CN213736676U - Height-adjustable freezing device - Google Patents

Abstract

The utility model discloses a freezing device with adjustable height, which comprises a box body, a movable plate and a telescopic part, wherein the upper end surface of the box body is arranged at least one through hole; the movable plate is movably arranged in the box body and can move up and down along the vertical direction; the flexible portion sets up between fly leaf and through-hole in order enclosing to become the first cavity that is used for placing the cryopreserving pipe, form the second cavity between flexible portion and the box body, the second cavity intussuseption is filled with buffer solution. The utility model discloses a setting up the fly leaf that reciprocates along vertical direction, the fly leaf reciprocates the height of adjusting first cavity to the not co-altitude cryopreserved pipe is placed in the adaptation, in order to match different clinical trial's needs.

Description

Height-adjustable freezing device

Technical Field

The utility model belongs to the technical field of blood specimen preservation, more specifically, relate to but height-adjusting's cryopreserving device.

Background

Currently, the clinical drug test is to analyze the concentration of the drug or its metabolites in blood to form a complete blood concentration-time curve, thereby reflecting the dynamic change rule of absorption, distribution, metabolism and excretion of the drug in human body. In clinical drug tests, blood samples after centrifugation cannot be immediately sent to an analysis and detection center for detection and analysis, so that plasma or serum samples after centrifugation need to be filled into a cryopreservation tube, the cryopreservation tube is placed in an environment with ultralow temperature of minus 80 ℃ for storage, and in the whole storage process, the temperature of the stored samples needs to be maintained within a temperature range specified in a test scheme, so that drugs or metabolites thereof in blood are prevented from being decomposed, and the detection accuracy is prevented from being influenced.

The current common methods are: the centrifuged serum/plasma sample is firstly put into a freezing tube, then the freezing tube is put into a plastic box with holes, and finally the plastic box is put into an ultra-low temperature refrigerator with the temperature of minus 80 ℃. Particularly, in a phase I clinical test or a drug bioequivalence test of a drug, at least 11-12 sampling time points exist at the time point of blood collection, and each time point usually has a sample size of about 12-24 persons. In the whole test process, due to the fact that sampling time points are multiple, the plastic box needs to be taken from the ultralow-temperature refrigerator repeatedly, and due to the fact that the temperature of the plastic box is extremely low, operators are easily frostbitten. The distance between the freezing storage tubes in the plastic box is small, so that the samples are inconvenient to take and check.

The ultra-low temperature refrigerator has a large temperature difference between the inside and the outside (generally, the temperature in the ultra-low temperature refrigerator is about minus 80 ℃, and the outside temperature is about 25 ℃), and the sample amount in the cryopreservation tube is small. After the plastic box is taken out of the ultra-low temperature refrigerator, the frozen sample in the plastic box is easily redissolved or the storage temperature exceeds the storage temperature specified by the test scheme, namely, the overtemperature phenomenon occurs, when the overtemperature phenomenon occurs to the sample, the accuracy of the detection of the drug or the metabolite thereof in the sample can be influenced, and particularly, in the phase I clinical test or the drug bioequivalence test of the drug, a plurality of samples need to be frozen at each sampling time point. The sample is put into the plastic box for a long time, and the overtemperature phenomenon is easy to occur when the sample in the plastic box is at room temperature for a long time, so that the test quality is influenced. Different clinical trials, the specimen volume that needs to freeze to deposit is different, and the height of freezing the pipe is different.

SUMMERY OF THE UTILITY MODEL

A primary object of the utility model is to provide a but height-adjusting's cryopreserving device, fly leaf reciprocate the height of adjusting first cavity to the not co-altitude cryopreserved pipe is placed in the adaptation.

According to the utility model discloses an aspect provides height-adjusting's cryopreserving device, include:

the upper end surface of the box body is provided with at least one through hole;

the movable plate is movably arranged in the box body and can move up and down along the vertical direction;

the flexible portion, the flexible portion sets up in order enclosing the first cavity that becomes to be used for placing the cryopreserving pipe between fly leaf and through-hole, form the second cavity between flexible portion and the box body, the second cavity intussuseption is filled with buffer solution.

The utility model discloses a specific embodiment, be provided with the actuating mechanism who orders about the fly leaf and reciprocate between box body and the fly leaf, actuating mechanism passes the interior sleeve pipe of box body up end including fixing the outer tube on the fly leaf and one end, the outer tube is equipped with the internal thread, interior sheathed tube surface is equipped with the external screw thread.

In a specific embodiment of the present invention, the side wall of the outer sleeve is provided with at least one first hole communicating with the inside of the outer sleeve.

In a particular embodiment of the invention, a seal is provided between the inner sleeve and the housing.

In a particular embodiment of the invention, the inner sleeve is provided with a handle, which is provided with cotton cloth or pearl sponge.

In a specific embodiment of the present invention, the movable plate is provided with at least one second hole.

In a specific embodiment of the present invention, the flexible portion is a membrane structure having a folded shape.

In a specific embodiment of the present invention, the buffer solution is absolute alcohol.

The utility model discloses a technical scheme has following advantage or one of beneficial effect at least among the above-mentioned technical scheme: the utility model discloses a setting up the fly leaf that reciprocates along vertical direction, the fly leaf reciprocates the height of adjusting first cavity to the not co-altitude cryopreserved pipe is placed in the adaptation, in order to match different clinical trial's needs. The specific heat capacity of the buffer of box body is great, and after the buffer absorbed or released heat energy, the temperature of buffer just can rise or descend, and the ambient temperature that the sample was deposited just can be influenced in the rise or the decline of the temperature of buffer to play the effect of buffering to the inside temperature of cryopreserving pipe, reduce the temperature difference change of sample storage environment, increase sample storage ambient temperature's stability.

Drawings

The present invention will be further described with reference to the accompanying drawings and examples;

fig. 1 is a schematic structural diagram of a first embodiment of the present invention.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, it should be understood that the orientation or positional relationship indicated with respect to the orientation description, such as up, down, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, a plurality of means are one or more, a plurality of means are two or more, and the terms greater than, less than, exceeding, etc. are understood as not including the number, and the terms greater than, less than, within, etc. are understood as including the number. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more features.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, and may be, for example, a fixed connection or a movable connection, a detachable connection or a non-detachable connection, or an integral connection; may be mechanically connected, may be electrically connected or may be in communication with each other; they may be directly connected or indirectly connected through intervening media, or may be connected through one or more other elements or indirectly connected through one or more other elements or in an interactive relationship between two elements.

The following disclosure provides many different embodiments or examples for implementing different aspects of the invention.

Referring to fig. 1, height-adjusting freezes deposits device, including box body 1, fly leaf 2 and pars contractilis 7, wherein, the up end setting of box body 1 is at least one through-hole 9, and box body 1 is bilayer structure, and it has heat preservation material, like polyurethane foam to fill in the intermediate layer of box body 1. The outer side of the box body 1 is wrapped with a heat insulation material which can be pearl wool.

The movable plate 2 is movably arranged in the box body 1 and can move up and down along the vertical direction;

the flexible portion 7 sets up between fly leaf 2 and through-hole 9 in order to enclose into the first cavity 11 that is used for placing the cryopreserving pipe, form second cavity 10 between flexible portion 7 and the box body 1, second cavity 10 intussuseption is filled with buffer solution. The movable plate 2 moves up and down to adjust the height of the first cavity 11 so as to adapt to the freezing storage tubes with different heights to match the requirements of different clinical tests. It should be noted that one cryopreservation tube corresponds to one first cavity 11. When the up end of box body 1 had a plurality of through-holes 9, the pars contractilis 7 enclosed into the first cavity 11 that does not communicate each other with every through-hole 9 to guarantee every independence of freezing and depositing the pipe.

The buffer solution is preferably absolute alcohol, the specific heat capacity of the absolute alcohol is large, the temperature of the absolute alcohol can rise or fall after the absolute alcohol absorbs or releases heat energy, and the environmental temperature for storing the sample can be influenced only by the rise or fall of the temperature of the absolute alcohol, so that the temperature inside the frozen storage tube can be buffered, the temperature difference change of the sample storage environment can be reduced, and the stability of the sample storage environmental temperature can be improved.

The utility model discloses a specific embodiment, be provided with the actuating mechanism who orders about fly leaf 2 and reciprocate between box body 1 and the fly leaf 2, actuating mechanism passes the interior sleeve pipe 5 of box body 1 up end including fixing outer tube 4 and the one end on fly leaf 2, and in order to make the fly leaf go up and down steadily, the both ends of fly leaf are provided with outer tube 4 respectively, and correspondingly, interior sleeve pipe 5 also sets up 2, outer tube 4 is equipped with internal thread 13, the surface of interior sleeve pipe 5 is equipped with external screw thread 12. The internal threads 13 and the external threads 12 correspond one to one. When the inner sleeve 5 is rotated to make the inner sleeve 5 enter/extend into/out of the outer sleeve 4, the distance between the movable plate 2 and the upper end face of the box body 1 is reduced/increased. So as to adapt to the freezing storage pipes with different heights.

In a specific embodiment of the present invention, the side wall of the outer sleeve 4 is provided with at least one first hole 8 communicating with the inside of the outer sleeve 4. When the inner sleeve 5 is rotated to enable the inner sleeve 5 to enter/extend out of the outer sleeve 4, the first hole 8 on the outer sleeve 4 can enable the buffer solution in the outer sleeve 4 to automatically flow out, and the situation that the inner sleeve 5 cannot enter the outer sleeve 4 is avoided.

In a specific embodiment of the present invention, a sealing member is disposed between the inner sleeve 5 and the box body 1 to improve the sealing property and prevent the buffer solution from overflowing.

The utility model discloses a specific embodiment, interior sleeve pipe 5 is provided with handle 6, can drive interior sleeve pipe 5 when rotatory handle 6 and rotate, there is cotton or pearl sponge on the handle 6, when preventing rotatory handle 6, frostbite the operator.

In a specific embodiment of the present invention, the movable plate 2 is provided with at least one second hole 3. When the distance between the movable plate 2 and the upper end surface of the box body 1 is reduced/increased, the buffer solution can flow from the second hole 3, and the resistance when the movable plate 2 moves up and down is reduced.

In a specific embodiment of the present invention, the flexible portion 7 is a folded membrane structure. The pars contractilis 7 can be low temperature resistant pellosil or plastic film, and pars contractilis 7 is folding commentaries on classics, like the accordion style, pars contractilis 7 can be along with fly leaf 2 highly elongates or shortens in freezing box body 1, pars contractilis 7 are used for the separation buffer solution and freezes deposits pipe direct contact, avoids the buffer solution pollution to freeze and deposits the pipe.

While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (8)

1. But height-adjusting's cryopreserving device, its characterized in that includes:

the upper end surface of the box body is provided with at least one through hole;

the movable plate is movably arranged in the box body and can move up and down along the vertical direction;

the flexible portion, the flexible portion sets up in order enclosing the first cavity that becomes to be used for placing the cryopreserving pipe between fly leaf and through-hole, form the second cavity between flexible portion and the box body, the second cavity intussuseption is filled with buffer solution.

2. The apparatus according to claim 1, wherein a driving mechanism for driving the movable plate to move up and down is disposed between the box and the movable plate, the driving mechanism includes an outer sleeve fixed on the movable plate and an inner sleeve having one end penetrating the upper end surface of the box, the outer sleeve is provided with an internal thread, and the outer surface of the inner sleeve is provided with an external thread.

3. The adjustable height cryopreservation device of claim 2 wherein the side wall of the outer sleeve is provided with at least one first hole communicating with the interior of the outer sleeve.

4. The adjustable height cryopreservation device of claim 2 wherein a seal is provided between the inner sleeve and the box.

5. The adjustable height cryopreservation device of claim 2 wherein the inner sleeve is provided with a handle, and the handle is provided with cotton cloth or pearl sponge.

6. The adjustable height cryopreservation device of claim 1 wherein the movable plate is provided with at least one second hole.

7. The adjustable height cryopreservation device of claim 1 wherein the telescoping section is a membrane structure in an accordion shape.

8. The adjustable height cryopreservation device of claim 1, wherein the buffer is absolute alcohol.

Images