CN112424220A - 用于癌症诊断和治疗的方法和组合物 - Google Patents

用于癌症诊断和治疗的方法和组合物 Download PDF

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Publication number
CN112424220A
CN112424220A CN201980045963.4A CN201980045963A CN112424220A CN 112424220 A CN112424220 A CN 112424220A CN 201980045963 A CN201980045963 A CN 201980045963A CN 112424220 A CN112424220 A CN 112424220A
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CN
China
Prior art keywords
edb
binding
arg
binding peptide
cys
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201980045963.4A
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English (en)
Chinese (zh)
Inventor
U·沙欣
B·G·卢伊
N·萨洛蒙
J·维斯特胡贝-劳施
M·达内施达尔
H-U·施莫尔特
M·菲德勒
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Biotechnology Europe Inc
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Biotechnology Europe Inc
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Publication date
Application filed by Biotechnology Europe Inc filed Critical Biotechnology Europe Inc
Priority to CN202310907634.4A priority Critical patent/CN116987180A/zh
Publication of CN112424220A publication Critical patent/CN112424220A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
CN201980045963.4A 2018-06-08 2019-06-06 用于癌症诊断和治疗的方法和组合物 Pending CN112424220A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310907634.4A CN116987180A (zh) 2018-06-08 2019-06-06 用于癌症诊断和治疗的方法和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2018/065205 2018-06-08
PCT/EP2018/065205 WO2019233605A1 (en) 2018-06-08 2018-06-08 Compositions and methods for diagnosis and treatment of cancer
PCT/EP2019/064872 WO2019234190A1 (en) 2018-06-08 2019-06-06 Compositions and methods for diagnosis and treatment of cancer

Related Child Applications (1)

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CN202310907634.4A Division CN116987180A (zh) 2018-06-08 2019-06-06 用于癌症诊断和治疗的方法和组合物

Publications (1)

Publication Number Publication Date
CN112424220A true CN112424220A (zh) 2021-02-26

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CN201980045963.4A Pending CN112424220A (zh) 2018-06-08 2019-06-06 用于癌症诊断和治疗的方法和组合物
CN202310907634.4A Pending CN116987180A (zh) 2018-06-08 2019-06-06 用于癌症诊断和治疗的方法和组合物

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Country Status (10)

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US (2) US11673939B2 (https=)
EP (1) EP3802585A1 (https=)
JP (1) JP7466466B2 (https=)
KR (2) KR20240142617A (https=)
CN (2) CN112424220A (https=)
AU (1) AU2019282316B2 (https=)
BR (1) BR112020024034A2 (https=)
CA (1) CA3101246A1 (https=)
MX (1) MX2020013205A (https=)
WO (2) WO2019233605A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer
KR102649794B1 (ko) * 2020-10-19 2024-03-22 고려대학교 산학협력단 암 및/또는 뇌질환 바이오마커인 엑스트라-도메인 b 파이브로넥틴 및 이를 이용한 진단 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048161A1 (en) * 2005-05-05 2009-02-19 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US20140205599A1 (en) * 2010-12-27 2014-07-24 Maria Johanna J.E. Van Driel Polypeptide that binds aberrant cells and induces apoptosis
CN105121639A (zh) * 2013-04-11 2015-12-02 默克专利股份有限公司 衍生自MCoTI-II变体的人matriptase的高效力抑制剂
WO2017049009A1 (en) * 2015-09-15 2017-03-23 Genentech, Inc. Cystine knot scaffold platform
US20170218040A1 (en) * 2016-02-02 2017-08-03 Julio A. Camarero Palao Proteolically resistant cyclotides with angiotensin 1-7 like activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111302A1 (en) 2000-11-30 2002-08-15 Y. Tom Tang Novel nucleic acids and polypeptides
EP1892248A1 (en) * 2006-08-21 2008-02-27 Eidgenössische Technische Hochschule Zürich Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase
CA2741040C (en) * 2008-10-20 2015-09-22 Gwangju Institute Of Science And Technology Bipodal-peptide binder
WO2016022597A1 (en) * 2014-08-04 2016-02-11 Case Western Reserve University Targeting peptides and methods of use
WO2016146174A1 (en) 2015-03-17 2016-09-22 Biontech Ag Compositions and methods for diagnosis and treatment of cancer
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048161A1 (en) * 2005-05-05 2009-02-19 Valorisation Hsj, Societe En Commandite Cytokine receptor modulators and uses thereof
US20140205599A1 (en) * 2010-12-27 2014-07-24 Maria Johanna J.E. Van Driel Polypeptide that binds aberrant cells and induces apoptosis
CN105121639A (zh) * 2013-04-11 2015-12-02 默克专利股份有限公司 衍生自MCoTI-II变体的人matriptase的高效力抑制剂
WO2017049009A1 (en) * 2015-09-15 2017-03-23 Genentech, Inc. Cystine knot scaffold platform
US20170218040A1 (en) * 2016-02-02 2017-08-03 Julio A. Camarero Palao Proteolically resistant cyclotides with angiotensin 1-7 like activity

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BONNY GABY LUI等: "Targeting the tumor vasculature with engineered cystine-knot miniproteins", NATURE COMMUNICATIONS, vol. 11, no. 1 *
LIZHI CAO等: "Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo", PROC NATL ACAD SCI USA., vol. 109, no. 19, pages 7251 - 7256 *
OLGA AVRUTINA等: "Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II", BIOL CHEM., vol. 386, no. 12, pages 1301 - 1306, XP009178830, DOI: 10.1515/BC.2005.148 *
SHELLEY E ACKERMAN等: "Cystine-knot peptides: emerging tools for cancer imaging and therapy", EXPERT REV PROTEOMICS, vol. 11, no. 5, pages 561 - 572, XP055365048, DOI: 10.1586/14789450.2014.932251 *
ZHENG HAN等: "EDB Fibronectin Specific Peptide for Prostate Cancer Targeting", BIOCONJUG CHEM., vol. 26, no. 5, pages 830 - 838, XP055432466, DOI: 10.1021/acs.bioconjchem.5b00178 *

Also Published As

Publication number Publication date
JP2021526808A (ja) 2021-10-11
JP7466466B2 (ja) 2024-04-12
EP3802585A1 (en) 2021-04-14
US20210246191A1 (en) 2021-08-12
CN116987180A (zh) 2023-11-03
WO2019233605A1 (en) 2019-12-12
MX2020013205A (es) 2021-02-26
KR20210020006A (ko) 2021-02-23
BR112020024034A2 (pt) 2021-02-23
CA3101246A1 (en) 2019-12-12
US20240002471A1 (en) 2024-01-04
WO2019234190A1 (en) 2019-12-12
NZ770391A (en) 2024-09-27
KR20240142617A (ko) 2024-09-30
US11673939B2 (en) 2023-06-13
AU2019282316A1 (en) 2020-12-24
US12516104B2 (en) 2026-01-06
AU2019282316B2 (en) 2023-07-20

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