CN112451541A - Composition for preventing and treating diarrhea of dogs and cats - Google Patents
Composition for preventing and treating diarrhea of dogs and cats Download PDFInfo
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- CN112451541A CN112451541A CN202011559125.XA CN202011559125A CN112451541A CN 112451541 A CN112451541 A CN 112451541A CN 202011559125 A CN202011559125 A CN 202011559125A CN 112451541 A CN112451541 A CN 112451541A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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Abstract
The invention discloses a composition for preventing and treating dog and cat diarrhea, which takes kaolin and pectin as main components, and is added with an electrolyte regulator, so that the composition is used for the auxiliary treatment of dog and cat diarrhea, the gastrointestinal mucosa of dogs and cats is protected, the electrolyte disorder is corrected, the acidosis is corrected and the energy is supplemented.
Description
Technical Field
The invention relates to a composition for preventing and treating diarrhea of dogs and cats, belonging to the field of veterinary drugs.
Background
The dog and cat have an important position in our life as an important companion animal for human, the feeding amount of companion animals such as dog and cat is increased year by year with the development of economic society and aging of population in China, and the amount of existing companion animals in China reaches more than one hundred million according to statistics. Pets become indispensable members in human life, but dogs and cats are easy to suffer from adverse stress and pathogen invasion in our living environment, have great influence on intestines and stomach, and are easy to cause diarrhea problems of dogs and cats, so that the health of pets is more and more valued, and various special veterinary medicines for pets also become the focus of current veterinary medicine development.
Diarrhea diseases are one of the most common diseases of pets such as dogs, cats and the like, and the diarrhea diseases can cause the loss of water and electrolytes of the dogs, cats and the like, cause dehydration of organisms, electrolyte disorder and acidosis, and can seriously cause the death of the dogs, cats and the like. Pathogenic diarrhea of dogs and cats caused by parvovirus, coronavirus, rotavirus and the like is mostly infected with opportunistic pathogenic enterotoxin escherichia coli, and the currently commonly used medicaments for preventing and treating pet diarrhea are mainly antibiotic medicaments. For viral diarrhea, the use of antibiotics is ineffective, and for diarrhea caused by escherichia coli, the drug resistance of the escherichia coli is too strong, and the effect of the antibiotics is not ideal, so that the difficulty in preventing and treating the diarrhea of dogs and cats is increased. In addition, the number of resistant strains is increasing due to the increase of the use amount and frequency of antibiotics. The incidence of diarrhea diseases of dogs and cats is higher and higher, and the treatment cost is higher and higher.
Disclosure of Invention
The composition takes kaolin and pectin as main components, and is added with an electrolyte regulator, so that the composition is used for the auxiliary treatment of dog and cat diarrhea, protects the gastrointestinal mucosa of dogs and cats, corrects electrolyte disturbance, acidosis and supplements energy.
The composition for preventing and treating diarrhea of dogs and cats comprises the following raw materials in parts by weight:
1-30 parts of toxin adsorbent, 1-90 parts of intestinal mucosa protective agent, 1-5 parts of electrolyte and energy regulator, 0-15 parts of flavoring agent, 10-30 parts of water and 0.01-0.1 part of auxiliary material;
the toxin adsorbent is kaolin; the intestinal mucosa protective agent is pectin.
Furthermore, the electrolyte and the energy regulator are one or a combination of more of sodium chloride, potassium chloride, sodium bicarbonate and ATP (adenosine triphosphate).
Further, the electrolyte and the energy regulator are sodium chloride, potassium chloride, sodium bicarbonate and adenosine triphosphate according to a mass ratio of 20:9: 15: (2-3) Mixed composition
Furthermore, the flavoring agent is one or a combination of more of beef essence, pork essence, lemon essence, sweetener, meat paste and animal protein powder.
Further, the beef essence is bought from beef essence of Qingdao flavor food Limited, the pork essence is bought from pork essence of Qingdao flavor food Limited, the lemon essence is DJ-2052 lemon essence bought from Hangzhou Dahaojia food ingredient Limited, the aspartame is neotame bought from Shanxi Tianhan Biotech Limited, the animal protein powder is a composition of whey protein powder and hydrolyzed fish protein powder mixed according to a ratio of 1:1, the whey protein powder and the hydrolyzed fish protein powder are whey protein powder and hydrolyzed fish protein powder bought from Neisseria, and the minced meat is minced meat formed by mincing chicken by using a common mincer.
Further, the auxiliary material is one or a combination of more of methylcellulose, sodium carboxymethylcellulose, glycerol, nipalgin, sodium dodecyl benzene sulfonate, dextran, gum arabic, xanthan gum, benzoic acid and sodium benzoate.
Further, the preparation method of the composition for preventing and treating diarrhea of dogs and cats comprises the following steps:
1) weighing the raw materials, putting the raw materials into a mixer, and mixing to obtain a mixture A;
2) adding the mixture A obtained above into a ball mill, and grinding for 2-3 times to obtain the suspension of the composition for preventing and treating diarrhea of dogs and cats.
Further, the preparation method of the composition for preventing and treating diarrhea of dogs and cats comprises the following steps:
weighing the raw materials, adding water into a liquid preparation tank, heating to 50 ℃, then sequentially adding kaolin, electrolyte, an energy regulator, a flavoring agent and auxiliary materials, stirring into slurry, finally slowly adding pectin, and uniformly mixing to obtain the paste of the composition for preventing and treating diarrhea of dogs and cats.
The application method of the suspension of the composition for preventing and treating diarrhea of dogs and cats comprises the following steps: the suspension is sprayed into oral cavities of dogs and cats for administration.
The application method of the ointment of the composition for preventing and treating diarrhea of dogs and cats comprises the following steps: the paste is placed in a dosing syringe and pushed into the oral cavity of dogs and cats by using the syringe for taking.
Kaolinitum, and china clay are white or quasi-white fine powder or friable block. The kaolin is used as an adsorbent, can adsorb various exotoxin and exotoxin generated by bacteria in intestinal tracts, prevents the absorption of the toxicant in gastrointestinal tracts, and has a protective effect on inflamed mucosa. The kaolin has no toxic or side effect, and the physical adsorption does not generate drug resistance.
Pectin is a polysaccharide, white to yellow powder, which is mostly present in plant cell walls and cell inner layers, and is abundantly present in pericarp of citrus, lemon, grapefruit, etc. Pectin is a safe and non-toxic natural food additive recommended by the FAO/WHO food additive joint committee, and has no daily addition limit. Pectin can not only adsorb toxic substances in intestinal tract, but also protect intestinal mucosa from injury. In addition, pectin is rich in dietary fiber, so that the fluidity of excrement is reduced, the excrement is shaped, and the effect of adjuvant therapy of diarrhea is achieved.
Has the advantages that:
the composition for preventing and treating dog and cat diarrhea prepared by the application can be used for assisting in treating dog and cat diarrhea, protecting the gastrointestinal mucosa of dogs and cats, correcting electrolyte disturbance, acidosis and supplementing energy, and compared with the existing antibiotic treatment method and montmorillonite powder treatment method, the treatment course of the compound for treating dog and cat diarrhea is obviously shortened, and the curative effect is rapid.
Detailed Description
In order to make the technical solutions in the present application better understood, the present invention is further described below with reference to examples, which are only a part of examples of the present application, but not all examples, and the present invention is not limited by the following examples.
Example 1
A composition for preventing and treating diarrhea of dogs and cats is prepared by the following weight portions:
2kg of kaolin, 90kg of pectin, 30kg of water, 1kg of sodium chloride, 0.45kg of potassium chloride, 0.75kg of sodium bicarbonate, 0.12kg of adenosine triphosphate and 0.012kg of sodium benzoate, which are weighed according to the weight and then put into a mixer for mixing, and then a ball mill is used for grinding for 2-3 times, thus obtaining the suspension formulation of the composition for preventing and treating canine and feline diarrhea.
Example 2
A composition for preventing and treating diarrhea of dogs and cats is prepared by the following weight portions:
90kg of kaolin, 4kg of pectin, 12.7kg of water, 5kg of whey protein powder, 5kg of hydrolyzed fish protein powder, 5kg of meat paste, 1kg of sodium chloride, 0.45kg of potassium chloride, 0.75kg of sodium bicarbonate, 0.12kg of adenosine triphosphate and 0.012kg of sodium benzoate
Firstly, adding water into a liquid preparation tank, heating to 50 ℃, then adding kaolin, whey protein powder, hydrolyzed fish protein powder, minced meat, sodium chloride, potassium chloride, sodium bicarbonate, adenosine triphosphate and sodium benzoate, stirring into a slurry, finally slowly adding pectin, and uniformly mixing to obtain the composition paste for preventing and treating diarrhea of dogs and cats.
Example 3
One set of experiments: the therapeutic agent is the suspension prepared in the example 1, and is administrated 3 times a day, the interval between the two administrations is 8 hours, and the diet is managed conventionally;
two groups of experiments were carried out: the therapeutic drug is the paste prepared in example 2, and is administered 3 times a day, with the interval between two administrations being 8 hours, and is managed by conventional diet;
blank control group: the mineral water is fed in the same time with the experimental group without feeding the medicine, the interval between the two times of medicine is 8 hours, and the conventional diet management is carried out;
positive control group: the therapeutic agent is enrofloxacin chewable tablet (product of Bayer animal health products company), and is administered 3 times per day with interval of 8 hr, and is administered by conventional diet management.
Two groups of positive controls: the therapeutic agent is montmorillonite powder, and is administered 3 times per day with interval of 8 hr, and administered by conventional diet management.
Laboratory animal
The experimental animals adopt an artificial morbidity model, and Shigella shigella is used for causing diarrhea of dogs and cats;
each group of dogs and cats is 6 dogs and cats;
the weight of the experimental animals is weighed before the artificial attack, and the average feed intake 3 days before the attack is recorded.
Criteria for determination
The standard of cure is as follows: diarrhea symptoms completely disappear, feces are formed, the feed intake is recovered to the position before the onset of the disease, and the body weight is recovered to the position before the onset of the disease.
Diarrhea rate (number of diarrhea animals/total number of reorganized animals) × 100%
Diarrhea index (rate of loose stool x average degree of loose stool)
The stool dilution ratio is the ratio of the number of stool dilutions to the total number of stool dilutions per animal
The diluted feces stage is graded according to the diameter of the diluted feces polluted filter paper and is divided into 4 stages: grade 1 is less than 1 cm; grade 2, 1-1.9 cm; grade 3, 2-3 cm; 4 grade > 3cm
Results of the experiment
Table 1 comparison table of effect of use
Test results show that the two compositions have good treatment effect on diarrhea of dogs and cats, and can cure diarrhea diseases of dogs and cats after continuous administration for 3 days. Compared with the existing antibiotic treatment method and montmorillonite powder treatment method, the treatment course of the compound for treating diarrhea of dogs and cats is obviously shortened, and the curative effect is rapid. The main reason is that the compound can repair gastrointestinal tract mucosa of dogs and cats, recover the physiological function of the gastrointestinal tract and provide electrolytes and energy necessary for the recovery of organisms for sick dogs and cats while quickly inhibiting diarrhea, so that the treatment course is shorter than that of the traditional treatment method and the organisms can be recovered more quickly.
Claims (9)
1. The composition for preventing and treating diarrhea of dogs and cats is characterized by comprising the following raw materials in parts by weight:
1-90 parts of toxin adsorbent, 4-90 parts of intestinal mucosa protective agent, 1-5 parts of electrolyte and energy regulator, 0.1-10 parts of flavoring agent, 10-30 parts of water and 10-90 parts of auxiliary material;
the toxin adsorbent is kaolin; the intestinal mucosa protective agent is pectin.
2. The composition for preventing and treating diarrhea in dogs and cats according to claim 1, wherein the electrolyte and energy regulator is one or more of sodium chloride, potassium chloride, sodium bicarbonate and ATP.
3. The composition for preventing and treating diarrhea in dogs and cats according to claim 2, wherein the electrolyte and energy regulator is sodium chloride, potassium chloride, sodium bicarbonate, adenosine triphosphate according to the mass ratio of 20:9: 15: (2-3) mixed composition.
4. The composition for preventing and treating diarrhea in dogs and cats according to claim 1, wherein the composition comprises one or more of flavoring agents such as beef flavor, pork flavor, lemon flavor, sweetener, meat paste and animal protein powder.
5. The composition for preventing and treating diarrhea in dogs and cats according to claim 1, wherein the adjuvant is one or more of methylcellulose, sodium carboxymethylcellulose, glycerol, nipagin, sodium dodecyl benzene sulfonate, dextran, gum arabic, xanthan gum, benzoic acid, and sodium benzoate.
6. The method for preparing a composition for preventing and treating diarrhea in dogs and cats according to any one of claims 1-5, comprising the steps of:
1) weighing the raw materials, putting the raw materials into a mixer, and mixing to obtain a mixture A;
2) adding the mixture A obtained above into a ball mill, and grinding for 2-3 times to obtain the suspension of the composition for preventing and treating diarrhea of dogs and cats.
7. The method for preparing the composition for preventing and treating diarrhea of dogs and cats according to any one of claims 1-5, comprising the following steps:
weighing the raw materials, adding water into a liquid preparation tank, heating to 50 ℃, then sequentially adding kaolin, electrolyte, an energy regulator, a flavoring agent and auxiliary materials, stirring into slurry, finally slowly adding pectin, and uniformly mixing to obtain the paste of the composition for preventing and treating diarrhea of dogs and cats.
8. Use of a suspension prepared by the process of claim 6, wherein the suspension is administered by spraying into the oral cavity of a canine or feline.
9. The method of using the paste prepared by the method of claim 7, wherein the paste is contained in a syringe for administration and is pushed into the oral cavity of dogs and cats using the syringe for administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011559125.XA CN112451541A (en) | 2020-12-25 | 2020-12-25 | Composition for preventing and treating diarrhea of dogs and cats |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011559125.XA CN112451541A (en) | 2020-12-25 | 2020-12-25 | Composition for preventing and treating diarrhea of dogs and cats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112451541A true CN112451541A (en) | 2021-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011559125.XA Pending CN112451541A (en) | 2020-12-25 | 2020-12-25 | Composition for preventing and treating diarrhea of dogs and cats |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101257892A (en) * | 2005-05-18 | 2008-09-03 | 达沃尔泰拉公司 | Colonic delivery of adsorbents |
-
2020
- 2020-12-25 CN CN202011559125.XA patent/CN112451541A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101257892A (en) * | 2005-05-18 | 2008-09-03 | 达沃尔泰拉公司 | Colonic delivery of adsorbents |
Non-Patent Citations (4)
| Title |
|---|
| 余展飞: "抗腹泻性药物分类和应用", 《中国医师进修杂志》 * |
| 周贵，李淑琴，张利: "犬大肠疾病的诊断与治疗", 《农业与技术》 * |
| 谢慧胜 等: "《小动物疾病防治手册》", 30 April 1990, 北京农业大学出版社 * |
| 赵兴绪 等: "《无公害养殖药物使用指南》", 31 August 2005, 金盾出版社 * |
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