CN112402286A - Sunscreen cream and preparation method thereof - Google Patents
Sunscreen cream and preparation method thereof Download PDFInfo
- Publication number
- CN112402286A CN112402286A CN202011356089.7A CN202011356089A CN112402286A CN 112402286 A CN112402286 A CN 112402286A CN 202011356089 A CN202011356089 A CN 202011356089A CN 112402286 A CN112402286 A CN 112402286A
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- CN
- China
- Prior art keywords
- parts
- mass
- sunscreen
- mixture
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 73
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 55
- 239000006071 cream Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 150000008442 polyphenolic compounds Chemical class 0.000 claims abstract description 45
- 235000013824 polyphenols Nutrition 0.000 claims abstract description 45
- 229920001661 Chitosan Polymers 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims abstract description 15
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 claims abstract description 15
- 150000001413 amino acids Chemical class 0.000 claims abstract description 15
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims abstract description 15
- 241000196324 Embryophyta Species 0.000 claims abstract description 12
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 12
- 239000000341 volatile oil Substances 0.000 claims abstract description 12
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 10
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000004519 grease Substances 0.000 claims abstract description 9
- 239000003906 humectant Substances 0.000 claims abstract description 9
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 49
- 238000003756 stirring Methods 0.000 claims description 38
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 23
- 238000010438 heat treatment Methods 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 9
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 235000006708 antioxidants Nutrition 0.000 claims description 8
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 8
- 239000010666 rose oil Substances 0.000 claims description 8
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 8
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 7
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 7
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 claims description 7
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 7
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 7
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 7
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 claims description 7
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- 239000010619 basil oil Substances 0.000 claims description 5
- 229940018006 basil oil Drugs 0.000 claims description 5
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 5
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- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 5
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- 239000010668 rosemary oil Substances 0.000 claims description 5
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims description 4
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- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 4
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- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 235000019337 sorbitan trioleate Nutrition 0.000 claims description 4
- 229960000391 sorbitan trioleate Drugs 0.000 claims description 4
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 claims description 4
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- 239000011718 vitamin C Substances 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 3
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
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- 229940075529 glyceryl stearate Drugs 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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Abstract
The invention belongs to the technical field of sunscreen cream, and discloses sunscreen cream and a preparation method thereof. The sunscreen cream provided by the invention comprises the following components in parts by mass: 0.5-5 parts of tea polyphenol, 1-6 parts of barbaloin, 0.5-8 parts of apple polyphenol, 2-10 parts of mycosporine-like amino acid, 0.5-8 parts of chitosan, 2-8 parts of emulsifier, 10-45 parts of grease, 0.5-6 parts of humectant, 1-5 parts of film forming agent, 0.1-2 parts of aromatic plant essential oil, 0.2-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-3 parts of other auxiliary agent and 10-60 parts of water. The sunscreen cream disclosed by the invention adopts a natural sunscreen agent, and does not use an organic sunscreen agent and an inorganic sunscreen agent, so that the sunscreen cream is friendly to the marine environment, does not generate pollution, has a good protection effect on ultraviolet rays, is lasting and stable in sunscreen effect, and has certain moisturizing and antioxidant skin care effects.
Description
Technical Field
The invention relates to the technical field of sunscreen cream, in particular to sunscreen cream and a preparation method thereof.
Background
With the rapid development of industrialization process, the environment is affecting human beings, such as the destruction of the ozone layer, resulting in the increasing of ultraviolet rays reaching the earth's surface. Excessive ultraviolet radiation is not good for human health, and when the ultraviolet radiation is exposed to the environment for a long time, mild people cause sunburn of the skin, and severe people may have erythema, even sunburn, skin cancer and the like. With the increasing awareness of the ultraviolet hazard, sunscreen products have become a daily necessity for personal care.
In the using and production process of the sunscreen product, the sunscreen agent used in the sunscreen product inevitably enters coastal water areas through various ways (such as discharge of a sewage treatment plant, runoff input, entertainment activities in water and the like), brings a considerable threat to marine ecological environment, and becomes a novel marine pollutant. Among them, coastal tourism and marine tourism are the fastest developing parts in the global tourism industry, and marine recreational activities such as swimming in a sea water bathing place, diving, surfing and the like are the most direct ways for the sunscreen agent to enter the marine environment.
The sunscreens currently used in sunscreen products are mainly classified into two categories: inorganic sunscreens and organic sunscreens. Researches show that the most commonly used inorganic sun-screening agents (such as nano titanium dioxide and nano zinc oxide) have the characteristics of small particle size, large specific surface area, strong adsorption capacity, difficult water dissolution and the like, are easy to aggregate and deposit, and show toxic mechanisms such as oxidation damage, physical damage, ion release and the like; the organic sun-screening agents (BP-3, 4-MBC, EHMC and the like) have the characteristics of strong lipid solubility, easy biological accumulation and the like, show negative effects of oxidative damage, endocrine disturbance, neurotoxicity, biological accumulation and the like, have obvious toxic effect on various marine organisms (bacteria, fishes, algae, shellfish, corals and the like) and damage the whole marine ecosystem.
In the prior art, the research on environment-friendly sunscreen products without using inorganic sunscreens and organic sunscreens is less, and the number of alternative environment-friendly sunscreen products on the market is less. Therefore, the new green and environment-friendly sun cream is provided, a plurality of choices are provided for the market, the promotion of the environment-friendly sun cream is promoted, and the problem to be solved by the research personnel in the field is further reduced in the pollution of the conventional sun cream to the environment.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention mainly aims to provide the environment-friendly sunscreen cream which does not contain organic sunscreen agents and inorganic sunscreen agents and has good UVA and UVB resisting effects.
The invention also aims to provide a preparation method of the sunscreen cream.
In order to achieve the purpose, the invention adopts the following technical scheme:
the sunscreen cream comprises the following components in parts by mass: 0.5-5 parts of tea polyphenol, 1-6 parts of barbaloin, 0.5-8 parts of apple polyphenol, 2-10 parts of mycosporine-like amino acid, 0.5-8 parts of chitosan, 2-8 parts of emulsifier, 10-45 parts of grease, 0.5-6 parts of humectant, 1-5 parts of film forming agent, 0.1-2 parts of aromatic plant essential oil, 0.2-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-3 parts of other auxiliary agent and 10-60 parts of water.
Preferably, the sunscreen cream comprises the following components in parts by mass: 2-5 parts of tea polyphenol, 3-6 parts of barbaloin, 5-8 parts of apple polyphenol, 3-8 parts of mycosporine-like amino acid, 2-5 parts of chitosan, 2-6 parts of emulsifier, 20-40 parts of grease, 2-5 parts of humectant, 2-4 parts of film forming agent, 0.1-1 part of aromatic plant essential oil, 0.5-1 part of antioxidant, 0.1-0.5 part of pH regulator, 0.5-3 parts of other additives and 20-50 parts of water.
Preferably, the sunscreen cream comprises the following components in parts by mass: 4 parts of tea polyphenol, 5 parts of barbaloin, 6 parts of apple polyphenol, 8 parts of mycosporine-like amino acid, 5 parts of chitosan, 6 parts of emulsifier, 30 parts of grease, 4 parts of humectant, 3 parts of film forming agent, 1 part of aromatic plant essential oil, 0.5 part of antioxidant, 0.2 part of pH regulator, 3 parts of other auxiliary agents and 45 parts of water.
Preferably, the average molecular weight of the chitosan is 30-80 KDa, and the deacetylation degree is 70-85%.
Preferably, the tea polyphenol, the apple polyphenol and the chitosan are added after being prepared into a tea polyphenol-apple polyphenol-chitosan compound.
Preferably, the preparation method of the tea polyphenol-apple polyphenol-chitosan compound comprises the following steps: dispersing chitosan in water to obtain a chitosan dispersion solution, adding tea polyphenol, apple polyphenol and a carbodiimide crosslinking agent into absolute ethyl alcohol, stirring for 1-2 hours at 0-4 ℃, then adding N-hydroxysuccinimide, stirring for 1-2 hours at 0-4 ℃ to obtain a mixed solution, slowly adding the chitosan dispersion solution into the mixed solution, stirring for 1-2 hours at 0-4 ℃, stirring for 20-24 hours at room temperature, dialyzing, and freeze-drying to obtain the tea polyphenol-apple polyphenol-chitosan composite.
Preferably, the mass concentration of chitosan in the chitosan dispersion liquid is 0.5-3 wt%.
Preferably, the mass ratio of the tea polyphenol to the apple polyphenol to the carbodiimide to the N-hydroxysuccinimide is (2-6): (2-6): (1-2): (1-2).
Preferably, the mass concentration of the tea polyphenol in the mixed solution is 0.1-3 wt%
Preferably, the dialysis is performed by using a dialysis bag with a molecular weight of 3000Da and is dialyzed for 2-3 days by using deionized water.
Preferably, the grease comprises at least one of dioctyl carbonate, C12-15 alcohol benzoate, polydimethylsiloxane, phenyl trimethicone, cetostearyl alcohol and the like.
Preferably, the emulsifier includes at least one of polyhydroxystearic acid, potassium cetyl phosphate, PEG-100 stearate, polysorbate-20, sorbitan trioleate, decyl glucoside, glyceryl stearate, and the like.
More preferably, the emulsifier is prepared by compounding polyhydroxystearic acid, potassium cetyl phosphate, PEG-100 stearate, polysorbate-20, sorbitan trioleate and decyl glucoside.
Preferably, the humectant comprises at least one of glycerin, propylene glycol, butylene glycol, sodium hyaluronate, fibroin, sodium alginate and the like.
Preferably, the aromatic plant essential oil comprises at least one of rose oil, tea tree oil, rosemary oil, lavender oil, basil oil, peppermint oil, and the like.
More preferably, the aromatic plant essential oil is a compound oil of rose oil, tea tree oil, rosemary oil, lavender oil, basil oil and peppermint oil, and the mass ratio of the compound oil is (2-5): (3-6): (4-6): (3-5): (2-3): (1-3), under a compound system, the essential oils have a better ultraviolet absorption effect and an antioxidant effect under the synergistic effect, and the sun protection effect of the sunscreen cream is improved.
Preferably, the film forming agent includes at least one of polyvinylpyrrolidone, hydroxypropyl cellulose, and the like.
Preferably, the pH regulator is at least one of sodium hydroxide, disodium ethylene diamine tetraacetate and the like.
Preferably, the other auxiliary agent may include at least one of a skin feel modifier, a thickener, an emulsion stabilizer, and the like.
Preferably, the skin feel modifier may comprise silica.
Preferably, the emulsion stabilizer may include polyacrylate-13.
Preferably, the thickener may include at least one of polyisobutylene, xanthan gum, and the like.
Preferably, the antioxidant is at least one of tocopherol, vitamin C, carotenoid, coenzyme Q10, and the like.
The invention also provides a preparation method of the environment-friendly sunscreen cream, which comprises the following steps:
(1) under the condition of normal temperature, adding tea polyphenol, barbaloin, apple polyphenol, mycosporine-like amino acid and chitosan into a part of water according to a proportion, and uniformly mixing to obtain a mixture A;
(2) adding an emulsifier, a film-forming agent and a humectant into the rest water, uniformly mixing to obtain a mixture B, and heating to 75-80 ℃;
(3) uniformly mixing the grease and other auxiliaries to obtain a mixture C, and heating to 75-80 ℃;
(4) slowly adding the mixture C into the mixture B at 75-80 ℃, homogenizing for 3-5 min, continuously stirring for 20-40 min, cooling to below 40 ℃, continuously adding the mixture A, the antioxidant, the aromatic plant essential oil and the pH regulator, and uniformly mixing to obtain the novel environment-friendly sunscreen cream.
Preferably, the tea polyphenol, the apple polyphenol and the chitosan in the step (1) can be prepared into a tea polyphenol-apple polyphenol-chitosan compound and then added; the method specifically comprises the following steps: preparing tea polyphenol, apple polyphenol and chitosan into a tea polyphenol-apple polyphenol-chitosan compound according to a proportion; and then under the condition of normal temperature, adding the barbaloin, the mycosporine-like amino acid and the tea polyphenol-apple polyphenol-chitosan compound into a part of water according to a proportion, and uniformly mixing to obtain a mixture A.
Compared with the prior art, the invention has the following advantages and technical effects:
(1) the sunscreen cream provided by the invention adopts a natural sunscreen agent, and no organic sunscreen agent or inorganic sunscreen agent is used, so that the influence on a marine ecosystem is reduced, the sunscreen cream is more green and environment-friendly, the selected natural sunscreen agent can greatly absorb ultraviolet rays, namely tea polyphenol has strong absorption at 280-315 nm; the aloin has strong absorption within 290-320 nm; the apple polyphenol has strong absorption at 200-300 nm; the maximum absorption wavelength of the mycosporine-like amino acid is 310-360 nm, so that the sunscreen cream has the effects of resisting UVA and UVB, and has the advantages of resisting inflammation, resisting allergy, repairing and relieving after-sun, degradability, environmental friendliness and the like.
(2) The chitosan adopted by the invention has good antibacterial and antiseptic effects, and no antiseptic is required to be additionally adopted.
(3) The addition of the aromatic plant essential oil can bring rich and various olfactory feelings to people, and has good biological activity, and the sun cream provided by the invention mainly has the following three functions: 1) the sunscreen cream has an absorption effect on ultraviolet rays, and can improve the sunscreen effect of the sunscreen cream; 2) the skin care product has good antioxidation effect, can remove free radicals to block signal conduction activated by the free radicals, and protects the skin from photodamage; 3) the sun cream is fragrant in smell, is natural plant perfume, and does not need to be added with essence.
(4) Because the apple polyphenol and the tea polyphenol can be decomposed under the long-time illumination condition, and the sun-screening effect of the sun-screening cream is reduced along with the prolonging of the time, the tea polyphenol, the apple polyphenol and the chitosan are prepared into the covalent compound for use in the preferred technical scheme of the invention, and the tea polyphenol-apple polyphenol-chitosan covalent compound has excellent light stability, thermal stability and better antioxidant effect, so that the sun-screening effect and sun-screening endurance of the sun-screening cream are further improved, and the coating times of the sun-screening cream are reduced.
Detailed Description
The present invention will be described in further detail with reference to specific examples, but the embodiments of the present invention are not limited thereto. All the raw materials and reagents used in the present invention are commercially available raw materials and reagents, unless otherwise specified. In the examples, the components are used in g and mL in parts by mass.
Example 1
(1) Adding 4 parts by mass of tea polyphenol, 5 parts by mass of barbaloin, 6 parts by mass of apple polyphenol, 8 parts by mass of mycosporine-like amino acid and 5 parts by mass of chitosan into 10 parts by mass of water at normal temperature, and stirring for 30min at 3000r/min to obtain a mixture A;
(2) adding 4 parts by mass of potassium cetyl phosphate, 1 part by mass of polyhydroxystearic acid, 1 part by mass of PEG-100 stearate, 2 parts by mass of polyvinylpyrrolidone, 1 part by mass of hydroxypropyl cellulose, 2 parts by mass of glycerol, 1 part by mass of propylene glycol and 1 part by mass of butanediol into 30 parts by mass of water, stirring for 30min at the condition of 3000r/min, homogenizing for 2min to obtain a mixture B, and heating to 75 ℃;
(3) stirring 10 parts by mass of dioctyl carbonate, 10 parts by mass of C12-15 alcohol benzoate, 10 parts by mass of cetearyl alcohol, 2 parts by mass of silica, 0.5 part by mass of polyacrylate-13 and 0.5 part by mass of xanthan gum for 30min at the condition of 3000 r/min. Homogenizing for 2min to obtain mixture C, and heating to 75 deg.C;
(4) slowly adding the mixture C into the mixture B at 75 ℃, homogenizing for 5min, continuously stirring for 30min under the condition of 3000r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.5 part by mass of tocopherol, 0.5 part by mass of rose oil, 0.5 part by mass of lavender oil, 0.1 part by mass of sodium hydroxide, 0.1 part by mass of disodium ethylene diamine tetraacetate, and continuously stirring for 30min under the condition of 3000r/min to obtain the novel environment-friendly sunscreen cream.
Example 2
(1) Adding 5 parts by mass of tea polyphenol, 3 parts by mass of barbaloin, 8 parts by mass of apple polyphenol, 5 parts by mass of mycosporine-like amino acid and 4 parts by mass of chitosan into 15 parts by mass of water at normal temperature, and stirring for 20min at 3500r/min to obtain a mixture A;
(2) adding 3 parts by mass of potassium cetyl phosphate, 0.5 part by mass of polysorbate-20, 0.5 part by mass of polyhydroxystearic acid, 1 part by mass of polyvinylpyrrolidone, 3 parts by mass of hydroxypropyl cellulose, 3 parts by mass of glycerol and 2 parts by mass of butanediol into 35 parts by mass of water, stirring for 20min at 3500r/min, homogenizing for 3min to obtain a mixture B, and heating to 80 ℃;
(3) stirring 5 parts by mass of dioctyl carbonate, 5 parts by mass of C12-15 alcohol benzoate, 10 parts by mass of cetostearyl alcohol, 1 part by mass of silica, 0.5 part by mass of polyacrylate-13 and 0.5 part by mass of xanthan gum for 30min under the condition of 3500r/min, homogenizing for 3min to obtain a mixture C, and heating to 80 ℃;
(4) slowly adding the mixture C into the mixture B at the temperature of 80 ℃, homogenizing for 4min, continuously stirring for 30min under the condition of 3500r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.2 part by mass of tocopherol, 0.2 part by mass of vitamin C, 0.1 part by mass of rose oil, 0.2 part by mass of tea tree oil, 0.2 part by mass of rosemary oil, 0.2 part by mass of sodium hydroxide, 0.1 part by mass of disodium ethylene diamine tetraacetate, and continuously stirring for 30min under the condition of 3500r/min to obtain the novel environment-friendly sunscreen cream.
Example 3
(1) Adding 2 parts by mass of tea polyphenol, 6 parts by mass of barbaloin, 5 parts by mass of apple polyphenol, 3 parts by mass of mycosporine-like amino acid and 2 parts by mass of chitosan into 5 parts by mass of water at normal temperature, and stirring for 20min at 3500r/min to obtain a mixture A;
(2) adding 1 part by mass of polyhydroxystearic acid, 1 part by mass of potassium cetyl phosphate, 3 parts by mass of polyvinylpyrrolidone, 1 part by mass of glycerol and 1 part by mass of sodium hyaluronate into 40 parts by mass of water, stirring for 20min at 3500r/min, homogenizing for 3min to obtain a mixture B, and heating to 80 ℃;
(3) 10 parts by mass of dioctyl carbonate, 5 parts by mass of C12-15 alcohol benzoate, 3 parts by mass of polydimethylsiloxane, 2 parts by mass of phenyl trimethicone, 20 parts by mass of cetearyl alcohol, 1.5 parts by mass of silica, 0.5 part by mass of polyacrylate-13, 0.5 part by mass of xanthan gum and 0.5 part by mass of polyisobutylene are stirred for 30min at 3500 r/min. Homogenizing for 3min to obtain mixture C, and heating to 80 deg.C;
(4) slowly adding the mixture C into the mixture B at the temperature of 80 ℃, homogenizing for 3min, continuously stirring for 40min under the condition of 3500r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.5 part by mass of tocopherol, 0.3 part by mass of vitamin C, 0.2 part by mass of carotenoid, 0.2 part by mass of rose oil, 0.1 part by mass of basil oil, 0.2 part by mass of peppermint oil, 0.4 part by mass of sodium hydroxide and 0.1 part by mass of disodium ethylene diamine tetraacetate, and continuously stirring for 40min under the condition of 3500r/min to obtain the novel environment-friendly sunscreen cream.
Example 4
(1) Adding 3 parts by mass of tea polyphenol, 4 parts by mass of barbaloin, 6 parts by mass of apple polyphenol, 5 parts by mass of mycosporine-like amino acid and 8 parts by mass of chitosan into 30 parts by mass of water at normal temperature, and stirring for 20min at 3500r/min to obtain a mixture A;
(2) adding 4 parts by mass of potassium cetyl phosphate, 2 parts by mass of polyhydroxystearic acid, 1 part by mass of PEG-100 stearate, 0.5 part by mass of decyl glucoside, 0.2 part by mass of polysorbate-20, 0.3 part by mass of sorbitan trioleate, 2 parts by mass of polyvinylpyrrolidone, 3 parts by mass of hydroxypropyl cellulose, 3 parts by mass of glycerol, 1 part by mass of propylene glycol, 1 part by mass of butanediol, 0.5 part by mass of sodium hyaluronate and 0.5 part by mass of sodium alginate into 30 parts by mass of water, stirring for 20min under the condition of 3500r/min, homogenizing for 3min to obtain a mixture B, and heating to 80 ℃;
(3) 20 parts by mass of dioctyl carbonate, 10 parts by mass of C12-15 alcohol benzoate, 5 parts by mass of polydimethylsiloxane, 5 parts by mass of phenyl trimethicone, 5 parts by mass of cetearyl alcohol, 1.5 parts by mass of silica, 0.5 part by mass of polyacrylate-13, 0.5 part by mass of xanthan gum and 0.5 part by mass of polyisobutylene are stirred for 30min at 3500 r/min. Homogenizing for 3min to obtain mixture C, and heating to 80 deg.C;
(4) slowly adding the mixture C into the mixture B at the temperature of 80 ℃, homogenizing for 4min, continuously stirring for 20min under the condition of 3500r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.5 part by mass of tocopherol, 0.2 part by mass of carotenoid, 0.3 part by mass of coenzyme Q10, 0.5 part by mass of rose oil, 0.4 part by mass of tea tree oil, 0.3 part by mass of rosemary oil, 0.3 part by mass of lavender oil, 0.3 part by mass of basil oil, 0.2 part by mass of peppermint oil, 0.8 part by mass of sodium hydroxide and 0.2 part by mass of disodium ethylene diamine tetraacetate, and continuously stirring for 40min under the condition of 3500r/min to obtain the novel environment-friendly sun cream.
Example 5
(1) Adding 0.5 mass part of tea polyphenol, 6 mass parts of barbaloin, 0.5 mass part of apple polyphenol, 10 mass parts of mycosporine-like amino acid and 0.5 mass part of chitosan into 5 mass parts of water at normal temperature, and stirring for 20min at 3500r/min to obtain a mixture A;
(2) adding 2 parts by mass of potassium cetyl phosphate, 1 part by mass of hydroxypropyl cellulose and 0.5 part by mass of glycerol into 5 parts by mass of water, stirring for 20min at 3500r/min, homogenizing for 3min to obtain a mixture B, and heating to 80 ℃;
(3) stirring 5 parts by mass of C12-15 alcohol benzoate, 5 parts by mass of cetostearyl alcohol, 0.2 part by mass of silica, 0.1 part by mass of polyacrylate-13 and 0.2 part by mass of xanthan gum at 3500r/min for 30min, homogenizing for 3min to obtain a mixture C, and heating to 80 ℃;
(4) slowly adding the mixture C into the mixture B at the temperature of 80 ℃, homogenizing for 2min, continuously stirring for 20min under the condition of 3500r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.2 part by mass of tocopherol, 0.1 part by mass of lavender oil and 0.1 part by mass of sodium hydroxide, and continuously stirring for 40min under the condition of 3500r/min to obtain the novel environment-friendly sun cream.
Example 6
(1) Dispersing 5 parts by mass of chitosan in 250 parts by volume of water to obtain chitosan dispersion, adding 5 parts by mass of tea polyphenol, 6 parts by mass of apple polyphenol and 1 part by mass of carbodiimide crosslinking agent into 200 parts by volume of absolute ethyl alcohol, stirring for 2 hours at 4 ℃, then adding 1 part by mass of N-hydroxysuccinimide, stirring for 2 hours at 4 ℃ to obtain mixed solution I, slowly adding the chitosan dispersion into the mixed solution I, stirring for 2 hours at 4 ℃, then stirring for 24 hours at room temperature to obtain mixed solution II, carrying out dialysis bag on the mixed solution II with the molecular weight of 3000Da, dialyzing for 2 days with water, and freeze-drying to obtain the tea polyphenol-apple polyphenol-chitosan composite.
(2) Adding 5 parts by mass of barbaloin and 8 parts by mass of mycosporine-like amino acid into 20 parts of water at normal temperature, and stirring at 3000r/min for 30min to obtain a mixture A;
(3) adding 4 parts by mass of potassium cetyl phosphate, 1 part by mass of polyhydroxystearic acid, 1 part by mass of PEG-100 stearate, 2 parts by mass of polyvinylpyrrolidone, 1 part by mass of hydroxypropyl cellulose, 2 parts by mass of glycerol, 1 part by mass of propylene glycol and 1 part by mass of butanediol into 30 parts by mass of water, stirring for 30min at the condition of 3000r/min, homogenizing for 2min to obtain a mixture B, and heating to 75 ℃;
(4) stirring 10 parts by mass of dioctyl carbonate, 10 parts by mass of C12-15 alcohol benzoate, 10 parts by mass of cetearyl alcohol, 2 parts by mass of silica, 0.5 part by mass of polyacrylate-13 and 0.5 part by mass of xanthan gum for 30min at the condition of 3000 r/min. Homogenizing for 2min to obtain mixture C, and heating to 75 deg.C;
(5) slowly adding the mixture C into the mixture B at 75 ℃, homogenizing for 5min, continuously stirring for 30min under the condition of 3000r/min, cooling to below 40 ℃, continuously adding the mixture A, 0.5 part by mass of tocopherol, 0.5 part by mass of rose oil, 0.5 part by mass of lavender oil, 0.1 part by mass of sodium hydroxide, 0.1 part by mass of disodium ethylene diamine tetraacetate, and continuously stirring for 30min under the condition of 3000r/min to obtain the novel environment-friendly sunscreen cream.
The UV absorbance values of the novel environmentally friendly sunscreen creams prepared in examples 1-6 and the commercially available sunscreen cream with SPF30PA + + + as comparative example 1 were determined by the following specific steps:
a breathable medical adhesive tape produced by 3M company is attached to one side surface of an absorption cell of 1cm in length, 8mg of a sample is weighed and attached to the adhesive tape on the surface of the absorption cell, the adhesive tape is uniformly coated, the absorption values of 280 nm-320 nm and 320-360 nm wave bands are measured on an ultraviolet spectrophotometer after the adhesive tape is placed for 30min to obtain average absorption values A1 and A2, then the absorption cells of examples 1-6 and comparative example 1 are placed under sunlight for 2h, the absorption values of 280 nm-320 nm and 320-360 nm wave bands are measured on the ultraviolet spectrophotometer again to obtain average absorption values A3 and A4.
The specific measurements are shown in Table 1.
TABLE 1 measurement of the absorbance values of the sunscreens of the different examples
| Absorbance value | A1 | A2 | A3 | A4 |
| Example 1 | 2.055 | 1.842 | 1.675 | 1.516 |
| Example 2 | 1.972 | 1.828 | 1.523 | 1.415 |
| Example 3 | 1.851 | 1.626 | 1.208 | 1.154 |
| Example 4 | 1.881 | 1.623 | 1.221 | 1.241 |
| Example 5 | 1.489 | 1.347 | 1.153 | 1.036 |
| Example 6 | 2.156 | 1.962 | 1.952 | 1.827 |
| Comparative example 1 | 1.965 | 1.724 | 1.487 | 1.297 |
As can be seen from the data in table 1, the novel environmentally friendly sunscreen cream provided by the present invention has good absorbance values in two absorption wavelengths, i.e., the sunscreen cream of the present invention has good UVA and UVB resistance effects at the same time, wherein examples 1 and 6 are preferred examples provided by the present invention; meanwhile, after 2 hours of sunlight irradiation, the absorbance values of the examples 1 to 5 and the comparative example 1 are obviously reduced, while the example 6 adopts the method that the tea polyphenol, the apple polyphenol and the chitosan are prepared into the covalent compound for use, and the absorbance value is not greatly changed after 2 hours of sunlight irradiation.
The above embodiments are the best mode for carrying out the present invention, but the embodiments of the present invention are not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be regarded as equivalent substitutions and are included in the scope of the present invention.
Claims (10)
1. The sunscreen cream is characterized by comprising the following components in parts by mass: 0.5-5 parts of tea polyphenol, 1-6 parts of barbaloin, 0.5-8 parts of apple polyphenol, 2-10 parts of mycosporine-like amino acid, 0.5-8 parts of chitosan, 2-8 parts of emulsifier, 10-45 parts of grease, 0.5-6 parts of humectant, 1-5 parts of film forming agent, 0.1-2 parts of aromatic plant essential oil, 0.2-1 part of antioxidant, 0.1-1 part of pH regulator, 0.1-3 parts of other auxiliary agent and 10-60 parts of water.
2. The sunscreen of claim 1, wherein: the grease comprises at least one of dioctyl carbonate, C12-15 alcohol benzoate, polydimethylsiloxane, phenyl trimethicone and cetearyl alcohol.
3. The sunscreen of claim 1, wherein: the emulsifier comprises at least one of polyhydroxystearic acid, potassium cetyl phosphate, PEG-100 stearate, polysorbate-20, sorbitan trioleate, decyl glucoside and glyceryl stearate.
4. The sunscreen of claim 1, wherein: the humectant comprises at least one of glycerol, propylene glycol, butanediol, sodium hyaluronate, fibroin and sodium alginate.
5. The sunscreen of claim 1, wherein: the aromatic plant essential oil comprises at least one of rose oil, tea tree oil, rosemary oil, lavender oil, basil oil, and peppermint oil.
6. The sunscreen of claim 1, wherein: the film forming agent comprises at least one of polyvinylpyrrolidone and hydroxypropyl cellulose.
7. The sunscreen of claim 1, wherein: the pH regulator is at least one of sodium hydroxide, disodium ethylene diamine tetraacetate and citric acid.
8. The sunscreen of claim 1, wherein: the antioxidant comprises at least one of tocopherol, vitamin C, carotenoid, and coenzyme Q10.
9. The sunscreen of claim 1, wherein: the other auxiliary agents comprise at least one of a skin feel regulator, a thickening agent and an emulsion stabilizer.
10. The preparation method of the sunscreen cream according to any one of claims 1 to 9, characterized by comprising the following steps:
(1) under the condition of normal temperature, adding tea polyphenol, barbaloin, apple polyphenol, mycosporine-like amino acid and chitosan into a part of water according to a proportion, and uniformly mixing to obtain a mixture A;
(2) adding an emulsifier, a film-forming agent and a humectant into the rest water, uniformly mixing to obtain a mixture B, and heating to 75-80 ℃;
(3) uniformly mixing the grease and other auxiliaries to obtain a mixture C, and heating to 75-80 ℃;
(4) slowly adding the mixture C into the mixture B at 75-80 ℃, homogenizing for 3-5 min, continuously stirring for 20-40 min, cooling to below 40 ℃, continuously adding the mixture A, the antioxidant, the aromatic plant essential oil and the pH regulator, and uniformly mixing to obtain the novel environment-friendly sunscreen cream.
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| CN113999525B (en) * | 2021-10-28 | 2023-06-30 | 东莞市骏青电子科技有限公司 | Ultraviolet-resistant protective film and preparation method thereof |
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