio of 40:12:12:15:33 at room temperature, placing the mixed solution in a heating tank, setting the temperature to be 70 ℃, vacuumizing, and heating and stirring for 30min until a gel block is molten;
s1.2, mixing the animal collagen with water at room temperature according to a ratio of 1:1, heating to 64 ℃ in vacuum, and stirring for 42min until the animal collagen is melted.
The glycerol is colorless and odorless, has warm and sweet taste, can absorb moisture and keep moisture, can dissolve certain inorganic matters, can improve the transparent color clarity of the gelatin solution, enables the gelatin solution to be finer and more uniform in texture, and further can improve the mouth feel and high quality of the finished capsule shell; sorbitol is colorless and has warm sweet taste, can be neutralized with glycerol to form moderate slightly sweet taste, can absorb moisture, improves the viscosity of gelatin solution, and is convenient for subsequent molding operation.
In addition, it is worth mentioning that excessive amounts of sorbitol taken orally can cause diarrhea or digestive disorders and therefore can only be added in small amounts.
Specifically, in S1.2, the animal collagen adopts collagen peptide with relative molecular mass less than 2KD, so that the collagen is fine and smooth, and is easy to dissolve quickly, and then the uniform collagen solution is obtained.
Further, in S1.2, when the selected animal collagen is fish skin collagen, the dissolving condition is set to vacuum heating to 55 ℃, and stirring for 30min, and the dissolving condition needs to be reduced because the fish skin is thinner and finer, thereby preventing the fish skin collagen from being excessively damaged and reducing the surface activity thereof.
Further, in S1.2, when the selected animal collagen is pig skin or donkey skin collagen, the dissolving condition is set to vacuum heating to 64 deg.C, and stirring for 42 min.
In this embodiment, in S2, the mass fraction of the plasticizer is 0.1% to 30%, the mass fraction of the surfactant is 0.1% to 30%, the surfactant can retain the active components of collagen, and the plasticizer can improve the plasticity of the collagen solution, so that the collagen solution can be used in different applications.
In this embodiment, in S4, the ultrasonic frequency is set to 20kHz to 120kHz and the vacuum pressure is set to 0.08 to 0.09MPa during the ultrasonic degassing, and the gas in the mixed sol can be further removed by using the ultrasonic and vacuum treatments simultaneously, so that the capsule shell is more uniform in texture after the capsule shell is molded.
In this embodiment, in S6, the process of dipping glue and cooling to solidify includes the following steps:
s6.1, immersing the die rod of the capsule grinding tool into mustard oil for sufficient lubrication, so that the surface of the die rod is uniformly covered with a layer of mustard oil;
s6.2, immersing the lubricated mould rod of the capsule grinding tool into the glue solution for about 5-20S, slowly lifting the mould, and turning over for 3-7 times to uniformly distribute the glue solution on the surface of the mould;
and S6.3, quickly extending the part, covered with the glue solution, of the die rod of the grinding tool into purified cold water for cooling and solidification.
Example 2
Four sets of experiments were performed on the gelatin solution in this example:
experiment 1
The gelatin solution comprises the following raw materials in parts by mass: 40% gelatin, 12% glycerol, 15% sorbitol and 33% water.
Experiment 2
The gelatin solution comprises the following raw materials in parts by mass: 40% gelatin, 27% glycerol and 33% water.
Experiment 3
The gelatin solution comprises the following raw materials in parts by mass: 40% gelatin, 15% sorbitol and 45% water.
Experiment 4
The gelatin solution comprises the following raw materials in parts by mass: 50% gelatin and 50% water.
The four experiments were compared for solution appearance, solution taste, solution viscosity and shape after mixing with collagen solution, as shown in the following table:
as can be seen from the above table, in the preparation method of the animal gelatin capsule shell of the embodiment, by changing the components and the ratio of the gelatin solution, the gelatin solution is transparent and clear, the solubility is improved, the uniformity and the viscosity of the solution texture are improved, an excellent wall material can be prepared, the molding is facilitated, the mouth feel of the gelatin solution can be improved, and the mouth feel and the quality of the finished capsule shell are further improved.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and the preferred embodiments of the present invention are described in the above embodiments and the description, and are not intended to limit the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (8)
1. A preparation method of animal gelatin capsule shells is characterized in that: the method comprises the following steps:
s1, respectively carrying out dissolving operation on gelatin and animal collagen;
s2, setting the preheating temperature of the reaction tank to 60 ℃, mixing the dissolved gelatin and the collagen according to the ratio of 8:2 after the temperature is reached, and simultaneously adding a plasticizer and a surfactant according to mass percentage to fully and uniformly mix various materials;
s3, placing the uniformly mixed glue solution prepared in the step into a water bath kettle at the constant temperature of 40-70 ℃ and stirring until a wall material solution flowing uniformly is formed;
s4, carrying out ultrasonic degassing on the wall material solution, and then placing the wall material solution under vacuum pressure until the solution becomes clear and transparent to form a uniform shell material;
s5, transferring the degassed shell material into a preheated holding tank, setting the temperature to be 60 ℃ and the time to be 4 hours for later encapsulation;
s6, carrying out glue dipping, cooling and solidifying operations through the mold rod of the capsule grinding tool;
s7, transferring the solidified capsules into a constant-temperature dryer, setting the drying temperature to be 40-60 ℃ and the drying time to be 45 min;
s8, pulling out the blastocyst after the blastocyst is remoistened, cutting the blastocyst according to the required proportion size, and combining the cut capsule body and the cut capsule cap to obtain a finished capsule shell product;
s9, sterilizing the hollow capsule prepared in the above steps by adopting an ozone sterilization method, wherein the ozone pressure is set to be 0.2MPa, and the sterilization time is set to be 1-10 min.
2. The process for the preparation of animal gelatin capsule shells as claimed in claim 1, wherein: in S1, the process of dissolving gelatin and animal collagen includes the following steps:
s1.1, mixing gelatin, glycerol, sorbitol and water at a ratio of 40:12:12:15:33 at room temperature, placing the mixed solution in a heating tank, setting the temperature to be 70 ℃, vacuumizing, and heating and stirring for 30min until a gel block is molten;
s1.2, mixing the animal collagen with water at room temperature according to a ratio of 1:1, heating to 64 ℃ in vacuum, and stirring for 42min until the animal collagen is melted.
3. The process for the preparation of animal gelatin capsule shells as claimed in claim 2, wherein: in S1.2, the animal collagen is collagen peptide with relative molecular mass less than 2 KD.
4. The process for the preparation of animal gelatin capsule shells as claimed in claim 2, wherein: in S1.2, when the selected animal collagen is fish skin collagen, the dissolving condition is set to vacuum heating to 55 ℃, and stirring for 30 min.
5. The process for the preparation of animal gelatin capsule shells as claimed in claim 2, wherein: in S1.2, when the selected animal collagen is pig skin or donkey skin collagen, the dissolving condition is set to vacuum heating to 64 ℃, and stirring is carried out for 42 min.
6. The process for the preparation of animal gelatin capsule shells as claimed in claim 1, wherein: in the S2, the mass fraction of the added plasticizer is 0.1-30%, and the mass fraction of the added surfactant is 0.1-30%.
7. The process for the preparation of animal gelatin capsule shells as claimed in claim 1, wherein: in the S4, in the ultrasonic degassing process, the ultrasonic frequency is set to be 20 kHz-120 kHz, and the vacuum pressure is set to be 0.08-0.09 MPa.
8. The process for the preparation of animal gelatin capsule shells as claimed in claim 1, wherein: in S6, the process of dipping glue and cooling to solidify includes the following steps:
s6.1, immersing the die rod of the capsule grinding tool into mustard oil for sufficient lubrication, so that the surface of the die rod is uniformly covered with a layer of mustard oil;
s6.2, immersing the lubricated mould rod of the capsule grinding tool into the glue solution for about 5-20S, slowly lifting the mould, and turning over for 3-7 times to uniformly distribute the glue solution on the surface of the mould;
and S6.3, quickly extending the part, covered with the glue solution, of the die rod of the grinding tool into purified cold water for cooling and solidification.
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| CN202011409786.4A CN112569203A (en) | 2020-12-03 | 2020-12-03 | Preparation method of animal gelatin capsule shell |
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| CN202011409786.4A CN112569203A (en) | 2020-12-03 | 2020-12-03 | Preparation method of animal gelatin capsule shell |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050069581A1 (en) * | 2003-09-29 | 2005-03-31 | Suheung Capsule Co., Ltd. | Fish gelatin hard capsule and its preparation method |
| CN102511909A (en) * | 2012-01-07 | 2012-06-27 | 中国海洋大学 | Microcapsule |
| CN102525994A (en) * | 2010-12-10 | 2012-07-04 | 上海春芝堂生物制品有限公司 | Fish gelatin soft capsule and preparation method thereof |
| CN103784418A (en) * | 2012-10-26 | 2014-05-14 | 中国科学院烟台海岸带研究所 | Fish skin gelatin hollow capsules and preparation method thereof |
| CN103992746A (en) * | 2014-06-04 | 2014-08-20 | 上海海洋大学 | Method for preparing pharmaceutical gelatin with different gel strength by using tilapia skins |
-
2020
- 2020-12-03 CN CN202011409786.4A patent/CN112569203A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050069581A1 (en) * | 2003-09-29 | 2005-03-31 | Suheung Capsule Co., Ltd. | Fish gelatin hard capsule and its preparation method |
| CN102525994A (en) * | 2010-12-10 | 2012-07-04 | 上海春芝堂生物制品有限公司 | Fish gelatin soft capsule and preparation method thereof |
| CN102511909A (en) * | 2012-01-07 | 2012-06-27 | 中国海洋大学 | Microcapsule |
| CN103784418A (en) * | 2012-10-26 | 2014-05-14 | 中国科学院烟台海岸带研究所 | Fish skin gelatin hollow capsules and preparation method thereof |
| CN103992746A (en) * | 2014-06-04 | 2014-08-20 | 上海海洋大学 | Method for preparing pharmaceutical gelatin with different gel strength by using tilapia skins |
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Application publication date: 20210330 |
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