CA3104885A1 - Systems and methods for treatment of cancer using alternating electric field generation - Google Patents
Systems and methods for treatment of cancer using alternating electric field generation Download PDFInfo
- Publication number
- CA3104885A1 CA3104885A1 CA3104885A CA3104885A CA3104885A1 CA 3104885 A1 CA3104885 A1 CA 3104885A1 CA 3104885 A CA3104885 A CA 3104885A CA 3104885 A CA3104885 A CA 3104885A CA 3104885 A1 CA3104885 A1 CA 3104885A1
- Authority
- CA
- Canada
- Prior art keywords
- electric field
- alternating electric
- operable
- deep
- electrodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000005684 electric field Effects 0.000 title claims abstract description 68
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000011282 treatment Methods 0.000 title claims abstract description 18
- 206010028980 Neoplasm Diseases 0.000 title claims description 13
- 201000011510 cancer Diseases 0.000 title claims description 11
- 208000003174 Brain Neoplasms Diseases 0.000 claims abstract description 5
- 210000004556 brain Anatomy 0.000 claims description 33
- 238000012545 processing Methods 0.000 claims description 12
- 238000004891 communication Methods 0.000 claims description 8
- 238000004088 simulation Methods 0.000 claims description 8
- 238000005457 optimization Methods 0.000 claims description 7
- 230000004936 stimulating effect Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 210000003484 anatomy Anatomy 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000001951 dura mater Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000013551 empirical research Methods 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
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- 231100000475 skin irritation Toxicity 0.000 description 1
- 231100000046 skin rash Toxicity 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0531—Brain cortex electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36002—Cancer treatment, e.g. tumour
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36146—Control systems specified by the stimulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37235—Aspects of the external programmer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/375—Constructional arrangements, e.g. casings
- A61N1/37514—Brain implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862699146P | 2018-07-17 | 2018-07-17 | |
| US62/699,146 | 2018-07-17 | ||
| PCT/US2019/042197 WO2020018662A1 (en) | 2018-07-17 | 2019-07-17 | Systems and methods for treatment of cancer using alternating electric field generation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3104885A1 true CA3104885A1 (en) | 2020-01-23 |
Family
ID=69164762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3104885A Pending CA3104885A1 (en) | 2018-07-17 | 2019-07-17 | Systems and methods for treatment of cancer using alternating electric field generation |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11565111B2 (enExample) |
| EP (1) | EP3823714B1 (enExample) |
| JP (2) | JP7384895B2 (enExample) |
| CN (1) | CN112423836A (enExample) |
| AU (1) | AU2019306571B2 (enExample) |
| CA (1) | CA3104885A1 (enExample) |
| WO (1) | WO2020018662A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| DK3474760T3 (da) | 2016-06-27 | 2023-03-20 | Galvanize Therapeutics Inc | Generator og et kateter med en elektrode til at behandle en lungepassage |
| AU2018397478B2 (en) | 2017-12-26 | 2024-11-07 | Galvanize Therapeutics, Inc. | Optimization of energy delivery for various applications |
| US11565111B2 (en) * | 2018-07-17 | 2023-01-31 | Dignity Health | Systems and methods for treatment of cancer using alternating electric field generation |
| CA3147592A1 (en) | 2019-07-16 | 2021-01-21 | Galary, Inc. | Treatment of the reproductive tract with pulsed electric fields |
| GB2604397A (en) | 2021-03-05 | 2022-09-07 | Qv Bioelectronics Ltd | Cranial Prosthetic |
| GB2604400A (en) | 2021-03-05 | 2022-09-07 | Qv Bioelectronics Ltd | Biphasic injectable electrode |
| WO2023168034A1 (en) * | 2022-03-03 | 2023-09-07 | Medtronic, Inc. | Electrode configurations for electric field therapy |
| WO2024003713A1 (en) * | 2022-06-27 | 2024-01-04 | Novocure Gmbh | Using a closed-loop technique to reduce electrosensation while treating a subject using alternating electric fields |
| US20250101406A1 (en) * | 2022-09-23 | 2025-03-27 | Novocure Gmbh | 3d models for predicting treatment responses to alternating electric fields |
| CN119455251A (zh) * | 2024-11-05 | 2025-02-18 | 海南派云科技有限公司 | 一种基于多模式的肿瘤治疗电场调节系统 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6340353B1 (en) * | 1996-09-30 | 2002-01-22 | Jeanne K. Pomatto | Manufacture of cranial remodeling orthosis |
| US20050021118A1 (en) | 2000-07-13 | 2005-01-27 | Chris Genau | Apparatuses and systems for applying electrical stimulation to a patient |
| EP1515775A4 (en) * | 2002-05-07 | 2010-03-03 | Oncostim Inc | METHOD AND DEVICE FOR TREATING CANCER WITH ELECTROTHERAPY ASSOCIATED WITH CHEMOTHERAPEAN MEDICAMENTS AND RADIOTHERAPY |
| US7826902B2 (en) * | 2006-02-24 | 2010-11-02 | Medtronic, Inc. | User interface with 2D views for configuring stimulation therapy |
| US20080046023A1 (en) * | 2006-08-16 | 2008-02-21 | Fischell David R | Electrode switch for a brain neuropacemaker |
| US8364284B2 (en) * | 2008-09-15 | 2013-01-29 | Boston Scientific Neuromodulation Corporation | Implantable electric stimulation system and methods of making and using |
| GB0821325D0 (en) * | 2008-11-21 | 2008-12-31 | Ucl Business Plc | Method and apparatus for performing deep brain stimulation with an electric field |
| EP2413833A1 (en) * | 2009-03-31 | 2012-02-08 | AngioDynamics, Inc. | System and method for estimating a treatment region for a medical treatment device and for interactively planning a treatment of a patient |
| WO2010120823A2 (en) * | 2009-04-13 | 2010-10-21 | Research Foundation Of The City University Of New York | Neurocranial electrostimulation models, systems, devices and methods |
| US9119543B2 (en) * | 2009-07-30 | 2015-09-01 | Medtronic Bakken Research Center B.V. | System and method for deep brain stimulation |
| US8996115B2 (en) * | 2011-04-07 | 2015-03-31 | Greatbatch, Ltd. | Charge balancing for arbitrary waveform generator and neural stimulation application |
| DE112014003405A5 (de) * | 2013-07-23 | 2016-05-19 | Florian König Enterprises Gmbh | Nachbildung und Erweiterung von naturnahen Sferics-Signalfolgen als elektromagnetisches Wechselfeld |
| US11167133B2 (en) * | 2015-05-14 | 2021-11-09 | London Health Sciences Centre Research Inc. | Intratumoral modulation therapy |
| CA2983333C (en) | 2015-05-31 | 2023-09-19 | Saluda Medical Pty Ltd | Brain neurostimulator electrode fitting |
| WO2016196790A1 (en) * | 2015-06-02 | 2016-12-08 | Battelle Memorial Institute | Closed loop deep brain stimulation systems and methods |
| US10188851B2 (en) | 2015-10-28 | 2019-01-29 | Novocure Limited | TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements |
| WO2018057953A2 (en) | 2016-09-23 | 2018-03-29 | Beth Isreal Deaconess Medical Center, Inc. | System and methods for cancer treatment using alternating electric fields |
| CN106823140B (zh) * | 2017-01-14 | 2023-03-03 | 北京品驰医疗设备有限公司 | 一种可调整电场方向的骶神经刺激器 |
| US11565111B2 (en) | 2018-07-17 | 2023-01-31 | Dignity Health | Systems and methods for treatment of cancer using alternating electric field generation |
-
2019
- 2019-07-17 US US17/260,019 patent/US11565111B2/en active Active
- 2019-07-17 CA CA3104885A patent/CA3104885A1/en active Pending
- 2019-07-17 EP EP19837750.9A patent/EP3823714B1/en active Active
- 2019-07-17 AU AU2019306571A patent/AU2019306571B2/en active Active
- 2019-07-17 WO PCT/US2019/042197 patent/WO2020018662A1/en not_active Ceased
- 2019-07-17 JP JP2021501284A patent/JP7384895B2/ja active Active
- 2019-07-17 CN CN201980047095.3A patent/CN112423836A/zh active Pending
-
2023
- 2023-01-18 US US18/155,849 patent/US12214196B2/en active Active
- 2023-11-09 JP JP2023191834A patent/JP2023184733A/ja active Pending
-
2025
- 2025-01-08 US US19/013,920 patent/US20250144424A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3823714A1 (en) | 2021-05-26 |
| AU2019306571B2 (en) | 2024-06-20 |
| US20230149713A1 (en) | 2023-05-18 |
| US20210308455A1 (en) | 2021-10-07 |
| AU2019306571A1 (en) | 2021-01-21 |
| US20250144424A1 (en) | 2025-05-08 |
| JP2021531090A (ja) | 2021-11-18 |
| EP3823714B1 (en) | 2025-05-07 |
| WO2020018662A1 (en) | 2020-01-23 |
| JP2023184733A (ja) | 2023-12-28 |
| JP7384895B2 (ja) | 2023-11-21 |
| EP3823714A4 (en) | 2022-04-20 |
| US11565111B2 (en) | 2023-01-31 |
| US12214196B2 (en) | 2025-02-04 |
| CN112423836A (zh) | 2021-02-26 |
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