CN112438914A - Denture cleaning tablet and preparation method thereof - Google Patents
Denture cleaning tablet and preparation method thereof Download PDFInfo
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- CN112438914A CN112438914A CN201910801677.8A CN201910801677A CN112438914A CN 112438914 A CN112438914 A CN 112438914A CN 201910801677 A CN201910801677 A CN 201910801677A CN 112438914 A CN112438914 A CN 112438914A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
Abstract
The invention discloses a denture cleaning tablet and a preparation method thereof. The denture cleaning tablet comprises pomegranate bark extract, sodium lauryl sulfoacetate, potassium peroxymonosulfate complex salt, disintegrant, lubricant and aromatic. The invention also discloses a preparation method of the denture cleaning tablet. The artificial tooth cleaning tablet prepared by the method can effectively remove various dirt and pigmentation on artificial teeth, kill various bacteria, prevent oral diseases, remove peculiar smell and halitosis, keep the breath clear, simultaneously the tablet is quick to disintegrate, has high solubility, fully utilizes effective components, not only retains the efficacy of various active components, but also has the characteristics of convenient carrying and use, and has wide market prospect.
Description
Technical Field
The invention relates to the field of pharmaceutical preparations, in particular to a denture cleaning tablet and a preparation method thereof.
Background
Denture cleaning sheets, also known as denture cleaning sheets, are products that are used specifically to clean and disinfect dentures. Use the denture cleaning sheet, can produce a large amount of active oxygen, disinfect and eliminate the peculiar smell, possess outstanding clean and deodorization dual function, can independently, thoroughly and quick cleanness the denture, guaranteed that the denture is inlayed and is worn person's health. Denture care products have been popular in developed countries such as europe and america for nearly 50 years, and will be in more widespread demand in china as the aging situation increases.
Dentures have become a potential for many fatal diseases due to the lack of scientific, proper cleaning care guidelines. Clinical studies have shown that: the false teeth are closely related to the whole body health, and the unclean false teeth have various bacteria and fungi which can cause serious diseases, and are the main causes of serious diseases such as denture stomatitis, bacterial pneumonia and bacteremia. Statistics show that because the false teeth are not clean, the infection rate in the oral cavity is more than 95 percent, periodontal diseases, oral ulcer and oral mucosa lesion are the most common oral diseases of a person wearing the false teeth, and the periodontal diseases are important factors for inducing heart diseases and pancreatic cancer; plaque is more likely to enter the lungs, causing pneumonia. Improper cleaning of dentures can cause fatal diseases, and is never critical, and dentures can cause such serious harm, mainly because the dentures are oral foreign bodies, bacterial plaque is gradually formed after entering the oral cavity, and if the dental plaque is not completely removed every day, pathogenic bacteria can abnormally proliferate and act together with other dangerous factors to cause serious oral and other systemic diseases.
Problems and hazards resulting from improper denture care are mainly found in the following areas:
(1) the denture is not thoroughly cleaned: the false teeth are not clean thoroughly, and are easy to generate peculiar smell, bad taste and bad appetite; bacteria growth, ulceration or other oral diseases; reducing gastrointestinal function, causing diabetes or other visceral diseases;
(2) fit loosely, insecure with the oral cavity: generating friction swelling pain and ulcer; food debris enters the gap between the oral cavity and the false teeth, so that germs are bred and the gastrointestinal function is influenced; oral diseases such as dental caries, periodontal disease, oral cancer, denture stomatitis, halitosis, etc.;
(3) improper treatment of dentures: the damage and deformation caused by soaking and washing with hot water or alcohol can reduce the service life; the toothbrush is easy to abrade false teeth, generates brush marks and hides bacteria to infect oral cavity; if the patient is not picked up or stored improperly at night, the patient may touch germs or be deformed or damaged.
The false teeth are closely related to the whole body health, and the unclean false teeth have various bacteria and fungi which can cause serious diseases, and are the main causes of serious diseases such as denture stomatitis, bacterial pneumonia and bacteremia. Based on the harm caused by improper denture care, the invention provides a denture cleaning tablet which contains pomegranate bark extract, sodium lauryl sulfoacetate, potassium peroxymonosulfate complex salt and other components, wherein the pomegranate bark extract has the effects of antibiosis, antifungal, antivirus, antioxidation and whitening. The sodium lauryl sulfoacetate salt has mild property, good washing, foaming, solubilizing and emulsifying properties, and can be used as a detergent and a foaming agent; meanwhile, the antibacterial disinfectant has antibacterial and disinfectant effects, and in-vitro antibacterial test results show that the antibacterial disinfectant has obvious antibacterial effects on various gram-positive and gram-negative bacteria. The potassium monopersulfate compound salt is an effective oxidant and disinfectant, and can be used for cleaning, disinfecting and bleaching oral articles.
Disclosure of Invention
The invention aims to provide a denture cleaning sheet and a preparation method thereof.
The invention discloses a denture cleaning tablet, which comprises the following components in parts by weight:
1-10 parts of pomegranate bark extract, 1-15 parts of sodium lauryl sulfoacetate, 10-70 parts of potassium hydrogen peroxymonosulfate composite salt,
20-60 parts of disintegrating agent, 1-5 parts of lubricant and 1-5 parts of aromatic.
Further, the pomegranate peel extract is obtained by extracting dried pericarp of pomegranate belonging to family punicaceae as a raw material;
the sodium lauryl sulfoacetate is prepared by carrying out esterification reaction on sulfoacetic acid and lauryl alcohol and then neutralizing by sodium hydroxide;
the potassium monopersulfate composite salt consists of potassium monopersulfate, potassium bisulfate and potassium sulfate;
the disintegrating agent consists of 10-30 parts by weight of acid source and 10-30 parts by weight of alkali source;
the lubricant is one or more of polyethylene glycol 4000, polyethylene glycol 6000, sodium lauryl sulfate, stearic acid, magnesium stearate and sodium stearyl fumarate;
the aromatic is one or more of menthol and menthol.
Further, the acid source in the disintegrant is one or more of sulfamic acid, citric acid, fumaric acid and adipic acid; the alkali source is one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and calcium carbonate;
the invention also discloses a preparation method of the denture cleaning tablet, which comprises the following three methods:
a first method of preparation comprising the steps of:
respectively sieving the pomegranate rind extract, lauryl alcohol sulfoacetate sodium salt, potassium hydrogen monosulfate composite salt, a lubricant and an aromatic with a 60-100-mesh sieve, respectively drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours, crushing and sieving with a 60-80-mesh sieve, uniformly mixing the materials, directly pressing into tablets, and controlling the environmental temperature at 25 ℃ and the humidity at 30% RH in the preparation process to prepare the denture cleaning tablet;
a second method of preparation comprising the steps of:
a. respectively sieving the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen monosulfate composite salt, a lubricant and an aromatic with a 60-100-mesh sieve, respectively drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours, crushing, sieving with a 60-80-mesh sieve, and hermetically storing for later use;
b. uniformly mixing the pomegranate peel extract prepared in the step a, sodium lauryl sulfoacetate, potassium peroxymonosulfate composite salt and an acid source, adding an ethanol solution with the volume concentration of 20-100% to prepare a soft material, sieving with a 20-mesh sieve to granulate, drying the granules at 50 ℃ for 2-4 hours, and granulating the dried granules to prepare granules A; b, adding the alkali source prepared in the step a into an ethanol solution with the volume concentration of 20-100% to prepare a soft material, then sieving the soft material with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 2-4 hours, and finishing the dried granules to prepare granules B;
c. mixing granule A and granule B, adding the lubricant and aromatic agent prepared in step a, mixing well to obtain mixture G, and pressing into tablet, and controlling environment temperature at 25 deg.C and humidity at 30% RH during preparation process to obtain denture cleaning tablet.
A third method of preparation comprising the steps of:
e. respectively sieving the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen monosulfate composite salt, a lubricant and an aromatic with a 60-100-mesh sieve, respectively drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours, crushing, sieving with a 60-80-mesh sieve, and hermetically storing for later use;
f. uniformly mixing the pomegranate peel extract prepared in the step E, sodium lauryl sulfoacetate, potassium peroxymonosulfate composite salt and an acid source, adding an ethanol solution with the volume concentration of 20-100% to prepare a soft material, sieving with a 20-mesh sieve to granulate, drying the granules at 50 ℃ for 2-4 hours, and granulating the dried granules to prepare granules E; adding the alkali source, lubricant and aromatic agent obtained in step E into the granules E, mixing well to obtain mixture H, and pressing into tablet, wherein the environmental temperature is controlled at 25 deg.C and humidity is 30% RH during preparation process to obtain denture cleaning tablet.
The invention has the advantages of
The invention provides a denture cleaning tablet, which is a tablet prepared by mixing pomegranate rind extract, sodium lauryl sulfoacetate, potassium peroxymonosulfate composite salt with specific proportion, effervescent disintegrant and other auxiliary materials, and is used for cleaning dentures.
The denture cleaning sheet of the invention has the following characteristics:
(1) specific descaling: the invention contains the components of removing dirt and whitening, and can effectively remove various dirt (food scraps, dental plaque, tartar, mucus, tartar and other various dirt) on the false teeth.
(2) Powerful whitening: the invention contains the components for removing the dirt and whitening, can effectively remove various pigmentation (smoke stain, tea dirt, pigmentation in various medicines and foods and the like) on the false teeth, has strong whitening effect and enables the false teeth to be bright and white as new.
(3) And (3) killing bacteria: the artificial tooth can efficiently kill various bacteria on the artificial tooth, the killing rate reaches 99.9%, and oral diseases are effectively prevented.
(4) Refreshing breath: the invention adopts mint flavor, can effectively remove various peculiar smells and halitosis on the false teeth, and enables the breath to be fresh and natural.
(5) The use is convenient: the artificial tooth cleaning sheet is used for cleaning artificial teeth, the traditional artificial tooth maintenance habit is not changed, and the use is convenient.
(6) Effervescent tablets: the effervescent tablet can be completely dissolved within 3 minutes, and has better cleaning effect.
(7) Neutral washing: the pH value of the solution after dissolution of the invention is neutral, and the solution has no damage to the false teeth.
(8) Prolonging the service life of the false tooth: the artificial tooth cleaning device can be used for cleaning the artificial tooth, the artificial tooth base can not deform, and the service life of the artificial tooth can be prolonged.
Use this artificial tooth cleaning sheet, can produce a large amount of active oxygen, disinfect and eliminate the peculiar smell, possess outstanding clean and deodorization dual function, can carry out independence, thoroughly and quick cleanness to the artificial tooth, guaranteed that the artificial tooth inlays the person of wearing's health. The tablet has the advantages of rapid disintegration, high solubility, full utilization of effective components, retained effects of various active components, portability, convenient use, and wide market prospect.
Detailed Description
The following detailed description of the present invention will be made with reference to specific examples, but the present invention is not limited to the claims.
Example 1
1.1 component proportion of denture cleaning tablet:
pomegranate rind extract 25g
Lauryl sulfoacetate sodium salt 25g
Potassium hydrogen peroxymonosulfate composite salt 125g
Fumaric acid 30g
Sodium bicarbonate 40g
Menthol 2.5g
Magnesium stearate 2.5g
Total 250g
Made into 100 pieces
1.2 preparation method of denture cleaning tablet:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt with a 60-mesh sieve, and then hermetically storing for later use; drying fumaric acid and sodium bicarbonate at 50 deg.C for 4 hr, respectively, pulverizing, sieving with 80 mesh sieve, and sealing for storage; sieving Mentholum and magnesium stearate with 80 mesh sieve, sealing and storing.
② mixing the prepared pomegranate rind extract, sodium lauryl sulfoacetate, potassium peroxymonosulfate, fumaric acid, sodium bicarbonate, menthol and magnesium stearate uniformly, and then directly pressing the powder into tablets to obtain 100 tablets of denture cleaning tablets. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 2
2.1. The component ratio is as follows:
pomegranate rind extract 15g
Lauryl alcohol sulfoacetate sodium salt 45g
Potassium hydrogen peroxymonosulfate composite salt 99g
Adipic acid 30g
Potassium carbonate 90g
Menthol 6g
Sodium dodecyl sulfate 15g
300g in total
Made into 100 pieces
2.2 the preparation method comprises the following steps:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt through a 100-mesh sieve, and then hermetically storing; respectively drying adipic acid and potassium carbonate at 60 deg.C for 2 hr, pulverizing, sieving with 60 mesh sieve, and sealing for storage. Sieving sodium laurylsulfate and menthol with 60 mesh sieve, and sealing for use.
② uniformly mixing the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen peroxymonosulfate composite salt and adipic acid, adding 20% ethanol solution to prepare soft material, then sieving with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 4 hours, and finishing the dried granules to prepare the granules A.
③ adding the potassium carbonate into 20 percent ethanol solution to prepare soft mass, sieving with a 20-mesh sieve to granulate, drying the granules for 4 hours at 50 ℃, and finishing the dried granules to prepare the granules B.
And fourthly, mixing the particles A and the particles B, adding the lauryl sodium sulfate and the menthol, and uniformly mixing.
Tabletting the mixture to obtain 100 denture cleaning sheets. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 3
3.1 component proportion:
pomegranate rind extract 3g
Lauryl sulfoacetate sodium salt 3g
Potassium monopersulfate composite salt (90 g)
Sulfamic acid 90g
Sodium carbonate 90g
Menthol 15g
Polyethylene glycol 40009 g
300g in total
Made into 100 pieces
3.2 the preparation method comprises the following steps:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt with a 80-mesh sieve, and then hermetically storing; respectively drying sulfamic acid and sodium carbonate at 50 deg.C for 3 hr, pulverizing, sieving with 60 mesh sieve, and sealing for storage. Sieving Mentholum and polyethylene glycol 4000 with 60 mesh sieve, and sealing for use.
② uniformly mixing the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen peroxymonosulfate composite salt and sulfamic acid, adding absolute ethanol solution to prepare soft material, then sieving with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 3 hours, and finishing the dried granules to prepare the granules.
Thirdly, adding sodium carbonate, polyethylene glycol 4000 and menthol into the granules after finishing the granules, and uniformly mixing.
And fourthly, tabletting the mixture to obtain 100 denture cleaning tablets. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 4
4.1 component proportion of denture cleaning tablet:
pomegranate rind extract 30g
Lauryl alcohol sulfoacetate sodium salt 45g
Potassium monopersulfate composite salt (105 g)
Citric acid 60g
Potassium bicarbonate 30g
Menthol 15g
Sodium stearyl fumarate 15g
300g in total
Made into 100 pieces
4.2 preparation method of denture cleaning tablet:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt with a 60-mesh sieve, and then hermetically storing for later use; respectively drying citric acid and potassium bicarbonate at 50 deg.C for 4 hr, pulverizing, sieving with 80 mesh sieve, and sealing for storage; sieving Mentholum and sodium stearyl fumarate with 80 mesh sieve, and sealing for use.
② uniformly mixing the prepared pomegranate rind extract, sodium lauryl sulfoacetate, potassium peroxymonosulfate, citric acid, potassium bicarbonate, menthol and sodium stearyl fumarate, and directly pressing the powder into tablets to obtain 100 tablets of the denture cleaning tablet. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 5
5.1 component proportion of denture cleaning sheet:
pomegranate rind extract 25g
Lauryl alcohol sulfoacetate sodium salt 37.5g
Potassium hydrogen peroxymonosulfate composite salt 25g
Fumaric acid 70g
Sodium bicarbonate 75g
Menthol 5g
Polyethylene glycol 600012.5 g
Total 250g
Made into 100 pieces
5.2 preparation method of denture cleaning tablet:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt through a 100-mesh sieve, and then hermetically storing; drying fumaric acid and sodium bicarbonate at 60 deg.C for 2 hr, pulverizing, sieving with 60 mesh sieve, and sealing for storage. Sieving polyethylene glycol 6000 and menthol with 60 mesh sieve, and sealing for storage.
② uniformly mixing the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen peroxymonosulfate composite salt and fumaric acid, adding 20% ethanol solution to prepare soft material, then sieving with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 4 hours, and finishing the dried granules to prepare the granules A.
③ adding the sodium bicarbonate into 20 percent ethanol solution to prepare soft mass, sieving with a 20-mesh sieve to granulate, drying the granules for 4 hours at 50 ℃, and finishing the dried granules to prepare the granules B.
And fourthly, mixing the particles A and the particles B, adding the polyethylene glycol 6000 and the menthol, and uniformly mixing.
Tabletting the mixture to obtain 100 denture cleaning sheets. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 6
6.1 component proportion of denture cleaning tablet:
pomegranate rind extract 6g
Lauryl alcohol sulfoacetate sodium salt 15g
Potassium hydrogen peroxymonosulfate composite salt 210g
Sulfamic acid 30g
Potassium carbonate 30g
Menthol 6g
Magnesium stearate 3g
300g in total
Made into 100 pieces
6.2 preparation method of denture cleaning tablet:
firstly, respectively sieving the pomegranate rind extract, sodium lauryl sulfoacetate and potassium hydrogen monosulfate composite salt with a 80-mesh sieve, and then hermetically storing; respectively drying sulfamic acid and calcium carbonate at 50 deg.C for 3 hr, pulverizing, sieving with 60 mesh sieve, and sealing for storage. Sieving menthol and magnesium stearate with 60 mesh sieve, sealing and storing for use.
② uniformly mixing the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen peroxymonosulfate composite salt and sulfamic acid, adding absolute ethanol solution to prepare soft material, then sieving with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 3 hours, and finishing the dried granules to prepare the granules.
And thirdly, adding calcium carbonate, magnesium stearate and menthol into the granules after finishing the granules, and uniformly mixing.
And fourthly, tabletting the mixture to obtain 100 denture cleaning tablets. The above preparation process is carried out in an environment with a temperature of 25 ℃ and a humidity of 30% RH.
Example 7 safety test
(1) Corrosion test
Warm water of about 40 c was added to a cup to ensure that the water level was high enough to completely cover the dentures, and then a denture cleanser prepared in example 1 was added. Weighing a pair of brand-new false teeth, putting the false teeth into a water cup, soaking for a period of time, taking out the false teeth, thoroughly washing the false teeth with clear water, putting the false teeth into a 50 ℃ oven to dry for 4 hours, taking out the false teeth, putting the false teeth into a drier to cool, and weighing, wherein the results are shown in table 1.
TABLE 1 Corrosion test
| Immersion time of artificial teeth | Weight (gram) | Appearance of the product | Colour(s) |
| Brand-new artificial tooth | 34.0827 | Standard new artificial tooth | Primary color |
| One week | 34.0824 | Standard new artificial tooth | Primary color |
| Two weeks | 34.0831 | Standard new artificial tooth | Primary color |
| Three weeks | 34.0827 | Standard new artificial tooth | Primary color |
| All around | 34.0825 | Standard new artificial tooth | Primary color |
It can be understood from Table 1 that the denture cleansing sheet of the present invention did not cause any damage or corrosion to the dentures.
(2) Pharmacological toxicological test
Test animals: the weight of the white mouse is 18-22 g in each half of male and female, and the white mouse is fasted for 12 hours before the experiment.
Test materials: denture cleaning sheet of example 1
The test method comprises the following steps: 80 mice are taken and randomly divided into 5 groups, each group comprises 16 mice, the male and female halves are respectively, each mouse is subjected to intragastric administration once in the morning on an empty stomach, the intragastric administration is continuously carried out for 7 days, and the death condition of the mice is observed. The amount of gastric lavage is: group 1 corresponded to 2.06g/kg, group 2 corresponded to 4.15g/kg, group 3 corresponded to 9.97g/kg, group 4 corresponded to 15.02g/kg, group 5 corresponded to 20.76g/kg, and the results are shown in Table 2.
TABLE 2 pharmacological toxicology test of white mice
As can be seen from table 2, after one week of gastric lavage of four groups of mice, 1 male and female mice in group 1 died, 2 male and 1 female mice in group 2 died, 3 male and 2 female mice in group 3 died, 5 male and 4 female mice in group 4 died, and 6 male and female mice in group 5 died. Calculated from the experimental results, the LD of the male white mouse50=10.41g/kg, female mouse LD50=14.18 g/kg. The denture cleanser of the present invention is virtually non-toxic, rated according to the risk of toxic substances.
Example 8 Performance test
(1) Test on an artificial contaminated specimen
The test method comprises the following steps: mixing the yolk and the jam according to the proportion of 1: mixing at a ratio of 1, coating on a polymethyl methacrylate test piece, and drying at 70 ℃. The test piece was immersed in the aqueous solution of the denture cleansing sheet of examples 1 to 6, and the detergency ratio was required to be not less than 80% within 15 minutes. The denture cleanser was left at 50 ℃ for 72 hours and then the detergency thereof was examined, and the results are shown in Table 3.
TABLE 3 test on artificially contaminated specimen
| Conditions for treating artificial tooth cleaning sheet | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Example 6 |
| Untreated | 99% | 96% | 98% | 95% | 98% | 97% |
| Standing at 50 deg.C for 72 hr | 98% | 94% | 95% | 91% | 97% | 95% |
As is clear from Table 3, the denture cleanser of the present invention is excellent in detergency and excellent in anti-aging properties.
(2) Bacteriostasis and sterilization test
The bacteria of the test group were treated with the aqueous denture cleanser film prepared in example 1 of the present invention, and the control group was not treated and then cultured under the same conditions, respectively, to see whether colonies grew, + sign indicating colony growth, and-sign indicating no colony growth. The bacteria in the dentures and saliva were cultured in bacterial and fungal media, respectively, to observe the inhibitory ability of the denture cleanser to bacteria and fungi in the oral cavity. The denture cleaning tablet contains various active substances and has strong inhibition and killing capability on common oral flora. The prepared aqueous solutions of denture cleansing sheets were used for the bacteriostatic tests of bacteria on dentures, bacteria in saliva and some molds, and the results are shown in Table 4.
TABLE 4 results of the bacteriostatic test for denture cleansing sheets
The test result shows that the artificial tooth cleaning sheet solution has no bacteria colony growth and has strong inhibiting capacity on other kinds of mold and saccharomycete.
The results of the tests are shown in Table 5, by performing a 30-min sterilization test on three common oral flora, i.e., Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus viridis.
TABLE 5 Sterilization test
| Name of flora | Example 1 |
| Golden yellow grapeCoccus bacterium | 99.99% |
| Staphylococcus epidermidis | 99.99% |
| Grass green streptococcus | 99.91% |
The test result shows that the denture cleaning sheet has the bactericidal effect of more than 99 percent on staphylococcus aureus, staphylococcus epidermidis and streptococcus viridis, can be used for washing dentures frequently, and has good effect on preventing oral diseases, bacterial plaque and tartar deposition.
Example 9 clinical efficacy test
Selecting 40 workers wearing artificial teeth from good doctor pharmaceutical industry group, wherein the ages of the workers are over 50 years, 28 men and 12 women; wherein 25 smokers, 31 tea drinkers and 14 sweet-eating people have the shortest wearing time of 8 months and the longest wearing time of 14 years. The comparative study was conducted using the method of dispensing tablets and final photographic observation.
The test method comprises the following steps: two methods of a soaking group and a soaking overnight group are adopted. And (3) soaking: adding warm water with the temperature of about 40 ℃ into a water cup to ensure that the water surface height can completely cover the false teeth, adding a piece of false tooth cleaning sheet prepared in the embodiment 1, putting the false teeth into the water cup, soaking for 15-30 minutes, and taking out the cleaned false teeth to thoroughly wash with clean water. Soaking overnight group: the operation method is the same as that of the soaking group, and after the soaking is continued overnight, the false teeth are taken out and thoroughly washed by clear water. The cleaning effect is shown in table 6.
TABLE 6 clinical Effect test
| Method under test | Total number of cases | Show effect | Is effective | Invalidation | High efficiency |
| Soaking group | 36 | 24 | 9 | 3 | 91.7% |
| Soaking overnight group | 39 | 36 | 2 | 1 | 97.4% |
As can be seen from Table 6, the denture cleaning sheet of the invention has an effective cleaning rate of 91.7 percent on residues, tartar and dental plaque on the denture within 30 minutes, and has more remarkable cleaning effect after being soaked overnight.
Comparative example 1
Test samples: the denture cleansing sheets according to examples 1 to 6 were commercially available as item 1 (yako diamond, tokyo diamond biotechnology limited) and item 2 (yabeishu, foizhu biotechnology limited).
The test method comprises the following steps:
after pouring 200ml of warm water of about 40 ℃ into 3 beakers, the denture cleansing sheets of examples 1 to 6, commercial product 1 and commercial product 2 were put into the beakers, and the results were shown in Table 7.
TABLE 7 comparative results
| Contrast item | Tablet weight | Disintegration time | Clarity of solution |
| Example 1 | 2.5g | 2 minutes | Clarification |
| Example 2 | 3g | 1 minute and half clock | Clarification |
| Example 3 | 3g | 1 minute and half clock | Clarification |
| Example 4 | 3g | 2 minutes | Clarification |
| Example 5 | 2.5g | 1 minute and half clock | Clarification |
| Example 6 | 3g | 2 minutes | Clarification |
| Commercial product 1 | 3g | 3 minutes half clock | Clarification |
| Commercial product 2 | 2.5g | 2 minutes and half clock | Turbidity |
As can be seen from Table 7, the denture cleansing tablets of examples 1 to 6 completely disintegrated within 2 minutes, and the solutions were clear and transparent; the product 1 sold in the market can be completely disintegrated within 3 minutes and half minutes, and the solution is clear and transparent; commercial product 2 disintegrated completely within 2 minutes and half minutes, and the solution was turbid. The denture cleaning tablet of the invention is superior to the market products in indexes such as disintegration time, clarity and the like.
While the present invention has been described in detail with reference to the embodiments, it is not intended to limit the scope of the claims. Various modifications and adaptations which may occur to those skilled in the art without inventive faculty, within the scope defined by the claims, are still protected by the present patent.
Claims (6)
1. The denture cleaning sheet comprises the following components in parts by weight:
1-10 parts of pomegranate bark extract, 1-15 parts of sodium lauryl sulfoacetate, 10-70 parts of potassium hydrogen peroxymonosulfate composite salt,
20-60 parts of disintegrating agent, 1-5 parts of lubricant and 1-5 parts of aromatic.
2. The denture cleansing tablet according to claim 1, wherein the pomegranate peel extract is obtained by extracting dried pomegranate peel, a punica granatum belonging to family punicaceae, as a raw material;
the sodium lauryl sulfoacetate is prepared by carrying out esterification reaction on sulfoacetic acid and lauryl alcohol and then neutralizing by sodium hydroxide;
the potassium monopersulfate composite salt consists of potassium monopersulfate, potassium bisulfate and potassium sulfate;
the disintegrating agent consists of 10-30 parts by weight of acid source and 10-30 parts by weight of alkali source;
the lubricant is one or more of polyethylene glycol 4000, polyethylene glycol 6000, sodium lauryl sulfate, stearic acid, magnesium stearate and sodium stearyl fumarate;
the aromatic is one or more of menthol and menthol.
3. The denture cleansing tablet according to claim 2, wherein the acid source in the disintegrant is one or more of sulfamic acid, citric acid, fumaric acid and adipic acid; the alkali source is one or more of sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and calcium carbonate.
4. A method for preparing a denture cleansing sheet, comprising the steps of:
the preparation method comprises the steps of respectively sieving a pomegranate peel extract, a sodium lauryl sulfoacetate salt, a potassium hydrogen monosulfate composite salt, a lubricant and an aromatic through a 60-100-mesh sieve, respectively drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours, crushing and sieving through a 60-80-mesh sieve, uniformly mixing the materials, directly pressing into tablets, and controlling the environment temperature to be 25 ℃ and the humidity to be 30% RH in the preparation process to prepare the denture cleaning tablet.
5. A method for preparing a denture cleansing sheet, comprising the steps of:
a. respectively sieving the pomegranate peel extract, sodium lauryl sulfoacetate, potassium hydrogen monosulfate composite salt, a lubricant and an aromatic with a 60-100-mesh sieve, respectively drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours, crushing, sieving with a 60-80-mesh sieve, and hermetically storing for later use;
b. uniformly mixing the pomegranate peel extract prepared in the step a, sodium lauryl sulfoacetate, potassium peroxymonosulfate composite salt and an acid source, adding an ethanol solution with the volume concentration of 20-100% to prepare a soft material, sieving with a 20-mesh sieve to granulate, drying the granules at 50 ℃ for 2-4 hours, and granulating the dried granules to prepare granules A; b, adding the alkali source prepared in the step a into an ethanol solution with the volume concentration of 20-100% to prepare a soft material, then sieving the soft material with a 20-mesh sieve to granulate, then drying the granules at 50 ℃ for 2-4 hours, and finishing the dried granules to prepare granules B;
c. mixing granule A and granule B, adding the lubricant and aromatic agent prepared in step a, mixing well to obtain mixture G, and pressing into tablet, and controlling environment temperature at 25 deg.C and humidity at 30% RH during preparation process to obtain denture cleaning tablet.
6. A method for preparing a denture cleansing sheet, comprising the steps of:
sieving a pomegranate peel extract, a sodium lauryl sulfoacetate salt, a potassium hydrogen monosulfate composite salt, a lubricant and an aromatic agent with a sieve of 60-100 meshes respectively, drying an acid source and an alkali source at 50-60 ℃ for 2-4 hours respectively, crushing, sieving with a sieve of 60-80 meshes, and hermetically storing for later use;
uniformly mixing the pomegranate peel extract prepared in the step one, sodium lauryl sulfoacetate, potassium peroxymonosulfate composite salt and an acid source, adding an ethanol solution with the volume concentration of 20-100% to prepare a soft material, sieving with a 20-mesh sieve to granulate, drying the granules at 50 ℃ for 2-4 hours, and granulating the dried granules to prepare granules E; adding the alkali source, the lubricant and the aromatic agent prepared in the step I into the granules E, uniformly mixing to prepare a mixture H, then pressing into tablets, and controlling the environmental temperature to be 25 ℃ and the humidity to be 30% RH in the preparation process to prepare the denture cleaning tablet.
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| CN201910801677.8A CN112438914A (en) | 2019-08-28 | 2019-08-28 | Denture cleaning tablet and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557903A (en) * | 2022-03-11 | 2022-05-31 | 扬州美星口腔护理用品有限公司 | Denture cleaning tablet and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509704A (en) * | 2002-12-25 | 2004-07-07 | 朱素真 | Artificial tooth cleaning agent |
| JP2005154323A (en) * | 2003-11-25 | 2005-06-16 | Hosoda Shc:Kk | Antibacterial deodorant |
| WO2011157898A1 (en) * | 2010-06-18 | 2011-12-22 | Paernaenen Pirjo | A preparation for balancing the composition of the oral microbial flora |
| CN104688648A (en) * | 2013-12-05 | 2015-06-10 | 耿福能 | Oral composition and preparation method thereof |
| CN106109384A (en) * | 2016-08-05 | 2016-11-16 | 郭迎庆 | A kind of preparation method of denture cleansing agent |
| CN107184414A (en) * | 2017-05-11 | 2017-09-22 | 江苏苏沃尚新材料科技有限公司 | A kind of artificial tooth cleaning agent |
| CN108245436A (en) * | 2016-12-28 | 2018-07-06 | 斯特凡纳·博赫内克 | Trona tooth whitening gel without peroxide |
-
2019
- 2019-08-28 CN CN201910801677.8A patent/CN112438914A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1509704A (en) * | 2002-12-25 | 2004-07-07 | 朱素真 | Artificial tooth cleaning agent |
| JP2005154323A (en) * | 2003-11-25 | 2005-06-16 | Hosoda Shc:Kk | Antibacterial deodorant |
| WO2011157898A1 (en) * | 2010-06-18 | 2011-12-22 | Paernaenen Pirjo | A preparation for balancing the composition of the oral microbial flora |
| CN104688648A (en) * | 2013-12-05 | 2015-06-10 | 耿福能 | Oral composition and preparation method thereof |
| CN106109384A (en) * | 2016-08-05 | 2016-11-16 | 郭迎庆 | A kind of preparation method of denture cleansing agent |
| CN108245436A (en) * | 2016-12-28 | 2018-07-06 | 斯特凡纳·博赫内克 | Trona tooth whitening gel without peroxide |
| CN107184414A (en) * | 2017-05-11 | 2017-09-22 | 江苏苏沃尚新材料科技有限公司 | A kind of artificial tooth cleaning agent |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114557903A (en) * | 2022-03-11 | 2022-05-31 | 扬州美星口腔护理用品有限公司 | Denture cleaning tablet and preparation method thereof |
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