CN112444623A - Sample detection device, sampling needle clogging detection circuit, and clogging detection method - Google Patents
Sample detection device, sampling needle clogging detection circuit, and clogging detection method Download PDFInfo
- Publication number
- CN112444623A CN112444623A CN201910815036.8A CN201910815036A CN112444623A CN 112444623 A CN112444623 A CN 112444623A CN 201910815036 A CN201910815036 A CN 201910815036A CN 112444623 A CN112444623 A CN 112444623A
- Authority
- CN
- China
- Prior art keywords
- preset time
- sampling needle
- circuit
- signal
- duration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L11/00—Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group G01L7/00 or G01L9/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
- G01V9/00—Prospecting or detecting by methods not provided for in groups G01V1/00 - G01V8/00
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Geophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Hydrology & Water Resources (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The application discloses sample detection equipment and sampling needle jam detection circuitry thereof. Sampling needle passes through the liquid way and connects sampling device, and this sampling needle jam detection circuitry includes: the detection circuit includes: the device comprises a pressure sensor, an amplifying circuit and a controller; the pressure sensor is arranged on the liquid path and used for outputting a first differential signal or a second differential signal according to the detected pressure value; the amplifying circuit is connected with the pressure sensor and is used for amplifying the first differential signal or the second differential signal at the same time to obtain an amplified signal; the controller is connected with the amplifying circuit and used for processing the amplified signal so as to determine the blockage condition of the sampling needle or the liquid path.
Description
Technical Field
The present application relates to the field of medical equipment technology, and in particular, to a sample detection device, a sampling needle blockage detection circuit, and a sampling needle blockage detection method.
Background
In the using process of the sample detection device, a sample needs to be sucked by the sampling needle for detection or the sampling needle is used for sampling and spitting the sample.
Because the inner diameter of the sampling needle is small, and floccules or clots (such as blood cells, fibrin, and the like) occasionally appear in the sample, in the process of analyzing the sample, when the sampling needle sucks the sample or samples and spits the sample, the sample often contains floccules or clots and causes blockage, which leads to inaccurate suction or sample loading, and further affects the accuracy of the test result.
Disclosure of Invention
The application provides this check out test set, sampling needle jam detection circuitry and sampling needle jam detection method to solve the lower problem of sampling needle jam detection precision among the correlation technique.
In order to solve the technical problem, the application adopts a technical scheme that: a sampling needle clogging detection circuit is provided. Sampling needle passes through the liquid way and connects sampling device, and this sampling needle jam detection circuitry includes: the detection circuit includes: the device comprises a pressure sensor, an amplifying circuit and a controller; the pressure sensor is arranged on the liquid path and used for outputting a first differential signal or a second differential signal according to the detected pressure value; the amplifying circuit is connected with the pressure sensor and is used for amplifying the first differential signal or the second differential signal at the same time to obtain an amplified signal; the controller is connected with the amplifying circuit and used for processing the amplified signal so as to determine the blockage condition of the sampling needle or the liquid path.
In order to solve the technical problem, the application adopts a technical scheme that: a method for detecting clogging of a sampling needle is provided. The sampling needle blockage detection method is realized by the sampling needle blockage detection circuit, and comprises the steps of obtaining a comparison signal; detecting a duration of the comparison signal; and comparing the duration time with the preset time to obtain a judgment result.
Be different from prior art, the sampling needle jam detection circuitry that this application provided, through setting up pressure sensor in the liquid way, pressure sensor is used for exporting first difference signal or second difference signal according to the pressure value that detects, amplifier circuit connects pressure sensor and is used for obtaining the signal of enlargiing after enlargiing first difference signal or second difference signal simultaneously, the amplifier circuit is connected to the controller, be used for handling the signal of enlargiing, with at the in-process that the sampling needle inhaled the appearance or spit the appearance, real-time detection liquid way in pressure variation, can confirm the jam condition of sampling needle or liquid way fast and improve the detection precision to the jam condition.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts, wherein:
FIG. 1 is a schematic structural diagram of an embodiment of a sampling pin blockage detection circuit according to the present application;
FIG. 2 is a schematic structural diagram of another embodiment of a sampling needle blockage detection circuit according to the present application;
FIG. 3 is a schematic structural diagram of a sampling needle blockage detection circuit according to yet another embodiment of the present application;
fig. 4 is a schematic flowchart of an embodiment of a sampling needle blockage detection method according to the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
The terms "first" and "second" in the embodiments of the present application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. Furthermore, the terms "include" and "have," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sampling pin blockage detection circuit according to the present application.
In this embodiment, the sampling needle is connected to the sampling device through the liquid path, and the sampling needle blockage detection circuit 100 includes: pressure sensor 10, amplifier circuit 20, and controller 30.
The pressure sensor 10 is disposed in the fluid path, and the pressure sensor 10 is configured to output a first differential signal or a second differential signal according to a detected pressure value.
The pressure sensor 10 is a device or apparatus that senses pressure signals and converts the pressure signals into usable output electrical signals according to a certain rule. The pressure sensor 10 is provided in the liquid path, and is capable of detecting a pressure change of the sampling needle during a sample suction or a sample discharge process, and outputting a first differential signal or a second differential signal according to a detected pressure value.
The amplifying circuit 20 is connected to the pressure sensor 10, and the amplifying circuit 20 is configured to amplify the first differential signal or the second differential signal to obtain an amplified signal.
The amplifying circuit 20 may be an instrumentation amplifier. Since the voltage change caused by the pressure change is small, the first differential signal or the second differential signal needs to be amplified by the amplifying circuit 20 to obtain an amplified signal, and the amplified signal is favorable for subsequent processing and judgment, so that the detection precision is improved.
The controller 30 is connected to the amplifying circuit 20 for processing the amplified signal to determine the blockage of the sampling needle or the fluid path.
The controller 30 processes the amplified signal to obtain detection data, and compares the detection data with reference data (i.e., data obtained when no clogging occurs) to determine the clogging of the sampling needle or the fluid path.
In this embodiment, the pressure sensor 10 is disposed in the liquid path, the pressure sensor 10 is configured to output a first differential signal or a second differential signal according to a detected pressure value, the amplifying circuit 20 is connected to the pressure sensor 10 and configured to amplify the first differential signal and the second differential signal simultaneously to obtain an amplified signal, and the controller 30 is connected to the amplifying circuit 20 and configured to process the amplified signal, so as to detect a pressure change in the liquid path in real time during a sample suction or a sample spitting process of the sampling needle, and can quickly determine a blocking condition of the sampling needle or the liquid path and improve detection accuracy of the blocking condition.
Alternatively, the controller 3033 may be an integrated circuit chip having signal processing capabilities. The controller 3033 may also be a Microprocessor (MCU), a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic, discrete hardware components.
The detection principle of the sampling needle blockage detection circuit 100 is as follows:
when the sampling needle contacts the liquid level and starts to suck samples, the pressure in the liquid pipeline can change, so that a jump is generated, and after the samples are sucked, the pressure value of the liquid pipeline is recovered, and the jump is generated, so that a pressure pulse is formed.
The main characteristics of the pulse are waveform, amplitude, width and repetition frequency. The width of the pulse is a duration of a high level with respect to a reference signal acquired when the sampling needle does not perform sampling or discharging.
Referring to fig. 2, fig. 2 is a schematic structural diagram of another embodiment of a sampling pin blockage detection circuit according to the present application.
In this embodiment, on the basis of an embodiment of the sampling pin blockage detection circuit 100, the detection circuit 100 further includes a signal processing circuit 40 connected to the amplifying circuit 20, and the signal processing circuit 40 is configured to compare the amplified signal with a reference signal to obtain a comparison signal, and input the comparison signal to the controller 30.
The controller 30 is configured to process the comparison signal to determine a blockage in the sampling needle or fluid path.
In this embodiment, the signal processing circuit 40 is configured to compare the amplified signal with a reference signal to obtain a pressure pulse when the sampling needle performs sample sucking or sample discharging, and the controller 30 processes the comparison signal to obtain a pulse width, i.e., a duration time of a high level, and compares the pulse width with a preset value (the duration time of the high level detected when the sampling needle is not blocked) to determine a blocking condition of the sampling needle or the liquid path.
Referring to fig. 3, fig. 3 is a schematic structural diagram of a sampling needle blockage detection circuit according to another embodiment of the present application.
In this embodiment, on the basis of the previous embodiment of the sampling needle blockage detection circuit 100, the detection circuit 100 further includes a positive and negative power supply 50, and the amplification circuit 20 is powered by the positive and negative power supply 50. That is, the amplification circuit 20 is powered by dual power sources.
The P + output end of the pressure sensor 10 is connected with the I + input end of the amplifying circuit 20, and the P-output end of the positive and negative power supply 50 is connected with the I-input end of the amplifying circuit 20.
Or the P + output end of the pressure sensor 10 is connected with the I-input end of the amplifying circuit 20, and the P-output end of the positive and negative power supply 50 is connected with the I + input end of the amplifying circuit 20.
Wherein, the P + output end is the positive phase output end of the pressure sensor 10, and the P-output end is the negative phase output end of the pressure sensor 10; the I-input terminal is a non-inverting input terminal of the amplifying circuit 20, and the I + input terminal is an inverting input terminal of the amplifying circuit 20.
When the amplifying circuit 20 is powered by dual power sources, the P + output terminal is connected to one of the I + input terminal and the I-input terminal, and the P-output terminal is connected to the other of the I + input terminal and the I-input terminal, the sampling pin blockage detection circuit 100 of this embodiment can detect positive and negative pressures in the liquid path.
Further, the signal processing circuit 40 includes: a first signal processing circuit 41 and a second signal processing circuit 41, the first signal processing circuit 41 and the second signal processing circuit 42 being connected to the amplifying circuit 20, respectively; .
When the controller 30 determines that the sampling needle performs the sampling operation, the first signal processing circuit 41 is configured to compare the amplified signal with a first reference signal to obtain a comparison signal, and input the comparison signal to the controller 30.
When the controller 30 determines that the sampling needle performs a sample sucking operation, the second signal processing circuit 42 is configured to compare the amplified signal with a second reference signal to obtain a comparison signal, and input the comparison signal to the controller 30.
When the sampling needle sucks a sample, the pressure in the liquid path firstly forms a negative pressure jump, and after the sample is sucked, the pressure in the liquid path is recovered and then a positive pressure jump is generated, so that a pressure pulse is formed. When the sampling needle spits a sample, the pressure in the liquid path firstly forms a positive pressure jump, and after the sample is spitted, the pressure value of the liquid path pipeline is recovered, and then a negative pressure jump is generated, so that a pressure pulse is formed.
In general, the pressure sensor 10 detects a negative pressure during the sample suction process of the sampling needle, and the pressure sensor 10 detects a positive pressure during the sample discharge process of the sampling needle.
In the embodiment, the amplifying circuit 20 is provided with dual power supplies, and the first signal processing circuit 41 is used for outputting samples when the sampling needle outputs samples, the amplified signal is compared with the first reference signal to obtain a comparison signal, the second signal processing circuit 42 compares the amplified signal with the second reference signal to obtain a comparison signal when the sampling needle sucks a sample, that is, the first signal processing circuit 41 and the second signal processing circuit 42 can process the differential signal generated when detecting the positive voltage and the differential signal generated when detecting the negative voltage, so that the sampling needle blockage detection circuit 100 can detect both positive pressure and negative pressure, that is, the sampling needle clogging detection circuit 100 of the present embodiment can perform clogging detection when the sampling needle performs both sampling and discharging, therefore, the detection application scene is enlarged, whether the sampling needle is blocked or not can be detected in time, and the detection precision can be further improved.
Optionally, in other embodiments, the detection circuit 100 further comprises a positive power supply, and the amplification circuit 20 is powered by the positive power supply. I.e. the amplifier circuit 20 is powered by a single power supply.
The P + output end of the pressure sensor 10 is connected with the I + input end of the amplifying circuit 20, and the P-output end of the pressure sensor 10 is connected with the I-input end of the amplifying circuit 20.
When the amplifying circuit 20 supplies power to the single power supply, the P + output terminal of the pressure sensor 10 is connected to the I + input terminal of the amplifying circuit 20, and the P-output terminal of the pressure sensor 10 is connected to the I-input terminal of the amplifying circuit 20, the detection circuit 100 can detect positive voltage, that is, the detection circuit 100 can perform blockage detection when the sampling needle performs sampling.
The P + output end of the pressure sensor 10 is connected with the I-input end of the amplifying circuit 20, and the P-output end of the pressure sensor 10 is connected with the I + input end of the amplifying circuit 20.
When the amplifying circuit 20 supplies power for a single power supply, the P + output end of the pressure sensor 10 is connected to the I-input end of the amplifying circuit 20, the P-output end of the pressure sensor 10 is connected to the I + input end of the amplifying circuit 20, and the detection circuit 100 can detect negative pressure, that is, the detection circuit 100 can perform blockage detection when a sampling needle performs sample suction.
Based on the method, the application also provides a sampling needle blockage detection method.
Referring to fig. 4, fig. 4 is a schematic flowchart illustrating a sampling needle blockage detection method according to an embodiment of the present application.
The method for detecting clogging of a sampling needle in this embodiment is implemented by the circuit 100 for detecting clogging of a sampling needle in any of the above embodiments.
The sampling needle blockage detection method comprises the following steps:
s120: a comparison signal is acquired.
Before step S120, the method further includes: the pressure sensor 10 outputs a first differential signal or a second differential signal according to the detected pressure value, and the amplifying circuit 20 amplifies the first differential signal and the second differential signal, respectively, to obtain amplified signals.
The controller 30 acquires an amplified signal obtained by the amplification processing performed by the amplification circuit 20.
S140: the duration of the comparison signal is detected.
After the controller 30 processes the comparison signal output from the signal processing circuit 40, the duration of the comparison signal, i.e. the duration of the amplified signal being greater than the reference signal, is detected.
The amplified signal is greater than the duration of the reference signal, i.e. the duration of the high level of the pulses of the amplified signal.
S160: and comparing the duration time with the preset time to obtain a judgment result.
In the related art, it is generally determined whether or not the sampling needle is clogged by detecting a pressure value during the sample suction or the sample discharge, but since the pressure value during the sample suction or the sample discharge is not stable, the determination can be made only by detecting a maximum value and a minimum value of the pressure, and the detection accuracy is not high.
The sampling needle blockage detection method provided by the embodiment judges whether the sampling needle is blocked or not by comparing the detected duration with the preset time, can improve the detection precision, and can detect the blockage degree of the sampling needle by setting different preset time, for example, the preset time is set to be the time required when the corresponding sampling needle is completely blocked, whether the sampling needle is completely blocked or not can be judged, the preset time is set to be less than the time required when the sampling needle is completely blocked or not, but is more than the time required when the sampling needle is not blocked or not, whether the sampling needle is slightly blocked or not can be judged, so that the sampling needle is controlled not to be completely blocked or not, but the sampling is stopped when the condition of the micro-blockage influencing the sampling precision occurs, and the accuracy of sample detection is improved.
Alternatively, when the pressure value detected by the pressure sensor 10 is a positive value, the first signal processing circuit 41 is controlled to compare the amplified signal with the first reference signal to obtain a comparison signal, and accordingly, the first preset time is a time during which the high level of the detected pulse lasts when the sampling needle performs sampling without clogging.
When the pressure value detected by the pressure sensor 10 is a negative value, the second signal processing circuit 42 is controlled to compare the amplified signal with the second reference signal to obtain a comparison signal, and accordingly, the second preset time is the duration of the high level of the detected pulse when the sampling needle performs sampling without blockage.
Optionally, step S160: comparing the detected duration with the preset time to obtain a judgment result, wherein the judgment result comprises the following steps:
and when the duration time is less than the preset time, judging that the sampling needle is not blocked.
And when the duration time is longer than the preset time, judging that the sampling needle is blocked.
When the sample properties, concentrations, etc. are different, the preset times may also be different. For example, the preset time may be 3.5s, 4s, 4.5 s. The predetermined time may be determined experimentally before performing the tests on the different samples.
Optionally, the preset time includes a first preset time and a second preset time.
Step S160: comparing the detected duration with the preset time to obtain a judgment result, wherein the judgment result comprises the following steps:
s161: and when the sampling needle is determined to execute the sample spitting action, comparing the detected duration time with the first preset time to obtain a judgment result.
The controller 30 may control the power mechanism to operate so that the sampling needle performs a sample discharging or a sample sucking operation. Therefore, the controller 30 can determine whether the sampling needle is performing the spitting operation or the aspirating operation at the same time.
When the controller 30 determines that the sampling needle performs the sample ejection operation, the detected sample ejection duration is compared with the first preset time. The first preset time is a time during which the high level of the detected pulse continues when the sampling needle performs sampling without clogging.
And when the duration is less than the first preset time, judging that the sampling needle is not blocked. And when the duration time is longer than the first preset time, judging that the sampling needle is blocked.
S162: and when the sampling needle is determined to execute the sample sucking action, comparing the detected duration time with the second preset time to obtain a judgment result.
The controller 30 compares the detected sample sucking duration time with a second preset time when determining that the sampling needle performs the sample sucking action. The second preset time is the duration of the high level of the detected pulse when the sampling needle performs sampling without blockage.
And when the duration is less than the second preset time, judging that the sampling needle is not blocked. And when the duration time is longer than the second preset time, judging that the sampling needle is blocked.
Optionally, the first preset time includes a preset time a, a preset time B, and a preset time C, where the preset time a is less than the preset time B and less than the preset time C.
Step S160: comparing the detected duration time with the first preset time to obtain a judgment result, which may include:
when the duration time is less than or equal to the preset time A, judging that the sampling needle is not blocked;
when the duration time B is less than or equal to the preset time C, judging that the sampling needle is blocked but not completely blocked;
when the duration time is longer than the preset time C, judging that the sampling needle is completely blocked;
optionally, the second preset time includes a preset time D, a preset time E, and a preset time F, where the preset time D is less than the preset time E and less than the preset time F.
When the duration time is less than or equal to the preset time D, judging that the sampling needle is not blocked;
when the duration time E is less than or equal to the preset time F, judging that the sampling needle is blocked but not completely blocked;
and when the duration time is longer than the preset time F, judging that the sampling needle is completely blocked.
The preset time A and the preset time D are divided into the time required by sample spitting and sucking when the sampling needle is not blocked. And the preset time C and the preset time F are divided into the time required by sample spitting and sample sucking when the sampling needle is completely blocked.
Therefore, the preset time a, the preset time D, the preset time C and the preset time F can be determined through experiments before the detection of different samples is performed. When the detection sample is determined, the values of the preset time A, the preset time D, the preset time C and the preset time F are relatively fixed.
There are many instances where the sampling needle is clogged but not completely clogged, and the severity of the clogging varies. Accordingly, the preset time B may be determined according to the values of the preset time a, the preset time C, and the detection check and detection requirement, and correspondingly, the preset time E may also be determined according to the values of the preset time D, the preset time F, and the detection check and detection requirement.
For example, when the accuracy of the amount of sample application required for the test is good, the difference between the preset time B and the preset time E may be relatively small. When the difference between the preset time B and the preset time E is relatively small, namely the difference between the preset time B and the preset time A is smaller, the difference between the preset time E and the preset time D is smaller, and the detection precision of the micro plug is higher.
When the requirements on the continuity and the efficiency of detection are high, in order to avoid influence on the experimental process caused by suspension of sample injection due to micro-blocking, the difference value between the preset time B and the preset time E can be relatively large. That is, the larger the difference between the preset time B and the preset time a is, the larger the difference between the preset time E and the preset time D is.
The sample detection apparatus according to the embodiment of the present application includes the sampling needle blockage detection circuit 100 described in the above-described embodiment.
Optionally, the sample detection apparatus may further comprise a sample introduction device, a sample adding device, a delivery device, a sampling device, a reaction device, an incubation device, a magnetic separation device, and the like.
The sampling needle is connected with a sampling device through a liquid path, and the sampling needle blockage detection circuit 100 is used for detecting the blockage condition of the sampling needle or the liquid path.
In this application, through setting up pressure sensor in the liquid way, pressure sensor is used for exporting first difference signal or second difference signal according to the pressure value that detects, amplifier circuit connects pressure sensor and is used for obtaining the signal of enlargiing after enlargiing first difference signal or second difference signal simultaneously, amplifier circuit is connected to the controller, be used for handling the signal of enlargiing, in order at the in-process that the sampling needle inhaled the appearance or spit the appearance, real-time detection liquid way in pressure variation, can confirm the jam condition of sampling needle or liquid way fast and improve the detection precision to the jam condition.
The above description is only an example of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings, or which are directly or indirectly applied to other related technical fields, are intended to be included within the scope of the present application.
Claims (12)
1. A sampling needle blockage detection circuit, wherein the sampling needle is connected with a sampling device through a liquid path, and the detection circuit comprises:
the pressure sensor is arranged on the liquid path and used for outputting a first differential signal or a second differential signal according to a detected pressure value;
the amplifying circuit is connected with the pressure sensor and is used for simultaneously amplifying the first differential signal and the second differential signal to obtain an amplified signal;
and the controller is connected with the amplifying circuit and is used for processing the amplified signal so as to determine the blockage condition of the sampling needle or the liquid path.
2. The detection circuit of claim 1, further comprising: the signal processing circuit is connected with the amplifying circuit and used for comparing the amplifying signal with a reference signal to obtain a comparison signal and inputting the comparison signal to the controller;
the controller is used for processing the comparison signal to determine the blockage condition of the sampling needle or the liquid path.
3. The circuit according to claim 1, wherein the detection circuit further comprises a positive and negative power supply, the amplification circuit being powered by the positive and negative power supply;
the P + output end of the pressure sensor is connected with the I + input end of the amplifying circuit, and the P-output end of the positive and negative power supply is connected with the I-input end of the amplifying circuit; or
The P + output end of the pressure sensor is connected with the I-input end of the amplifying circuit, and the P-output end of the positive and negative power supply is connected with the I + input end of the amplifying circuit.
4. The circuit according to claim 3, wherein the signal processing circuit comprises a first signal processing circuit and a second signal processing circuit, and the first signal processing circuit and the second signal processing circuit are respectively connected to the amplifying circuit;
when the controller determines that the sampling needle performs a sample spitting action, the first signal processing circuit is used for comparing the amplified signal with a first reference signal to obtain a comparison signal and inputting the comparison signal into the controller;
and when the controller determines that the sampling needle performs a sample sucking action, the second signal processing circuit is used for comparing the amplified signal with a second reference signal to obtain a comparison signal and inputting the comparison signal into the controller.
5. The circuit according to claim 2, wherein the detection circuit further comprises a positive power supply, and the amplification circuit is powered by the positive power supply;
the P + output end of the pressure sensor is connected with the I + input end of the amplifying circuit, and the P-output end of the pressure sensor is connected with the I-input end of the amplifying circuit.
6. The circuit according to claim 1, wherein the detection circuit further comprises a positive power supply, and the amplification circuit is powered by the positive power supply;
the P + output end of the pressure sensor is connected with the I-input end of the amplifying circuit, and the P-output end of the pressure sensor is connected with the I + input end of the amplifying circuit.
7. A sampling needle blockage detection method implemented by the sampling needle blockage detection circuit according to any one of claims 1 to 6, the method comprising:
acquiring a comparison signal;
detecting a duration of the comparison signal;
and comparing the duration time with the preset time to obtain a judgment result.
8. The method for detecting clogging of a sampling needle according to claim 7,
the comparing the detected duration time with the preset time to obtain a judgment result comprises:
when the duration time is less than the preset time, judging that the sampling needle is not blocked;
and when the duration is longer than the preset time, judging that the sampling needle is blocked.
9. The method according to claim 7, wherein the preset time includes a first preset time and a second preset time;
the comparing the detected duration time with the preset time to obtain a judgment result comprises:
when the sampling needle is determined to execute a sample spitting action, comparing the detected duration time with a first preset time to obtain a judgment result;
and when the sampling needle is determined to execute the sample sucking action, comparing the detected duration time with the second preset time to obtain a judgment result.
10. The method for detecting clogging of a sampling needle according to claim 9,
the first preset time comprises a preset time A, a preset time B and a preset time C, wherein the preset time A is smaller than the preset time B and is smaller than the preset time C;
the comparing the detected duration time with the first preset time to obtain a judgment result comprises:
when the duration time is less than or equal to the preset time A, judging that the sampling needle is not blocked;
when the preset time B is less than the duration and is less than or equal to the preset time C, judging that the sampling needle is blocked but not completely blocked;
and when the duration is greater than the preset time C, judging that the sampling needle is completely blocked.
11. The method for detecting clogging of a sampling needle according to claim 9,
the second preset time comprises a preset time D, a preset time E and a preset time F, and the preset time C is less than the preset time D and less than the preset time F;
the comparing the detected duration time with the second preset time to obtain a judgment result comprises:
when the duration time is less than or equal to the preset time D, judging that the sampling needle is not blocked;
when the preset time E is less than the duration and is less than or equal to the preset time F, judging that the sampling needle is blocked but not completely blocked;
and when the duration is greater than the preset time F, judging that the sampling needle is completely blocked.
12. A sample detection device characterized in that it comprises a sampling needle blockage detection circuit according to any one of claims 1 to 6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910815036.8A CN112444623A (en) | 2019-08-30 | 2019-08-30 | Sample detection device, sampling needle clogging detection circuit, and clogging detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910815036.8A CN112444623A (en) | 2019-08-30 | 2019-08-30 | Sample detection device, sampling needle clogging detection circuit, and clogging detection method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112444623A true CN112444623A (en) | 2021-03-05 |
Family
ID=74733943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910815036.8A Pending CN112444623A (en) | 2019-08-30 | 2019-08-30 | Sample detection device, sampling needle clogging detection circuit, and clogging detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112444623A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0682258A1 (en) * | 1994-05-09 | 1995-11-15 | Ciba Corning Diagnostics Corp. | Obstruction detection circuit for sample probe |
| CN203148944U (en) * | 2013-03-25 | 2013-08-21 | 深圳市蓝韵实业有限公司 | Needle blockage detecting device for biochemical analyzer |
| CN205333664U (en) * | 2016-01-08 | 2016-06-22 | 苏州长光华医生物医学工程有限公司 | Plug -hole monitoring devices of chemiluminiscence tester ware |
-
2019
- 2019-08-30 CN CN201910815036.8A patent/CN112444623A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0682258A1 (en) * | 1994-05-09 | 1995-11-15 | Ciba Corning Diagnostics Corp. | Obstruction detection circuit for sample probe |
| US5503036A (en) * | 1994-05-09 | 1996-04-02 | Ciba Corning Diagnostics Corp. | Obstruction detection circuit for sample probe |
| JPH08170963A (en) * | 1994-05-09 | 1996-07-02 | Ciba Corning Diagnostics Corp | Method and circuit for detecting clogging of sample probe |
| CN203148944U (en) * | 2013-03-25 | 2013-08-21 | 深圳市蓝韵实业有限公司 | Needle blockage detecting device for biochemical analyzer |
| CN205333664U (en) * | 2016-01-08 | 2016-06-22 | 苏州长光华医生物医学工程有限公司 | Plug -hole monitoring devices of chemiluminiscence tester ware |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20210260283A1 (en) | Multi-sensor infusion system for detecting air or an occlusion in the infusion system | |
| US8863593B2 (en) | Sampling device and method | |
| JP3877053B2 (en) | Fluid handler and method for processing fluid | |
| US7836763B2 (en) | Method and apparatus to reject electrical interference in a capacitive liquid level sensor system | |
| EP1607746A3 (en) | Clinical specimen processing apparatus and clinical specimen processing system | |
| MX2015001170A (en) | System and method for detecting used and dried sensors. | |
| CN110857910A (en) | Micropore blockage detection device and method and blood cell analyzer | |
| JP2934557B2 (en) | Blood coagulation time measuring method and apparatus | |
| CN113640354A (en) | Method, device and equipment for detecting blocked needle and storage medium | |
| JP6814213B2 (en) | Eakring detector for plasma processing | |
| CN112444623A (en) | Sample detection device, sampling needle clogging detection circuit, and clogging detection method | |
| US20120309099A1 (en) | Automatic analyzing device | |
| US10281370B2 (en) | Syringe assembly and method of using the same | |
| CN114112513B (en) | Liquid level detection method, blood analysis device and storage medium | |
| CN111426853B (en) | Automatic analysis device and recording medium | |
| CN207677691U (en) | Audio amplifier circuit and signal amplify module | |
| US20200093391A1 (en) | Pulse discrimination device and electrocardiogram analyzer | |
| CN112444621B (en) | Blood cell analyzer and counting method thereof | |
| JP3183947B2 (en) | Interface detection device | |
| JPH10132640A (en) | Liquid level detection device and method therefor, and automatic analysis device | |
| EP3003429B1 (en) | Multi-sensor infusion system for detecting air or an occlusion in the infusion system | |
| US20170276662A1 (en) | Electrical characteristic measuring device and program | |
| CN216349750U (en) | Sampling needle, sampling needle device and sperm quality analyzer | |
| JP4275608B2 (en) | Dispensing device | |
| JPH08114604A (en) | Automatic analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210305 |
|
| RJ01 | Rejection of invention patent application after publication |