CN112526149A - Automatic virus detection pretreatment system - Google Patents
Automatic virus detection pretreatment system Download PDFInfo
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- CN112526149A CN112526149A CN202011604866.5A CN202011604866A CN112526149A CN 112526149 A CN112526149 A CN 112526149A CN 202011604866 A CN202011604866 A CN 202011604866A CN 112526149 A CN112526149 A CN 112526149A
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- 241000700605 Viruses Species 0.000 title claims abstract description 32
- 238000001514 detection method Methods 0.000 title claims abstract description 32
- 238000007710 freezing Methods 0.000 claims abstract description 58
- 230000008014 freezing Effects 0.000 claims abstract description 58
- 238000005070 sampling Methods 0.000 claims abstract description 58
- 239000007788 liquid Substances 0.000 claims abstract description 46
- 239000002184 metal Substances 0.000 claims abstract description 25
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 16
- 238000010276 construction Methods 0.000 claims abstract description 4
- 238000005138 cryopreservation Methods 0.000 claims description 16
- 239000011148 porous material Substances 0.000 claims description 13
- 238000012360 testing method Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 230000007246 mechanism Effects 0.000 claims description 4
- 230000009849 deactivation Effects 0.000 claims description 2
- 238000012113 quantitative test Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 9
- 230000002779 inactivation Effects 0.000 abstract description 4
- 238000000926 separation method Methods 0.000 abstract description 3
- 238000013461 design Methods 0.000 abstract description 2
- 239000000284 extract Substances 0.000 abstract description 2
- 238000005034 decoration Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 230000003321 amplification Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00435—Refrigerated reagent storage
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00445—Other cooling arrangements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0403—Sample carriers with closing or sealing means
- G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0434—Sample carriers adapted for special purposes in the form of a syringe or pipette tip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0496—Other details
- G01N2035/0498—Drawers used as storage or dispensing means for vessels or cuvettes
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Robotics (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The invention relates to the technical field of automation equipment, and discloses a virus automatic detection pretreatment system which comprises a sample input unit, a sampling unit, a turntable unit, a freezing tube unit, a metal bath unit, a pretreatment output unit and a mechanical arm unit, wherein the sample input unit is used for arranging sampling tubes, the freezing tube unit sends the freezing tubes to the turntable unit through the mechanical arm unit, the sampling unit extracts reagents from the sampling tubes and then separately packs the reagents in three freezing tubes through the turntable unit, the mechanical arm unit sends one freezing tube to the metal bath unit, two freezing tubes are sent back to the freezing tube unit, the metal bath unit inactivates the reagents in the freezing tubes and then sends the reagents to the pretreatment output unit to output to a subsequent system construction system, and the split freezing tubes of the freezing tube unit are sent to freezing and preserving equipment. The invention completes the pretreatment processes of mixing, liquid separation, subpackaging, inactivation and the like after virus sampling through the reasonable design of the automatic equipment.
Description
Technical Field
The invention relates to the technical field of automation equipment, in particular to a virus automatic detection pretreatment system.
Background
The virus automatic detection process replaces manual detection, the virus detection comprises a plurality of processes, the virus sampling to the culture amplification detection are all realized manually, the efficiency is low, the detection process cannot be effectively monitored, and the detection result varies from person to person. In addition, viruses cause potential safety hazards to human bodies, and although the viruses are carried out in a biological safety cabinet, safety accidents cannot be avoided.
The operation process of detection, including the operation such as the sample of liquid, the lid of opening and shutting of container, accurate notes liquid still relate to the operation control of each equipment, not only test operating personnel's working strength, still be one to operating personnel's patience and test.
And the operator is liberated from boring repeated labor, the detection precision and the traceability of detection data are improved, and the detection automation is imperative.
Disclosure of Invention
The invention aims to solve the problems and provides a virus automatic detection pretreatment system which completes pretreatment processes such as mixing, liquid separation, subpackaging, inactivation and the like after virus sampling through reasonable design of automatic equipment.
The technical scheme adopted by the invention is as follows:
the utility model provides an automatic preliminary treatment system that detects of virus, characterized by includes sample input unit, sampling unit, carousel unit, freezes deposits a tub unit, metal bath unit, preliminary treatment output unit and arm unit, sample input unit is used for arranging the sampling tube, freezes deposits the tub unit and will freeze and deposit the pipe and send to the carousel unit through the arm unit, the sampling unit is after mentioning the sampling tube and draw reagent, and divide the dress in three freezes deposits the pipe through the carousel unit, the arm unit sends a freezes deposits the pipe to the metal bath unit, and two freezes deposits the pipe unit of returning, metal bath unit is after freezing intraductal reagent deactivation, send to preliminary treatment output unit, output to follow-up system construction system, the partial shipment freezes of freezing and deposits the pipe of tub unit and sends to freezing save equipment.
Further, the sample input unit still includes the vibration module, set up the sample frame on the vibration module, arrange the sampling tube on the sample frame, set up canceling release mechanical system on the vibration module, canceling release mechanical system makes the sample frame returns initial position after the vibration is accomplished.
Further, the mechanical arm unit is provided with a clamping device, a liquid taking device and a cover opening and closing device, and the clamping device carries the containers of all the units.
Further, the sampling unit is located between the sample input unit and the turntable unit, the sampling unit comprises a sampling tube fixing part, after the sampling tube on the sample rack is conveyed to the sample fixing part by the clamping device of the mechanical arm unit to be fixed, the cover opening and closing device opens the cover of the sampling tube, the liquid taking device sucks quantitative test liquid from the sampling tube, the cover opening and closing device closes the cover of the sampling tube again, and the sampling tube is conveyed back to the original position of the sample rack by the clamping device.
Further, set up a plurality of on the carousel unit and freeze and deposit a pipe station, set up on every station and freeze and deposit a pipe and press from both sides tight frock, carousel unit one side still sets up and freezes and deposit pipe cover part that opens and shuts, the liquid device of getting sends the interior test solution of sample tube to the freezing of carousel unit and deposits the pipe.
Further, the cryopreserved pipe unit comprises a cryopreserved pipe array, the clamping device of the mechanical arm unit takes out three cryopreserved pipes from the cryopreserved pipe array and sends the three cryopreserved pipes to the turntable unit, the liquid taking device divides the test liquid in the sampling pipe to the three cryopreserved pipes, the clamping device sends two cryopreserved pipes back to the cryopreserved pipe array, and one cryopreserved pipe is sent to the metal bath unit.
Further, the cryopreserved pipe unit further comprises a rotary conveying frame, the rotary conveying frame conveys the three cryopreserved pipes to the turntable unit at one time, and the cryopreserved pipes are conveyed back by the rotary conveying frame after liquid injection is completed.
Further, the metal bath unit is located between the rotary table unit and the freezing pipe unit, and the metal bath unit heats and inactivates one freezing pipe.
Further, the pretreatment output unit comprises a pore plate and an output rotating arm, the pore plate is arranged on the output rotating arm, and the inactivated cryopreservation tubes are respectively arranged in the pore plate by the liquid taking device.
Further, still include the suction head unit between sample input unit and the carousel unit, the suction head unit includes suction head box and suction head abandons the box, get liquid device and get when liquid and adorn the suction head in the suction head box, accomplish the drain back, abandon the suction head in the suction head abandons the box.
The invention has the beneficial effects that:
(1) automatically realizing the technical processes of oscillating mixing, liquid separation and subpackaging, inactivation and subpackaging and the like of a sample;
(2) various pretreatment operations are completed by using the mechanical arm unit through reasonable layout;
(3) the data can be traced, the consistency of the generated pore plate sample is good, and powerful guarantee is provided for the subsequent virus detection precision.
Drawings
FIG. 1 is a schematic perspective view of the present invention (with the biosafety cabinet removed);
FIG. 2 is an enlarged partial view of the sample input unit of the present invention;
FIG. 3 is a partial enlarged view of the sampling unit;
FIG. 4 is a partially enlarged view of the tip unit and the pretreatment output unit;
FIG. 5 is an enlarged partial view of the turntable unit;
FIG. 6 is an enlarged partial view of the cryopreserved tube unit and the metal bath unit.
The reference numbers in the drawings are respectively:
1. a sample input unit; a sampling unit;
3. a suction head unit; 4. a turntable unit;
5. freezing and storing the tube unit; a metal bath unit;
7. a preprocessing output unit; a robot arm unit;
9. a sampling tube; 10, a clamping device;
11. a liquid taking device; 12, opening and closing the cover device;
13. a sample holder; a tip cartridge;
15. a suction head discarding box; freezing and storing a pipe clamping tool;
17. rotating the transfer frame; 18. an aperture plate;
19. an output rotating arm; and 20, opening and closing the cover part of the freezing storage tube.
Detailed Description
The following describes in detail a specific embodiment of the virus automated pretreatment system according to the present invention with reference to the drawings.
Referring to the attached figure 1, the virus automatic detection pretreatment system is installed in a biological safety cabinet, is standardized according to the national virus safety detection requirements strictly, and performs necessary parameter optimization on different types of virus samples to meet the virus detection requirements.
The virus detection pretreatment system is set to be arranged in an L shape, and comprises a sample input unit 1, a sampling unit 2, a suction head unit 3, a turntable unit 4, a freezing tube unit 5, a metal bath unit 6, a pretreatment output unit 7 and a mechanical arm unit 8, wherein the sample input unit 1, the sampling unit 2, the suction head unit 3, the turntable unit 4, the metal bath unit 6, the pretreatment output unit 7 is positioned in a row, the freezing tube unit 5 is positioned on one side of the L shape, the mechanical arm unit 8 is arranged at a plurality of positions above the system through a rail, and the virus detection pretreatment system is reasonably arranged according to the moving requirement.
The sample input unit 1 is used for arranging sampling tubes 9, the freezing tube unit 5 sends the freezing tubes to the turntable unit 4 through the mechanical arm unit 8, the sampling unit 2 extracts reagents from the sampling tubes 9, the reagents are respectively loaded into three freezing tubes through the turntable unit 4, the mechanical arm unit 8 sends one freezing tube to the metal bath unit 6, the two freezing tubes are sent back to the freezing tube unit 5, the metal bath unit 6 inactivates the reagents in the freezing tubes, then sends the reagents to the pretreatment output unit 7 and outputs the reagents to the subsequent system construction system, and the sub-loading freezing tubes of the freezing tube unit 5 are sent to the freezing storage equipment.
The mechanical arm unit 8 comprises cross beams arranged in the XYZ directions on the side edges of the working units, functional mechanical arms such as a clamping device 10, a liquid taking device 11, a cover opening and closing device 12 and the like are arranged on the cross beams respectively, the functions of clamping movement, extraction and injection of quantitative solution, clamping rotation and the like are achieved, the actions of carrying, opening and closing the cover, taking and injecting liquid of containers such as a sampling tube 9 and a freezing tube are achieved, and the orderly development of virus detection pretreatment work is achieved.
Referring to fig. 2, the sample input unit 1 further includes a vibration module, the vibration module is provided with a sample holder 13, the sample holder 13 is provided with a sampling tube 9, and the vibration module is provided with a reset mechanism, which enables the sample holder 13 to return to an initial position after the vibration is completed. The vibration module is realized by driving an eccentric connecting rod through a motor, and the reset is realized through a motor encoder or a conical hole positioning mode. The sample holders 13 are arranged in two rows and arranged in a controllable range of the mechanical arm, and positioning can be realized through a positioning mechanism, so that the mechanical arm can be accurately positioned for operation and control.
Referring to fig. 3, the sampling unit 2 is located between the sample input unit 1 and the turntable unit 4, the sampling unit 2 includes a sampling tube 9 fixing part, after the sampling tube 9 on the sample rack 13 is conveyed to the sample fixing part by the clamping device of the mechanical arm unit 8 and fixed, the sampling tube 9 is opened by the cover opening and closing device 12, the liquid taking device 11 takes a certain amount of sample liquid from the sampling tube 9, the sampling tube 9 is closed by the cover opening and closing device 12, and the sampling tube is returned to the original position of the sample rack 13 by the clamping device. The sampling tube 9 fixing part limits the sampling tube 9 at a fixed position through an elastic clamp and a positioning plate, and facilitates the direct operation of the mechanical arm unit 8.
Referring to fig. 4, the tip unit 3 is located between the sample input unit 1 and the turntable unit 4, the tip unit 3 includes a tip box 14 and a tip discard box 15, the tip is loaded from the tip box 14 when the liquid taking device 11 takes the liquid, and the tip is discarded in the tip discard box 15 after the liquid discharge is completed. In the liquid treatment process of different kinds of test solutions, the tip is replaced as required in the flow. For example, the types of liquids are changed, when reagents are changed at different stages, the suction head is required to be changed, the suction head is pressed into the suction head box 14 through the liquid taking device 11 on the mechanical arm in the changing process, and the suction head is directly removed above the suction head discarding box 15 when the reagents are discarded.
Referring to fig. 5, a plurality of freezing tube stations are arranged on the turntable unit 4, a freezing tube clamping tool 16 is arranged on each station, an opening and closing cover part of the freezing tube is further arranged on one side of the turntable unit 4, and the liquid taking device 11 sends the test liquid in the sampling tube 9 to the freezing tube on the turntable unit 4. The freezing pipe clamping tool 16 on each station is a double-spring device, clamping blocks are arranged between two springs, the freezing pipe is placed between the clamping blocks, the clamping blocks clamp the freezing pipe through force application to the clamping blocks, and after the freezing pipe is clamped by the freezing pipe clamping tool 16, the opening and closing of the freezing pipe are completed by the freezing pipe opening and closing cover component 20.
Referring to fig. 6, the cryopreservation tube unit 5 includes a cryopreservation tube array, one side of which is a part of the mechanical arm unit 8 and is used for grabbing the cryopreservation tubes from the cryopreservation tube array to the turntable unit 4, in a general process, a clamping device of the mechanical arm unit 8 takes out three cryopreservation tubes from the cryopreservation tube array and sends the three cryopreservation tubes to the turntable unit 4, a liquid taking device 11 divides liquid in a sampling tube 9 into three cryopreservation tubes, the clamping device sends two cryopreservation tubes back to the cryopreservation tube array, and one cryopreservation tube is sent to the metal bath unit 6.
The freezing pipe unit 5 further comprises a rotary conveying frame 17, the rotary conveying frame 17 conveys three freezing pipes to the turntable unit 4 once, and the freezing pipes are conveyed back by the rotary conveying frame 17 after liquid injection is completed. Through the rotatory conveying frame 17, realize the transition that the frozen pipe of one side shifts to carousel unit 4, reduced the size of equipment greatly, realize the miniaturized compactness of equipment.
The metal bath unit 6 is positioned between the turntable unit 4 and the freezing tube unit 5, and the metal bath unit 6 heats and inactivates one freezing tube. The metal bath unit 6 achieves constant temperature inactivation through electric heating and temperature control components, and the temperature is maintained at 56 ℃.
With continued reference to fig. 4, the pretreatment output unit 7 comprises a pore plate 18 and an output rotating arm 19, the pore plate 18 is arranged on the output rotating arm 19, and the inactivated cryopreservation tube is respectively packed in the pore plate 18 by the liquid taking device 11. The pore plates 18 are generally two standard 96-pore plate 18 which are arranged side by side, and after the operation, the output rotating arm 19 rotates to output, so that the pore plates 18 extend out of the biological safety cabinet, and the subsequent robot taking-out operation is convenient. The inactivated cryopreservation tube is also conveyed through the turntable unit 4, and then liquid operation is carried out through the liquid taking device 11 of the mechanical arm unit 8.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A virus automatic detection pretreatment system is characterized in that: including sample input unit, sampling unit, carousel unit, cryopreserved pipe unit, metal bath unit, pretreatment output unit and arm unit, sample input unit is used for arranging the sampling tube, cryopreserved pipe unit will cryopreserved pipe through the arm unit and send to the carousel unit, the sampling unit is from lifting after extracting reagent in the sampling tube, in three cryopreserved pipe of split charging of reagent through the carousel unit, the arm unit sends a cryopreserved pipe to metal bath unit, and two cryopreserved pipes send back the cryopreserved pipe unit, the metal bath unit sends the intraductal reagent deactivation back of cryopreserved to pretreatment output unit, exports to follow-up system construction system, the partial shipment cryopreserved pipe of cryopreserved pipe unit sends to the cryopreservation equipment.
2. The system for processing virus before automatic detection according to claim 1, wherein: the sample input unit further comprises a vibration module, a sample frame is arranged on the vibration module, a sampling tube is arranged on the sample frame, a reset mechanism is arranged on the vibration module, and the reset mechanism enables the sample frame to return to an initial position after vibration is completed.
3. The system for processing virus before automatic detection according to claim 1, wherein: the mechanical arm unit is provided with a clamping device, a liquid taking device and a cover opening and closing device, and the clamping device carries the containers of all the units.
4. The system for processing virus before automatic detection according to claim 2, wherein: the sampling unit is located between the sample input unit and the turntable unit, the sampling unit comprises a sampling tube fixing part, after the sampling tube on the sample rack is conveyed to the sample fixing part by the clamping device of the mechanical arm unit to be fixed, the cover opening and closing device opens the cover of the sampling tube, the liquid taking device sucks quantitative test liquid from the sampling tube, the cover opening and closing device closes the cover of the sampling tube, and the sampling tube is conveyed back to the original position of the sample rack by the clamping device.
5. The system for processing virus before automatic detection according to claim 4, wherein: the rotary plate unit is provided with a plurality of freezing tube stations, each station is provided with a freezing tube clamping tool, one side of the rotary plate unit is also provided with a freezing tube opening and closing cover part, and the liquid taking device sends the test liquid in the sampling tube to the freezing tube on the rotary plate unit.
6. The system for processing virus before automatic detection according to claim 5, wherein: the cryopreserved pipe unit comprises a cryopreserved pipe array, the clamping device of the mechanical arm unit takes out three cryopreserved pipes from the cryopreserved pipe array and sends the three cryopreserved pipes to the turntable unit, the liquid taking device divides liquid of test liquid in a sampling pipe to the three cryopreserved pipes, the clamping device sends back two cryopreserved pipes to the cryopreserved pipe array, and one cryopreserved pipe is sent to the metal bath unit.
7. The system for processing virus before automatic detection according to claim 6, wherein: the freezing pipe unit further comprises a rotary conveying frame, the rotary conveying frame conveys three freezing pipes to the turntable unit at one time, and the freezing pipes are conveyed back by the rotary conveying frame after liquid injection is completed.
8. The system for processing virus before automatic detection according to claim 6, wherein: the metal bath unit is located between the rotary table unit and the freezing pipe unit, and the metal bath unit heats and inactivates one freezing pipe.
9. The system for processing virus before automatic detection according to claim 6, wherein: the pretreatment output unit comprises a pore plate and an output rotating arm, the pore plate is arranged on the output rotating arm, and the inactivated cryopreservation tubes are respectively arranged in the pore plate by the liquid taking device.
10. The system for processing virus before automatic detection according to claim 3, wherein: still include the suction head unit between sample input unit and the carousel unit, the suction head unit includes suction head box and suction head abandons the box, install the suction head from the suction head box when getting liquid device and getting liquid, accomplish the drain back, abandon the suction head in the suction head abandons the box.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011604866.5A CN112526149A (en) | 2020-12-30 | 2020-12-30 | Automatic virus detection pretreatment system |
| PCT/CN2021/077499 WO2022141778A1 (en) | 2020-12-30 | 2021-02-23 | Automated virus test pretreatment system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011604866.5A CN112526149A (en) | 2020-12-30 | 2020-12-30 | Automatic virus detection pretreatment system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112526149A true CN112526149A (en) | 2021-03-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011604866.5A Pending CN112526149A (en) | 2020-12-30 | 2020-12-30 | Automatic virus detection pretreatment system |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN112526149A (en) |
| WO (1) | WO2022141778A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN113375995A (en) * | 2021-06-29 | 2021-09-10 | 上海汇像信息技术有限公司 | Full-automatic filtration system |
| CN114480310A (en) * | 2022-01-28 | 2022-05-13 | 内蒙金属材料研究所 | Packaging process and inactivation method for infectious virus liquid |
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| CN116678707B (en) * | 2023-08-04 | 2023-09-29 | 百泉聚兴(北京)科技有限公司 | Automatic pretreatment device for metabonomics samples |
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| WO2022141778A1 (en) | 2022-07-07 |
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