CN112568870A - Photoacoustic imaging apparatus and driving device - Google Patents
Photoacoustic imaging apparatus and driving device Download PDFInfo
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- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The application provides a photoacoustic imaging device, photoacoustic imaging device includes drive conversion mechanism, motor and photoacoustic probe, drive conversion mechanism will the rotary motion of motor converts the straight line reciprocating motion into, and drives photoacoustic probe is straight line reciprocating motion. The rotation speed of the motor can reach thousands of revolutions per minute, so that the photoacoustic probe can be driven to synchronously do high-speed linear reciprocating motion. In addition, the linear reciprocating motion distance of the photoacoustic probe is related to the size of the drive conversion mechanism, and the size of the drive conversion mechanism can be designed reasonably to achieve the required imaging field of view. The present application further provides a drive arrangement that includes a drive conversion mechanism and a motor. The photoacoustic imaging device provided by the application not only can achieve the photoacoustic imaging effect of a high-speed large visual field, but also has the advantages of simple structure and low cost through applying the driving device.
Description
Technical Field
The present application relates to the field of photoacoustic imaging technology, and in particular, to a photoacoustic imaging apparatus and a driving device.
Background
Currently, in the field of biomedical imaging, photoacoustic imaging technology is widely applied. The optical imaging technology is mainly based on the photoacoustic effect principle, when a sample to be imaged selectively absorbs pulse laser, partial light energy is converted into heat energy, so that the sample generates thermoelastic effect, ultrasonic waves, namely photoacoustic signals, are emitted, and the photoacoustic signals are reconstructed by a processor after being received by a photoacoustic probe, so that corresponding images are obtained. The photoacoustic imaging combines high contrast and high resolution of optical imaging and large imaging depth of ultrasonic imaging, can reflect morphological structure characteristics of biological tissues, can realize functional imaging according to selective absorption of the biological tissues to spectra, and is a non-invasive, non-ionizing and nondestructive biomedical imaging method.
The traditional photoacoustic imaging method is mainly based on raster scan imaging: the photoacoustic probe scans point by point under the drive of the two-dimensional translation stage, and then forms a two-dimensional image through reconstruction. The imaging method has a plurality of collected data points and a large field of view, but the moving speed of the translation stage is limited, generally 10mm/s, so the imaging speed of the imaging method is very slow. For example, under the conditions that the laser repetition frequency is 2000Hz and the step pitch is 5 μm, at least 40min is required for obtaining an image of 10mm × 10 mm.
To increase imaging speed, MEMS and galvanometer technology are introduced into photoacoustic imaging systems. However, in the technology, because defocusing phenomena exist at two sides of a field of view, the imaging field of view is very small, and the diameter of the field of view is generally less than 1 mm. A jigsaw is required if a two-dimensional image of a large area is to be acquired, but this results in a decrease in imaging speed and difficulty in acquiring a two-dimensional image of a large area in a short time.
Disclosure of Invention
In order to solve the above technical problem, the present application provides a photoacoustic imaging apparatus capable of achieving a high-speed and large field of view and a driving device applied to the photoacoustic imaging apparatus, wherein the photoacoustic imaging apparatus obtains a large field of view image while increasing a photoacoustic imaging speed by using the driving device.
The application provides a photoacoustic imaging device, photoacoustic imaging device includes drive conversion mechanism, motor and photoacoustic probe, photoacoustic probe set up in on the drive conversion mechanism, the drive conversion mechanism with the motor is connected, wherein, the drive conversion mechanism be used for with the rotary motion of motor converts the straight line reciprocating motion into, and drives photoacoustic probe is straight line reciprocating motion, the motor is rotatory a week, photoacoustic probe straight line reciprocating motion is once.
The photoacoustic imaging device further comprises a displacement table, the displacement table is fixedly connected with the drive conversion mechanism, and the photoacoustic probe is driven by the drive conversion mechanism to linearly move along the direction perpendicular to the linear reciprocating motion, so that the photoacoustic imaging device can realize two-dimensional scanning.
On one hand, the rotation speed of the motor is fast, reaches thousands of revolutions per minute, and can drive the photoacoustic probe to synchronously make high-speed linear reciprocating motion, so that the photoacoustic imaging speed can be obviously improved. On the other hand, the scanning range of the photoacoustic probe is related to the sizes of the drive conversion mechanism and the displacement table, and the sizes of the drive conversion mechanism and the displacement table can be designed reasonably to achieve the required imaging field of view.
The application also provides a driving device, which comprises a drive conversion mechanism and a motor, wherein the drive conversion mechanism is connected with the motor, the drive conversion mechanism is used for converting the rotary motion of the motor into the linear reciprocating motion, and the motor drives the drive conversion mechanism to perform the high-speed linear reciprocating motion when rotating at a high speed.
The photoacoustic imaging device provided by the application not only can achieve the photoacoustic imaging effect of a high-speed large visual field, but also has the advantages of simple structure and low cost through applying the driving device.
Drawings
In order to more clearly illustrate the technical solution of the present application, the drawings needed to be used in the embodiments will be briefly described below, and obviously, the drawings in the following description are some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
Fig. 1 is a schematic diagram of a photoacoustic imaging apparatus provided in an embodiment of the present application.
FIG. 2 is a side view of the connection of the crank, pusher and motor of FIG. 1.
Fig. 3 is a plan view of a motion state of a drive conversion mechanism provided in an embodiment of the present application.
Fig. 4 is a block diagram of a driving device according to an embodiment of the present application.
Fig. 5 is a mouse abdomen photoacoustic image imaged using the photoacoustic imaging apparatus provided by the embodiment of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without inventive step, are within the scope of the present disclosure.
In the description of the present application, the terms "first", "second", etc. are used for distinguishing different objects and not for describing a particular order, and further, the terms "upper", "lower", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the present application.
Throughout the description of the present application, unless expressly stated or limited otherwise, the term "coupled" is to be construed broadly, e.g., as meaning fixedly attached, detachably attached, or integrally attached; they may be connected directly or indirectly through intervening media, or may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
Referring to fig. 1, fig. 1 is a schematic diagram of a photoacoustic imaging apparatus 100 according to an embodiment of the present application. As shown in fig. 1, the photoacoustic imaging apparatus 100 includes a drive conversion mechanism 10, a motor 20, and a photoacoustic probe 30.
The photoacoustic probe 30 is disposed on the drive conversion mechanism 10, and the drive conversion mechanism 10 is connected to the motor 20, wherein the drive conversion mechanism 10 is configured to convert the rotational motion of the motor 20 into a linear reciprocating motion, so as to drive the photoacoustic probe 30 to make the linear reciprocating motion.
Therefore, in the present application, the driving conversion mechanism 10 converts the rotation of the motor 20 into the linear reciprocating motion to drive the photoacoustic probe 30 to make the linear reciprocating motion, and when the motor 20 is controlled to rotate at a high speed, the photoacoustic probe 30 can make the linear reciprocating motion at a high speed to realize the fast scanning of a large area.
The drive conversion mechanism 10 comprises a crank 11, a pushing piece 12, a sliding rod 13 and a mounting plate 14.
The crank 11 is connected with the sliding rod 13 in a sliding manner through the pushing piece 12, the sliding rod 13 is connected with the mounting plate 14 in a sliding manner through a sliding guide piece on the mounting plate 14, the crank 11 is connected with the motor 20, and the crank 11 is used for rotating under the driving of the motor 20 and driving the sliding rod 13 to do linear reciprocating motion along the sliding guide piece on the mounting plate 14.
The crank 11 includes a first end and a second end opposite to each other, the first end of the crank 11 is fixedly connected to a rotating shaft 21 of the motor 20, the second end of the crank 11 is fixedly connected to the pushing member 12, the rotating shaft 21 of the motor 20 and the pushing member 12 are respectively located on two sides of the crank 11, in some embodiments, a bracket is further disposed on the mounting plate 14, the motor 20 is fixed to the bracket on the mounting plate 14, and in particular, the motor 20 may further include a motor body (not shown), the motor body of the motor 20 is fixed to the bracket on the mounting plate 14 and is kept stationary relative to the mounting plate 14, and only the rotating shaft 21 of the motor 20 is rotatable. Therefore, when the crank 11 rotates along with the rotating shaft 21 of the motor 20, the motor 20 is kept stationary relative to the crank 11 by the fixing effect of the mounting plate 14, so that the crank 11 rotates around the first end of the crank 11 and the length of the crank 11 is the radius.
The first end of the crank 11 is fixedly connected to the rotating shaft 21 of the motor 20, and the first end of the crank 11 is fixedly connected to the rotating shaft 21 of the motor 20 on the rotating plane of the rotating shaft 21 of the motor 20, so that the rotating shaft 21 of the motor 20 rotates to drive the crank 11 to rotate.
Referring to fig. 2, fig. 2 is a side view illustrating the connection relationship of the crank 11, the pusher 12 and the motor 20. As shown in fig. 2, the crank 11 includes a first surface 111 and a second surface 112 that are opposite to each other, and the rotating shaft 21 of the motor 20 is located on the first surface 111 side of the crank 11 and is fixedly connected to the first surface 111 at the first end of the crank 11. For example, a first surface 111 of the first end of the crank 11 is provided with a groove (not shown in fig. 2), and the rotating shaft 21 is accommodated and fixed in the groove to realize a fixed connection with the first end of the crank 11. Wherein, the rotating shaft 21 and the groove can be in interference fit, or further fixed by glue. Alternatively, the recess may be a polygonal recess, an end of the rotating shaft 21 facing the first surface 111 of the crank 11 is a polygonal shaft end, the polygonal shaft end of the rotating shaft 21 is adapted to the polygonal recess, and when the polygonal shaft end of the rotating shaft 21 is received in the polygonal recess, the first end of the crank 11 is fixedly connected to the rotating shaft 21 of the motor 20 on a rotating plane of the rotating shaft 21 of the motor 20.
Wherein the pushing member 12 is fixed on the second face 112 of the second end of the crank 11 and is vertically connected with the second face 112 of the second end of the crank 11, so that the rotating shaft 21 of the motor 20 and the pushing member 12 are respectively fixed on the first face 111 and the second face 112 of the crank 11, i.e. respectively located on both sides of the crank 11. In some embodiments, the pusher 12 may be integrally formed with the crank 11 and extend from the second face 112 of the second end of the crank 11. Or a groove (not shown in fig. 2) is formed on the second surface 112 of the second end of the crank 11, and the pushing element 12 is accommodated in the groove to be fixed in the groove, so as to achieve the fixed connection with the second end of the crank 11, wherein the pushing element 12 and the groove can be in interference fit, or further fixed through glue. Or, the groove may be a polygonal groove, one end of the pushing element 12 facing the second surface 112 of the crank 11 is a polygonal shaft end, the polygonal shaft end of the pushing element 12 is adapted to the polygonal groove, and one end of the pushing element 12 facing the second surface 112 of the crank 11 is fixed to the groove formed on the second surface 112 of the crank 11 by glue or the like.
The slide bar 13 includes a first slide bar portion and a second slide bar portion, the second slide bar portion is vertically connected to a middle portion of the first slide bar portion to form the T-shaped slide bar 13, in this embodiment, the first slide bar portion and the second slide bar portion are integrally formed, and in other embodiments, other connection manners, such as screw locking, riveting, or clamping, may also be used between the first slide bar portion and the second slide bar portion.
Furthermore, the first sliding rod portion is provided with a sliding groove, the pushing member 12 is embedded in the sliding groove and can slide along the sliding groove, the crank 11 is connected with the sliding rod 13 in a sliding manner through the pushing member 12, and when the crank 11 rotates under the action of the motor 20, the sliding rod 13 is driven to move.
Wherein the part of the pushing member 12 embedded in the sliding groove is a circular column, so that the pushing member 12 rotates in the sliding groove along with the rotation of the crank 11 and slides in the sliding groove to drive the sliding rod 13. Since the portion of the crank 11 embedded in the sliding slot is a circular column, friction can be reduced, so that the crank 11 can smoothly slide back and forth at both ends of the sliding slot. Obviously, in other embodiments, the portion of the pushing member 12 embedded in the sliding groove may have other shapes, such as an oval column.
In some embodiments, the pushing member 12 includes a bearing (not shown in fig. 1) and a connecting shaft (not shown in fig. 1), the connecting shaft includes a first end and a second end opposite to each other, the first end of the connecting shaft is fixedly connected to the bearing, the second end of the connecting shaft is fixedly connected to the second end of the crank 11, the bearing is embedded in the sliding groove and slides along the sliding groove, and the friction between the pushing member 12 and the sliding groove can be reduced, so that the pushing member 12 can smoothly slide in the sliding groove.
In other embodiments, the pusher 12 may also be a cylindrical or elliptic cylindrical boss or the like extending from the second face 112 of the second end of the crank 11, for example, a cylindrical or elliptic cylindrical pin or the like.
Further, the second sliding rod portion is slidably connected to the mounting plate 14 through a sliding guide member provided on the mounting plate 14, an extending direction (X-axis direction in fig. 1) of the second sliding rod portion is parallel to the sliding guide member, and the sliding guide member guides a moving direction of the first sliding rod portion and the second sliding rod portion, so that the sliding rod 13 makes a linear photoacoustic reciprocating motion along the X-axis direction along with the rotation of the crank 11, and drives the probe 30 fixed to the second sliding rod portion to make a linear photoacoustic reciprocating motion along the X-axis direction.
In the present application, the sliding guide on the mounting plate 14 may be a sliding rail, or a guide rail, or a linear bearing, or other structures with a linear guiding function, and the sliding guide enables the sliding rod to perform a linear reciprocating motion along the X-axis direction stably and less obstructed.
The center point of the rotational motion of the crank 11 and the center line of the linear reciprocating motion of the slide bar 13 have no offset distance, that is, when the pushing member 12 slides to the intersection point of the first slide bar part and the second slide bar part, the center line of the crank 11 and the center line of the second slide bar part can be located on a straight line, so that the slide bar 13 performs a symmetrical linear reciprocating motion with the first end of the crank 11 as a symmetrical center, and drives the probe 30 fixed to the second slide bar part to perform a symmetrical linear reciprocating motion with the first end of the crank 11 as a symmetrical center, thereby avoiding the scanning dislocation problem caused by the asymmetrical linear reciprocating motion of the photoacoustic probe 30 in the linear reciprocating motion.
Referring to fig. 3, fig. 3 is a top view of a motion state of a drive conversion mechanism according to an embodiment of the present application. The crank 11 rotates clockwise around the first end of the crank 11, the pushing element 12 fixedly connected to the second end of the crank 11 slides in the sliding slot of the first sliding rod part along the extending direction of the first sliding rod part (the a-axis direction shown in fig. 3), the second end of the crank 11 makes a circular motion, so that the pushing element 12 slides in the sliding slot, the pushing element 12 follows the second end to make a circular motion, and a force F (shown in fig. 3-1 to 3-4) along the extending direction of the second sliding rod part (the b-axis direction shown in fig. 3) is applied to the sliding slot wall of the first sliding rod part. The sliding groove walls comprise a first sliding groove wall and a second sliding groove wall, the first sliding groove wall is positioned on one side of the sliding groove close to the second sliding rod part, and the second sliding groove wall is positioned on one side of the sliding groove far away from the second sliding rod part; the area formed by the a-axis and the b-axis is divided into four quadrants, namely, a first quadrant, a second quadrant, a third quadrant and a fourth quadrant (as shown in fig. 3); the a-axis direction is divided into a 1-axis direction (shown in FIG. 3) and a 2-axis direction (shown in FIG. 3); the b-axis direction is divided into a b1 axis direction (as shown in fig. 3) and a b2 axis direction (as shown in fig. 3). When the crank 11 is located in the fourth quadrant and the first quadrant (as shown in fig. 3-1, 3-4), the crank 11 applies a force F in the b2 axis direction to the first chute wall, and the slide bar 13 slides in the b2 axis direction under the linear guiding action of the slide guide on the slide bar 13 in the b axis direction; when the crank 11 is located in the third quadrant and the second quadrant (as shown in 3-2 and 3-3 of fig. 3), the crank 11 applies a force F in the b1 axis direction to the second chute wall of the chute, and the slide bar 13 slides in the b1 axis direction under the linear guiding action of the slide guide on the slide bar 13 in the b axis direction. Therefore, the slide rod 13 is linearly reciprocated in the b-axis direction by the force F and the linear guide of the slide guide. In addition, the sliding groove wall of the first sliding rod part is also subjected to friction force along the a-axis direction due to the sliding of the pushing part 12, and preferably, lubricating oil is coated in the sliding groove, so that the friction force is small and even can be ignored. Therefore, the shaking of the sliding rod 13 during the sliding process can be avoided, and the smoothness of the rotation of the crank 11 can also be improved.
The motion displacement S of the slide rod 13 along the b-axis direction is in a sine function relationship with the rotation angle θ (as shown in fig. 3) of the crank 11, i.e., S ═ Lsin θ, where S is the motion displacement of the slide rod 13 along the b-axis direction, L is the length of the crank 11, and θ is the angle between the crank 11 and the a1 axis.
When the included angle theta between the crank 11 and the a1 shaft is 0 degrees, 180 degrees and 360 degrees, the crank 11 is overlapped with the first slide bar part, and the slide bar 13 is located at the middle position of the linear reciprocating motion stroke; when the included angle theta between the crank 11 and the a1 shaft is 90 degrees, the extending directions of the crank 11 and the second slide bar part are overlapped, and at this time, the slide bar 13 moves linearly to the extreme position in the b2 shaft direction; when the included angle theta between the crank 11 and the a1 shaft is 270 degrees, the crank 11 is overlapped with the second slide bar part, and at this time, the slide bar 13 moves linearly to the limit position in the b1 shaft direction.
The distance from the extreme position in the b1 axis direction to the first end of the crank 11 is equal to the distance from the extreme position in the b2 axis direction to the first end of the crank 11, and both are the length L of the crank 11.
Therefore, when the crank 11 rotates once, the slide bar 13 can move linearly to the extreme positions in the b1 axis and b2 axis directions once respectively, and the single stroke distance of the slide bar 13 is 2 times the length of the crank 11, so that the single stroke distance of the photoacoustic probe 30 fixed to the second slide bar part is also 2 times the length of the crank 11.
In addition, when the included angle θ between the crank 11 and the a1 shaft is 0 °, 180 °, and 360 °, the crank 11 overlaps with the first sliding rod portion, so the length of the crank 11 should be less than or equal to half of the length of the sliding slot, and the crank 11 is prevented from being too long to rotate until the crank 11 overlaps with the first sliding rod portion and being locked, so that the sliding rod 13 can continuously perform the linear reciprocating motion along with the cyclic rotation motion of the crank 11.
Referring again to fig. 1, as shown in fig. 1, the photoacoustic imaging apparatus further includes a displacement stage 40. In this application, the displacement table may be a ball screw transmission device, or a synchronous belt transmission device, or a linear motor or the like that can perform linear motion. In the present embodiment, the displacement table is a ball screw transmission device, and the displacement table 40 includes a stage 41, a ball screw structure 42, a displacement table guide rail 43, and a driver 44.
The ball screw structure 42 includes a screw 421 and a nut (not shown in fig. 1), the nut is movably connected to the screw 421 through a thread, a through hole is formed in the center of the object stage 41, and the nut is fixedly connected to the object stage 41 in the through hole, so that the nut moves along with the screw 421 to drive the object stage 41 to move.
Further, the outside of the object stage 41 is slidably connected to the displacement stage guide rail 43 through a mounting groove, the screw 421 is fixedly connected to the displacement stage guide rail 43, and the object stage 41 linearly moves along the Y-axis direction due to the guiding function of the screw 421 and the displacement stage guide rail 43.
Further, the ball screw structure 42 is fixedly connected to the displacement table driver 44, and the driver 44 drives the screw 421 to move so as to move the nut, and further drives the object table 41 fixedly connected to the nut to move linearly along the Y-axis direction.
Further, the mounting plate 14 is fixedly disposed on the stage 41 and can follow the stage 41 to perform linear motion along the Y-axis direction, and when the mounting plate 14 follows the stage 41 to perform linear motion along the Y-axis direction, the mounting plate 14 is synchronously performed linear motion along the Y-axis direction by the sliding rod 13 slidably connected to the mounting plate 14, so as to drive the photoacoustic probe 30 to perform linear motion along the Y-axis direction, wherein the fixed connection between the stage 41 and the mounting plate 14 can be realized by screw locking or by detachable fixed connection such as pin connection, so that the stage 41 or the mounting plate 14 can be conveniently detached and re-installed when needed to be replaced.
Thus, the photoacoustic probe 30 can be driven by the motor 20 to reciprocate linearly in the X-axis direction with the drive conversion mechanism 10 and can be driven by the displacement stage 40 to move linearly in the Y-axis direction, thereby realizing high-speed two-dimensional scanning.
Moreover, the distance of the linear motion of the photoacoustic probe 30 along the Y-axis direction depends on the lengths of the screw 421 and the displacement table guide 43 in the displacement table 40, and in combination with the above-mentioned distance of the single stroke of the photoacoustic probe 30 in the X-axis direction being 2 times the length of the crank 11, the two-dimensional imaging field of view of the photoacoustic imaging apparatus 100 can be achieved by reasonably designing the length of the crank 11 and the size of the displacement table 40 according to actual requirements, so that the photoacoustic imaging apparatus 100 can achieve the two-dimensional scanning imaging effect of a high-speed large field of view.
Referring to fig. 1 again, as shown in fig. 1, the photoacoustic imaging apparatus 100 further includes an encoder 50, a laser 60, and an optical fiber 70, the optical fiber 70 is respectively connected to the laser 60 and the photoacoustic probe 30, the encoder 50 is configured to generate an output signal, and the output signal triggers the laser 60, so that the laser 60 emits a laser pulse, and the laser pulse is transmitted to the photoacoustic probe 30 connected to the optical fiber 70 through the optical fiber 70 and emitted by the photoacoustic probe 30, thereby eliminating image misalignment.
In some embodiments, the encoder 50 includes a first encoder 51, the first encoder 51 is connected to the drive conversion mechanism 10 and configured to generate a first output signal according to the change of the displacement of the photoacoustic probe 30, and the first output signal can trigger the laser 60 to enable the laser 60 to emit a laser pulse, and the laser pulse is transmitted to the photoacoustic probe 30 connected to the optical fiber 70 through the optical fiber 70 and emitted by the photoacoustic probe 30, so as to eliminate the image misalignment phenomenon.
The first encoder 51 is a grating ruler, and of course, the first encoder 51 may also be a pull rod encoder or a pull rope encoder. The grating scale comprises a main scale 511 and a reading head 512, the reading head 512 comprises a light source (not shown in fig. 1) and a photosensitive element (not shown in fig. 1), the main scale 511 has grating scales and is fixedly mounted on the mounting plate 14, the reading head 512 is fixedly mounted on the second slide bar portion, moves along with the second slide bar portion and reflects the displacement value of the photoacoustic probe 30 fixed on the second slide bar portion in real time.
The slide bar 13 drives the reading head 512 to move when moving, the reading head 512 reads the grating scale of the main scale 511 through the optical signal emitted by the light source during moving, so as to determine the displacement value of the photoacoustic probe 30, and the optical signal is converted into the first output signal through the photosensitive element, and the first output signal can trigger the laser 60.
Further, the laser 60 emits the laser pulse, which is transmitted to the photoacoustic probe 30 through the optical fiber 70 and irradiates the sample. The sample is excited after being irradiated by the laser pulse to generate a photoacoustic signal, and the photoacoustic signal is received, processed and amplified by the photoacoustic probe 30 and then transmitted to a computer for imaging.
Wherein the laser 60 emits the laser pulse according to the received first output signal reflecting the displacement change of the photoacoustic probe 30, and the laser pulse irradiates the sample and forms an image, so that the image misalignment phenomenon can be eliminated.
In other embodiments, the encoder 50 includes a second encoder 52, and the second encoder 52 is fixedly coupled to the motor 20. The second encoder 52 is a photoelectric encoder, but may also be a magnetoelectric encoder, and the like, and the photoelectric encoder includes a light source (not shown in fig. 1), a code wheel (not shown in fig. 1), and a photosensitive element (not shown in fig. 1). The code wheel is arranged on the rotating shaft 21 of the motor 20, and the scale value of the code wheel can reflect the movement change of the rotating shaft 21 of the motor 20.
When the motor 20 rotates, the optical signal emitted by the light source scans the code disc and reads the scale value of the code disc to determine the rotation speed of the motor 20, the photosensor converts the optical signal into a second output signal and outputs the second output signal, the second output signal can trigger the laser 60 to emit the laser pulse, the laser pulse is transmitted to the photoacoustic probe 30 through the optical fiber 70 and irradiates a sample, the sample is excited after being irradiated by the laser pulse to generate a photoacoustic signal, and the photoacoustic signal is received, processed and amplified by the photoacoustic probe 30 and then transmitted to a computer for imaging.
Wherein, the laser 60 emits the laser pulse according to the second output signal received by the second encoder 52 and reflecting the rotation speed change of the motor 20, and the laser pulse irradiates the sample and forms an image, thereby eliminating the image dislocation phenomenon.
In summary, the motor 20 drives the driving conversion mechanism 10 to move and drives the photoacoustic probe 30 to move, the first encoder 51 sends out the first output signal according to the displacement change of the photoacoustic probe 30 or the second encoder 52 sends out the second output signal according to the rotation speed change of the motor 20, and the first output signal or the second output signal triggers the laser 60, so that the laser 60 sends out the laser pulse, and the laser pulse is transmitted to the photoacoustic probe 30 through the optical fiber 70 and sent out by the photoacoustic probe 30.
In the present embodiment, the photoacoustic probe 30 is a photoacoustic microscopic imaging probe, and in other embodiments, the photoacoustic probe 30 may be a photoacoustic tomography probe.
Referring to fig. 4, fig. 4 is a structural block diagram of a driving device 200 according to an embodiment of the present application, where the driving device 200 includes a driving conversion mechanism 201 and a motor 202, and the driving conversion mechanism 201 is connected to the motor 202, where the driving conversion mechanism 201 is configured to convert a rotational motion of the motor 202 into a linear reciprocating motion. For a more detailed structure and a driving process of the driving apparatus 200, reference is made to the related description of the photoacoustic imaging apparatus 100, and details are not repeated here.
Referring to fig. 5, fig. 5 is a photoacoustic image of a mouse abdomen imaged by using the photoacoustic imaging apparatus 100 provided in this embodiment. The imaging field of view was 20mm × 8mm, and the imaging time was 160 s.
The foregoing is an implementation of the embodiments of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the embodiments of the present application, and these modifications and decorations are also regarded as the protection scope of the present application.
Claims (12)
1. The photoacoustic imaging device is characterized by comprising a drive conversion mechanism, a motor and a photoacoustic probe, wherein the photoacoustic probe is arranged on the drive conversion mechanism, and the drive conversion mechanism is connected with the motor, and is used for converting the rotary motion of the motor into linear reciprocating motion so as to drive the photoacoustic probe to make linear reciprocating motion.
2. The photoacoustic imaging apparatus of claim 1 wherein the drive conversion mechanism comprises a crank, a pusher, a slide bar, and a mounting plate, the crank being slidably connected to the slide bar via the pusher, the slide bar being slidably connected to the mounting plate via a slide guide on the mounting plate, the crank being connected to the motor, the crank being configured to rotate upon actuation of the motor to drive the slide bar to reciprocate linearly along the slide guide on the mounting plate.
3. The photoacoustic imaging apparatus of claim 2, wherein the crank comprises a first end and a second end opposite to each other, the first end of the crank is fixedly connected to the motor, the crank is driven to synchronously rotate around the first end when the motor rotates, the second end of the crank is fixedly connected to the pushing member, and the sliding rod is driven to linearly reciprocate along the sliding guide on the mounting plate by the pushing member at the second end of the crank when the crank rotates around the first end, wherein the motor rotates once to linearly reciprocate the sliding rod.
4. The photoacoustic imaging apparatus of claim 3 wherein the slide bar comprises a first slide bar portion and a second slide bar portion, the second slide bar part is vertically connected with the middle part of the first slide bar part to form the T-shaped slide bar, the first slide bar part is provided with a sliding groove, the pushing piece is embedded in the sliding groove, and can slide along the sliding groove, the extending direction of the second sliding rod part is parallel to the sliding guide part, the second sliding rod part is connected with the sliding guide part in a sliding way, and is slidably coupled to the mounting plate by the sliding guide and is guided by the sliding guide, so that the slide bar makes a linear reciprocating motion along the slide guide in accordance with the rotational motion of the crank, and the photoacoustic probe fixed on the second sliding rod part is driven to do linear reciprocating motion along the sliding guide piece.
5. The photoacoustic imaging apparatus of claim 4 wherein the single stroke distance of the linear back and forth movement of the photoacoustic probe along the sliding guide is related to the length of the crank.
6. The photoacoustic imaging apparatus of claim 5, wherein the photoacoustic imaging apparatus further comprises a displacement stage, the displacement stage is fixedly connected to the mounting plate, and the displacement stage drives the photoacoustic probe to move linearly along the extending direction of the first slide bar portion by driving the mounting plate to make the slide bar move linearly along the extending direction of the first slide bar portion.
7. The photoacoustic imaging apparatus of claim 6, wherein the photoacoustic imaging apparatus further comprises a laser and an optical fiber, wherein the laser pulses emitted by the laser are transmitted through the optical fiber to and emitted through the photoacoustic probe.
8. The photoacoustic imaging apparatus of claim 7, further comprising an encoder for generating an output signal that triggers the laser such that the laser pulses to eliminate image misalignment.
9. The photoacoustic imaging apparatus of claim 8 wherein the encoder comprises a first encoder coupled to the drive conversion mechanism and generating a first output signal in response to a change in displacement of the photoacoustic probe secured to the drive conversion mechanism, the first output signal being used to trigger the laser such that the laser pulses to eliminate image misalignment.
10. The photoacoustic imaging apparatus of claim 8, wherein the photoacoustic imaging apparatus comprises a second encoder connected to the motor and generating a second output signal in accordance with the change in the rotational speed of the motor, the second output signal being used to trigger the laser such that the laser pulses to eliminate image misalignment.
11. The photoacoustic imaging apparatus of any of claims 1 to 10, wherein the photoacoustic probe comprises a photoacoustic microscopy imaging probe or a photoacoustic tomography imaging probe that receives photoacoustic signals for imaging.
12. A driving device is characterized by comprising a drive conversion mechanism and a motor, wherein the drive conversion mechanism is connected with the motor, and is used for converting the rotary motion of the motor into linear reciprocating motion.
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| CN112568870B (en) | 2024-05-28 |
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