CN1125591A - Stomach tranquilizer - Google Patents

Abstract

The tablet for curing atrophic gastritis and general gastritis with distinct curative effect is made up of 9 Chinese-medicinal materials such as corydalis tuber, astragalus root, Chinese angelica root, subprostrate sophora root, prunella spike, etc. through washing, thermal extraction, filter, concentration, baking, crushing, addition of excipient and tabletting.

Description

Stomach is flat

The present invention relates to a kind of Chinese patent medicine oral formulations of diseases such as chronic atrophic gastritis, gastritis and preparation technology of tablet thereof for the treatment of.

Chronic atrophic gastritis is one of common illness of middle-aged and elderly people, and its pathogeny it be unclear that.Therefore, not having the specific treatment method at present, only is to impose symptomatic treatment.Though constantly have new medicine to come out in recent years, but still majority is the medication of suiting the medicine to the illness, and is the Individual testwas report at the medicine that its tissue changes, what have still is in animal experiment stage, and curative effect is not also affirmed.

Therefore, an object of the present invention is to provide a kind of Chinese patent medicine that can change diseases such as treatment chronic atrophic gastritis, gastritis at tissue, promptly stomach is flat.

Another object of the present invention provides the preparation technology of a kind of above-mentioned Chinese patent medicine oral formulations and tablet.

The object of the present invention is achieved like this: the medicine of this treatment atrophic gastritis, gastritis is to be formed through effective component extracting, mixing, tabletting by following Chinese crude drug, and its raw material composition is by weight percentage:

Rhizoma Corydalis 5-10% Radix Angelicae Sinensis 5-10% Radix Astragali 5-10%

Radix Sophorae Tonkinensis 10-20 Spica Prunellae 10-20 Rhizoma Dioscoreae Bulbiferae 5-10

Cortex Dictamni 15-20 Herba Patriniae 10-20 Endothelium Corneum Gigeriae Galli 5-10

Above-mentioned Chinese crude drug can be made the flat tablet of called after stomach, capsule, oral liquid, electuary by above-mentioned percentage by weight.

This property of medicine shape:

1) tablet: the plain sheet of light brown, gas perfume (or spice), lightly seasoned, little hardship.

2) capsule: light brown powder, gas perfume (or spice), lightly seasoned, little hardship.

3) oral liquid: brown fluid, gas perfume (or spice), mildly bitter flavor has the Mel sweet taste.

4) electuary: the light brown granule, gas perfume (or spice), it is sweet to distinguish the flavor of, little hardship.

Its principal character is that chemical constituent is Rhizoma Corydalis second element, oxymatrine etc.

The tablet producing technology that stomach of the present invention is flat comprises the steps:

1) get that Cortex Dictamni half amount is cleaned with other medical material, mixing, place in the extraction pot, under normal pressure and temperature, add the water that 6-8 doubly measures, boil and carry secondary, each 2 hours, filtrate, concentrate oven dry, pulverize, standby;

2) medicated powder of pulverizing is measured Cortex Dictamni 80 order powder mixings with second half, add the ethanol binding agent, make particulate powder, tabletting is then made the tablet of 0.3 gram/sheet, and is bottled or be packaged in the aluminum platinum of blister.

In chronic atrophic gastritis, the enteraden epithelial metaplasia of gastric epithelial and atypical hyperplasia are very outstanding pathological changes, and with gastric cancer getting in touch of statistics arranged.

The enteraden epithelial metaplasia is meant has the enteraden epithelium to exist in the gastric mucosa.According to what of its existence, be divided into light, in, weigh three degree.

The atypical hyperplasia of gastric epithelial (dysplasia) mainly shows as the cell abnormal shape, structure disturbance and disdifferentiation.According to its degree also be divided into gently, in, weigh three grades.For the degree atypical hyperplasia, advocate with operative treatment.If any a kind of new medicine enteraden epithelial metaplasia and atypical hyperplasia are taken a turn for the better or disappearance, both can exempt the hardship of operating on, can reduce the incidence rate of gastric cancer again greatly.To the financial burden and the sensual misery that alleviate the patient all is that realistic meaning is arranged very much.Show that through clinical trial stomach is flat to have effective inhibitory action to enteraden epithelial metaplasia and atypical hyperplasia, can stop epithelial cell to transform to heterocyst, its effective percentage can reach more than 90%.

We use stomach and bring chronic atrophic gastritis 26 examples of treatment with enteraden epithelial metaplasia and atypical hyperplasia under control.

The selection strictness of chronic atrophic gastritis is undertaken by international standard.Gastric epithelialization is given birth to and the degree of atypical hyperplasia is also passed judgment on by international related standards is strict.Before the clothes stomach is flat, carry out gastroscopy by experienced scope doctor, describe finding under the mirror in detail, get mucosa tissue by pertinent regulations at the fixed position pincers and carry out pathologic finding, pathological section is detected by experienced pathology doctor, conformance with standard is promptly done selected case, and its symptom of itemized record, checks hemocyte and hepatic and renal function.3 of the flat each clothes of stomach, every day, secondary serve on three months, the medicine of other treatment chronic atrophic gastritis of stopping using simultaneously.Finish the course of treatment, record symptom variation, the afterreaction of taking medicine, check hemocyte, hepatic and renal function.Carry out the gastroscope check by former scope doctor simultaneously, the observed and recorded mirror changes down, and gets mucosa tissue in the same area pincers, does the section check by former pathology doctor again and confirms.

As a result, all 26 routine chronic atrophic gastritis patients all have no adverse reaction and side effect.Hemocyte regulating liver-QI, renal function Non Apparent Abnormality change before and after taking medicine.Upper abdominal pain after 16 examples in 26 examples (accounting for 61.5%) were taken medicine one month, heating installation, original symptom such as abdominal distention obviously alleviates.Symptom disappears 22 examples (accounting for 85.4%) substantially after two months, after three months only a routine symptom do not have obvious improvement, the doing well,improving total effective rate reaches 96.2%.

Down performance of scope before and after the treatment: obviously alleviate after 7 examples are taken medicine with partial points, lamellar erosion person or disappear; And the performance down of the common scope of other atrophic gastritis, significant change is not seen in perusal.

Through pathologic finding, 7 examples become chronic superficial gastritis by chronic atrophic gastritis in 26 examples.Severe enteraden epithelial metaplasia 12 examples, the change moderate is 5 examples, degree of lightening 5 examples, 2 examples disappear; Moderate intestinalization 9 examples, degree of lightening 3 examples, 6 examples disappear; Slight intestinalization 5 examples all disappear after taking medicine.Atypical hyperplasia: severe degree of lightening 4 examples, severe becomes 2 examples that disappear, and moderate becomes 8 examples that disappear, slight 12 examples that disappear that become.

Above result shows that the stomach plain film has no side effect, and hemocyte, hepatic and renal function are had no adverse effects, and chronic atrophic gastritis and enteraden epithelial metaplasia and atypical hyperplasia are had good effect.

The toxicological experiment that stomach is flat

1. anxious poison: it is 40g/kg that this experiment provides day maximum tolerated dose, is equivalent to 863 times of human body, illustrates that the flat toxicity of stomach is extremely low.

2. slow poison: oral stomach flat half a year, the sign that does not cause rat and Canis familiaris L. changes, do not influence activity, appetite and growth promoter and leukocyte, hematochrome, platelet, blood urea nitrogen and the Electrocardiographic significant change of rat and Canis familiaris L., illustrate that stomach is flat to hemopoietic system and hepatic and renal function free of toxic effects.Main organs such as the heart of rat and Canis familiaris L., liver, spleen, lung, kidney, adrenal gland, stomach, small intestinal, pancreas, brain, lymph gland, testis or ovary are not seen obvious pathological change.The clothes stomach is flat for a long time, and lymph corpuscle percentage ratio raises, and helps the defensive enginery of body.The result proves that the flat chronic toxicity of stomach is very little, and it is safe taking for a long time.

3. mutagenesis: stomach par extract 100Mg/ ware.Inducing action is in TA ₁₀₀± S-9 and TA ₉₈± S-9 does not see mutagenic action, illustrates that the stomach plain film does not have mutagenesis.

The therapeutic effect that stomach is flat:

Cure mainly: 1. chronic atrophic gastritis and intestinal epithelial metaplasia and atypical hyperplasia;

2. be used for various chronic atrophic gastritis, esophagitis, gastritis.

Claims (2)

1. medicine for the treatment of atrophic gastritis, gastritis is characterized in that its main component is by weight percentage:

Rhizoma Corydalis 5-10% Radix Angelicae Sinensis 5-10% Radix Astragali 5-10%

Radix Sophorae Tonkinensis 10-20 Spica Prunellae 10-20 Rhizoma Dioscoreae Bulbiferae 5-10

Cortex Dictamni 15-20 Herba Patriniae 10-20 Endothelium Corneum Gigeriae Galli 5-10

2. the tablet producing technology of medicine according to claim 1 is characterized in that comprising the steps:

1) get that Cortex Dictamni half amount is cleaned with other medical material, mixing, place in the extraction pot, under normal pressure and temperature, add the water that 6-8 doubly measures, boil and carry secondary, each 2 hours, filtrate, concentrate oven dry, pulverize, standby;

2) with medicated powder and second half amount Cortex Dictamni 80 order powder mixings pulverized, add the ethanol binding agent, make particulate powder, tabletting is made tablet then.