CN112512579A - Tlr激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 - Google Patents
Tlr激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 Download PDFInfo
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract
一种TLR激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途。具体而言，所述的TLR激动剂为式(I)所示化合物或其可药用盐，所述的免疫检查点抑制剂选自PD‑1抑制剂、PD‑L1抑制剂或CTLA‑4抑制剂。
Description
PCT国内申请，说明书已公开。
Claims (23)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018111479465 | 2018-09-29 | ||
| CN201811147946 | 2018-09-29 | ||
| CN201910467950 | 2019-05-31 | ||
| CN2019104679508 | 2019-05-31 | ||
| PCT/CN2019/108529 WO2020063858A1 (zh) | 2018-09-29 | 2019-09-27 | Tlr激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112512579A true CN112512579A (zh) | 2021-03-16 |
| CN112512579B CN112512579B (zh) | 2024-05-17 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201980049832.3A Active CN112512579B (zh) | 2018-09-29 | 2019-09-27 | Tlr激动剂与免疫检查点抑制剂联合在制备治疗肿瘤的药物中的用途 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN112512579B (zh) |
| TW (1) | TW202027792A (zh) |
| WO (1) | WO2020063858A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3100873A1 (en) * | 2018-05-25 | 2019-11-28 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of hydrochloride of pyrazoloheteroaryl derivative and preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999574A (zh) * | 2014-10-10 | 2017-08-01 | 伊黛拉制药有限公司 | 使用tlr9激动剂与检查点抑制剂对癌症的治疗 |
| WO2018078620A1 (en) * | 2016-10-25 | 2018-05-03 | Urogen Pharma Ltd. | Immunomodulating treatments of body cavities |
| WO2018095426A1 (zh) * | 2016-11-28 | 2018-05-31 | 江苏恒瑞医药股份有限公司 | 吡唑并杂芳基类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10392444B2 (en) * | 2014-08-08 | 2019-08-27 | Oncoquest, Inc. | Tumor antigen specific antibodies and TLR3 stimulation to enhance the performance of checkpoint interference therapy of cancer |
| AU2016304597B2 (en) * | 2015-08-06 | 2022-10-06 | Memorial Sloan Kettering Cancer Center | Methods and compositions for tumor therapy |
-
2019
- 2019-09-27 WO PCT/CN2019/108529 patent/WO2020063858A1/zh active Application Filing
- 2019-09-27 CN CN201980049832.3A patent/CN112512579B/zh active Active
- 2019-09-27 TW TW108135197A patent/TW202027792A/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106999574A (zh) * | 2014-10-10 | 2017-08-01 | 伊黛拉制药有限公司 | 使用tlr9激动剂与检查点抑制剂对癌症的治疗 |
| WO2018078620A1 (en) * | 2016-10-25 | 2018-05-03 | Urogen Pharma Ltd. | Immunomodulating treatments of body cavities |
| WO2018095426A1 (zh) * | 2016-11-28 | 2018-05-31 | 江苏恒瑞医药股份有限公司 | 吡唑并杂芳基类衍生物、其制备方法及其在医药上的应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202027792A (zh) | 2020-08-01 |
| CN112512579B (zh) | 2024-05-17 |
| WO2020063858A1 (zh) | 2020-04-02 |
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