CN112451774A - Adsorption enhanced dialyzer - Google Patents
Adsorption enhanced dialyzer Download PDFInfo
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- CN112451774A CN112451774A CN202011398141.5A CN202011398141A CN112451774A CN 112451774 A CN112451774 A CN 112451774A CN 202011398141 A CN202011398141 A CN 202011398141A CN 112451774 A CN112451774 A CN 112451774A
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- 238000001179 sorption measurement Methods 0.000 title claims abstract description 47
- 239000012528 membrane Substances 0.000 claims abstract description 112
- 239000012510 hollow fiber Substances 0.000 claims abstract description 97
- 238000001631 haemodialysis Methods 0.000 claims abstract description 31
- 230000000322 hemodialysis Effects 0.000 claims abstract description 31
- 230000004907 flux Effects 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 14
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 239000002041 carbon nanotube Substances 0.000 claims description 4
- 229910021393 carbon nanotube Inorganic materials 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 4
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 4
- -1 polytetrafluoroethylene Polymers 0.000 claims description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 4
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910003460 diamond Inorganic materials 0.000 claims 1
- 239000010432 diamond Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 20
- 229920002521 macromolecule Polymers 0.000 abstract description 19
- 238000000034 method Methods 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 6
- 230000008569 process Effects 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 230000010412 perfusion Effects 0.000 abstract description 5
- 230000009467 reduction Effects 0.000 abstract description 5
- 230000000274 adsorptive effect Effects 0.000 abstract description 4
- 230000001934 delay Effects 0.000 abstract description 3
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 3
- 230000001965 increasing effect Effects 0.000 description 9
- 150000002605 large molecules Chemical class 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229920006253 high performance fiber Polymers 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 239000002441 uremic toxin Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/08—Hollow fibre membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention discloses an adsorption enhanced dialyzer which comprises a hemodialysis cavity (1), wherein a plurality of first hollow fiber membrane filaments (2) and a plurality of second hollow fiber membrane filaments (3) are arranged in the hemodialysis cavity (1), and the membrane flux of the second hollow fiber membrane filaments (3) is greater than that of the first hollow fiber membrane filaments (2). By applying the technical scheme provided by the embodiment of the invention, the middle and large molecular substances of a patient are removed by improving the adsorption effect in the process of hemodialysis of the patient; meanwhile, an additional perfusion device is not needed, and additional replacement liquid is not needed, so that the burden of a patient is relieved, the extracorporeal circulation blood volume of the patient can be reduced, and the cardiovascular burden of the patient is relieved; in addition, the internal filtration performance of the high-performance dialyzer effectively delays the problem of flux reduction of the special adsorptive hollow fibers and enhances the removal capacity of the dialyzer for macromolecular substances.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an adsorption enhanced dialyzer.
Background
The dialyzer is a blood purification device which removes redundant water and toxin in the body of a patient by adopting a convection and dispersion mode. Although convection and diffusion can better remove small and medium molecules in the body of a patient, in order to ensure that the patient can reduce the loss of nutrients such as protein and the like as much as possible, the structure of the dialysis membrane hole is determined not to be too large, so that the removal of macromolecular substances in the body of the patient by a dialyzer is limited, and medium and large molecules are accumulated in the body of the patient to cause complications. For the removal of the medium-large molecular substances, the prior art means adopts a hemodialysis filtration mode (the convection flow of a dialyzer is increased to remove more medium-large molecular substances). And secondly, removing medium and large molecular substances by adsorption in a blood perfusion mode. And thirdly, the combination of dialysis and perfusion combines convection, dispersion and adsorption modes, so that the removal of medium and large molecular substances can be greatly improved. And fourthly, an adsorptive membrane material is adopted, but due to the limitation of the characteristics of the membrane material, the pores of the surface material of the membrane are relatively small, so that the dialyzer has weak convective clearing capability and cannot effectively clear small and medium molecules and water in the body of a patient.
However, the hemofiltration method requires a special dialyzer and a large amount of replacement fluid, and the cost of the patient for performing one-time hemodiafiltration is basically 1 time of the price of the common dialysis.
The adsorption dialyzer can increase the performance of removing medium molecular substances, but the flux of the membrane is continuously reduced due to a large amount of adsorbed medium-molecular substances in the use process, so that the capability of removing uremic toxins by the dialyzer is reduced.
The method of combining hemodialysis and hemoperfusion can compensate the problem of weak hemodialysis adsorption function, but the economic burden of the patient is increased due to the need of adding an additional perfusion apparatus.
In conclusion, how to effectively provide a new dialyzer which can better eliminate the middle and large molecules in the body of a patient by introducing the adsorption function and ensuring the convection effect of the dialyzer is a problem which needs to be solved by those skilled in the art.
Disclosure of Invention
The invention aims to provide an adsorption enhanced dialyzer which can enhance the adsorption function and better eliminate the medium and large molecules in the body of a patient under the condition of ensuring the convection effect of the dialyzer.
In order to solve the technical problems, the invention provides the following technical scheme:
an adsorption enhanced dialyzer comprises a hemodialysis cavity, wherein a plurality of first hollow fiber membrane filaments and a plurality of second hollow fiber membrane filaments are arranged in the hemodialysis cavity, and the membrane flux of the second hollow fiber membrane filaments is greater than that of the first hollow fiber membrane filaments.
Preferably, the second hollow fiber membrane yarn is made of sodium methyl acrylate-acrylonitrile copolymer, ethylene vinyl alcohol copolymer, polymethyl methacrylate, polytetrafluoroethylene or carbon nano tube.
Preferably, all the second hollow fiber membrane filaments in the hemodialysis cavity are made of the same material.
Preferably, the average pore diameter of the second hollow fiber membrane filaments is larger than the average pore diameter of the first hollow fiber membrane filaments.
Preferably, the average pore diameter of the second hollow fiber membrane filaments is 8-10 nm.
Preferably, the wall thickness of the second hollow fiber membrane filaments is 0.9-2 times the wall thickness of the first hollow fiber membrane filaments.
Preferably, the diameter of the second hollow fiber membrane filaments is 1.5 to 3 times the diameter of the first hollow fiber membrane filaments.
Preferably, the number of the second hollow fiber membrane filaments accounts for 10% -40% of the total number of membrane filaments of the dialyzer.
Preferably, a plurality of said second hollow fiber membrane filaments are evenly distributed within the hemodialysis chamber.
Preferably, the distribution shape of the plurality of second hollow fiber membrane filaments in the hemodialysis cavity is triangular distribution, square distribution, annular distribution, rhombic distribution or multi-circular distribution.
The adsorption-enhanced dialyzer provided by the invention comprises a hemodialysis cavity, wherein a plurality of first hollow fiber membrane filaments and a plurality of second hollow fiber membrane filaments are arranged in the hemodialysis cavity, and the first hollow fiber membrane filaments are the existing high-performance fiber membrane filaments and have limited adsorption capacity on macromolecular substances. During the use process, the flux of the membrane is continuously reduced due to the continuous increase of adsorbed macromolecular substances, and the capacity of removing the substances is continuously reduced.
Adding a part of second hollow fiber membrane filaments with adsorption function in the middle of the existing first hollow fiber membrane filaments, wherein the second hollow fiber membrane filaments are specially-made hollow fiber membrane filaments with adsorption function, the membrane flux of the second hollow fiber membrane filaments is greater than that of the first hollow fiber membrane filaments, the flux of an adsorption dialyzer is improved, and the adsorption dialyzer has stronger adsorption capacity on medium-macromolecule substances; meanwhile, the enhanced internal filtration performance of the high-performance dialyzer can effectively alleviate the problem of the flux reduction of the first hollow fiber membrane filaments, and the adsorption and convection are combined, so that the removing capacity of the dialyzer on the middle molecular substances is improved.
By applying the technical scheme provided by the embodiment of the invention, the middle and large molecular substances of a patient are removed by improving the adsorption effect in the process of hemodialysis of the patient; meanwhile, an additional perfusion device is not needed, and additional replacement liquid is not needed, so that the burden of a patient is relieved, the extracorporeal circulation blood volume of the patient can be reduced, and the cardiovascular burden of the patient is relieved; in addition, the internal filtration performance of the high-performance dialyzer effectively delays the problem of flux reduction of the special adsorptive hollow fibers and enhances the removal capacity of the dialyzer for macromolecular substances.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of a sorbent enhanced dialyzer in accordance with one embodiment of the present invention;
fig. 2 is a cross-sectional view taken at a-a in fig. 1.
The drawings are numbered as follows:
hemodialysis cavity 1, first hollow fiber membrane silk 2, second hollow fiber membrane silk 3.
Detailed Description
The core of the invention is to provide an adsorption enhanced dialyzer, which enhances the adsorption function and can better eliminate the medium and large molecules in the body of a patient under the condition of ensuring the convection effect of the dialyzer in advance.
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 2, fig. 1 is a schematic structural diagram of an adsorption enhanced dialyzer according to an embodiment of the present invention; fig. 2 is a cross-sectional view taken at a-a in fig. 1.
In a specific embodiment, the adsorption enhanced dialyzer provided by the invention comprises a hemodialysis cavity 1, wherein a plurality of first hollow fiber membrane filaments 2 and a plurality of second hollow fiber membrane filaments 3 are arranged in the hemodialysis cavity 1, and the membrane flux of the second hollow fiber membrane filaments 3 is greater than that of the first hollow fiber membrane filaments 2.
In the above-mentioned structure, adsorb enhancement mode cerini dialyser cerini includes hemodialysis cavity 1, be provided with a plurality of first hollow fiber membrane silks 2 and a plurality of second hollow fiber membrane silk 3 in the hemodialysis cavity 1, first hollow fiber membrane silk 2 is current high performance fiber membrane silk, and the adsorption efficiency of centering macromolecular substance is limited. During the use process, the flux of the membrane is continuously reduced due to the continuous increase of adsorbed macromolecular substances, and the capacity of removing the substances is continuously reduced.
A part of second hollow fiber membrane filaments 3 with adsorption function are added in the middle of the existing first hollow fiber membrane filaments 2, the second hollow fiber membrane filaments 3 are specially-made hollow fiber membrane filaments with adsorption function, the membrane flux of the second hollow fiber membrane filaments 3 is greater than that of the first hollow fiber membrane filaments 2, the flux of an adsorption dialyzer is improved, and the adsorption dialyzer has strong adsorption capacity on middle and large molecular substances; meanwhile, the problem of flux reduction of the first hollow fiber membrane filaments 2 can be effectively solved by utilizing the enhanced internal filtration performance of the high-performance dialyzer, and adsorption and convection are combined, so that the removing capacity of the dialyzer on the middle molecular substances is improved.
By applying the technical scheme provided by the embodiment of the invention, the middle and large molecular substances of a patient are removed by improving the adsorption effect in the process of hemodialysis of the patient; meanwhile, an additional perfusion device is not needed, and additional replacement liquid is not needed, so that the burden of a patient is relieved, the extracorporeal circulation blood volume of the patient can be reduced, and the cardiovascular burden of the patient is relieved; in addition, the internal filtration performance of the high-performance dialyzer effectively delays the problem of flux reduction of the special adsorptive hollow fibers and enhances the removal capacity of the dialyzer for macromolecular substances.
On the basis of the above specific embodiment, the second hollow fiber membrane wire 3 has many ways of enhancing the flux, for example, a material with better adsorbability is used, the material of the second hollow fiber membrane wire 3 is specifically a material with good biocompatibility, such as sodium methallylsulfonate-acrylonitrile copolymer, ethylene vinyl alcohol copolymer, polymethyl methacrylate, polytetrafluoroethylene or carbon nanotube, etc., compared with the polysulfone material of the first hollow fiber membrane wire 2 in the prior art, sodium methallylsulfonate-acrylonitrile copolymer, ethylene vinyl alcohol copolymer, polymethyl methacrylate, polytetrafluoroethylene, carbon nanotube all have stronger adsorbability, and the removing capability of the dialyzer for middle macromolecular substances can be enhanced. Of course, the materials with stronger adsorbability are more, and can be selected according to different specific situations, and all are within the protection scope of the invention.
It should be noted that, the materials of all the second hollow fiber membrane filaments 3 in the hemodialysis cavity 1 may be the same, for example, all the second hollow fiber membrane filaments are ethylene vinyl alcohol copolymer, so that the setup is simpler and more convenient; all in the hemodialysis cavity 1 the material of second hollow fiber membrane silk 3 also can not be the same, can partially be the same, and the part is different, also can all be inequality, selects according to the different conditions, and the result of use is better, and in a word, the hollow fiber that can satisfy the practicality and strengthen the adsorptivity all is within optional range.
In another more reliable embodiment, based on any of the above embodiments, the average pore diameter of the second hollow fiber membrane filaments 3 is larger than the average pore diameter of the first hollow fiber membrane filaments 2, and under the condition that other conditions are not changed or the adsorption performance is increased, the adsorption performance of the second hollow fiber membrane filaments 3 can be further enhanced by relatively increasing the pore diameter of the second hollow fiber membrane filaments 3, so that the removal capacity of the dialyzer for macromolecular substances is enhanced.
Further optimizing the above technical solution, the average pore diameter of the second hollow fiber membrane filaments 3 is any value between 8-10nm, including end points such as 8nm, 9nm, 10nm, and compared with the pore diameter of the first hollow fiber membrane filaments 2 of 5-6nm, the average pore diameter of the second hollow fiber membrane filaments 3 is significantly increased, and the ability of adsorbing middle-molecular substances is significantly enhanced.
In another more reliable embodiment, based on any of the above embodiments, the wall thickness of the second hollow fiber membrane wire 3 is 0.9-2 times the wall thickness of the first hollow fiber membrane wire 2, including an end point, for example, the wall thickness of the second hollow fiber membrane wire 3 is 1 time the wall thickness of the first hollow fiber membrane wire 2, the wall thickness of the second hollow fiber membrane wire 3 may be equal to the wall thickness of the first hollow fiber membrane wire 2, or slightly larger than the wall thickness of the first hollow fiber membrane wire 2, in a case that the wall thickness is not different greatly, the diameter of the second hollow fiber membrane wire 3 may be increased relatively less, and the number of membrane wires may be increased in the hemodialysis chamber 1 with the same diameter to improve the ability of removing the middle-sized macromolecular substance.
In another more reliable embodiment, based on any of the above embodiments, the diameter of the second hollow fiber membrane wire 3 is 1.5-3 times the diameter of the first hollow fiber membrane wire 2, and in the case of a large diameter increase and a small wall thickness change, the pore diameter of the second hollow fiber membrane wire 3 is relatively increased, so as to enhance the removal capacity of the dialyzer for macromolecular substances.
In another more reliable embodiment, on the basis of any one of the above embodiments, the number of the second hollow fiber membrane filaments 3 accounts for any value between 10% and 40% of the total number of membrane filaments of the dialyzer, including an end value, such as 20%, and the specific number of the second hollow fiber membrane filaments 3 is not limited, and can be set by itself according to different specific use conditions, such as blood conditions. When the amount of the large molecular substance contained is large, the number of the second hollow fiber membrane filaments 3 can be increased; it is within the scope of the present invention that the number of second hollow fiber membrane filaments 3 can be reduced when the number of the contained significant molecular substances is small.
In another more reliable embodiment, on the basis of any one of the above embodiments, the plurality of second hollow fiber membrane wires 3 are uniformly distributed in the hemodialysis chamber 1, and at this time, the second hollow fiber membrane wires 3 can ensure that the medium-macromolecule substances are uniformly removed, the removal is more thorough, and the consistency of the removal range is maintained for the medium-macromolecule substances uniformly adsorbed in the hemodialysis chamber 1.
Further optimize above-mentioned technical scheme, a plurality of the distribution shape of second hollow fiber membrane silk 3 in hemodialysis cavity 1 can be symmetrical figure such as triangle-shaped distribution, square distribution, annular distribution, rhombus distribution or many circles, and concrete arrangement form is unrestricted, can be according to the practical application condition and decide, guarantees that the cerini dialyser cerini is to macromolecular material clearance comparatively thoroughly, even.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The adsorption enhanced dialyzer provided by the present invention is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. An adsorption enhanced dialyzer is characterized by comprising a hemodialysis cavity (1), wherein a plurality of first hollow fiber membrane filaments (2) and a plurality of second hollow fiber membrane filaments (3) are arranged in the hemodialysis cavity (1), and the membrane flux of the second hollow fiber membrane filaments (3) is greater than that of the first hollow fiber membrane filaments (2).
2. The adsorption-enhanced dialyzer according to claim 1, wherein the material of the second hollow fiber membrane filaments (3) is specifically sodium methallylsulfonate-acrylonitrile copolymer, ethylene vinyl alcohol copolymer, polymethyl methacrylate, polytetrafluoroethylene or carbon nanotubes.
3. The sorption-enhanced dialyzer according to claim 2, characterized in that all the second hollow fiber membrane filaments (3) within the hemodialysis chamber (1) are of the same material.
4. The adsorption-enhanced dialyzer according to any of claims 1 to 3, characterized in that the average pore diameter of the second hollow fiber membrane filaments (3) is larger than the average pore diameter of the first hollow fiber membrane filaments (2).
5. The adsorption-enhanced dialyzer according to claim 4, characterized in that the average pore diameter of the second hollow fiber membrane filaments (3) is 8-10 nm.
6. The adsorption-enhanced dialyzer of claim 4, characterized in that the wall thickness of the second hollow fiber membrane filaments (3) is 0.9-2 times the wall thickness of the first hollow fiber membrane filaments (2).
7. The adsorption-enhanced dialyzer according to claim 4, characterized in that the diameter of the second hollow fiber membrane filaments (3) is 1.5-3 times the diameter of the first hollow fiber membrane filaments (2).
8. The sorption-enhanced dialyzer according to claim 4, characterized in that the number of the second hollow fiber membrane filaments (3) amounts to 10% -40% of the total number of membrane filaments of the dialyzer.
9. The sorption-enhanced dialyzer according to claim 4, characterized in that a plurality of the second hollow fiber membrane filaments (3) are evenly distributed within the hemodialysis chamber (1).
10. The sorption-enhanced dialyzer according to claim 9, characterized in that the distribution shape of the plurality of second hollow fiber membrane filaments (3) within the hemodialysis chamber (1) is a triangular distribution, a square distribution, a circular distribution, a diamond distribution, or a multi-circular distribution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011398141.5A CN112451774A (en) | 2020-12-03 | 2020-12-03 | Adsorption enhanced dialyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011398141.5A CN112451774A (en) | 2020-12-03 | 2020-12-03 | Adsorption enhanced dialyzer |
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| Publication Number | Publication Date |
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| CN112451774A true CN112451774A (en) | 2021-03-09 |
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| CN202011398141.5A Pending CN112451774A (en) | 2020-12-03 | 2020-12-03 | Adsorption enhanced dialyzer |
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Address after: No.20, Xingshan Road, Weihai Torch hi tech Industrial Development Zone, Weihai City, Shandong Province, 264210 Applicant after: Shandong Weigao blood purification products Co.,Ltd. Address before: No. 20, Xingshan Road, Weigao Industrial Park, chucun, Weihai high tech District, Weihai City, Shandong Province, 264210 Applicant before: WEIHAI WEIGAO BLOOD PURIFICATION PRODUCTS Co.,Ltd. |