CN112552566A - Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof - Google Patents
Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof Download PDFInfo
- Publication number
- CN112552566A CN112552566A CN202011450405.7A CN202011450405A CN112552566A CN 112552566 A CN112552566 A CN 112552566A CN 202011450405 A CN202011450405 A CN 202011450405A CN 112552566 A CN112552566 A CN 112552566A
- Authority
- CN
- China
- Prior art keywords
- modified chitosan
- disposable
- washing
- medical glove
- hand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L9/00—Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
- C08L9/02—Copolymers with acrylonitrile
- C08L9/04—Latex
-
- A—HUMAN NECESSITIES
- A41—WEARING APPAREL
- A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
- A41D19/00—Gloves
- A41D19/0055—Plastic or rubber gloves
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2296—Oxides; Hydroxides of metals of zinc
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Textile Engineering (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Gloves (AREA)
Abstract
The application relates to the field of gloves, and particularly discloses disposable butyronitrile medical gloves with a bacteriostatic function and a preparation method thereof. The disposable butyronitrile medical glove with the antibacterial function comprises the following components: nitrile latex; zinc oxide; a vulcanizing agent; a vulcanization accelerator; chloroprene rubber; modifying chitosan; sodium hydroxide. The preparation steps of the disposable butyronitrile medical glove with the antibacterial function are as follows: step 1, cleaning a hand model: washing residues and dirt on the hand membrane with soap water and a bleaching agent, then brushing the hand membrane with a rotary brush, washing the hand membrane with hot water, and airing; step 2, dipping: preparing rubber latex for dipping, dipping the rubber latex, cooling the hand mould dipped with the rubber latex to room temperature, washing with water, vulcanizing at the temperature of 130-150 ℃ for 15-25 minutes, and naturally cooling to the room temperature to obtain the disposable butyronitrile medical glove. This application has the antibiotic effect advantage of wearing gloves in improving the longer time.
Description
The present application relates to the field of gloves, and more particularly, it relates to disposable butyronitrile medical gloves having bacteriostatic function.
Background
The disposable gloves are used only once, so that in the medical industry, the disposable gloves can avoid cross infection and greatly save replacement cost, and a user can wear the gloves to serve as a protection physical barrier mode to reduce the risk of hand exposure to viruses or bacteria.
The antibacterial disposable gloves can further reduce the harm of germs to people, and are widely popular with people. The disposable gloves generally need to improve the compactness of the gloves so as to reduce the entrance of external bacteria into the gloves from the surfaces of the gloves, but after a user wears the gloves for a long time, a humid environment is easily formed in the gloves, and the humid environment easily causes a large amount of propagation of germs, bacteria and other microorganisms, so that the antibacterial effect is reduced, and therefore, the improvement space is provided.
Disclosure of Invention
In order to improve the antibiotic effect of wearing gloves in the longer time, this application provides a disposable butyronitrile medical gloves with antibacterial function.
In a first aspect, the application provides a disposable butyronitrile medical glove with antibacterial function, which adopts the following technical scheme:
a disposable butyronitrile medical glove with an antibacterial function comprises the following components in parts by mass
100 parts of butyronitrile latex;
4-6 parts of zinc oxide;
5-7 parts of a vulcanizing agent;
0.4-0.7 part of vulcanization accelerator;
20-30 parts of chloroprene rubber;
2-3 parts of modified chitosan;
0.06-0.1 part of sodium hydroxide.
By adopting the technical scheme, the epoxy resin is combined with the modified chitosan through the ether bond by matching the modified chitosan, the chloroprene rubber and the sodium hydroxide, so that the compatibility of the modified chitosan, the chloroprene rubber latex and the nitrile rubber latex is greatly improved, the antibacterial effect of the glove is kept better, meanwhile, the excellent antibacterial effect is given to the glove after the modified chitosan is added, meanwhile, the modified chitosan has larger polarity, better film forming property, hygroscopicity and permeability and better affinity to the human body, the hygroscopicity of the glove is favorably improved after the nitrile rubber latex and the chloroprene rubber are vulcanized, the air permeability of the glove is also improved, the generation of hand sweat is reduced, the hand of a user is favorably kept in a dry and comfortable state, the hand environment is not easily kept in a damp and hot state, the comfort of the user is favorably improved, and the generation of bacteria is further reduced, improve the wearing travelling comfort when improving the antibiotic effect of gloves.
Preferably, the vulcanizing agent is tetrabenzylthiuram disulfide, and the vulcanization accelerator is zinc dimethyldithiocarbamate and 2-mercaptobenzothiazole.
By adopting the technical scheme, the vulcanization system consisting of zinc oxide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole and tetrabenzylthiuram disulfide is matched with the modified chitosan, so that the vulcanization temperature of the nitrile latex is reduced, the vulcanization time is better, the cross-linking density of the nitrile rubber and the chloroprene rubber is better, the antibacterial effect and the air permeability of the glove are improved, and the elasticity and the flexibility of the rubber are improved.
Preferably, the zinc dimethyldithiocarbamate is 0.2-0.4 part, and the 2-mercaptobenzothiazole is 0.1-0.2 part.
By adopting the technical scheme, a vulcanization system consisting of zinc oxide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole and tetrabenzylthiuram disulfide in a specific proportion is added to be matched with the modified chitosan, so that the received crosslinking effect is better, and the air permeability and the antibacterial performance of the glove are better.
Preferably, tetramethylthiuram disulfide is used in place of tetrabenzylthiuram disulfide, the added mass of tetramethylthiuram disulfide being one half of that of tetrabenzylthiuram disulfide.
By adopting the technical scheme, the tetramethylthiuram disulfide is used for replacing tetrabenzylthiuram disulfide, and the added mass of the tetramethylthiuram disulfide is one half of that of the tetrabenzylthiuram disulfide, so that the gloves obtain a better vulcanization effect, the production cost is reduced, and the industrial production is facilitated.
Preferably, the solid content of the butyronitrile latex is 45-50%.
By adopting the technical scheme, the solid content of the butyronitrile latex is 45-50%, so that the tensile strength and the puncture resistance of the glove are better, the glove is not easy to damage, and the glove can keep a better antibacterial effect.
In a second aspect, the application provides a preparation method of disposable butyronitrile medical gloves with antibacterial function, which adopts the following technical scheme:
a preparation method of disposable butyronitrile medical gloves with antibacterial function comprises the following steps:
step 1, cleaning a hand model: scrubbing the hand membrane with a rotary brush, washing the hand membrane with water at 60-70 ℃, and drying in the air;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring the butyronitrile latex, the zinc oxide, the vulcanizing agent, the vulcanization accelerator, the chloroprene rubber, the modified chitosan and the sodium hydroxide in a clockwise manner at the stirring speed of 100-150 r/min; soaking the hand mold in a coagulant, drying at the temperature of 100-120 ℃ for 10-15min, then soaking rubber latex, soaking for 20-30s, drying the hand mold soaked with the rubber latex at the temperature of 60-70 ℃ for 1-2h, naturally cooling to room temperature, then washing with pure water at the temperature of 5-10 ℃, vulcanizing at the temperature of 130-150 ℃ for 15-25 min, and naturally cooling to room temperature to obtain the disposable butyronitrile medical glove.
Preferably, the coagulant is a methanol solution of calcium nitrate.
Through adopting above-mentioned technical scheme, be the methyl alcohol solution of calcium nitrate through the coagulant, be favorable to improving the travelling comfort of wearing of gloves, still be favorable to improving the tensile strength and the resistant puncture performance of gloves for gloves are difficult impaired, make the thallus be difficult for getting into gloves from the damage, thereby make the antibiotic effect preferred of gloves.
Preferably, the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with a mass ratio of 10:1, raising the temperature to 45-55 ℃, gradually dropwise adding butanone, reacting while stirring, stopping adding butanone after 30-40min, adjusting the pH of the solution to 6-7, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 2-3 times, and performing vacuum drying at 40-45 ℃ to constant weight to obtain a modified chitosan intermediate;
mixing the modified chitosan intermediate with 100mL of isopropanol, then adding 8-12mL of sodium hydroxide solution with the mass concentration of 40%, heating to 45-55 ℃, adding trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH value to 7, soaking and washing for 2-3 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 40-45 ℃ to constant weight to obtain modified chitosan;
the mass ratio of the modified chitosan intermediate to trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate is 1.5: 1.
By adopting the technical scheme, the antibacterial effect of the modified chitosan intermediate is greatly improved, meanwhile, the solubility of the modified chitosan intermediate is greatly improved, the improvement of the matching effect of the modified chitosan intermediate and the chloroprene rubber is facilitated, so that the modified chitosan intermediate is not easy to separate from the nitrile rubber under the action of sweat after being worn for a long time, thereby ensuring that the gloves keep better antibacterial effect, greatly reducing the risk of medical care personnel being exposed in the thalli, improving the health safety of the medical care personnel, and is convenient for medical care personnel to wear gloves for a long time and is not easy to be polluted by thalli, and the modified chitosan intermediate has certain healing effect on skin wounds, the antibacterial and skin-care product can promote skin wound healing while exerting a better antibacterial effect, and has a better care effect on human skin.
Preferably, after the sodium hydroxide solution with the mass concentration of 40% is added, ultrasonic treatment is carried out for 2-3h at 25 ℃.
By adopting the technical scheme, after the sodium hydroxide solution with the mass concentration of 40% is added, ultrasonic treatment is carried out for 2-3h at 25 ℃, so that the modified chitosan intermediate has better solubility, the solubility of the modified chitosan intermediate is favorably improved greatly, the quality of the obtained modified chitosan is better, the matching effect of the modified chitosan and the chloroprene rubber is favorably improved, and the antibacterial effect of the glove is improved.
Preferably, the butanone is added dropwise at a rate of 15 s/mL.
By adopting the technical scheme, the butanone is gradually added at the speed of 15s/mL, so that the generated modified chitosan intermediate has fewer impurities, the quality of the modified chitosan intermediate is favorably improved, the quality of the modified chitosan is further improved, the matching effect of the modified chitosan and the chloroprene rubber is further improved, and the antibacterial effect of the glove is further improved.
In summary, the present application has the following beneficial effects:
1. because this application adopts through modified chitosan, chloroprene rubber, the cooperation of sodium hydroxide, make epoxy combine with the ether bond with modified chitosan, make modified chitosan and chloroprene rubber latex and butyronitrile latex compatibility improve greatly, be favorable to improving the hygroscopicity of gloves, the gas permeability of gloves has still been improved, thereby reduce the production of hand sweat, the hand that is favorable to the user keeps dry and comfortable state, make the hand environment be difficult for keeping the damp and hot state, be favorable to improving user's travelling comfort, still further reduce the production of bacterium.
2. In this application, zinc oxide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole and tetrabenzylthiuram disulfide are preferably adopted to form a vulcanization system and are matched with the modified chitosan, so that the vulcanization temperature of the nitrile latex is reduced, the vulcanization time is better, the cross-linking density of the nitrile rubber and the chloroprene rubber is better, the antibacterial effect and the air permeability of the glove are improved, and the elasticity and the softness of the rubber are also improved.
3. This application improves greatly through the antibiotic effect of modified chitosan, still make the solubility of modified chitosan improve greatly simultaneously, be favorable to modified chitosan midbody can improve with chloroprene rubber's cooperation effect, thereby make modified chitosan midbody also be difficult for separating with butadiene-acrylonitrile rubber under the effect of sweat after the longer time is dressed, thereby make gloves keep the antibiotic effect of preferred, make medical personnel expose the risk greatly reduced in the thallus, medical personnel's health safety has been improved, and make things convenient for medical personnel to wear gloves and be difficult for receiving the thallus pollution in the longer time, and because modified chitosan midbody has certain healing effect to skin wound.
Detailed Description
The following description is given of the raw materials of examples and comparative examples:
the solid content of the butyronitrile latex is 45-50%, and the butyronitrile latex with the brand number sh850 sold by Dongguan expensive plastic raw material limited is adopted in the application. This application uses a 5042 neoprene latex available from Qianyuan synthetic materials, Inc. of Guangzhou city. The application adopts the neoprene latex sold by Shanxi Chengming Biotechnology GmbH under the brand asdf.
Example 1
A disposable butyronitrile medical glove with an antibacterial function is prepared by the following steps:
step 1, cleaning a hand model: scrubbing the hand membrane by using a rotary brush, washing the hand membrane by using water at 70 ℃, and drying;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring the butyronitrile latex, zinc oxide, tetrabenzylthiuram disulfide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole, chloroprene rubber, modified chitosan and sodium hydroxide in a clockwise way, wherein the stirring speed is 120 r/min; immersing the hand mold in a methanol solution of calcium nitrate, drying at 110 ℃ for 12min, then immersing rubber latex in the rubber latex for 25s, drying the hand mold immersed with the rubber latex at 65 ℃ for 1.5h, naturally cooling to room temperature, then washing with pure water at 8 ℃, vulcanizing at 140 ℃ for 20 min, and naturally cooling to normal temperature to obtain the disposable butyronitrile medical glove;
the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, raising the temperature to 50 ℃, gradually dripping butanone at the speed of 15s/mL, reacting while stirring, stopping adding butanone after 35min, adjusting the pH value of the solution to 6, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 3 times, and performing vacuum drying at 40 ℃ to constant weight to obtain a modified chitosan intermediate; mixing 1.5kg of modified chitosan intermediate with 100mL of isopropanol, then adding 10mL of sodium hydroxide solution with the mass concentration of 40%, carrying out ultrasonic treatment at 25 ℃ for 3h, heating to 42 ℃, adding 1kg of trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH to 7, soaking and washing for 3 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 42 ℃ to constant weight to obtain modified chitosan; the rubber latex comprises the following components: 100kg of nitrile latex, 5kg of zinc oxide, 6kg of tetrabenzylthiuram disulfide, 0.3kg of zinc dimethyldithiocarbamate, 0.15kg of 2-mercaptobenzothiazole, 25kg of chloroprene rubber, 2.5kg of modified chitosan and 0.08kg of sodium hydroxide.
Example 2
A disposable butyronitrile medical glove with an antibacterial function is prepared by the following steps:
step 1, cleaning a hand model: scrubbing the hand membrane by using a rotary brush, washing the hand membrane by using water at 60 ℃, and drying;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring the butyronitrile latex, zinc oxide, tetrabenzylthiuram disulfide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole, chloroprene rubber, modified chitosan and sodium hydroxide in a clockwise way, wherein the stirring speed is 120 r/min; immersing the hand mold into a methanol solution of calcium nitrate, drying at 100 ℃ for 10min, then immersing rubber latex into the rubber latex, immersing for 20s, drying the hand mold immersed with the rubber latex at 60 ℃ for 1.5h, naturally cooling to room temperature, then washing with pure water at 5 ℃, vulcanizing at 130 ℃ for 15 minutes, and naturally cooling to normal temperature to obtain the disposable butyronitrile medical glove;
the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, raising the temperature to 55 ℃, gradually dripping butanone at the speed of 15s/mL, reacting while stirring, stopping adding butanone after 30min, adjusting the pH value of the solution to 6, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 2 times, and performing vacuum drying at 45 ℃ to constant weight to obtain a modified chitosan intermediate; mixing 1kg of modified chitosan intermediate with 100mL of isopropanol, then adding 8mL of sodium hydroxide solution with the mass concentration of 40%, carrying out ultrasonic treatment at 25 ℃ for 2h, heating to 55 ℃, adding 1kg of trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH value to 7, soaking and washing for 2 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 45 ℃ to constant weight to obtain modified chitosan; the rubber latex comprises the following components: 100kg of nitrile latex, 4kg of zinc oxide, 5kg of tetrabenzylthiuram disulfide, 0.2kg of zinc dimethyldithiocarbamate, 0.1kg of 2-mercaptobenzothiazole, 20kg of chloroprene rubber, 2kg of modified chitosan and 0.06kg of sodium hydroxide.
Example 3
A disposable butyronitrile medical glove with an antibacterial function is prepared by the following steps:
step 1, cleaning a hand model: scrubbing the hand membrane by using a rotary brush, washing the hand membrane by using water at 70 ℃, and drying;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring the butyronitrile latex, zinc oxide, tetrabenzylthiuram disulfide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole, chloroprene rubber, modified chitosan and sodium hydroxide in a clockwise way, wherein the stirring speed is 150 r/min; immersing the hand mold in a methanol solution of calcium nitrate, drying at 120 ℃ for 15min, then immersing rubber latex in the rubber latex for 30s, drying the hand mold immersed with the rubber latex at 70 ℃ for 2h, naturally cooling to room temperature, then washing with pure water at 10 ℃, vulcanizing at 150 ℃ for 25 min, and naturally cooling to normal temperature to obtain the disposable butyronitrile medical glove;
the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, raising the temperature to 45 ℃, gradually dripping butanone at the speed of 15s/mL, reacting while stirring, stopping adding butanone after 40min, adjusting the pH value of the solution to 6, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 3 times, and performing vacuum drying at 40 ℃ to constant weight to obtain a modified chitosan intermediate; mixing the modified chitosan intermediate with 100mL of isopropanol, then adding 12mL of sodium hydroxide solution with the mass concentration of 40%, carrying out ultrasonic treatment at 25 ℃ for 3h, heating to 40 ℃, adding trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH value to 7, soaking and washing for 3 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 40 ℃ to constant weight to obtain modified chitosan; the mass ratio of the modified chitosan intermediate to trimethyl- (oxiranyl-2-ylmethyl) ammonium acetate was 1.5: 1.
The rubber latex comprises the following components: 100kg of nitrile latex, 6kg of zinc oxide, 7kg of tetrabenzylthiuram disulfide, 0.4kg of zinc dimethyldithiocarbamate, 0.2kg of 2-mercaptobenzothiazole, 30kg of chloroprene rubber, 3kg of modified chitosan and 0.1kg of sodium hydroxide.
Example 4
A disposable butyronitrile medical glove with an antibacterial function is prepared by the following steps:
step 1, cleaning a hand model: scrubbing the hand membrane by using a rotary brush, washing the hand membrane by using water at 70 ℃, and drying;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring butyronitrile latex, zinc oxide, tetramethyl thiuram disulfide, zinc dimethyldithiocarbamate, 2-mercaptobenzothiazole, chloroprene rubber, modified chitosan and sodium hydroxide in a clockwise way, wherein the stirring speed is 120 r/min; immersing the hand mold in a methanol solution of calcium nitrate, drying at 110 ℃ for 12min, then immersing rubber latex in the rubber latex for 25s, drying the hand mold immersed with the rubber latex at 65 ℃ for 1.5h, naturally cooling to room temperature, then washing with pure water at 8 ℃, vulcanizing at 140 ℃ for 20 min, and naturally cooling to normal temperature to obtain the disposable butyronitrile medical glove;
the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, raising the temperature to 50 ℃, gradually dripping butanone at the speed of 15s/mL, reacting while stirring, stopping adding butanone after 35min, adjusting the pH value of the solution to 6, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 3 times, and performing vacuum drying at 40 ℃ to constant weight to obtain a modified chitosan intermediate;
mixing 1.5kg of modified chitosan intermediate with 100mL of isopropanol, then adding 10mL of sodium hydroxide solution with the mass concentration of 40%, carrying out ultrasonic treatment at 25 ℃ for 3h, heating to 40 ℃, adding 1kg of trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH to 7, soaking and washing for 3 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 40 ℃ to constant weight to obtain modified chitosan;
the rubber latex comprises the following components: 100kg of nitrile latex, 5kg of zinc oxide, 3kg of tetramethyl thiuram disulfide, 0.3kg of zinc dimethyldithiocarbamate, 0.15kg of 2-mercaptobenzothiazole, 25kg of chloroprene rubber, 2.5kg of modified chitosan and 0.08kg of sodium hydroxide.
Comparative example 1
The only difference from example 1 is: the nano silver powder antibacterial agent is used to replace the modified chitosan in equal amount.
Comparative example 2
The only difference from example 1 is: the neoprene latex is replaced by the butyronitrile latex with equal quantity.
Experiment 1
25 healthy subjects of 20-30 years old are selected and divided into 5 groups, the subjects correspondingly wear the glove samples of the embodiments and the comparative examples for 8h, and the bacteriostasis rate of the glove samples worn for 8h is tested according to the microbiological indexes of GB 15979-.
Experiment 2
The glove specimens of the examples and comparative examples were tested for tensile strength at break and elongation at break according to GB 7543-2006 "Disposable sterilized surgical gloves".
| Breaking force (N) | Elongation at Break (%) | |
| Example 1 | 30 | 940 |
| Example 2 | 27 | 920 |
| Example 3 | 28 | 920 |
| Example 4 | 26 | 900 |
| Comparative example 1 | 16 | 740 |
| Comparative example 2 | 13 | 690 |
Compared with the example 1, the comparison examples 1 and 2 show that the total number of bacteria and fungi in the glove sample is greatly reduced by adding the modified chitosan, and the modified chitosan is proved to be matched with the chloroprene rubber and has better antibacterial effect by adding the chitosan, so that the better antibacterial effect can be kept for a longer time, the growth and the reproduction of the bacteria and the fungi are inhibited to a greater extent, and the detection results of escherichia coli and staphylococcus aureus show that the modified chitosan has very superior inhibition effect on the growth and the reproduction of escherichia coli and staphylococcus aureus.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. A disposable butyronitrile medical glove with antibacterial function which is characterized in that: comprises the following components in parts by mass
100 parts of butyronitrile latex;
4-6 parts of zinc oxide;
5-7 parts of a vulcanizing agent;
0.4-0.7 part of vulcanization accelerator;
20-30 parts of chloroprene rubber;
2-3 parts of modified chitosan;
0.06-0.1 part of sodium hydroxide.
2. The disposable butyronitrile medical glove with bacteriostatic function according to claim 1, wherein: the vulcanizing agent is tetrabenzylthiuram disulfide, and the vulcanization accelerator is zinc dimethyldithiocarbamate and 2-mercaptobenzothiazole.
3. The disposable butyronitrile medical glove with bacteriostatic function according to claim 1 or 2, wherein: 0.2-0.4 part of zinc dimethyldithiocarbamate and 0.1-0.2 part of 2-mercaptobenzothiazole.
4. The disposable butyronitrile medical glove with bacteriostatic function according to claim 2, wherein: tetramethyl thiuram disulfide is adopted to replace tetrabenzyl thiuram disulfide, and the mass of the added tetramethyl thiuram disulfide is one half of that of the tetrabenzyl thiuram disulfide.
5. The disposable butyronitrile medical glove with bacteriostatic function according to claim 1, wherein: the solid content of the butyronitrile latex is 45-50%.
6. A preparation method of disposable butyronitrile medical gloves with antibacterial function is characterized in that: the method comprises the following steps:
step 1, cleaning a hand model: washing residues and dirt on the hand membrane with soap water and a bleaching agent, then brushing the hand membrane with a rotary brush, washing the hand membrane with hot water, and airing;
step 2, dipping: preparing rubber latex for dipping: fully and uniformly stirring the butyronitrile latex, the zinc oxide, the vulcanizing agent, the vulcanization accelerator, the chloroprene rubber, the modified chitosan and the sodium hydroxide in a clockwise manner at the stirring speed of 100-150 r/min; soaking the hand mold in a coagulant, drying at the temperature of 100-120 ℃ for 10-15min, then soaking rubber latex, soaking for 20-30s, drying the hand mold soaked with the rubber latex at the temperature of 60-70 ℃ for 1-2h, naturally cooling to room temperature, then washing with pure water at the temperature of 5-10 ℃, vulcanizing at the temperature of 130-150 ℃ for 15-25 min, and naturally cooling to room temperature to obtain the disposable butyronitrile medical glove.
7. The disposable butyronitrile medical glove with bacteriostatic function according to claim 6, characterized in that: the coagulant is a methanol solution of calcium nitrate.
8. The disposable butyronitrile medical glove with bacteriostatic function according to claim 6, characterized in that: the preparation method of the modified chitosan comprises the following steps: the preparation method of the modified chitosan comprises the following steps: adding chitosan into a mixed solvent of anhydrous methanol and acetic acid with a mass ratio of 10:1, raising the temperature to 45-55 ℃, gradually dropwise adding butanone, reacting while stirring, stopping adding butanone after 30-40min, adjusting the pH of the solution to 6-7, performing suction filtration, taking the upper-layer solid, washing with cyclohexane for 2-3 times, and performing vacuum drying at 40-45 ℃ to constant weight to obtain a modified chitosan intermediate;
mixing the modified chitosan intermediate with 100mL of isopropanol, then adding 8-12mL of sodium hydroxide solution with the mass concentration of 40%, heating to 45-55 ℃, adding trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate, reacting for 1h, adjusting the pH value to 7, soaking and washing for 2-3 times by using a mixed solvent of anhydrous methanol and acetic acid with the mass ratio of 10:1, and drying in vacuum at 40-45 ℃ to constant weight to obtain modified chitosan;
the mass ratio of the modified chitosan intermediate to trimethyl- (ethylene oxide-2-ylmethyl) ammonium acetate is 1.5: 1.
9. The disposable nitrile-butadiene medical glove with bacteriostatic function according to claim 8, wherein: and (3) adding the sodium hydroxide solution with the mass concentration of 40%, and performing ultrasonic treatment at 25 ℃ for 2-3 h.
10. The disposable nitrile-butadiene medical glove with bacteriostatic function according to claim 8, wherein: the butanone was added dropwise at a rate of 15 s/mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011450405.7A CN112552566A (en) | 2020-12-09 | 2020-12-09 | Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011450405.7A CN112552566A (en) | 2020-12-09 | 2020-12-09 | Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112552566A true CN112552566A (en) | 2021-03-26 |
Family
ID=75061084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011450405.7A Pending CN112552566A (en) | 2020-12-09 | 2020-12-09 | Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112552566A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113416354A (en) * | 2021-04-30 | 2021-09-21 | 百事基材料（青岛）股份有限公司 | Big biological butyronitrile gloves |
| CN113943446A (en) * | 2021-11-16 | 2022-01-18 | 安徽和佳医疗用品科技有限公司 | Manufacturing process of medical disposable glove material |
| CN113980369A (en) * | 2021-11-15 | 2022-01-28 | 安徽和佳医疗用品科技有限公司 | Production process of antibacterial medical gloves |
| CN114874517A (en) * | 2022-06-13 | 2022-08-09 | 安徽英科医疗用品有限公司 | Preparation process of medical antibacterial gloves |
| CN115286849A (en) * | 2022-08-04 | 2022-11-04 | 上海科邦医用乳胶器材有限公司 | Antibacterial and wear-resistant medical rubber gloves and preparation process thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3649616A (en) * | 1970-02-06 | 1972-03-14 | Stein Hall & Co Inc | Process for making starch ethers |
| CN101870778A (en) * | 2010-07-09 | 2010-10-27 | 中国热带农业科学院农产品加工研究所 | Pre-vulcanized natural rubber latex/chitosan blended membrane material and preparation method thereof |
| CN103211331A (en) * | 2013-05-06 | 2013-07-24 | 中国热带农业科学院南亚热带作物研究所 | Antibacterial and anti-inflammation lubricative glove containing natural cinnamyl aldehyde and manufacturing method thereof |
| CN104412977A (en) * | 2013-09-05 | 2015-03-18 | 无锡新亚安全用品有限公司 | Antibacterial fluid and production method of antibacterial rubber gloves |
| CN105639777A (en) * | 2016-01-29 | 2016-06-08 | 山东星宇手套有限公司 | Wear-resistant flannelette nitrile gloves and preparation technology thereof |
| CN106835720A (en) * | 2017-01-17 | 2017-06-13 | 南通强生安全防护科技股份有限公司 | A kind of preparation method of NBR latex frosted gloves |
| CN108440774A (en) * | 2018-01-23 | 2018-08-24 | 浙江康隆达特种防护科技股份有限公司 | A kind of corrosion-resistant gloves and preparation method thereof |
-
2020
- 2020-12-09 CN CN202011450405.7A patent/CN112552566A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3649616A (en) * | 1970-02-06 | 1972-03-14 | Stein Hall & Co Inc | Process for making starch ethers |
| CN101870778A (en) * | 2010-07-09 | 2010-10-27 | 中国热带农业科学院农产品加工研究所 | Pre-vulcanized natural rubber latex/chitosan blended membrane material and preparation method thereof |
| CN103211331A (en) * | 2013-05-06 | 2013-07-24 | 中国热带农业科学院南亚热带作物研究所 | Antibacterial and anti-inflammation lubricative glove containing natural cinnamyl aldehyde and manufacturing method thereof |
| CN104412977A (en) * | 2013-09-05 | 2015-03-18 | 无锡新亚安全用品有限公司 | Antibacterial fluid and production method of antibacterial rubber gloves |
| CN105639777A (en) * | 2016-01-29 | 2016-06-08 | 山东星宇手套有限公司 | Wear-resistant flannelette nitrile gloves and preparation technology thereof |
| CN106835720A (en) * | 2017-01-17 | 2017-06-13 | 南通强生安全防护科技股份有限公司 | A kind of preparation method of NBR latex frosted gloves |
| CN108440774A (en) * | 2018-01-23 | 2018-08-24 | 浙江康隆达特种防护科技股份有限公司 | A kind of corrosion-resistant gloves and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 林峥: "《实用密封手册》", vol. 1, 31 July 2008, 上海科学技术出版社, pages: 7 * |
| 段久芳: "《天然高分子材料》", vol. 1, 30 September 2016, 华中科技大学出版社, pages: 190 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113416354A (en) * | 2021-04-30 | 2021-09-21 | 百事基材料（青岛）股份有限公司 | Big biological butyronitrile gloves |
| CN113980369A (en) * | 2021-11-15 | 2022-01-28 | 安徽和佳医疗用品科技有限公司 | Production process of antibacterial medical gloves |
| CN113980369B (en) * | 2021-11-15 | 2023-03-28 | 安徽和佳医疗用品科技有限公司 | Production process of antibacterial medical gloves |
| CN113943446A (en) * | 2021-11-16 | 2022-01-18 | 安徽和佳医疗用品科技有限公司 | Manufacturing process of medical disposable glove material |
| CN114874517A (en) * | 2022-06-13 | 2022-08-09 | 安徽英科医疗用品有限公司 | Preparation process of medical antibacterial gloves |
| CN115286849A (en) * | 2022-08-04 | 2022-11-04 | 上海科邦医用乳胶器材有限公司 | Antibacterial and wear-resistant medical rubber gloves and preparation process thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112552566A (en) | Disposable butyronitrile medical gloves with antibacterial function and preparation method thereof | |
| EP3397687B1 (en) | Nitrile rubber article | |
| CN103554565A (en) | Natural rubber and nitrile rubber blended medical glove and preparation method thereof | |
| CN108976768B (en) | Antibacterial modifier and preparation method thereof, antibacterial modified thermoplastic elastomer and preparation method thereof | |
| CN109295711B (en) | Preparation method of washable antiviral and antibacterial fiber and fiber product | |
| CN112812261B (en) | Waterborne polyurethane emulsion, nitrile rubber-polyurethane composite glove and preparation method thereof | |
| CN114561810A (en) | Antibacterial anti-mite fabric and preparation method thereof | |
| CN111793854B (en) | Hyaluronic acid fiber material and preparation method thereof | |
| CN112773025A (en) | Antibacterial medical isolation clothes and manufacturing method thereof | |
| CN103289408A (en) | Method for preparing silicon rubber | |
| CN101473850A (en) | Antimicrobial liquid of medical gloves and manufacturing method thereof | |
| CN111004493A (en) | Antibacterial medical material and preparation method thereof | |
| CN109957155A (en) | A kind of preparation method of the modified polyisoprene surgical operation gloves of graphene oxide | |
| CA2780286A1 (en) | Use of polymeric or oligomeric active ingredients for medical articles | |
| CN114736406A (en) | Preparation process of low-temperature-resistant gloves with antibacterial effect | |
| JP4413465B2 (en) | Silver antibacterial agent | |
| CN107298826A (en) | A kind of antibacterial medical gloves and preparation method thereof | |
| KR100665719B1 (en) | Method for produce of Rubber gloves contain Nano silver | |
| CN110973137A (en) | Efficient environment-friendly disinfection composition and preparation method thereof | |
| CN111658814A (en) | Breathable wrapping material and preparation method thereof | |
| CN109796769B (en) | Medical nursing gloves | |
| CN111138828A (en) | Thin-layer material with disinfecting and filtering functions and application of thin-layer material in antiviral field | |
| CN117866417B (en) | Waterproof breathable antibacterial high-elastic TPU film for wound care and preparation method thereof | |
| CN112431022A (en) | Antibacterial material for clothes and preparation method thereof | |
| CN112109394A (en) | Antibacterial material for pediatric nursing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210326 |