CN213219787U - Blood purification device - Google Patents
Blood purification device Download PDFInfo
- Publication number
- CN213219787U CN213219787U CN202021193778.6U CN202021193778U CN213219787U CN 213219787 U CN213219787 U CN 213219787U CN 202021193778 U CN202021193778 U CN 202021193778U CN 213219787 U CN213219787 U CN 213219787U
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- Prior art keywords
- blood
- hollow fibers
- pellicle
- shell
- plasma
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- 210000004369 blood Anatomy 0.000 title claims abstract description 52
- 239000008280 blood Substances 0.000 title claims abstract description 52
- 238000000746 purification Methods 0.000 title claims abstract description 21
- 238000001179 sorption measurement Methods 0.000 claims abstract description 42
- 239000012510 hollow fiber Substances 0.000 claims abstract description 39
- 238000001914 filtration Methods 0.000 claims abstract description 29
- 238000000926 separation method Methods 0.000 claims abstract description 27
- 239000012528 membrane Substances 0.000 claims abstract description 19
- 239000000835 fiber Substances 0.000 claims abstract description 16
- 239000003463 adsorbent Substances 0.000 claims abstract description 15
- 238000007789 sealing Methods 0.000 claims abstract description 15
- 239000004745 nonwoven fabric Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 7
- 230000008929 regeneration Effects 0.000 claims description 6
- 238000011069 regeneration method Methods 0.000 claims description 6
- 230000002572 peristaltic effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 230000001172 regenerating effect Effects 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 description 38
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 3
- 230000008081 blood perfusion Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
The utility model discloses a blood purification device, which comprises a shell, hollow fibers, a sealing ring, a blood inlet, a blood outlet, a plasma outlet, a filtering semipermeable membrane and a fiber bracket, wherein the filtering semipermeable membrane and the fiber bracket are arranged in a separation adsorption cavity; the adjacent 3 hollow fibers are connected through a fiber bracket to form a separation adsorption unit; the filtration pellicle is vertical pipe form, and its both ends are connected with the sealing washer at casing both ends respectively, and it has the adsorbent to filter the pellicle intussuseption, and it has a plurality ofly to filter the pellicle, is equipped with a plurality of separation adsorption unit in every filtration pellicle. The utility model has the advantages that: the hollow fibers are fixed through the fiber support, so that the hollow fibers are prevented from swinging or shaking; through filtering pellicle evenly distributed hollow fiber, plasma that plasma maldistribution leads to when avoiding the casing slope or rocking adsorbs inequality, has improved adsorption efficiency.
Description
Technical Field
The utility model belongs to the technical field of medical instrument, especially, relate to a blood purification device.
Background
Blood purification is also called dialysis in daily life. It is characterized by that the blood of patient is led out of body, passed through a cleaning equipment to remove some pathogenic substances and clean blood so as to attain the goal of curing disease. The blood purification includes hemodialysis, blood perfusion, plasma replacement, immunoadsorption and the like. Hemodialysis utilizes the principle of a semipermeable membrane to remove various harmful and redundant metabolic wastes and excessive electrolytes in the body by diffusion and convection so as to achieve the aim of purifying blood and achieve the aim of correcting water electrolyte and acid-base balance by absorption. The principle of blood perfusion is to draw the blood of a patient out of the body, contact the blood with a solid adsorbent (such as resin in an HA resin blood perfusion device), remove certain metabolites, exogenous drugs or poisons and the like in the body in an adsorption mode, and then return the purified blood to the patient, thereby achieving the purpose of treating diseases. Two current adsorption treatment modes are available, one is a whole blood adsorption method, and the other is a plasma adsorption method; compared with the whole blood adsorption therapy, the plasma adsorption therapy has small damage to blood cells and small influence on the environment in human bodies, and is widely applied to the field of blood purification. The basic principle of the plasma adsorption therapy is to introduce blood of a patient into the body, separate blood plasma from blood cells, and specifically adsorb and remove pathogenic substances in the blood plasma, so as to achieve the purpose of treating diseases. The existing immunoadsorption treatment technology is that blood flows out of a human body and then enters a plasma separator through a blood pump, the plasma and blood cells are separated through the screening effect of the plasma separator, the separated plasma is introduced into an immunoadsorption column through a blood pump, and pathogenic substances in the plasma are removed in a targeted manner by utilizing the adsorption effect of an immunoadsorbent loaded in the immunoadsorption column. However, because various instruments are various during treatment, the pipelines are disordered and the operation is inconvenient, the safety risk during treatment is increased, and in recent years, a bioreactor integrating a plasma separator and an adsorber is provided, so that the operation flow of the instruments is simplified. However, the adsorption efficiency of such an integrated bioreactor is greatly influenced by the environment, for example, when the reactor is in an inclined state or the hollow fibers in the reactor are partially inclined, separated plasma is easily accumulated on one side of the reactor or the hollow fibers, resulting in uneven distribution of plasma in the reactor, thereby reducing the adsorption efficiency of plasma and the adsorbent.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome the defect that the uneven distribution of plasma leads to absorption efficiency low in the bioreactor among the blood purification equipment among the prior art, provide an even blood purification device of plasma distribution.
In order to achieve the purpose, the blood purification device designed by the utility model comprises a shell, hollow fibers and a sealing ring, wherein the shell is provided with a blood inlet, a blood outlet and a plasma outlet which are communicated with the inner cavity of the shell; the hollow fibers are vertically arranged in the inner cavity of the shell, the hollow fibers are fixed with the shell through sealing rings arranged at two ends of the hollow fibers, and the two ends of the hollow fibers are respectively communicated with the blood inlet and the blood outlet; an inner cavity between the two sealing rings in the shell forms a separation adsorption cavity; the device also comprises a filtering semipermeable membrane and a fiber bracket which are arranged in the separation adsorption cavity; the adjacent 3 hollow fibers are connected through a fiber bracket to form a separation adsorption unit; the filter pellicle is vertical pipe form, and its both ends are connected with the sealing washer at casing both ends respectively, it has the adsorbent to filter the pellicle intussuseption, it has a plurality ofly, every to filter the pellicle be equipped with a plurality of separation adsorption unit in the pellicle.
Furthermore, the inner wall of the filtering semipermeable membrane is provided with non-woven fabrics; non-woven fabrics one end and filtration pellicle inner wall connection, the non-woven fabrics other end is the free end.
Further, the separation and adsorption cavity is filled with regeneration liquid which can pass through the filtering semipermeable membrane and is used for regenerating with the adsorbent.
Further, the shell is also provided with a sample adding port communicated with the separation adsorption cavity; the sample adding port is communicated with the box body through a sample adding pump.
Further, the purification device also comprises a return pipe which is communicated with the blood outlet and the plasma outlet; the return pipe is provided with a peristaltic pump.
The utility model has the advantages that: the hollow fibers are fixed through the fiber support, so that the hollow fibers are prevented from swinging or shaking; through filtering pellicle evenly distributed hollow fiber, plasma that plasma maldistribution leads to when avoiding the casing slope or rocking adsorbs inequality, has improved adsorption efficiency.
Drawings
Fig. 1 is a schematic structural diagram of a blood purification device of the present invention.
FIG. 2 is a schematic sectional view of the plane A-A in FIG. 1.
Fig. 3 is a partially enlarged schematic view of fig. 1.
Fig. 4 is a schematic perspective view of a separation and adsorption unit in fig. 2.
In the figure, a casing 1, a hollow fiber 2, a sealing ring 3, a blood inlet 4, a blood outlet 5, a plasma outlet 6, a return pipe 7, a peristaltic pump 8, a separation and adsorption cavity 9, a filtering semipermeable membrane 10, a fiber support 11, a non-woven fabric 12, a sample adding port 13, a sample adding pump 14 and a box body 15.
Detailed Description
The invention is described in further detail below with reference to the figures and the specific embodiments.
The blood purification device shown in fig. 1-4 comprises a shell 1, hollow fibers 2 and a sealing ring 3, wherein the shell 1 is provided with a blood inlet 4, a blood outlet 5 and a plasma outlet 6 which are communicated with the inner cavity of the shell, and the purification device further comprises a return pipe 7 which is communicated with the blood outlet 5 and the plasma outlet 6; a peristaltic pump 8 is arranged on the return pipe 7; the hollow fibers 2 are vertically arranged in the inner cavity of the shell 1, the hollow fibers 2 are fixed with the shell 1 through sealing rings 3 arranged at two ends of the hollow fibers 2, and two ends of the hollow fibers 2 are respectively communicated with the blood inlet 4 and the blood outlet 5; an inner cavity between the two sealing rings 3 in the shell 1 forms a separation adsorption cavity 9; also comprises a filtering semipermeable membrane 10 and a fiber bracket 11 which are arranged in the separation adsorption cavity 9; as shown in fig. 2 or 4, adjacent 3 hollow fibers 2 are connected by the fiber support 11 to form a separation and adsorption unit, in practice, the number of hollow fibers 2 in a separation and adsorption unit may not be 3, for example, a separation and adsorption unit may be composed of 4 hollow fibers 2; filtration pellicle 10 is vertical pipe form, and its both ends are connected with the sealing washer 3 at 1 both ends of casing respectively, and the intussuseption of filtration pellicle 10 is filled with the adsorbent, and filtration pellicle 10 has a plurality ofly, is equipped with a plurality of separation adsorption unit in every filtration pellicle 10.
The inner wall of the filtering semipermeable membrane 10 is provided with a non-woven fabric 12; one end of the non-woven fabric 12 is connected with the inner wall of the filtering semipermeable membrane 10, and the other end of the non-woven fabric 12 is a free end. The non-woven fabrics 12 support for the adsorbent, and the adsorbent evenly distributed can improve plasma adsorption efficiency on non-woven fabrics 12. In addition, the non-woven fabric 12 can also play a role in supporting the central fibers, the supporting role mainly occurs when the purification device is inclined or horizontally placed, and the hollow fibers 2 are longer and can be partially laid or bent, so that the non-woven fabric 12 can support the hollow fibers 2, the bending degree of the hollow fibers 2 is reduced, and plasma accumulation at the bending part is avoided. By the action of the filtering semipermeable membrane 10, the plasma partition adsorption effect is achieved, and the hollow fiber 2 can be supported; for example, the fiber tubes in the existing plasma adsorption and filtration device are not effectively supported and fixed, when the device is placed horizontally or obliquely, one side of the device is bent under the compression action of the plasma and the rest fiber tubes, and plasma aggregation is formed at the bent part, so that the plasma distribution is uneven, and the adsorption efficiency of the adsorbent is affected; the hollow fiber 2 of the present embodiment does not have the above-mentioned problems by the fiber holder 11 and the filtering semipermeable membrane 10.
The separation and adsorption cavity 9 is filled with a regeneration liquid which can pass through the filtering semipermeable membrane 10 for regenerating with the adsorbent. The shell 1 is also provided with a sample adding port 13 communicated with the separation and adsorption cavity 9; the sample addition port 13 is communicated with a cassette body 15 through a sample addition pump 14, and a regeneration liquid or other supplement liquid can be stored in the cassette body 15. The regeneration of the adsorbent can be realized through the regeneration liquid, and the use cost can be effectively reduced.
During treatment, blood enters the hollow fibers 2 through the blood inlet 4, and plasma separation is realized under the action of the hollow fibers 2, namely, the plasma in the blood penetrates through the hollow fibers 2 to enter the circular tubular filtering semipermeable membrane 10 in the separation and adsorption cavity 9, and the formed components in the blood flow out from the blood outlet 5. The plasma contacts with the adsorbent in the filtering semipermeable membrane 10, pathogenic substances in the plasma are adsorbed by the adsorbent, the plasma is purified, the purified plasma permeates the filtering semipermeable membrane 10 and is discharged through the plasma outlet 6, and the purified plasma is recombined with blood visible components discharged from the liquid outlet through the return pipe 7 and then is input into a human body.
Claims (5)
1. A blood purification device comprises a shell, hollow fibers and a sealing ring, wherein a blood inlet, a blood outlet and a plasma outlet which are communicated with an inner cavity of the shell are formed in the shell; the hollow fibers are vertically arranged in the inner cavity of the shell, the hollow fibers are fixed with the shell through sealing rings arranged at two ends of the hollow fibers, and the two ends of the hollow fibers are respectively communicated with the blood inlet and the blood outlet; an inner cavity between the two sealing rings in the shell forms a separation adsorption cavity; the method is characterized in that: the device also comprises a filtering semipermeable membrane and a fiber bracket which are arranged in the separation adsorption cavity; the adjacent 3 hollow fibers are connected through a fiber bracket to form a separation adsorption unit; the filter pellicle is vertical pipe form, and its both ends are connected with the sealing washer at casing both ends respectively, it has the adsorbent to filter the pellicle intussuseption, it has a plurality ofly, every to filter the pellicle be equipped with a plurality of separation adsorption unit in the pellicle.
2. A blood purification apparatus according to claim 1, wherein: the inner wall of the filtering semipermeable membrane is provided with non-woven fabrics; non-woven fabrics one end and filtration pellicle inner wall connection, the non-woven fabrics other end is the free end.
3. A blood purification apparatus according to claim 1, wherein: the separation and adsorption cavity is filled with regeneration liquid which can pass through the filtering semipermeable membrane and is used for regenerating with the adsorbent.
4. A blood purification apparatus according to claim 3, wherein: the shell is also provided with a sample adding port communicated with the separation adsorption cavity; the sample adding port is communicated with the box body through a sample adding pump.
5. A blood purification apparatus according to claim 1, wherein: the purification device also comprises a return pipe which is communicated with the blood outlet and the plasma outlet; the return pipe is provided with a peristaltic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021193778.6U CN213219787U (en) | 2020-06-24 | 2020-06-24 | Blood purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021193778.6U CN213219787U (en) | 2020-06-24 | 2020-06-24 | Blood purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213219787U true CN213219787U (en) | 2021-05-18 |
Family
ID=75885776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021193778.6U Expired - Fee Related CN213219787U (en) | 2020-06-24 | 2020-06-24 | Blood purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213219787U (en) |
-
2020
- 2020-06-24 CN CN202021193778.6U patent/CN213219787U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210518 |