CN112516029A - Skin care composition containing plant fullerene - Google Patents

Skin care composition containing plant fullerene Download PDF

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Publication number
CN112516029A
CN112516029A CN202011482496.2A CN202011482496A CN112516029A CN 112516029 A CN112516029 A CN 112516029A CN 202011482496 A CN202011482496 A CN 202011482496A CN 112516029 A CN112516029 A CN 112516029A
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parts
plant
fullerene
ceramide
care composition
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CN202011482496.2A
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张应贤
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Guangzhou Lakel Stem Cell Research Institute
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Guangzhou Lakel Stem Cell Research Institute
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Priority to CN202011482496.2A priority Critical patent/CN112516029A/en
Publication of CN112516029A publication Critical patent/CN112516029A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55Phosphorus compounds
    • A61K8/553Phospholipids, e.g. lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/82Preparation or application process involves sonication or ultrasonication

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Birds (AREA)
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  • Dermatology (AREA)
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  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a skin care composition containing plant fullerene, which comprises the following components in parts by mass: 0.2 to 5 parts of plant fullerene, 3 to 8 parts of squalane, 1 to 5 parts of olive (Olea EUROPAEA) fruit oil, 0.001 to 0.01 part of plant ceramide, 0.1 to 3 parts of peony root extract, 2 to 5 parts of butanediol, 0.1 to 0.3 part of xanthan gum, 0.8 to 2 parts of lecithin, 20 to 55 parts of water and 0.01 to 0.15 part of carnosine. Compared with the prior art, the invention has the advantages that: the antioxidant cream has strong, lasting and stable antioxidant effect, effectively resists skin aging caused by peroxidation, improves skin relaxation and improves skin roughness; the skin cutin normalization is maintained, the skin moisture retention is realized, and the skin brightness is improved.

Description

Skin care composition containing plant fullerene
Technical Field
The invention relates to the technical field of cosmetics, in particular to a skin care composition containing plant fullerene.
Background
Fullerene was found in 1985 to be an allotrope of elemental carbon. Any substance consisting of carbon, in a spherical, ellipsoidal, or tubular structure, can be called a fullerene. Fullerenes are structurally similar to graphite, which is built up from graphene layers consisting of six-membered rings, whereas fullerenes contain not only six-membered rings but also five-membered rings and occasionally seven-membered rings. Present in hundreds of millions of years ago in underground ores and in cosmic clouds. Fullerene has a unique antioxidant mechanism, is insoluble in water, and cannot be simply compounded in cosmetics. The fullerene used in the market is synthesized, has high manufacturing cost and is not environment-friendly. The high added value of the product is realized through natural sources, and the product is easy to compound in cosmetics and has sustainability and environmental protection.
Skin aging is mainly characterized by sagging, increased and deepened wrinkles, dry, rough, dull, and lack of luster and elasticity.
Disclosure of Invention
The invention aims to provide a novel antioxidant composition which has strong, lasting and stable antioxidant effect, effectively resists skin aging caused by peroxidation, improves skin relaxation and improves skin roughness; the skin care composition containing the plant fullerene can maintain skin cutin to be normal, realize skin moisture retention and improve skin brightness.
The purpose of the invention is realized by the following technical scheme:
the skin care composition containing plant fullerene comprises the following components in parts by mass: 0.2 to 5 parts of plant fullerene, 3 to 8 parts of squalane, 1 to 5 parts of olive (Olea EUROPAEA) fruit oil, 0.001 to 0.01 part of plant ceramide, 0.1 to 3 parts of peony root extract, 2 to 5 parts of butanediol, 0.1 to 0.3 part of xanthan gum, 0.8 to 2 parts of lecithin, 20 to 55 parts of water and 0.01 to 0.15 part of carnosine.
Further, the feed comprises the following components in parts by mass: 2.5 parts of plant fullerene, 5 parts of squalane, 3 parts of olive (OLEA EUROPAEA) fruit oil, 0.005 part of plant ceramide, 1.5 parts of peony root extract, 3.5 parts of butanediol, 0.15 part of xanthan gum, 1.4 parts of lecithin, 28 parts of water and 0.1 part of carnosine.
Further, the feed comprises the following components in parts by mass: 0.2 part of plant fullerene, 3 parts of squalane, 1 part of olive (Olea EUROPAEA) fruit oil, 0.001 part of plant ceramide, 0.1 part of peony root extract, 2 parts of butanediol, 0.1 part of xanthan gum, 0.8 part of lecithin, 20 parts of water and 0.01 part of carnosine.
Further, the feed comprises the following components in parts by mass: 5 parts of plant fullerene, 8 parts of squalane, 5 parts of olive (Olea EUROPAEA) fruit oil, 0.01 part of plant ceramide, 3 parts of peony root extract, 5 parts of butanediol, 0.3 part of xanthan gum, 2 parts of lecithin, 55 parts of water and 0.15 part of carnosine.
Further, the plant ceramide is one or a mixture of more of ceramide 1, ceramide 2 and ceramide 3.
A preparation method of a skin care composition containing plant fullerene comprises the following steps:
s1, accurately weighing plant fullerene, plant ceramide, squalane, olive (Olea EUROPAEA) fruit oil, carnosine, peony root extract, xanthan gum, butanediol, lecithin and water;
s2, mixing squalane, plant fullerene, and olive (Olea EUROPAEA) fruit oil, and ultrasonically dispersing to obtain phase A;
s3, slightly heating, mixing and dissolving butanediol and plant ceramide uniformly to obtain a B phase;
s4, uniformly dispersing xanthan gum, lecithin, carnosine and water by ultrasonic waves to obtain a phase C;
s5, adding A, B phases into the C phase under low-speed stirring, performing ultrasonic stirring and micro-emulsification, adding the peony root extract, and uniformly stirring under low speed to obtain the skin care composition containing plant fullerene.
The skin care composition containing plant fullerene is used as additive for preparing cosmetics, and is added at 50 deg.C with addition amount of 0.1-3%.
Compared with the prior art, the invention has the advantages that:
lecithin is an indispensable substance for every cell of the human body, and if it is lacking, the regenerative capacity of skin cells is reduced, resulting in rough skin and wrinkles. When the lecithin is properly taken, the skin regeneration activity can be guaranteed, and the lecithin has good hydrophilicity and lipophilicity.
Paeonia SUFFRUTICOSA ROOT EXTRACT has anti-inflammatory and antiallergic effects, and can be used for preventing melanogenesis and freckle; and can be used for resisting skin aging caused by peroxidation. The peony root extract has the main effects of skin conditioner and antioxidant in cosmetics and skin care products, has a risk coefficient of 1, is safe, can be used safely, has no influence on pregnant women, and has no pox-causing property.
Phytoceramides are the most important component of the stratum corneum intercellular substance, representing 40% of lipids. The plant ceramide can help supplement ceramide lacked in skin, reconstruct skin barrier, increase water retention capacity of skin, make skin soft and smooth, and restore elasticity.
The selected fullerene is purely natural plant source and is derived from forest natural fir, and the comprehensive matching of all the components has strong, lasting and stable antioxidant effect, effectively resists skin aging caused by peroxidation, improves skin relaxation and improves skin roughness; the skin cutin normalization is maintained, the skin moisture retention is realized, and the skin brightness is improved.
Drawings
FIG. 1 is a graph showing antioxidant activity.
FIG. 2 is a schematic diagram of gloss, elasticity, and roughness.
Fig. 3 is a schematic diagram of the amount of pore size change.
Detailed Description
Example 1
The skin care composition containing plant fullerene comprises the following components in parts by mass: 2.5 parts of plant fullerene, 5 parts of squalane, 3 parts of olive (OLEA EUROPAEA) fruit oil, 0.005 part of plant ceramide, 1.5 parts of peony root extract, 3.5 parts of butanediol, 0.15 part of xanthan gum, 1.4 parts of lecithin, 28 parts of water and 0.1 part of carnosine.
Example 2
The skin care composition containing plant fullerene comprises the following components in parts by mass: 0.2 part of plant fullerene, 3 parts of squalane, 1 part of olive (Olea EUROPAEA) fruit oil, 0.001 part of plant ceramide, 0.1 part of peony root extract, 2 parts of butanediol, 0.1 part of xanthan gum, 0.8 part of lecithin, 20 parts of water and 0.01 part of carnosine.
Example 3
The skin care composition containing plant fullerene comprises the following components in parts by mass: 5 parts of plant fullerene, 8 parts of squalane, 5 parts of olive (Olea EUROPAEA) fruit oil, 0.01 part of plant ceramide, 3 parts of peony root extract, 5 parts of butanediol, 0.3 part of xanthan gum, 2 parts of lecithin, 55 parts of water and 0.15 part of carnosine.
Examples 1-3 a method of preparing a plant fullerene containing skin care composition, comprising the steps of:
s1, accurately weighing plant fullerene, plant ceramide, squalane, olive (Olea EUROPAEA) fruit oil, carnosine, peony root extract, xanthan gum, butanediol, lecithin and water;
s2, mixing squalane, plant fullerene, and olive (Olea EUROPAEA) fruit oil, and ultrasonically dispersing to obtain phase A;
s3, slightly heating, mixing and dissolving butanediol and plant ceramide uniformly to obtain a B phase;
s4, uniformly dispersing xanthan gum, lecithin, carnosine and water by ultrasonic waves to obtain a phase C;
s5, adding A, B phases into the C phase under low-speed stirring, performing ultrasonic stirring and micro-emulsification, adding the peony root extract, and uniformly stirring under low speed to obtain the skin care composition containing plant fullerene.
And (3) verifying the antioxidant effect:
ultraviolet stability the antioxidant capacity was tested using the beta-carotene fading method, the test results are shown in fig. 1, vitamin C and vitamin E still exhibit stronger antioxidant capacity compared to the same, fullerene can effectively scavenge free radicals generated under various conditions, and especially can still stably exert super-strong antioxidant capacity under ultraviolet irradiation.
Increase the gloss and elasticity of the skin and improve the roughness of the skin:
80 healthy hundred volunteers aged 25-60 are selected, and have one or more skin problems, poor sleeping, stress bearing, environmental pollution, smoking and unhealthy eating habits, and the skin is lack of luster and elasticity, more wrinkles and fine lines, coarse pores and rough skin.
And (3) testing: the emulsion containing 0.5% of the skin care composition of the present invention was used with the blank control emulsion for 1 month 2 times a day on the face.
The test result is shown in fig. 2, the data result obviously improves the skin, the glossiness is improved along with the change of time, and the glossiness is improved by 43 percent after 28 days; the elasticity is also improved along with the change of time, and is improved by 25.6 percent after 28 days; skin roughness decreased with time, 38% after 28 days. The skin care composition containing the plant fullerene can improve the skin glossiness, the skin roughness and the skin elasticity.
And (3) improving the large pores:
the emulsion containing 0.5% of the skin care composition of the present invention was used with the blank control emulsion for 1 month 2 times a day on the face.
VISIA photographs were taken to show the change in pore size before and after use. Photographing parts: the transverse cheek part of the nose. As a result, as shown in fig. 3, the variation of the large pores of the skin decreased with the lapse of time, indicating that the skin care composition containing phytofullerene according to the present invention can improve the large pores, make the skin fine and smooth, and restore normal keratin.

Claims (7)

1. The skin care composition containing plant fullerene is characterized by comprising the following components in parts by mass: 0.2 to 5 parts of plant fullerene, 3 to 8 parts of squalane, 1 to 5 parts of olive (Olea EUROPAEA) fruit oil, 0.001 to 0.01 part of plant ceramide, 0.1 to 3 parts of peony root extract, 2 to 5 parts of butanediol, 0.1 to 0.3 part of xanthan gum, 0.8 to 2 parts of lecithin, 20 to 55 parts of water and 0.01 to 0.15 part of carnosine.
2. The plant fullerene containing skin care composition according to claim 1, which comprises the following components in parts by mass: 2.5 parts of plant fullerene, 5 parts of squalane, 3 parts of olive (OLEA EUROPAEA) fruit oil, 0.005 part of plant ceramide, 1.5 parts of peony root extract, 3.5 parts of butanediol, 0.15 part of xanthan gum, 1.4 parts of lecithin, 28 parts of water and 0.1 part of carnosine.
3. The plant fullerene containing skin care composition according to claim 1, which comprises the following components in parts by mass: 0.2 part of plant fullerene, 3 parts of squalane, 1 part of olive (Olea EUROPAEA) fruit oil, 0.001 part of plant ceramide, 0.1 part of peony root extract, 2 parts of butanediol, 0.1 part of xanthan gum, 0.8 part of lecithin, 20 parts of water and 0.01 part of carnosine.
4. The plant fullerene containing skin care composition according to claim 1, which comprises the following components in parts by mass: 5 parts of plant fullerene, 8 parts of squalane, 5 parts of olive (Olea EUROPAEA) fruit oil, 0.01 part of plant ceramide, 3 parts of peony root extract, 5 parts of butanediol, 0.3 part of xanthan gum, 2 parts of lecithin, 55 parts of water and 0.15 part of carnosine.
5. A plant fullerene containing skin care composition according to any one of claims 1 to 4, wherein the plant ceramide is one or more of ceramide 1, ceramide 2 and ceramide 3.
6. A preparation method of a skin care composition containing plant fullerene is characterized by comprising the following steps:
s1, accurately weighing plant fullerene, plant ceramide, squalane, olive (Olea EUROPAEA) fruit oil, carnosine, peony root extract, xanthan gum, butanediol, lecithin and water;
s2, mixing squalane, plant fullerene, and olive (Olea EUROPAEA) fruit oil, and ultrasonically dispersing to obtain phase A;
s3, slightly heating, mixing and dissolving butanediol and plant ceramide uniformly to obtain a B phase;
s4, uniformly dispersing xanthan gum, lecithin, carnosine and water by ultrasonic waves to obtain a phase C;
s5, adding A, B phases into the C phase under low-speed stirring, performing ultrasonic stirring and micro-emulsification, adding the peony root extract, and uniformly stirring under low speed to obtain the skin care composition containing plant fullerene.
7. The application of the skin care composition containing plant fullerene is characterized in that the plant fullerene is used as an additive for preparing cosmetics, and the plant fullerene is added at the temperature of 50 ℃ in the preparation process of the cosmetics, wherein the addition amount is 0.1-3%.
CN202011482496.2A 2020-12-15 2020-12-15 Skin care composition containing plant fullerene Pending CN112516029A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115381731A (en) * 2021-11-02 2022-11-25 广州雅纯化妆品制造有限公司 Plant-derived ceramide nano liposome composition and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115381731A (en) * 2021-11-02 2022-11-25 广州雅纯化妆品制造有限公司 Plant-derived ceramide nano liposome composition and preparation method thereof

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