CN112423836A - 利用交变电场产生治疗癌症的系统和方法 - Google Patents

利用交变电场产生治疗癌症的系统和方法 Download PDF

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Publication number
CN112423836A
CN112423836A CN201980047095.3A CN201980047095A CN112423836A CN 112423836 A CN112423836 A CN 112423836A CN 201980047095 A CN201980047095 A CN 201980047095A CN 112423836 A CN112423836 A CN 112423836A
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China
Prior art keywords
electric field
alternating electric
operable
controller module
waveform
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Pending
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CN201980047095.3A
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English (en)
Chinese (zh)
Inventor
B·亨德里克斯
K·史密斯
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Dignity Health
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Dignity Health
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37235—Aspects of the external programmer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/37514—Brain implants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Electrotherapy Devices (AREA)
CN201980047095.3A 2018-07-17 2019-07-17 利用交变电场产生治疗癌症的系统和方法 Pending CN112423836A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862699146P 2018-07-17 2018-07-17
US62/699,146 2018-07-17
PCT/US2019/042197 WO2020018662A1 (en) 2018-07-17 2019-07-17 Systems and methods for treatment of cancer using alternating electric field generation

Publications (1)

Publication Number Publication Date
CN112423836A true CN112423836A (zh) 2021-02-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980047095.3A Pending CN112423836A (zh) 2018-07-17 2019-07-17 利用交变电场产生治疗癌症的系统和方法

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Country Link
US (3) US11565111B2 (enExample)
EP (1) EP3823714B1 (enExample)
JP (2) JP7384895B2 (enExample)
CN (1) CN112423836A (enExample)
AU (1) AU2019306571B2 (enExample)
CA (1) CA3104885A1 (enExample)
WO (1) WO2020018662A1 (enExample)

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US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
DK3474760T3 (da) 2016-06-27 2023-03-20 Galvanize Therapeutics Inc Generator og et kateter med en elektrode til at behandle en lungepassage
AU2018397478B2 (en) 2017-12-26 2024-11-07 Galvanize Therapeutics, Inc. Optimization of energy delivery for various applications
US11565111B2 (en) * 2018-07-17 2023-01-31 Dignity Health Systems and methods for treatment of cancer using alternating electric field generation
CA3147592A1 (en) 2019-07-16 2021-01-21 Galary, Inc. Treatment of the reproductive tract with pulsed electric fields
GB2604397A (en) 2021-03-05 2022-09-07 Qv Bioelectronics Ltd Cranial Prosthetic
GB2604400A (en) 2021-03-05 2022-09-07 Qv Bioelectronics Ltd Biphasic injectable electrode
WO2023168034A1 (en) * 2022-03-03 2023-09-07 Medtronic, Inc. Electrode configurations for electric field therapy
WO2024003713A1 (en) * 2022-06-27 2024-01-04 Novocure Gmbh Using a closed-loop technique to reduce electrosensation while treating a subject using alternating electric fields
US20250101406A1 (en) * 2022-09-23 2025-03-27 Novocure Gmbh 3d models for predicting treatment responses to alternating electric fields
CN119455251A (zh) * 2024-11-05 2025-02-18 海南派云科技有限公司 一种基于多模式的肿瘤治疗电场调节系统

Citations (17)

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US20020010408A1 (en) * 1996-09-30 2002-01-24 Pomatto Jeanne K. Manufacture of cranial remodeling orthosis
JP2007521076A (ja) * 2003-06-26 2007-08-02 ノーススター ニューロサイエンス インコーポレイテッド 患者に電気刺激を印加するための装置及びシステム
US20070203539A1 (en) * 2006-02-24 2007-08-30 Medtronic, Inc. User interface with 2D views for configuring stimulation therapy
US20100070009A1 (en) * 2008-09-15 2010-03-18 Boston Scientific Neuromodulation Corporation Implantable electric stimulation system and methods of making and using
US20110313236A1 (en) * 2008-11-21 2011-12-22 Ucl Busines Plc Method and apparatus for performing deep brain stimulation with an electric field
US20120150256A1 (en) * 2009-07-30 2012-06-14 Sapiens Steering Brain Stimulation B.V. System and Method for Deep Brain Stimulation
US20120203307A1 (en) * 1999-04-09 2012-08-09 Schroeppel Edward A Method and device for treating abnormal tissue growth with electrical therapy
US20120259382A1 (en) * 2011-04-07 2012-10-11 Greatbatch, Ltd. Charge balancing for arbitrary waveform generator & neural stimulation application
US20120265261A1 (en) * 2009-04-13 2012-10-18 Marom Bikson Neurocranial Electrostimulation Models, Systems, Devices, and Methods
WO2015010682A1 (de) * 2013-07-23 2015-01-29 König Florian M Nachbildung und erweiterung von naturnahen sferics-signalfolgen als elektromagnetisches wechselfeld
WO2016179712A1 (en) * 2015-05-14 2016-11-17 London Health Sciences Centre Research Inc. Intratumoral modulation therapy
US20160354142A1 (en) * 2009-03-31 2016-12-08 Angiodynamics, Inc. System and Method for Estimating A Treatment Region for a Medical Treatment Device
US20170120041A1 (en) * 2015-10-28 2017-05-04 Novocure Limited TTField Treatment with Optimization of Electrode Positions on the Head Based on MRI-Based Conductivity Measurements
CN106823140A (zh) * 2017-01-14 2017-06-13 北京品驰医疗设备有限公司 一种可调整电场方向的骶神经刺激器
WO2018057953A2 (en) * 2016-09-23 2018-03-29 Beth Isreal Deaconess Medical Center, Inc. System and methods for cancer treatment using alternating electric fields
JP2018516149A (ja) * 2015-05-31 2018-06-21 サルーダ・メディカル・ピーティーワイ・リミテッド 脳神経刺激装置電極の取付け
US20180178013A1 (en) * 2015-06-02 2018-06-28 Battelle Memorial Institute Closed loop deep brain stimulation systems and methods

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US20080046023A1 (en) * 2006-08-16 2008-02-21 Fischell David R Electrode switch for a brain neuropacemaker
US11565111B2 (en) 2018-07-17 2023-01-31 Dignity Health Systems and methods for treatment of cancer using alternating electric field generation

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010408A1 (en) * 1996-09-30 2002-01-24 Pomatto Jeanne K. Manufacture of cranial remodeling orthosis
US20120203307A1 (en) * 1999-04-09 2012-08-09 Schroeppel Edward A Method and device for treating abnormal tissue growth with electrical therapy
JP2007521076A (ja) * 2003-06-26 2007-08-02 ノーススター ニューロサイエンス インコーポレイテッド 患者に電気刺激を印加するための装置及びシステム
US20070203539A1 (en) * 2006-02-24 2007-08-30 Medtronic, Inc. User interface with 2D views for configuring stimulation therapy
US20100070009A1 (en) * 2008-09-15 2010-03-18 Boston Scientific Neuromodulation Corporation Implantable electric stimulation system and methods of making and using
US20110313236A1 (en) * 2008-11-21 2011-12-22 Ucl Busines Plc Method and apparatus for performing deep brain stimulation with an electric field
US20160354142A1 (en) * 2009-03-31 2016-12-08 Angiodynamics, Inc. System and Method for Estimating A Treatment Region for a Medical Treatment Device
US20120265261A1 (en) * 2009-04-13 2012-10-18 Marom Bikson Neurocranial Electrostimulation Models, Systems, Devices, and Methods
JP2013500115A (ja) * 2009-07-30 2013-01-07 サピエンス ステアリング ブレイン スティムレーション ベー ヴィ 脳深部刺激用システムおよび方法
US20120150256A1 (en) * 2009-07-30 2012-06-14 Sapiens Steering Brain Stimulation B.V. System and Method for Deep Brain Stimulation
US20120259382A1 (en) * 2011-04-07 2012-10-11 Greatbatch, Ltd. Charge balancing for arbitrary waveform generator & neural stimulation application
WO2015010682A1 (de) * 2013-07-23 2015-01-29 König Florian M Nachbildung und erweiterung von naturnahen sferics-signalfolgen als elektromagnetisches wechselfeld
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US20170120041A1 (en) * 2015-10-28 2017-05-04 Novocure Limited TTField Treatment with Optimization of Electrode Positions on the Head Based on MRI-Based Conductivity Measurements
WO2018057953A2 (en) * 2016-09-23 2018-03-29 Beth Isreal Deaconess Medical Center, Inc. System and methods for cancer treatment using alternating electric fields
CN106823140A (zh) * 2017-01-14 2017-06-13 北京品驰医疗设备有限公司 一种可调整电场方向的骶神经刺激器

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Publication number Publication date
EP3823714A1 (en) 2021-05-26
CA3104885A1 (en) 2020-01-23
AU2019306571B2 (en) 2024-06-20
US20230149713A1 (en) 2023-05-18
US20210308455A1 (en) 2021-10-07
AU2019306571A1 (en) 2021-01-21
US20250144424A1 (en) 2025-05-08
JP2021531090A (ja) 2021-11-18
EP3823714B1 (en) 2025-05-07
WO2020018662A1 (en) 2020-01-23
JP2023184733A (ja) 2023-12-28
JP7384895B2 (ja) 2023-11-21
EP3823714A4 (en) 2022-04-20
US11565111B2 (en) 2023-01-31
US12214196B2 (en) 2025-02-04

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