CN112386253A - 一种针对人体局部静脉血流参数的近红外光学检测方法 - Google Patents
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Abstract
本发明公开一种针对人体局部静脉血流参数的近红外光学检测方法；光电传感器由一个三波长(760nm，850nm，805nm)发光二极管和两个光电探测器组成；基于组织代谢中氧合与还原血红蛋白的不同光谱特性，根据光在组织中吸收与散射的规律，获得人体局部组织血氧参量；三波长发光二极管与两个光电探测器排列与一条直线上，并且光源与两个光电探测器的间距分别为30mm和40mm(成人)或20mm和30mm(儿童)。
Description
技术领域
本发明属于生物医学工程技术领域，涉及一种针对人体局部静脉血流参数的近红外光学检测方法；
背景技术
组织氧合和还原血红蛋白的浓度的监测有助于了解缺氧缺血脑病患者及手术过程中患者局部组织的血容量，对治疗效果评定有重要意义；基于光学测量的无创监测人体组织氧代谢状况稳定可靠，使用方便安全；本技术是利用近红外光谱对血液参数进行检测的一种检测方法，结合基于光谱分析的凝血分析、血流分析，构成对血液参数的床旁检测，形成对血栓、血流和血供的综合分析；
由于在近红外波段，人体组织中的氧合、还原血红蛋白是主要的吸收体，故一些研究者假定组织光密度的变化只是由还原、氧合血红蛋白浓度的变化导致；在基于这一假设的情况下，比较常用的算法为基于修正的两波长朗伯-比尔定律的组织血氧检测；但实际情况是组织内的其他色素成分也会对组织光密度变化造成影响，比如细胞色素氧化酶(cyt-aa3cytochrome，oxidase)，水分等等；虽然它们的含量较少，但是为了更精准的测量组织血氧，在实际应用中也希望将这些物质的变化引起的光密度变化消除掉，以提高测量系统的灵敏度和准确度；由于HbO2和Hb在波长805nm附近具有相等的消光系数，本专利提出近红外多光谱的组织血氧检测方法将波长为760nm与850nm的出射光密度差同时减去805nm的出射光密度差，可以消除掉背景吸收和外层组织对于测量结果的影响，进而提高系统的检测灵敏度和信噪比；
发明内容
本发明的目的是针对现有技术的不足，提供一种人体局部组织血氧参量的检测系统；
本发明系统包括三波长发光二极管LS、光电接收管OPT1、光电接收管OPT2；光电接收管OPT1与三波长发光二极管LS的水平距离为r1，光电接收管OPT2与三波长发光二极管LS的水平距离为r2；
三波长发光二极管与两个光电探测器排列与一条直线上，并且光源与两个光电探测器的间距分别为30mm和40mm(成人)或20mm和30mm(儿童)；
三波长发光二极管LS发出三个不同波长的光源；λ1＝760nm，λ2＝850nm，λ3＝805nm；
一种针对人体局部静脉血流参数的近红外光学检测方法包括如下步骤：
(1)在待测组织表面保持设定间距的两个位置上各安放一个光电接收管，分别为OPT1，OPT2；在上述两个光电接收管连线的延长线的一端，安放三个不同发光波长的发光二极管作为光源(LS)；
(2)发光二极管分时发出波长为λi的光，i＝1、2、3，用两个光电接收管OPT1，OPT2依次分别测量对应波长的散射光强值；
(3)利用光密度的计算公式，计算算出不同检测距离下，对应各个发光波长的光密度
以
为例：
其中
分别表示两个光电接收管OPT1和OPT2处的光密度；DPF表示深层组织中的部分差分路径因子，通过蒙特卡洛仿真和查表可获得；
(4)根据步骤(3)测定的
计算各个波长两个光电接收管OPT1和OPT2处的出射光密度差：
(5)在近红外光波段，可近似认为因子G与波长无关；将波长为760nm与850nm的出射光密度差同时减去805nm的出射光密度差，进而消除掉背景吸收和外层组织等干扰：
(6)根据步骤(5)计算氧合血红蛋白HbO2、还原血红蛋白Hb含量和局部组织氧饱和度rSO2：
本发明提出近红外多光谱的组织血氧检测方法将波长为760nm与850nm的出射光密度差同时减去805nm的出射光密度差，可以消除掉背景吸收和外层组织对于测量结果的影响，进而提高系统的检测灵敏度和信噪比；
附图说明
图1现有检测方法示意图；
图2本发明所述检测方法示意图；
图3本发明所述检测方法流程图；
具体实施方式
下面根据附图对本发明做进一步的分析；
图1现有检测方法示意图；
一种针对人体局部静脉血流参数的近红外光学检测方法包括如下步骤，如图3所示：
(1)在待测组织表面保持设定间距的两个位置上各安放一个光电接收管，分别为OPT1(检测器1)，OPT2(检测器2)；在上述两个光电接收管连线的延长线的一端，安放三个不同发光波长的发光二极管作为光源(LS)；如图2；
(2)发光二极管分时发出波长为λi的光，i＝1，2，3，用两个光电接收管OPT1，OPT2依次分别测量对应波长的散射光强值；
(3)利用光密度的计算公式，计算不同检测距离下，对应各个发光波长的光密度
其中
分别表示从左到右的两个光电接收管OPT1和OPT2处的光密度；DPF表示深层组织中的部分差分路径因子，通过蒙特卡洛仿真和查表可获得；
(4)根据步骤(3)测定的
计算各个波长两个光电接收管OPT1和OPT2处的出射光密度差：
(5)在近红外光波段，可近似认为因子G与波长无关；将波长为760nm与850nm的出射光密度差同时减去805nm的出射光密度差，进而消除掉背景吸收和外层组织等干扰：
(6)根据步骤(5)计算氧合血红蛋白HbO2、还原血红蛋白Hb含量和局部组织氧饱和度rSO2：
Claims (1)
1.一种针对人体局部静脉血流参数的近红外光学检测方法，包括以下步骤：
(1)在待测组织表面保持设定间距的两个位置上各安放一个光电接收管，分别为OPT1，OPT2；在上述两个光电接收管连线的延长线的一端，安放三个不同发光波长的发光二极管作为光源(LS)；
光电接收管OPT1与三波长发光二极管LS的水平距离为r1，光电接收管OPT2与三波长发光二极管LS的水平距离为r2；
(2)发光二极管分时发出波长为λi的光，i＝1、2、3，用两个光电接收管OPT1，OPT2依次分别测量对应波长的散射光强值；λ1＝760nm，λ2＝850nm，λ3＝805nm；
(3)利用光密度的计算公式，计算算出不同检测距离下，对应各个发光波长的光密度
以
为例：
其中
分别表示两个光电接收管OPT1和OPT2处的光密度；DPF表示深层组织中的部分差分路径因子，通过蒙特卡洛仿真和查表可获得；
(4)根据步骤(3)测定的
计算各个波长两个光电接收管OPT1和OPT2处的出射光密度差：
(5)在近红外光波段，可近似认为因子G与波长无关；将波长为760nm与850nm的出射光密度差同时减去805nm的出射光密度差，进而消除掉背景吸收和外层组织等干扰：
(6)根据步骤(5)计算氧合血红蛋白HbO2、还原血红蛋白Hb含量和局部组织氧饱和度rSO2：
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911172A (zh) * | 2006-08-25 | 2007-02-14 | 清华大学 | 人体组织氧合与还原血红蛋白浓度绝对量的检测方法 |
| CN101972148A (zh) * | 2010-11-19 | 2011-02-16 | 哈尔滨工业大学 | 基于经验模态分解的近红外脑功能检测的扰动消除方法 |
| CN107773217A (zh) * | 2017-09-29 | 2018-03-09 | 天津大学 | 活体组织微循环代谢动态测量装置及方法 |
| CN110013225A (zh) * | 2019-04-29 | 2019-07-16 | 河南大学 | 一种用于判别输尿管与血管的装置及方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1911172A (zh) * | 2006-08-25 | 2007-02-14 | 清华大学 | 人体组织氧合与还原血红蛋白浓度绝对量的检测方法 |
| CN101972148A (zh) * | 2010-11-19 | 2011-02-16 | 哈尔滨工业大学 | 基于经验模态分解的近红外脑功能检测的扰动消除方法 |
| CN107773217A (zh) * | 2017-09-29 | 2018-03-09 | 天津大学 | 活体组织微循环代谢动态测量装置及方法 |
| CN110013225A (zh) * | 2019-04-29 | 2019-07-16 | 河南大学 | 一种用于判别输尿管与血管的装置及方法 |
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