CN112485183A - Corrosion-resistant testing arrangement of vascular support - Google Patents
Corrosion-resistant testing arrangement of vascular support Download PDFInfo
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- CN112485183A CN112485183A CN202011305443.3A CN202011305443A CN112485183A CN 112485183 A CN112485183 A CN 112485183A CN 202011305443 A CN202011305443 A CN 202011305443A CN 112485183 A CN112485183 A CN 112485183A
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- 230000002792 vascular Effects 0.000 title claims abstract description 46
- 238000012360 testing method Methods 0.000 title claims abstract description 32
- 230000007797 corrosion Effects 0.000 title claims abstract description 25
- 238000005260 corrosion Methods 0.000 title claims abstract description 25
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 115
- 239000002473 artificial blood Substances 0.000 claims abstract description 79
- 230000007246 mechanism Effects 0.000 claims abstract description 28
- 238000005086 pumping Methods 0.000 claims abstract description 26
- 230000001737 promoting effect Effects 0.000 claims abstract description 20
- 230000017531 blood circulation Effects 0.000 claims abstract description 6
- 229910052802 copper Inorganic materials 0.000 claims description 67
- 239000010949 copper Substances 0.000 claims description 67
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 66
- 230000008595 infiltration Effects 0.000 claims description 33
- 238000001764 infiltration Methods 0.000 claims description 33
- 210000000078 claw Anatomy 0.000 claims description 21
- 238000010079 rubber tapping Methods 0.000 claims description 21
- 238000007789 sealing Methods 0.000 claims description 21
- 230000000149 penetrating effect Effects 0.000 claims description 10
- 230000003139 buffering effect Effects 0.000 claims description 6
- 239000004576 sand Substances 0.000 claims description 6
- 230000004323 axial length Effects 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 2
- 238000009736 wetting Methods 0.000 claims description 2
- 230000005389 magnetism Effects 0.000 claims 3
- 210000002889 endothelial cell Anatomy 0.000 abstract description 12
- 230000005684 electric field Effects 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 5
- 230000035755 proliferation Effects 0.000 abstract description 4
- 238000003780 insertion Methods 0.000 description 12
- 230000037431 insertion Effects 0.000 description 12
- 230000009286 beneficial effect Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 239000012531 culture fluid Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 210000001503 joint Anatomy 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 238000004904 shortening Methods 0.000 description 2
- 206010060965 Arterial stenosis Diseases 0.000 description 1
- 206010057469 Vascular stenosis Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N17/00—Investigating resistance of materials to the weather, to corrosion, or to light
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M13/00—Testing of machine parts
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Abstract
The invention discloses a corrosion resistance testing device for a vascular stent, which comprises an observation box, wherein an artificial blood vessel, a blood vessel fixing mechanism for supporting and installing the artificial blood vessel, a high-frequency intermittent pumping device for artificial blood circulation to pass through the artificial blood vessel, and an endothelialization promoting mechanism for promoting endothelialization of the vascular stent in the artificial blood vessel are arranged in the observation box; the endothelialization promoting mechanism comprises a nanosecond pulse generating device for generating a nanosecond pulse electric field and an energy guide part sleeved on the artificial blood vessel and provided with a blood vessel stent section. The high-frequency intermittent pumping device circularly pumps the artificial blood in the artificial blood vessel, and in the process, the energy guide part acts the nanosecond pulse electric field generated by the nanosecond pulse generating device on endothelial cells of the artificial blood vessel to promote the proliferation of the endothelial cells so as to greatly shorten the time for endothelialization of the vascular stent, so that the factor of endothelialization of the vascular stent is introduced into a corrosion-resistant test of the vascular stent, and the test error is reduced.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a corrosion resistance testing device for a vascular stent.
Background
The intravascular stent implantation is an interventional therapy method for clinically treating arterial stenosis, and an end support frame is mainly conveyed to a vascular lesion part through a balloon catheter, so that the vascular stenosis part is expanded and restored to a normal size after the end support frame is expanded, and the smoothness of a vascular cavity is kept.
With the rapid development of science and technology, the vascular stent mainly undergoes the development processes of a metal bare end stent, a drug-loaded end stent and a degradable end stent. The degradable end support frame overcomes the defect that the blood vessel support frame cannot be taken out after the blood vessel with the function is normalized, so that hidden danger exists, but before the blood vessel support frame is formally put into use, the blood vessel support frame needs to be subjected to tests of corrosion resistance, torsion resistance, fatigue degree and the like so as to ensure that the blood vessel support frame implanted into the blood vessel of a human body can normally realize the function within the estimated time.
The existing corrosion-resistant test equipment for the vascular stent is characterized in that artificial blood circulates through a blood end support frame implanted into an artificial blood vessel at high frequency, then the content of metal ions containing the blood end support frame in the artificial blood is detected through instruments such as a spectrometer, or the taken blood end support frame is aligned after being cleaned and dried, and the corrosion degree of the vascular stent is judged in a microscopic observation mode and the like.
Disclosure of Invention
The invention aims to provide a corrosion resistance testing device for a vascular stent, which aims to solve the technical problem that in the prior art, the testing result and the actual using result have larger errors due to the fact that the endothelialization testing adjustment of the vascular stent is not introduced.
In order to solve the technical problems, the invention specifically provides the following technical scheme:
a corrosion resistance test device for a vascular stent comprises a observation box, wherein an artificial blood vessel for installing the vascular stent, a blood vessel fixing mechanism for supporting and installing the artificial blood vessel, a high-frequency intermittent pumping device for artificial blood circulation through the artificial blood vessel, and an endothelialization promoting mechanism which is arranged on the blood vessel fixing mechanism and used for promoting endothelialization of the vascular stent in the artificial blood vessel are arranged in the observation box;
blood vessel fixed establishment is including installing tip support frame in the observation case both sides, both sides all install on the tip support frame with the high-frequency buffer interface of artificial blood vessel end connection and intercommunication, and both sides on the tip support frame high-frequency buffer interface respectively with high-frequency intermittent type pumping device's entry and export are connected, both sides connect through the culture solution pond that contains the culture solution between the tip support frame, artificial blood vessel is located in the culture solution pond, endothelial promotion mechanism is including installing the nanosecond pulse generation device on the tip support frame, and the cover is established artificial blood vessel install the vascular support section and with nanosecond pulse generation device electric connection's energy guide portion.
As a preferable scheme of the present invention, the energy guiding portion includes a blood vessel limiting convex strip disposed in the culture solution pool along the extending direction of the artificial blood vessel, a limiting groove penetrating through both ends of the blood vessel limiting convex strip is disposed on the surface of the blood vessel limiting convex strip, the blood vessel limiting convex strip is provided with a lower energy guiding portion, the top end of the lower energy guiding portion provided with the limiting groove is provided with an upper energy guiding portion disposed right opposite to the upper energy guiding portion, nanosecond pulse releasing portions are respectively packaged in the upper energy guiding portion and the lower energy guiding portion, and the upper energy guiding portion and the lower energy guiding portion are both provided with outer infiltration holes for the culture solution to enter the limiting groove.
As a preferable aspect of the present invention, the upper energy conducting portion and the lower energy conducting portion are connected by an electrical plug assembly, and the nanosecond pulse releasing portion in the upper energy conducting portion and the nanosecond pulse releasing portion in the lower energy conducting portion are electrically connected by the electrical plug assembly, the electrical plug assembly includes a plurality of copper pillars installed on both sides of an end surface of the lower energy conducting portion facing the upper energy conducting portion, one end of the plurality of copper pillars is electrically connected to the nanosecond pulse releasing portion in the lower energy conducting portion, a plurality of insertion holes corresponding to the copper pillars one by one are provided on both sides of the end surface of the upper energy conducting portion facing the lower energy conducting portion, claw-shaped copper sleeves for electrically connecting the copper pillars are installed in the insertion holes, and the claw-shaped copper sleeves are electrically connected to the nanosecond pulse releasing portion in the upper energy conducting portion.
In a preferred embodiment of the present invention, the claw-shaped copper sleeve includes a circular copper seat electrically connected to the nanosecond pulse emitting part, and a plurality of claw-shaped copper sheets with one ends arranged on one side of the round copper seat facing the opening of the jack, a plurality of convex clamping parts are arranged on the inner side wall of the claw-shaped copper sheet facing the axis of the jack, a plurality of guide grooves corresponding to the claw-shaped copper sheets one by one are arranged on the wall of the jack along the length direction of the claw-shaped copper sheet, the length of the guide groove is greater than that of the claw-shaped copper sheet, a plurality of annular grooves which are in one-to-one correspondence with the clamping parts are arranged on the side wall of the copper column along the length direction, and the opposite end surfaces of the lower energy-conducting part and the upper energy-conducting part are respectively provided with a magnetic auxiliary sealing gasket, and a plurality of abdicating holes which are in one-to-one correspondence with the copper columns and the jacks are formed in the magnetic auxiliary sealing gasket in a penetrating manner.
As a preferable scheme of the present invention, the magnetic auxiliary sealing gasket is mounted on end surfaces of the lower energy guiding portion and the upper energy guiding portion located at two sides of the limiting groove, the end surfaces of the upper energy guiding portion and the lower energy guiding portion are respectively provided with a fixing groove into which one side of the magnetic auxiliary sealing gasket is inserted, and the magnetic auxiliary sealing gasket includes a flexible sealing rubber sleeve with one side thereof inserted and fixed in the fixing groove, and a strip-shaped soft magnet encapsulated in a core portion of the flexible sealing rubber sleeve.
As a preferable scheme of the invention, the endothelialization promoting mechanism is provided with a plurality of groups, the upper energy guide parts of a plurality of endothelialization promoting mechanisms are all arranged on the end supporting frame through a supporting beam, and the supporting beams are connected with the upper energy guide part through the inserting and separating piece sliding in the extending direction of the jacks, the plug-in separation piece comprises an axial sliding rod with one end connected with the upper energy guide part, one end of the axial sliding rod opposite to the upper energy guide part is connected with an operating rod, one end of the operating rod, which is opposite to the axial sliding rod, is provided with a lifting handle positioned outside the observation box, the supporting beam is provided with a sliding hole in sliding fit with the axial sliding rod in a penetrating mode, the wall of the observation box is provided with a limiting hole in sliding fit with the operating rod in a penetrating mode, and the operating rod is detachably connected with the axial sliding rod through the quick tapping component.
As a preferable scheme of the present invention, the quick tapping assembly includes a tapping claw disc, the opposite ends of the axial sliding rod and the operating rod are both provided with the tapping claw disc, the end surfaces of two opposite tapping claw discs are provided with a plurality of claws arranged on the same circle around the axis of the claws, and the directions of the claws on two opposite tapping claw discs are opposite.
As a preferable scheme of the invention, the axial sliding rod is a square rod with a rectangular cross section, and the sliding hole is matched with the square rod.
As a preferable scheme of the present invention, the upper energy guiding portion and the lower energy guiding portion have the same structure, infiltration grooves are formed in the groove walls of the limiting grooves of the upper energy guiding portion and the lower energy guiding portion, an arc blood vessel supporting sheet for supporting and limiting the artificial blood vessel is installed in each infiltration groove, the arc blood vessel supporting sheet is installed on the groove wall of the infiltration groove through a plurality of supporting thin plates, a plurality of outer infiltration holes communicated with the infiltration grooves are formed in the lower energy guiding portion and the upper energy guiding portion on both sides of the limiting groove in a penetrating manner, the nanosecond pulse releasing portion is packaged between the outer infiltration holes on both sides, and a plurality of inner infiltration holes communicated with the infiltration grooves are formed in the arc blood vessel supporting sheet in a penetrating manner.
As a preferred scheme of the present invention, the high-frequency buffer interface includes a core tube having one end connected to the high-frequency intermittent pumping device, and a telescopic sleeve axially slidably fitted around the core tube, the artificial blood vessel is fitted over the telescopic sleeve, a buffer return spring groove having an axial length smaller than that of the telescopic sleeve and covered by the telescopic sleeve is formed in an outer wall of the core tube, an annular slider slidably fitted to the buffer return spring groove is formed in an inner wall of the telescopic sleeve, buffer return springs having one ends connected to the annular slider are mounted at both ends of the buffer return spring groove and located in an axial direction of the annular slider, and one end of the core tube facing the artificial blood vessel is located in the telescopic sleeve.
Compared with the prior art, the invention has the following beneficial effects:
the invention pumps artificial blood into the artificial blood vessel from the high-frequency buffer interface on the supporting frame at one end part of the high-frequency intermittent pumping device and returns the artificial blood into the high-frequency intermittent pumping device from the high-frequency buffer interface on the supporting frame at the other end part of the high-frequency intermittent pumping device, in the process, the artificial blood flows through the vascular stent, and the endothelialization promoting mechanism has the effect that a nanosecond pulse electric field generated by the nanosecond pulse generating device acts on endothelial cells of the artificial blood vessel through the energy guide part to promote the proliferation of the endothelial cells, so that the endothelialization of the vascular stent in the blood vessel of a human body is accelerated, the endothelialization time of the vascular stent is greatly shortened, the factor of the endothelialization of the vascular stent can be introduced into the corrosion resistance test of the vascular stent, the environment that the vascular stent is implanted into the blood vessel of the.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
FIG. 1 is a schematic diagram of the overall structure of an embodiment of the present invention;
FIG. 2 is a schematic view of an exemplary embodiment of an infiltration opening;
FIG. 3 is a schematic structural diagram of a lower energy guiding portion according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of a high frequency buffer interface according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of an electrical connector assembly according to an embodiment of the present invention;
FIG. 6 is a schematic structural view of a tapping claw disk according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a magnetic sealing sheet according to an embodiment of the present invention.
The reference numerals in the drawings denote the following, respectively:
1-observation box; 2-artificial blood vessel; 3-a vascular fixation mechanism; 4-high frequency intermittent pumping means; 5-endothelialization promoting mechanisms; 6-an electrical plug-in component; 7-a magnetic auxiliary gasket; 8-a support beam; 9-axial sliding bar; 10-an operating lever; 11-lifting a handle; 12-a tapping claw disc; 13-a claw; 14-a soaking tank; 15-arc blood vessel supporting sheet;
301-end support shelf; 302-high frequency buffer interface; 303-culture solution pool;
3021-core tube; 3022-telescoping tubes; 3023-buffer return spring groove; 3024-ring shaped slider; 3025-a buffer return spring;
501-nanosecond pulse generating device; 502-blood vessel limiting convex strip; 503-lower energy conducting part; 504-upper energy guide; 505-outer infiltration holes; 506-nanosecond pulse release section;
5021, a limit groove;
6-an electrical plug-in component; 601-copper cylinder; 602-claw copper sleeve; 603-a jack;
6011-an annular groove;
6021-round copper seat; 6022-claw copper sheet; 6023-card portion; 6031-guide groove;
701-flexible sealing rubber sleeve; 702-a strip of soft magnet;
1501-inner wetting holes.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 7, the present invention provides a corrosion resistance testing device for a vascular stent, which comprises an observation box 1, wherein an artificial blood vessel 2 for installing the vascular stent, a vascular fixing mechanism 3 for supporting and installing the artificial blood vessel 2, a high-frequency intermittent pumping device 4 for artificial blood circulation through the artificial blood vessel 2, and an endothelialization promoting mechanism 5 installed on the vascular fixing mechanism 3 and used for promoting endothelialization of the vascular stent in the artificial blood vessel 2 are arranged in the observation box 1.
The blood vessel fixing mechanism 3 comprises end supporting frames 301 arranged in two sides of the observation box 1, high-frequency buffer interfaces 302 connected with and communicated with the ends of the artificial blood vessel 2 are arranged on the end supporting frames 301 on the two sides, the high-frequency buffer interfaces 302 on the end supporting frames 301 on the two sides are respectively connected with an inlet and an outlet of the high-frequency intermittent pumping device 4, the end supporting frames 301 on the two sides are connected through a culture solution pool 303 containing a culture solution, the artificial blood vessel 2 is positioned in the culture solution pool 303, the endothelialization promoting mechanism 5 comprises a nanosecond pulse generating device 501 arranged on the end supporting frame 301, and an energy guide part which is sleeved on the artificial blood vessel 2, is provided with a blood vessel support section and is electrically connected with the nanosecond pulse generating device 501.
After the blood vessel stent is placed in the artificial blood vessel 2, the artificial blood is pumped into the artificial blood vessel 2 from the high-frequency buffer interface 302 on the supporting frame 301 at one end part through the high-frequency intermittent pumping device 4 connected with the artificial blood holding container and is returned to the high-frequency intermittent pumping device 4 from the high-frequency buffer interface 302 on the supporting frame 301 at the other end part. In the process, the artificial blood flows through the vascular stent, and the endothelialization promoting mechanism 5 has the functions of simulating the endothelialization of the vascular stent in the human blood vessel and greatly shortening the combination of the vascular stent and endothelial cells on the inner wall of the artificial blood vessel 2, namely the endothelialization time of the vascular stent, so that the factor of the endothelialization of the vascular stent can be introduced into the corrosion resistance test of the vascular stent, the environment of implanting the vascular stent into the human blood vessel can be fully simulated, and the test error can be reduced.
Specifically, the transparent observation box 1 is opened, two ends of the artificial blood vessel 2 implanted with the vascular stent are butted and fixed with the corresponding high-frequency buffer interfaces 302, then culture fluid for keeping the artificial blood vessel 2 moist and supplying nutrients required by endothelial cells is injected into the culture fluid pool 303, then the energy guide part is sleeved outside the section of the artificial blood vessel 2 implanted with the vascular stent, then the nanosecond pulse generation device 501 is controlled to start, and the energy for promoting the proliferation of the endothelial cells acts on the endothelial cells in the artificial blood vessel 2 through the energy guide part electrically connected with the nanosecond pulse generation device 501, so that the purpose of accelerating the endothelialization of the vascular stent is achieved.
In the present embodiment, the proliferation of endothelial cells in the artificial blood vessel 2 is promoted by the nanosecond pulse electric field, that is, the nanosecond pulse generator 501 functions to generate the nanosecond pulse electric field, and the energy guide portion functions to apply the nanosecond pulse electric field generated by the nanosecond pulse generator 501 to the endothelial cells in the artificial blood vessel 2.
It should be added that the high-frequency intermittent pumping device 4 is any device in the field having a liquid phase circulation pumping function, and the corrosion degree of the blood vessel stent can be detected by weighing, microscopic observation and the like after the blood vessel stent is taken out and dried, or by measuring the content of metal ions of the blood vessel stent contained in the circulated artificial blood by an instrument such as a spectrometer and the like to detect the corrosion degree of the blood vessel stent, and the specific implementation mode is selected according to the actual test environment and requirements.
Wherein, lead can the portion including set up the spacing sand grip 502 of blood vessel in culture solution pond 303 along artificial blood vessel 2 extending direction, the spacing sand grip 502 surface of blood vessel is seted up and is run through the spacing groove 5021 at its both ends, and the spacing sand grip 502 of blood vessel is provided with down leads can the portion 503, lead can the portion 503 down and be provided with the top of spacing groove 5021 and install rather than leading can the portion 504 on setting up relatively, lead can all be packaged with nanosecond pulse release portion 506 in portion 504 and the lower portion 503 of leading can, and lead can the portion 504 and lead can the portion 503 down and all run through and be provided with the outer infiltration hole 505 that is arranged in the culture solution entering spacing groove 5021.
The blood vessel limiting convex strip 502 with the limiting groove 5021 is beneficial to limiting the artificial blood vessel 2 and increasing the area of the nanosecond pulse release part 506 in the lower energy guide part 503 and the upper energy guide part 504, so that endothelial cells around the blood vessel stent can receive the energy of the impact-resistant electric field uniformly, namely, all parts of the blood vessel stent can be endothelialized synchronously and sufficiently, the arrangement of the outer infiltration holes 505 is beneficial to accelerating the flow exchange of the culture solution in the culture solution pool 303 and the limiting groove 5021, the phenomenon that the culture solution in the limiting groove 5021 influences the endothelialization speed of the blood vessel stent due to nutrient reduction and incapability of being supplemented quickly is avoided, and the culture solution in the limiting groove 5021 has a buffering effect, namely, when the high-frequency intermittent pumping device 4 simulates the intermittent pumping blood of a human body, the culture solution in the limiting groove 5021 shakes due to the intermittent pumping of the artificial blood vessel 2, the defect that the combination of endothelial cells and a vascular stent is influenced and even inner wall cells fall off from the inner wall of the blood vessel because the artificial blood vessel 2 directly collides with the lower energy guide part 503 and the upper energy guide part 504 is avoided.
In the present embodiment, the nanosecond pulse release unit 506 is any component having a function of receiving or cooperating with the nanosecond pulse generating device 501 to generate a nanosecond pulse electric field and release the nanosecond pulse electric field, and is a technical means that has been published in the art.
It is further optimized in the above embodiment that the upper energy conducting part 504 and the lower energy conducting part 503 are connected by the electrical plug assembly 6, and the nanosecond pulse releasing part 506 in the upper energy conducting part 504 and the nanosecond pulse releasing part 506 in the lower energy conducting part 503 are electrically connected by the electrical plug assembly 6, the electrical plug assembly 6 includes a plurality of copper pillars 601 installed on both sides of the end surface of the lower energy conducting part 503 facing the upper energy conducting part 504, one end of the plurality of copper pillars 601 is electrically connected with the nanosecond pulse releasing part 506 in the lower energy conducting part 503, both sides of the end surface of the upper energy conducting part 504 facing the lower energy conducting part are provided with a plurality of insertion holes 603 corresponding to the copper pillars 601 one by one, and claw-shaped copper sleeves 602 for electrically connecting the copper pillars 601 are installed in the insertion holes 603, and the claw-shaped copper sleeves 602 are electrically connected with the nanosecond pulse releasing part 506 in the upper energy conducting part 504.
The lower energy conducting part 503 is inserted into the insertion hole 603 at the bottom of the upper energy conducting part 504 through a plurality of copper columns 601 at the top, so that the lower energy conducting part 503 and the lower energy conducting part 503 are connected and fixed, and the electrical connection between the copper columns 601 and the claw-shaped copper sleeve 602 or the conduction of a nanosecond pulse electric field is realized.
In the above embodiment, it is further optimized that the claw-shaped copper sleeve 602 includes a circular copper seat 6021 electrically connected to the nanosecond pulse release part 506, and a plurality of claw-shaped copper sheets 6022 having one end installed on one side of the circular copper seat 6021 facing the opening of the insertion hole 603, a plurality of protruding clamping parts 6023 are disposed on the inner side wall of the claw-shaped copper sheets 6022 facing the axis of the insertion hole 603, a plurality of guide grooves 6031 corresponding to the claw-shaped copper sheets 6022 one to one are disposed on the hole wall of the insertion hole 603 along the length direction of the claw-shaped copper sheets 6022, the length of the guide grooves 6031 is greater than the length of the claw-shaped copper sheets 6022, a plurality of annular grooves 6011 corresponding to the clamping parts 6023 one to one are disposed on the side wall of the copper column 601 along the length direction thereof, and magnetic auxiliary gaskets 7 are disposed on the opposite end surfaces of the lower energy guiding part 503 and the upper energy guiding part 504, and a plurality of yielding holes corresponding.
The claw-shaped copper sheet 6022 is an elastic copper sheet with one end integrally formed on the circular copper seat 6021, when the copper column 601 is gradually inserted into the insertion hole 603, the copper column 601 presses the clamping part 6023 protruding on the inner wall of the claw-shaped copper sheet 6022, so that the length of the clamping part 6023 is extended and the protruding degree is reduced, meanwhile, the claw-shaped copper sheet 6022 extends in the guide groove 6031 relative to one end of the circular copper seat 6021 to adapt to the change of the length of the clamping part 6023, until the clamping parts 6023 are clamped into the corresponding annular grooves 6011 on the outer wall of the copper column 601, the claw-shaped copper sheet 6022 and the clamping part 6023 are reset under the self elastic force, at this time, the upper energy guiding part 504 and the lower energy guiding part 503 are fixed through the matching of the clamping part 6023 and the annular grooves 6011, and on the contrary, when the upper energy guiding part 504 is pulled by external force, the clamping part 6023 is gradually separated from the annular grooves 6011, that is the upper energy guiding part 504 can be.
The magnetic auxiliary sealing gasket 7 has the function of sealing a gap between the end surfaces of the butt joint of the upper energy guiding part 504 and the lower energy guiding part 503 after the copper column 601 is inserted into the insertion hole 603, so as to prevent the copper column 601 from contacting with the culture solution subsequently injected into the culture solution pool 303 to cause negative influence on the function of the energy guiding part.
The lower energy guiding part 503 positioned on two sides of the limit groove 5021 and the end surface of the upper energy guiding part 504 are provided with magnetic auxiliary sealing gaskets 7, the end surfaces of the upper energy guiding part 504 and the lower energy guiding part 503 are provided with fixing grooves for embedding one side of each magnetic auxiliary sealing gasket 7, each magnetic auxiliary sealing gasket 7 comprises a flexible sealing rubber sleeve 701 embedded at one side in each fixing groove, and strip-shaped soft magnets 702 packaged in the core parts of the flexible sealing rubber sleeves 701, the contact pressure of the flexible sealing rubber sleeves 701 is increased through the mutual attraction of the strip-shaped soft magnets 702, and therefore the sealing effect of the magnetic auxiliary sealing gaskets 7 is enhanced.
It is further optimized in the above embodiment that multiple sets of endothelialization promoting mechanisms 5 are provided, the upper energy guiding portions 504 of multiple endothelialization promoting mechanisms 5 are all mounted on the end supporting frame 301 through supporting beams 8, and multiple supporting beams 8 are all connected with the upper energy guiding portions 504 through inserting separation members sliding in the extending direction of the insertion holes 603, each inserting separation member includes an axial sliding rod 9 having one end connected with the upper energy guiding portion 504, one end of the axial sliding rod 9 opposite to the upper energy guiding portion 504 is connected with an operating rod 10, one end of the operating rod 10 opposite to the axial sliding rod 9 is mounted with a lifting handle 11 located outside the observation box 1, a sliding hole in sliding fit with the axial sliding rod 9 is formed in the supporting beam 8, a limiting hole in sliding fit with the operating rod 10 is formed in the box wall of the observation box 1, and the operating rod 10 is detachably connected with the axial sliding rod 9 through a fast tapping component.
The multiple groups of endothelialization promoting mechanisms 5 can realize the function of simultaneously testing a plurality of vascular stents, after the culture solution is injected into the culture solution pool 303, the lifting handle 11 on the observation box 1 is operated, and the lifting handle 11, the operating rod 10, the fast tapping component and the axial sliding rod 9 in turn push the corresponding upper energy guiding part 504 to move downwards and butt with the lower energy guiding part 503, and in the same way, during the test, the corresponding energy guide part can be separated from the lower energy guide part 503 by operating the lifting handle 11 outside the observation box 1, so as to observe the endothelialization state of the vascular stent by an equipment instrument or separate the upper energy guide part 504 from the lower energy guide part 503 after the endothelialization of the vascular stent, thereby avoiding the defects of culture solution pollution and the like caused by opening the observation box 1 in the test process, and the temperature and humidity in the observation box 1 are kept constant, and the defect of increased error of a test result caused by the change of environmental factors is overcome.
The quick tapping component comprises tapping claw discs 12, the opposite end parts of the axial sliding rod 9 and the operating rod 10 are respectively provided with the tapping claw discs 12, the end surfaces of the two opposite tapping claw discs 12 are provided with a plurality of claws 13 which are arranged on the same circle around the axes of the claws, and the directions of the claws 13 on the two opposite tapping claw discs 12 are opposite.
When the upper tap plate 12 is rotated by pulling the handle 11 and the operating lever 10, the plurality of hooks 13 provided in the circumferential direction and in the opposite directions on the upper tap plate 12 and the lower tap plate 12 are hooked or separated, thereby connecting the operating lever 10 to the axial slide bar and separating the operating lever 10 from the axial slide bar before opening the observation box 1.
It is further optimized in the above embodiment that the axial sliding rod 9 is a square rod with a rectangular cross section, and the sliding hole is adapted to the square rod, that is, the axial sliding rod 9 is fixedly connected to the sliding circumference, which is beneficial to the accurate butt joint of the upper energy guiding part 504 and the lower energy guiding part 503, and the opening and closing mode of the observation box 1 is adapted to the matching mode of the copper pillar 601 and the insertion hole 603.
In the above embodiment, it is preferable that the upper energy guiding portion 504 and the lower energy guiding portion 503 have the same structure, the slot walls of the limiting slots 5021 of the upper energy guiding portion 504 and the lower energy guiding portion 503 are both provided with an infiltration slot 14, the infiltration slot 14 is provided with an arc-shaped blood vessel supporting sheet 15 for supporting and limiting the artificial blood vessel 2, the arc-shaped blood vessel supporting sheet 15 is mounted on the slot wall of the infiltration slot 14 through a plurality of supporting thin plates, the lower energy guiding portion 503 and the upper energy guiding portion 504 are located at two sides of the limiting slot 5021 and are both provided with a plurality of outer infiltration holes 505 communicated with the infiltration slot 14 in a penetrating manner, the nanosecond pulse releasing portion 506 is packaged between the outer infiltration holes 505 at two sides, and the arc-shaped blood vessel supporting sheet 15 is provided with a plurality of inner infiltration holes 1501 communicated with the infiltration slot 14 in a.
The outer infiltration holes 505 arranged on the two sides avoid the adverse effect on the encapsulation of the nanosecond pulse release part 506, and the arc-shaped thin plate with the plurality of inner infiltration holes 1501 is beneficial to the culture solution entering the infiltration tank 14 from the outer infiltration holes 505 on the two sides, and the end of the artificial blood vessel 2 implanted with the vascular stent is fully infiltrated through the inner infiltration holes 1501.
It is further optimized in the above embodiment that the high-frequency buffer interface 302 includes a core tube 3021 having one end connected to the high-frequency intermittent pumping device 4, and an expandable sleeve 3022 axially slidably sleeved outside the core tube 3021, the artificial blood vessel 2 is sleeved on the expandable sleeve 3022, a buffer return spring groove 3023 having an axial length smaller than the axial length of the expandable sleeve 3022, that is, covered by the expandable sleeve 3022, is disposed on the inner wall of the expandable sleeve 3022, an annular slider 3024 slidably engaged with the buffer return spring groove 3023 is disposed on the inner wall of the expandable sleeve 3022, a buffer return spring 3025 having one end connected to the annular slider 3024 is disposed at both axial ends of the annular slider 3024 in the buffer return spring groove 3023, and one end of the core tube 3021 facing the artificial blood vessel 2 is disposed in the expandable sleeve 3022.
The artificial blood vessel 2 sleeved on the telescopic sleeve 3022 is fixed with the telescopic sleeve 3022 by clamping or binding, when the artificial blood vessel 2 has a movement trend in the artificial blood pumping direction due to the high-frequency intermittent pumping of the artificial blood, the telescopic sleeve 3022 slidably sleeved on the core tube 3021 meets the requirement of the artificial blood vessel 2 for movement, and through the cooperation of the annular slider 3024 in the buffering return spring groove 3023 and the buffering return spring 3025, the telescopic sleeve 3022 can be reset, and has the effect of buffering the thrust borne by the artificial blood vessel 2, thereby avoiding the disadvantages that the joint of the artificial blood vessel 2 and the high-frequency buffering interface 302 is loosened and broken due to the fact that the high-frequency thrust cannot be buffered, and the like, thereby being beneficial to improving the pumping frequency of the high-frequency intermittent pumping device 4 to the artificial blood, and shortening the testing time.
The above embodiments are only exemplary embodiments of the present application, and are not intended to limit the present application, and the protection scope of the present application is defined by the claims. Various modifications and equivalents may be made by those skilled in the art within the spirit and scope of the present application and such modifications and equivalents should also be considered to be within the scope of the present application.
Claims (10)
1. The utility model provides a corrosion-resistant testing arrangement of vascular support which characterized in that: the device comprises an observation box (1), wherein an artificial blood vessel (2) for installing a blood vessel stent, a blood vessel fixing mechanism (3) for supporting and installing the artificial blood vessel (2), a high-frequency intermittent pumping device (4) for artificial blood circulation through the artificial blood vessel (2), and an endothelialization promoting mechanism (5) which is arranged on the blood vessel fixing mechanism (3) and is used for promoting the endothelialization of the blood vessel stent in the artificial blood vessel (2) are arranged in the observation box (1);
the blood vessel fixing mechanism (3) comprises end supporting frames (301) arranged in two sides of the observation box (1), the end supporting frames (301) at two sides are respectively provided with a high-frequency buffer interface (302) connected and communicated with the end part of the artificial blood vessel (2), the high-frequency buffer interfaces (302) on the end supporting frames (301) at two sides are respectively connected with the inlet and the outlet of the high-frequency intermittent pumping device (4), the end supporting frames (301) at two sides are connected through a culture solution pool (303) filled with culture solution, the artificial blood vessel (2) is positioned in the culture solution pool (303), the endothelialization promoting mechanism (5) comprises a nanosecond pulse generating device (501) mounted on the end support frame (301), and the energy guide part is sleeved on the artificial blood vessel (2), is provided with a blood vessel bracket section and is electrically connected with the nanosecond pulse generating device (501).
2. The vessel stent corrosion resistance testing device according to claim 1, wherein: lead can the portion including following artificial blood vessel (2) extending direction sets up the spacing sand grip of blood vessel (502) in culture solution pond (303), spacing groove (5021) that runs through its both ends are seted up on the spacing sand grip of blood vessel (502) surface, just the spacing sand grip of blood vessel (502) is provided with down leads can the portion (503), it is provided with down to lead can the portion (503) the top of spacing groove (5021) is installed rather than leading can the portion (504) on relative setting, go up lead can the portion (504) with all be packaged with nanosecond pulse release portion (506) in leading can the portion (503) down, just go up lead can the portion (504) with lead can the portion (503) down and all run through and be provided with and be used for the culture solution to get into outer infiltration hole (505) in spacing groove (5021).
3. The vessel stent corrosion resistance testing device according to claim 2, wherein: the upper energy conducting part (504) and the lower energy conducting part (503) are connected through an electric splicing component (6), the nanosecond pulse releasing part (506) in the upper energy conducting part (504) is electrically connected with the nanosecond pulse releasing part (506) in the lower energy conducting part (503) through the electric splicing component (6), the electric splicing component (6) comprises a plurality of copper columns (601) installed on two sides of the end surface of the lower energy conducting part (503) facing to the upper energy conducting part (504), one ends of the copper columns (601) are electrically connected with the nanosecond pulse releasing part (506) in the lower energy conducting part (503), a plurality of jacks (603) corresponding to the copper columns (601) one by one are arranged on two sides of the end surface of the upper energy conducting part (504) facing to the lower energy conducting part, and claw-shaped copper sleeves (602) used for electrically connecting the copper columns (601) are installed in the jacks (603), the claw-shaped copper sleeve (602) is electrically connected with the nanosecond pulse release part (506) in the upper energy conducting part (504).
4. The vessel stent corrosion resistance testing device according to claim 3, wherein: the claw-shaped copper sleeve (602) comprises a circular copper seat (6021) electrically connected with the nanosecond pulse release part (506) and a plurality of claw-shaped copper sheets (6022) with one ends installed at one side of the circular copper seat (6021) facing the opening of the jack (603), a plurality of raised clamping parts (6023) are arranged on the inner side wall of the claw-shaped copper sheets (6022) facing the axis of the jack (603), a plurality of guide grooves (6031) corresponding to the claw-shaped copper sheets (6022) in a one-to-one manner are arranged on the wall of the jack (603) along the length direction of the claw-shaped copper sheets (6022), the length of each guide groove (6031) is greater than that of the claw-shaped copper sheet (6022), a plurality of annular grooves (6011) corresponding to the clamping parts (6023) in a one-to-one manner are arranged on the side wall of the copper column (601) along the length direction, and magnetic auxiliary sealing gaskets (7) are installed on the end faces of the lower energy guiding part (503) and the upper energy guiding, a plurality of yielding holes which correspond to the copper columns (601) and the jacks (603) one to one are formed in the magnetic auxiliary sealing gasket (7) in a penetrating mode.
5. The vessel stent corrosion resistance testing device according to claim 4, wherein: be located spacing groove (5021) both sides down lead can portion (503) with all install on the terminal surface of going up to lead can portion (504) magnetism supplementary seal pad (7), go up lead can portion (504) with lead can portion (503) terminal surface down and all be provided with the confession magnetism supplementary seal pad (7) one side embedded fixed recess, magnetism supplementary seal pad (7) are fixed including one side embedding flexible seal gum cover (701) in the fixed recess to and encapsulate in strip soft magnet (702) of flexible seal gum cover (701) core.
6. The vessel stent corrosion resistance testing device according to claim 5, wherein: endothelialization promotes mechanism (5) and is provided with the multiunit, and is a plurality of endothelialization promotes mechanism (5) go up lead can portion (504) all install through a supporting beam (8) on tip support frame (301), and a plurality of supporting beam (8) all through jack (603) extending direction gliding grafting separator with go up lead can portion (504) and connect, grafting separator include one end with axial slide bar (9) that last lead can portion (504) are connected, axial slide bar (9) for the one end of going up lead can portion (504) is connected with action bars (10), action bars (10) are installed for the one end of axial slide bar (9) and are located carry handle (11) outside observation case (1), run through on supporting beam (8) set up with axial slide bar (9) sliding fit's slide hole, run through on observation case (1) the tank wall set up with action bars (10) sliding fit's spacing hole The operating rod (10) and the axial sliding rod (9) are detachably connected through a quick tapping assembly.
7. The vessel stent corrosion resistance testing device according to claim 6, wherein: the quick tapping component comprises tapping claw discs (12), the axial sliding rod (9) and the end parts of the operating rods (10) in opposite directions are respectively provided with the tapping claw discs (12), a plurality of hooks (13) which are arranged on the same circle around the axes of the hooks are arranged on the end faces of the tapping claw discs (12) in opposite directions, and the hooks (13) on the tapping claw discs (12) in opposite directions.
8. The vessel stent corrosion resistance testing device according to claim 7, wherein: the axial sliding rod (9) is a square rod with a rectangular cross section, and the sliding hole is matched with the square rod.
9. The vessel stent corrosion resistance testing device according to claim 8, wherein: the upper energy guide part (504) and the lower energy guide part (503) have the same structure, the groove walls of the limiting groove (5021) of the upper energy guide part (504) and the lower energy guide part (503) are both provided with soaking grooves (14), an arc-shaped blood vessel supporting sheet (15) used for supporting and limiting the artificial blood vessel (2) is arranged in the infiltration groove (14), the arc-shaped blood vessel supporting sheet (15) is arranged on the wall of the infiltration tank (14) through a plurality of supporting thin plates, the lower energy guide part (503) and the upper energy guide part (504) are positioned at two sides of the limit groove (5021) and are provided with a plurality of outer infiltration holes (505) communicated with the infiltration groove (14) in a penetrating way, the nanosecond pulse release part (506) is packaged between the outer wetting holes (505) on two sides, a plurality of inner infiltration holes (1501) communicated with the infiltration groove (14) are formed in the arc-shaped blood vessel supporting sheet (15) in a penetrating mode.
10. The vessel stent corrosion resistance testing device according to claim 1, wherein: the high-frequency buffer interface (302) comprises a core tube (3021) with one end connected with the high-frequency intermittent pumping device (4), and an expansion sleeve (3022) which is axially sleeved outside the core tube (3021) in a sliding manner, the artificial blood vessel (2) is sleeved on the expansion sleeve (3022), the outer wall of the core tube (3021) is provided with a buffer reset spring groove (3023) which has the axial length smaller than that of the telescopic sleeve (3022) and is covered by the telescopic sleeve (3022), an annular sliding block (3024) which is in sliding fit with the buffering return spring groove (3023) is arranged on the inner wall of the telescopic sleeve (3022), a buffer return spring (3025) with one end connected with the annular sliding block (3024) is arranged at both ends of the buffer return spring groove (3023) in the axial direction of the annular sliding block (3024), and one end of the core tube (3021) facing the artificial blood vessel (2) is positioned in the telescopic sleeve (3022).
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| CN202011305443.3A CN112485183B (en) | 2020-11-19 | 2020-11-19 | Corrosion-resistant testing device for vascular stent |
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| CN202011305443.3A CN112485183B (en) | 2020-11-19 | 2020-11-19 | Corrosion-resistant testing device for vascular stent |
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| CN113654772A (en) * | 2021-06-30 | 2021-11-16 | 北京航空航天大学 | Composite loading device of intravascular stent, fatigue testing equipment and method |
| CN113654774A (en) * | 2021-06-30 | 2021-11-16 | 北京航空航天大学 | Intravascular stent fatigue test equipment |
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| JP2005337758A (en) * | 2004-05-24 | 2005-12-08 | Tissue Engineering Initiative Co Ltd | Method and instrument for evaluating compliance of artificial blood vessel |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113654772A (en) * | 2021-06-30 | 2021-11-16 | 北京航空航天大学 | Composite loading device of intravascular stent, fatigue testing equipment and method |
| CN113654774A (en) * | 2021-06-30 | 2021-11-16 | 北京航空航天大学 | Intravascular stent fatigue test equipment |
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