CN112478402A - Freeze storage container with adjustable width - Google Patents
Freeze storage container with adjustable width Download PDFInfo
- Publication number
- CN112478402A CN112478402A CN202011393606.8A CN202011393606A CN112478402A CN 112478402 A CN112478402 A CN 112478402A CN 202011393606 A CN202011393606 A CN 202011393606A CN 112478402 A CN112478402 A CN 112478402A
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- cavity
- side walls
- connecting plate
- cryopreservation
- storage container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/10—Devices to locate articles in containers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/02—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage
- B65D81/05—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents specially adapted to protect contents from mechanical damage maintaining contents at spaced relation from package walls, or from other contents
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/38—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
- B65D81/3813—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container
- B65D81/382—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container provided with liquid material between double walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/38—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
- B65D81/3813—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container
- B65D81/3823—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container formed of different materials, e.g. laminated or foam filling between walls
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
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Abstract
The invention discloses a freezing storage container with adjustable width, which comprises a box body, at least one freezing grid and a box cover, wherein the box body is provided with two first side walls which are oppositely arranged, the two first side walls are connected through two telescopic walls and a bottom layer with a telescopic function to form a first cavity, anhydrous alcohol is filled in the telescopic walls and the bottom layer, at least one second cavity and a third cavity are arranged in the first side walls, the second cavity is used for receiving the anhydrous alcohol of the telescopic walls, and the third cavity is used for receiving the anhydrous alcohol of the bottom layer; the freezing and storing grid is arranged in the first cavity; the case lid is used for covering the box. According to the invention, the two first side walls are connected through the telescopic wall with the telescopic function and the bottom layer, so that the distance between the two first side walls can be adjusted, and further, the space for placing the freezing grids in the first cavity and the number of the freezing grids can be adjusted to meet the requirements of different clinical tests.
Description
Technical Field
The invention belongs to the field of blood specimen cryopreservation research, and particularly relates to a cryopreservation storage container with adjustable width.
Background
The clinical test of medicine is to analyze the concentration of medicine or its metabolite in blood to form a complete blood concentration-time curve, so as to reflect the dynamic change rule of medicine absorption, distribution, metabolism and excretion in human body. In clinical drug tests, blood samples after centrifugation cannot be immediately sent to an analysis and detection center for detection and analysis, so that plasma or serum samples after centrifugation need to be filled into a cryopreservation tube, the cryopreservation tube is placed in an environment with ultralow temperature of minus 80 ℃ for storage, and in the whole storage process, the temperature of the stored samples needs to be maintained within a temperature range specified in a test scheme, so that drugs or metabolites thereof in blood are prevented from being decomposed, and the detection accuracy is prevented from being influenced.
The current common methods are: the centrifuged serum/plasma sample is firstly put into a freezing tube, then the freezing tube is put into a plastic box with holes, and finally the plastic box is put into an ultra-low temperature refrigerator with the temperature of minus 80 ℃. Particularly, in a phase I clinical test or a drug bioequivalence test of a drug, at least 11-12 sampling time points exist at the time point of blood collection, and each time point usually has a sample size of about 12-24 persons. In the whole test process, due to the fact that sampling time points are multiple, the plastic box needs to be taken from the ultralow-temperature refrigerator repeatedly, and due to the fact that the temperature of the plastic box is extremely low, operators are easily frostbitten. The distance between the freezing storage tubes in the plastic box is small, so that the samples are inconvenient to take and check.
The ultra-low temperature refrigerator has a large temperature difference between the inside and the outside (generally, the temperature in the ultra-low temperature refrigerator is about minus 80 ℃, and the outside temperature is about 25 ℃), and the sample amount in the cryopreservation tube is small. After the plastic box is taken out of the ultra-low temperature refrigerator, the frozen sample in the plastic box is easily redissolved or the storage temperature exceeds the storage temperature specified by the test scheme, namely, the overtemperature phenomenon occurs, when the overtemperature phenomenon occurs to the sample, the accuracy of the detection of the drug or the metabolite thereof in the sample can be influenced, and particularly, in the phase I clinical test or the drug bioequivalence test of the drug, a plurality of samples need to be frozen at each sampling time point. The sample is put into the plastic box for a long time, and the overtemperature phenomenon is easy to occur when the sample in the plastic box is at room temperature for a long time, so that the test quality is influenced. At present, the number of the frozen samples in the freezing storage box is fixed, and different clinical tests meet the requirements of different numbers of the samples needing to be frozen.
Disclosure of Invention
The invention mainly aims to provide a freezing storage container with adjustable width, wherein the distance between two first side walls can be adjusted, and different numbers of freezing grids can be placed in the freezing storage container.
According to a first aspect of the present invention there is provided an adjustable width cryopreservation storage container comprising:
the box body is provided with two first side walls which are oppositely arranged, the two first side walls are connected through two telescopic walls and a bottom layer with a telescopic function to form a first cavity, anhydrous alcohol is filled in the telescopic walls and the bottom layer, at least one second cavity and at least one third cavity are arranged in the first side walls, the second cavity is used for receiving the anhydrous alcohol of the telescopic walls, and the third cavity is used for receiving the anhydrous alcohol of the bottom layer;
at least one cryopreservation lattice, wherein the cryopreservation lattice is arranged in the first cavity;
and the box cover is used for covering the box body.
In a specific embodiment of the present invention, the side wall of the telescopic wall is folded, and the side wall of the bottom layer is folded.
In a particular embodiment of the invention, the second cavity is arranged above the telescopic wall and the third cavity is arranged above the bottom layer.
In a specific embodiment of the invention, a first connecting plate and a second connecting plate which are arranged in a relatively sliding manner are arranged in the bottom layer, the first connecting plate is fixed on one of the first side walls, the second connecting plate is fixed on the other first side wall, and one end of the first connecting plate is provided with a fourth cavity capable of accommodating one end of the second connecting plate.
In a specific embodiment of the invention, the upper end surface of the second connecting plate is provided with a plurality of grooves, and the first connecting plate is provided with a first latch, one end of which can extend into the grooves.
In a particular embodiment of the invention, the second connecting plate is provided with a second latch, the first latch and the second latch being adapted to define a maximum travel of the two first side walls.
In a specific embodiment of the present invention, the first connecting plate is provided with a plurality of holes communicating with the fourth cavity.
In a specific embodiment of the invention, the multiple freezing grids are connected through a bayonet structure, the bayonet structure comprises a first bayonet arranged at one end of each freezing grid and a second bayonet arranged at the other end of each freezing grid, and the connection of the two freezing grids is realized after the first bayonet and the second bayonet are clamped.
In a specific embodiment of the invention, a first connecting strip is arranged on the first bayonet, a second connecting strip is arranged on the second bayonet, and the first connecting strip and the second connecting strip are both provided with protrusions capable of being clamped to the positioning grooves of the first side wall.
In a particular embodiment of the invention, the second and third chambers are provided with valve assemblies for balancing the pressure, respectively.
One of the above technical solutions of the present invention has at least one of the following advantages or beneficial effects: according to the invention, the two first side walls are connected through the telescopic wall with the telescopic function and the bottom layer, so that the distance between the two first side walls can be adjusted, and further, the space for placing the freezing grids in the first cavity and the number of the freezing grids can be adjusted to meet the requirements of different clinical tests. The specific heat capacity of the anhydrous alcohol in flexible wall and the bottom layer is great, and after the anhydrous alcohol absorbed or released heat energy, the temperature of anhydrous alcohol could rise or fall, and the ambient temperature that the sample was deposited could only be influenced by the rise or fall of anhydrous alcohol's temperature to freezing the effect that plays the buffering to depositing check inside temperature, reducing the temperature difference change of sample storage environment, increasing sample storage ambient temperature's stability.
Drawings
The invention is further described below with reference to the accompanying drawings and examples;
FIG. 1 is a top view of a first embodiment of the present invention;
fig. 2 is a side view of a first embodiment of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, the meaning of a plurality of means is one or more, the meaning of a plurality of means is two or more, and larger, smaller, larger, etc. are understood as excluding the number, and larger, smaller, inner, etc. are understood as including the number. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more features.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, and may be, for example, a fixed connection or a movable connection, a detachable connection or a non-detachable connection, or an integral connection; may be mechanically connected, may be electrically connected or may be in communication with each other; they may be directly connected or indirectly connected through intervening media, or may be connected through one or more other elements or indirectly connected through one or more other elements or in an interactive relationship between two elements.
The following disclosure provides many different embodiments, or examples, for implementing different aspects of the invention.
Referring to fig. 1 to 2, the freezing storage container with adjustable width includes a box body 2, at least one freezing grid 15 and a box cover 1:
the box body 2 is provided with two first side walls 12 which are oppositely arranged, the two first side walls 12 are connected through two telescopic walls 11 and a bottom layer 6 with a telescopic function to form a first cavity, anhydrous alcohol is filled in the telescopic walls 11 and the bottom layer 6, at least one second cavity 17 and at least one third cavity 16 are arranged in the first side walls 12, the second cavity 17 is used for receiving the anhydrous alcohol of the telescopic walls 11, and the third cavity 16 is used for receiving the anhydrous alcohol of the bottom layer 6;
at least one freezing grid 15 is arranged in the first cavity, the freezing grids 15 are connected through a bayonet structure, the bayonet structure comprises a first bayonet 18 arranged at one end of the freezing grid 15 and a second bayonet 19 arranged at the other end of the freezing grid 15, and the first bayonet 18 and the second bayonet 19 are connected in a clamping manner to realize the connection of the two freezing grids 15;
case lid 1 is bilayer structure, and case lid 1 is the L type, it has the heat preservation material to fill in the 1 intermediate layer of case lid, like polyurethane foam, 1 lateral wall parcel heat preservation material of case lid, and the heat preservation material can be that the pearl is cotton, and 1 length of case lid is greater than the maximum distance between two first lateral walls 12, and case lid 1 is used for hiding box 2, makes to freeze and deposits the interior confined storage environment that forms of storage container.
The first sidewall 12 has a double-layer structure, the first sidewall 12 has a heat-insulating effect, and the interlayer of the first sidewall 12 is filled with a heat-insulating material, such as polyurethane foam. The outer side of the first side wall 12 is wrapped with a heat insulation material, and the heat insulation material can be pearl wool.
The operator can adjust the distance between two first lateral walls 12, and then adjusts the space that first cavity can place freezing check 15 and the quantity of freezing check 15 to match different clinical trial's needs. When the distance between the two first side walls 12 is reduced, the volumes of the first side walls 12 and the bottom layer 6 are reduced, the absolute alcohol in the telescopic wall 11 flows into the second cavity 17, and the absolute alcohol in the bottom layer 6 flows into the third cavity 16; as the distance between the two first side walls 12 increases, the volume in the first side walls 12 and the bottom layer 6 increases, the absolute alcohol in the second chamber 17 flows into the telescopic wall 11 to fill the varying volume in the first side walls 12, and the absolute alcohol in the third chamber 16 flows into the bottom layer 6 to fill the varying volume in the bottom layer 6. The specific heat capacity of the anhydrous alcohol in the flexible wall 11 and the bottom layer 6 is great, and after the anhydrous alcohol absorbed or released heat energy, the temperature of the anhydrous alcohol could rise or fall, and only the rise or fall of the temperature of the anhydrous alcohol could influence the ambient temperature that the sample was deposited, thereby playing the role of buffering to freezing the inside temperature of the check 15, reducing the temperature difference change of the sample storage environment, and increasing the stability of the sample storage ambient temperature.
In order to allow the second chamber 16 to be pressure balanced with the ambient holding pressure, the second chamber 16 is provided with a valve assembly for pressure balancing. The valve assembly comprises a balance piston 22 arranged in the second chamber 16. The balance piston 22 divides the interior of the second chamber 16 into an upper space and a lower space, and the balance piston 22 can move up or down by the pressure difference between the upper space and the lower space. The lower space is used for receiving anhydrous alcohol, and the upper space is provided with a balance air port 23 communicated with the outside. Preferably, the balance air port 23 of the second cavity 16 is disposed on the sidewall of the second cavity 16, and a balance stopper 24 is disposed below the balance air port 23 to prevent the balance piston 22 from blocking the balance air port 23.
In order to balance the third chamber 17 with the ambient holding pressure, the third chamber 17 is provided with a valve assembly for balancing the pressure. The valve assembly in the third chamber is similar in construction to the valve assembly in the second chamber, including a balance piston 22 and balance port 23. It should be noted that when the balance air opening 23 of the third cavity 17 is disposed on the side wall of the third cavity 17, a balance limiting block 24 is disposed in the third cavity 17. The balance air port 23 of the third cavity 17 is arranged at the top of the third cavity 23, and a balance limiting block 24 is not required to be arranged in the third cavity 17.
In one embodiment of the present invention, the side walls of the telescopic wall 11 are folded, and the folded shape is preferably in an accordion style. The telescopic wall 11 is of a double-layer structure, the interlayer of the telescopic wall 11 is filled with anhydrous alcohol, the telescopic wall 11 is made of low-temperature-resistant plastic, and the telescopic wall 11 can extend or shorten along with the change of the distance between the two first side walls 12; the side walls of the bottom layer 6 are folded, preferably in an accordion pattern. The bottom layer 6 is a double-layer structure, the interlayer of the bottom layer 6 is filled with anhydrous alcohol, the bottom layer 6 is made of low-temperature-resistant plastic, and the bottom layer 6 can extend or contract along with the change of the distance between the two first side walls 12.
In an embodiment of the present invention, the second cavity 17 is disposed above the telescopic wall 11, and the third cavity 16 is disposed above the bottom layer 6, so that when the distance between the two first sidewalls 12 is increased, the absolute alcohol in the second cavity 17 can smoothly flow into the first sidewalls 12, and the absolute alcohol in the third cavity 16 can smoothly flow into the bottom layer 6.
In one embodiment of the present invention, a first connecting plate 8 and a second connecting plate 4 are slidably disposed in the bottom layer 6, the first connecting plate 8 is fixed on one of the first side walls 12, the second connecting plate 4 is fixed on the remaining one of the first side walls 12, and one end of the first connecting plate 8 has a fourth cavity 20 capable of accommodating one end of the second connecting plate 4.
In one embodiment of the present invention, the upper end surface of the second connecting plate 4 is provided with a plurality of grooves 5, and the first connecting plate 8 is provided with a first latch 9, one end of which can extend into the groove 5. After the first latch 9 enters the groove 5, the distance between the first connecting plate 8 and the second connecting plate 4 is relatively fixed, and the relative position between the first connecting plate 8 and the second connecting plate 4 can be changed under the action of external force, so that the distance between the two first side walls 12 is changed.
In one embodiment of the invention, the second connecting plate 4 is provided with a second latch 7, and the first latch 9 and the second latch 7 are used for limiting the maximum travel of the two first side walls 12. When the second connecting plate 4 is maximally extended, the second latch 7 is blocked by the first latch 9, preventing the second connecting plate 4 from coming out of the first connecting plate 8. The second link plate 4 can move left and right within the first link plate 8. When the second web 4 enters the first web 8, the distance between the two first side walls 12 decreases and the volume of the first cavity decreases. Similarly, when the second connecting plate 4 extends from the first connecting plate 8, the distance between the two first side walls 12 increases and the volume of the first cavity increases.
Preferably, a pulley 3 is disposed below the second connecting plate 4 to facilitate the sliding of the second connecting plate 4 in the fourth cavity 20.
In an embodiment of the present invention, the first connecting plate 8 is provided with a plurality of holes 21 communicating with the fourth cavity 20, and when the distance between the two first sidewalls 12 changes, the anhydrous alcohol can conveniently enter and exit the fourth cavity 20.
In an embodiment of the present invention, the first bayonet 18 is provided with a first connecting strip 13, the second bayonet 19 is provided with a second connecting strip 10, and the first connecting strip 13 and the second connecting strip 10 both have protrusions capable of being clamped into the positioning grooves 14 of the first sidewall 12. After the freezing grids 15 are connected linearly through the first bayonets 18 and the second bayonets 19, the projections of the first connecting strips 13 and the second connecting strips 10 are embedded into the positioning grooves 14 of the first side walls 12, and therefore positioning of the freezing pipes is achieved.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. Freeze of adjustable width deposits storage container, its characterized in that includes:
the box body is provided with two first side walls which are oppositely arranged, the two first side walls are connected through two telescopic walls and a bottom layer with a telescopic function to form a first cavity, anhydrous alcohol is filled in the telescopic walls and the bottom layer, at least one second cavity and at least one third cavity are arranged in the first side walls, the second cavity is used for receiving the anhydrous alcohol of the telescopic walls, and the third cavity is used for receiving the anhydrous alcohol of the bottom layer;
at least one cryopreservation lattice, wherein the cryopreservation lattice is arranged in the first cavity;
and the box cover is used for covering the box body.
2. The adjustable width cryopreservation storage container of claim 1 wherein the side walls of the telescoping walls are folded and the side walls of the bottom layer are folded.
3. The adjustable width cryopreservation storage container of claim 1 wherein the second cavity is disposed above the telescoping wall and the third cavity is disposed above the floor.
4. The adjustable width cryopreservation storage container of claim 1 wherein a first connecting plate and a second connecting plate are slidably disposed in the bottom layer, the first connecting plate is fixed to one of the first side walls, the second connecting plate is fixed to the remaining one of the first side walls, and one end of the first connecting plate has a fourth cavity capable of receiving one end of the second connecting plate.
5. The adjustable width cryopreservation storage container of claim 4 wherein the second connecting plate is provided with a plurality of grooves at its upper end face, and the first connecting plate is provided with a first latch having an end capable of extending into the groove.
6. The adjustable width cryopreservation storage container of claim 5 wherein the second connecting plate is provided with a second latch, the first latch and the second latch being used to define the maximum travel of the two first side walls.
7. The adjustable width cryopreservation storage container of claim 4 wherein the first connecting plate is provided with a plurality of holes communicating with the fourth cavity.
8. The adjustable width cryopreservation storage container of claim 1, wherein the cryopreservation lattices are connected by a bayonet structure, the bayonet structure comprises a first bayonet arranged at one end of the cryopreservation lattice and a second bayonet arranged at the other end of the cryopreservation lattice, and the connection of the two cryopreservation lattices is realized after the first bayonet and the second bayonet are clamped.
9. The adjustable width cryopreservation storage container of claim 8, wherein a first connecting strip is provided on the first bayonet, a second connecting strip is provided on the second bayonet, and the first connecting strip and the second connecting strip are provided with protrusions capable of being clamped to the positioning grooves of the first side wall.
10. The adjustable width cryopreservation storage container of claim 1 wherein the second and third chambers are each provided with a valve assembly for equalizing pressure.
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