CN112372005B - Preparation method of collar buckle type artificial cornea - Google Patents
Preparation method of collar buckle type artificial cornea Download PDFInfo
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- CN112372005B CN112372005B CN202011064327.7A CN202011064327A CN112372005B CN 112372005 B CN112372005 B CN 112372005B CN 202011064327 A CN202011064327 A CN 202011064327A CN 112372005 B CN112372005 B CN 112372005B
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- 210000004087 cornea Anatomy 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 238000003754 machining Methods 0.000 claims abstract description 67
- 238000011282 treatment Methods 0.000 claims abstract description 38
- 238000004140 cleaning Methods 0.000 claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 238000004806 packaging method and process Methods 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 239000005022 packaging material Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 58
- 230000003287 optical effect Effects 0.000 claims description 24
- 229910052751 metal Inorganic materials 0.000 claims description 21
- 239000002184 metal Substances 0.000 claims description 21
- 238000005520 cutting process Methods 0.000 claims description 20
- 238000000137 annealing Methods 0.000 claims description 17
- 238000009826 distribution Methods 0.000 claims description 9
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 8
- 239000010936 titanium Substances 0.000 claims description 8
- 229910052719 titanium Inorganic materials 0.000 claims description 8
- 238000005553 drilling Methods 0.000 claims description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 5
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 5
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 5
- 238000005488 sandblasting Methods 0.000 claims description 5
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000001746 injection moulding Methods 0.000 claims description 3
- 230000001590 oxidative effect Effects 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000012797 qualification Methods 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 210000001508 eye Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 210000005252 bulbus oculi Anatomy 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 230000002980 postoperative effect Effects 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000007943 implant Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 238000007517 polishing process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- MZFIXCCGFYSQSS-UHFFFAOYSA-N silver titanium Chemical compound [Ti].[Ag] MZFIXCCGFYSQSS-UHFFFAOYSA-N 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23B—TURNING; BORING
- B23B5/00—Turning-machines or devices specially adapted for particular work; Accessories specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
- B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23B—TURNING; BORING
- B23B25/00—Accessories or auxiliary equipment for turning-machines
- B23B25/02—Arrangements for chip-breaking in turning-machines
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23B—TURNING; BORING
- B23B25/00—Accessories or auxiliary equipment for turning-machines
- B23B25/06—Measuring, gauging, or adjusting equipment on turning-machines for setting-on, feeding, controlling, or monitoring the cutting tools or work
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23Q—DETAILS, COMPONENTS, OR ACCESSORIES FOR MACHINE TOOLS, e.g. ARRANGEMENTS FOR COPYING OR CONTROLLING; MACHINE TOOLS IN GENERAL CHARACTERISED BY THE CONSTRUCTION OF PARTICULAR DETAILS OR COMPONENTS; COMBINATIONS OR ASSOCIATIONS OF METAL-WORKING MACHINES, NOT DIRECTED TO A PARTICULAR RESULT
- B23Q11/00—Accessories fitted to machine tools for keeping tools or parts of the machine in good working condition or for cooling work; Safety devices specially combined with or arranged in, or specially adapted for use in connection with, machine tools
- B23Q11/10—Arrangements for cooling or lubricating tools or work
Abstract
The invention discloses a preparation method of a collar buckle type artificial cornea, which is applied to the production process of the collar buckle type artificial cornea comprising a lens column, a back plate and a collar, and comprises the following steps: s1, preparing a processed blank, and inputting the processed blank into a numerical control lathe; s2, machining into a lens column, a rear plate and a clamping ring by using a numerical control lathe, deburring and cleaning; s3, drying treatment; s4, combining and packaging the lens column, the back plate and the clamping ring by using the cleaned packaging material to form a collar buckle type artificial cornea preoperative packaging kit; s5, sterilizing the collar buckle type artificial cornea preoperative packaging kit provided with the lens column, the rear plate and the collar. The invention can improve the precision and definition of the collar-buckle type artificial cornea, realize batch and standardized production of the collar-buckle type artificial cornea, greatly improve the production efficiency and the qualification rate of finished products, and reduce the risk of pollution and the risk of non-uniform accessories of the collar-buckle type artificial cornea in the preparation process.
Description
Technical Field
The invention relates to the technical field of biomedical engineering and artificial cornea production, in particular to a preparation method of a collar-buckle type artificial cornea.
Background
The optimization and industrial production of the domestic collarband type artificial cornea structure still needs to be developed and broken through. The collar buckle type artificial cornea comprises a lens column, a rear plate serving as a mounting bracket of the lens column and a clamping ring clamped on the outer side of one end part of the lens column. The lens post is made of a transparent material with excellent optical characteristics and stable physicochemical properties, and is used for replacing turbid cornea which obstructs an eyeball optical path after pathological changes, so that the lens post is required to have good optical resolution. The back plate is made of hard materials with better biocompatibility, the back plate is provided with a central through hole for installing a lens column, the central through hole has a supporting effect on a carrier cornea, so that the back plate can be attached to the cornea only by a certain curvature. In addition, the common artificial cornea preparation method also comprises 3D printing molding or mold casting integrated molding, the preparation process is relatively complicated, the preparation process is difficult to adapt to batch and standardized production, the preparation process is easy to be polluted, the product precision is low, and the rehabilitation difficulty is increased and the visual definition is reduced.
Disclosure of Invention
In view of the above, it is necessary to provide a method for preparing a collarband type artificial cornea, which can improve the precision and definition of the collarband type artificial cornea, realize batch and standardized production of the collarband type artificial cornea, greatly improve the production efficiency and the yield of finished products, and reduce the risks of pollution and non-uniform fittings of the collarband type artificial cornea in the preparation process.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the preparation method of the collar buckle type artificial cornea is applied to the production process of the collar buckle type artificial cornea comprising a lens column, a back plate and a clamping ring, and comprises the following steps of:
s1, preparing a processed blank, and inputting the processed blank into a numerical control lathe; a first processing blank with a transparent bar as a mirror column, a second processing blank with a metal bar as a rear plate, and a third processing blank with another metal bar as a clamping ring;
s2, machining the corresponding first machining blank into a lens column by using a first numerical control lathe according to a set first machining program, and then cleaning the machined lens column; machining the corresponding second machining blank into a rear plate by using a second numerical control lathe according to a set second machining program, and then deburring and cleaning the machined rear plate; machining the corresponding third machining blank into a collar by using a second numerical control lathe or a third numerical control lathe according to a set third machining program, and then deburring and cleaning the machined collar;
s3, drying the lens column, the rear plate and the clamping ring simultaneously or respectively;
s4, combining and packaging the lens column, the back plate and the clamping ring by using packaging materials to form a collar buckle type artificial cornea preoperative packaging kit;
s5, sterilizing the collar buckle type artificial cornea preoperative packaging kit provided with the lens column, the rear plate and the collar.
Further, in S1, the dried PMMA particles are injection molded using an injection molding machine, thereby obtaining a plurality of transparent bars as a first processed blank.
Further, the lens column is mushroom-shaped and comprises an optical umbrella body part and an optical column body part which are sequentially arranged, and an annular groove for clamping a clamping ring is formed in the outer side face of the optical column body part in a surrounding manner; in S2, the first machining program executes a first machining process by a first numerically controlled lathe, the first machining process including the steps of:
s211, positioning a machining zero point of the numerical control lathe;
s212, carrying out outer diameter rough turning on the first processing blank according to the outline dimension of the lens column;
s213, repeatedly finish turning the end face of the workpiece obtained in the S212;
s214, carrying out slot rough turning on the workpiece obtained in the S213, so as to process a rough machining groove structure corresponding to the position of the annular groove;
s215, performing external diameter finish turning on the workpiece obtained in S213 according to the external dimension of the lens column;
s216, carrying out slot repeated finish turning on the rough machining groove structure processed in the S215, so as to process the rough machining groove structure into the annular groove;
s217, repeatedly finish turning is carried out on the contour cambered surface of the inner umbrella surface of the optical umbrella body corresponding to the workpiece obtained in the S216;
s218, turning the contour cambered surface of the outer umbrella surface of the corresponding optical umbrella body of the workpiece obtained in S217;
s219, cutting the workpiece obtained in S218, thereby obtaining a mirror post.
Further, the rear plate is arc-dish-shaped and is provided with a first central through hole, and the rear plate is provided with a plurality of distribution through holes along the first central through hole in a surrounding manner; in S2, the second machining program executes a second machining process by a second numerically controlled lathe, the second machining process including the steps of:
s221, positioning a machining zero point of a numerical control lathe;
s222, roughly turning the second processed blank to obtain an inner arc surface of the rear plate;
s223, rough turning is carried out on the workpiece obtained in the S222 so as to open a plurality of end face holes corresponding to the distribution through holes;
s224, performing rough turning on the workpiece obtained in the S223 to form an outer arc surface of a rear plate;
s225, repeatedly performing finish turning on the inner arc surface on the workpiece obtained in the S224;
s226, repeatedly performing finish turning on the outer arc surface on the workpiece obtained in the S225;
s227, repeatedly performing finish turning on the end face holes on the workpiece obtained in the S226 so as to process the end face holes into the distribution through holes;
s228, drilling the workpiece obtained in the S227, so as to process a first rough machining center hole corresponding to the first center through hole;
s229, boring the first rough machining center hole on the workpiece obtained in the S228, so as to machine a first finish machining center hole corresponding to the first center through hole;
s2210, chamfering an inner hole groove cutter on the first finish machining center hole on the workpiece obtained in the S229, so as to machine the first center through hole;
s2211, cutting the workpiece obtained in S2210, thereby obtaining the rear plate.
Further, the clamping ring is ring-shaped and is provided with a second central through hole; in S2, the third machining program executes a third machining process through a second numerically controlled lathe or a third numerically controlled lathe, and the third machining process includes the following steps:
s231, positioning a machining zero point of the numerical control lathe;
s232, drilling the third machining blank according to the outline dimension of the clamping ring, so as to machine a second rough machining center hole corresponding to the second center through hole;
s233, performing primary boring on the second rough machining center hole machined in the S232, so as to machine a second finish machining center hole corresponding to the second center through hole;
s234, performing inner hole slotting cutter chamfering on the second finish machining center hole processed in the S233, so as to process a third finish machining center hole corresponding to the second center through hole;
s235, rough turning is carried out on the end face of the workpiece obtained in the S234 according to the outline dimension of the clamping ring;
s236, repeatedly boring the third finish machining center hole of the workpiece obtained in S235 according to the outline dimension of the clamping ring, so as to machine a fourth finish machining center hole corresponding to the second center through hole;
s237, chamfering an inner hole cutter on the fourth finish machining center hole machined in the S236, so as to machine the second center through hole;
s238, turning the end face of the workpiece obtained in the step S237 according to the outline dimension of the clamping ring, and chamfering the included angle between the end face and the outer side face of the workpiece, so as to process a rear chamfer;
s239, chamfering the workpiece obtained in the S238 according to the outline dimension of the clamping ring, so as to process a front chamfer; the front chamfer and the rear chamfer are respectively positioned at the peripheral edges of the two end faces of the clamping ring;
s2310, repeatedly finish turning the end face of the workpiece obtained in the S239 according to the outline dimension of the clamping ring;
s2311, cutting the workpiece obtained in S2310.
Further, between S2 and S3, further includes:
s2201, measuring or detecting the lens column, the rear plate and the clamping ring simultaneously or respectively;
s2202, repeatedly cleaning the lens column, the rear plate and the clamping ring by using an ultrasonic cleaner at the same time or respectively.
Further, the following steps are included between S2201 and S2202:
s2203, carrying out sand blasting treatment and cleaning again on the rear plate;
s2204, oxidizing the rear plate and the clamping ring simultaneously or respectively.
Further, in S5, the collar-clip type keratoprosthesis pre-operative package is sterilized using ethylene oxide and an oversterilization method.
Further, the first numerical control lathe uses air flow to remove scraps of a processed workpiece in the processing process; and the second numerical control lathe and/or the third numerical control lathe uses an emulsifying agent to remove scraps of a processed workpiece in the processing process.
Further, in S1, the metal bar as the second processing blank is made of a titanium alloy or a titanium metal, and the metal bar is subjected to secondary annealing treatment and secondary cryogenic treatment and then is machined by a numerically controlled lathe.
Further, the annealing temperature of the first annealing treatment is more than or equal to 255 ℃ and less than or equal to 265 ℃, and the annealing temperature of the second annealing treatment is more than or equal to 700 ℃ and less than or equal to 800 ℃; the cold treatment temperature of the first cryogenic treatment is greater than or equal to-180 and less than or equal to-100 ℃, and the cold treatment temperature of the second cryogenic treatment is greater than or equal to-230 and less than or equal to-200 ℃.
The beneficial effects of the invention are as follows:
according to the preparation method of the collar-buckle type artificial cornea, the automatic feeding and tool changing processing procedure is realized on the processed blank according to the processing procedure by the numerical control lathe, the processed workpiece meets the cleaning requirement of the ophthalmic operation by the deburring and cleaning procedure, and all parts of the cleaned collar-buckle type artificial cornea meet the E0-level medical sanitary requirement by the drying treatment, packaging and sterilization treatment, so that the batch and standardized production of the collar-buckle type artificial cornea is realized, the production efficiency and the finished product qualification rate are greatly improved, and the risks of pollution and non-uniform fittings of the collar-buckle type artificial cornea in the preparation process are reduced. The invention can improve the precision and definition of the collar-buckle type artificial cornea; the optical eccentricity of the lens column produced by the high-precision processing process of the numerical control lathe is kept within 10um, under the high-speed cutting, the surface finish and resolution of the artificial cornea meet the requirements when the cutting of the numerical control lathe is finished, the post polishing process is omitted, and the influence on the optical eccentricity of the lens column caused by the change of the curvature of the front plate of the artificial cornea due to the polishing process is avoided; the numerical control lathe automatically executes the machining procedure, so that the process that the workpiece needs to be reinstalled with the clamp is omitted, and the production efficiency is improved; the back plate processed by the numerical control lathe is free from internal stress in a mode of integrating the machining of the center and the curvature, and the back plate and the mirror column can be perfectly matched. The invention improves the biocompatibility, the eccentricity of the high-precision lens column accords with the eye structure of the human body, and the comfort level of the implanted patient can be improved.
Drawings
FIG. 1 is a schematic view of an exploded view of a collarband type artificial cornea according to the present invention;
FIG. 2 is a workflow diagram of a method for preparing a collarband type artificial cornea according to the present invention;
FIG. 3 is a feed path and a process diagram of a first process of the present invention;
fig. 4 is a feed path and a process diagram of a second process of the present invention;
fig. 5 is a feed path and a process diagram of a third process of the present invention;
FIG. 6 is a microstructure of a collarband type artificial cornea produced by the present invention;
FIG. 7 is a microstructure of a collarband type artificial cornea produced by a conventional process;
fig. 8 is a schematic perspective view of a collar-clip type artificial cornea with respect to an eyeball according to the present invention;
reference numerals illustrate:
a mirror post 1; a cornea implant 2; a rear plate 3; a first center through hole 31; a collar 4; a second center through hole 41; an optical umbrella body 11; an optical column portion 12; an annular groove 121; a first processed blank 100; a second processed blank 300; and a third process blank 400.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be further clearly and completely described in the following in conjunction with the embodiments of the present invention. It should be noted that the described embodiments are only some embodiments of the present invention, and not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It is to be understood that the terms "upper," "lower," "front," "rear," "left," "right," and the like indicate an orientation or positional relationship based on that shown in the drawings, and are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the apparatus or element in question must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
The terms "first," "second," "third," "fourth," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a definition of "a first", "a second", "a third" or a fourth "feature may explicitly or implicitly include one or more of such features.
Examples
As shown in fig. 1 and 2, a method for preparing a collar-buckle type artificial cornea is applied to a production process of a collar-buckle type artificial cornea (a cornea implant is denoted by a reference number 2 in fig. 1) comprising a lens column 1, a back plate 3 and a collar 4, and comprises the following steps:
s1, preparing a processed blank, and inputting the processed blank into a numerical control lathe; a transparent bar is used as a first processing blank 100 of the lens column 1, a metal bar is used as a second processing blank 300 of the rear plate 3, and another metal bar is used as a third processing blank 400 of the clamping ring 4; specifically, the transparent bar, the metal bar and the other metal bar are conveyed into a numerical control lathe through an automatic feeding device;
s2, machining the corresponding first machining blank 100 into a lens column 1 by using a first numerical control lathe according to a set first machining program, and then cleaning the machined lens column 1; machining the corresponding second machining blank 300 into a rear plate 3 by using a second numerical control lathe according to a set second machining program, and then deburring and cleaning the machined rear plate 3; machining the corresponding third machining blank 400 into a collar 4 by using a second numerical control lathe or a third numerical control lathe according to a set third machining program, and then deburring and cleaning the machined collar 4; specifically, the lens column 1, the rear plate 3 and the clamping ring 4 can be machined by starting different numerical control lathes at the same time, or can be machined at different times respectively; the rear plate 3 and the clamping ring 4 can be processed by using the same machine tool and feeding by using different programs, and can also be respectively processed by using a second numerical control lathe and a third numerical control lathe;
s3, drying the lens column 1, the rear plate 3 and the clamping ring 4 simultaneously or respectively; specifically, drying treatment is carried out by using a centrifugal drying and plasma fan drying mode;
s4, combining and packaging the lens column 1, the rear plate 3 and the clamping ring 4 by using the cleaned packaging material to form a collar buckle type pre-keratoprosthesis packaging kit;
s5, sterilizing the collar buckle type keratoprosthesis pre-operation packaging kit provided with the lens column 1, the rear plate 3 and the clamping ring 4.
Optimally, in S2, cleaning the workpiece before deburring the workpiece, and cleaning the workpiece again after deburring the workpiece; the processed rear plate 3 is cleaned by using water flow before deburring, and is cleaned by adding water by using an ultrasonic cleaner after deburring; when the ultrasonic cleaner is added with water for cleaning, the cleaning is required to be carried out in a dust-free space; after the machine processing and cleaning, the workpiece can be placed in a temporary storage cabinet for natural drying, and then deburring is carried out.
Specifically, the rear plate 3 and the collar 4 are subjected to deburring treatment by rotating the abrasive grinder, and then the rear plate 3 and the collar 4 are respectively screened out by different mesh screens.
Specifically, under high-speed cutting, the cutting speed related parameters of the numerically controlled lathe are specifically as follows: the cutting speed is 15-80 mm/min, the feeding amount is 0.1-0.25 mm/r, the cutting depth is 0.15-0.2 mm, under the combined condition, the surface finish and resolution of the artificial cornea meet the requirements when the cutting of the numerically controlled lathe is finished, the post polishing procedure is omitted, and the influence on the optical eccentricity of the lens column caused by the change of the curvature of the front plate of the artificial cornea due to the polishing procedure is avoided.
Further, as shown in fig. 2 and 3, in S1, the dried medical optical-grade PMMA particles are injection molded using an injection molding machine, thereby obtaining a plurality of transparent bars as the first processed blank 100.
Further, as shown in fig. 1-3, the lens column 1 is mushroom-shaped, and comprises an optical umbrella body 11 and an optical column body 12 which are sequentially arranged, and an annular groove 121 for clamping the clamping ring 4 is annularly arranged on the outer side surface of the optical column body 12; in S2, the first machining program executes a first machining process by a first numerically controlled lathe, the first machining process including the steps of:
s211, positioning a machining zero point of the numerical control lathe;
s212, performing outer diameter rough turning on the first processing blank 100 according to the outline dimension of the lens column 1;
s213, repeatedly finish turning the end face of the workpiece obtained in the S212;
s214, carrying out slot rough turning on the workpiece obtained in S213, so as to process a rough machining groove structure corresponding to the position of the annular groove 121;
s215, performing external diameter finish turning on the workpiece obtained in S213 according to the external dimension of the lens column 1;
s216, carrying out slot repeated finish turning on the rough machining groove structure processed in the S215, thereby processing the rough machining groove structure into the annular groove 121;
s217, repeatedly finish turning is carried out on the workpiece obtained in the S216, which corresponds to the contour cambered surface of the umbrella surface in the optical umbrella body 11;
s218, turning the contour cambered surface of the outer umbrella surface of the corresponding optical umbrella body 11 of the workpiece obtained in S217;
s219, cutting the workpiece obtained in S218, thereby obtaining the mirror post 1.
The process sequence of steps S211 to S219 ensures the processing precision of the lens column 1, improves the production efficiency of the lens column 1, and the processed lens column 1 fine structure meets the requirements of ophthalmic biocompatibility and postoperative visual definition.
Further, as shown in fig. 1, 2 and 4, the rear plate 3 is in an arc dish shape and is provided with a first central through hole 31, and the rear plate 3 is provided with a plurality of distribution through holes along the first central through hole 31 in a ring manner; in S2, the second machining program executes a second machining process by a second numerically controlled lathe, the second machining process including the steps of:
s221, positioning a machining zero point of a numerical control lathe;
s222, roughly turning the second processing blank 300 to obtain an inner arc surface of the rear plate 3;
s223, rough turning is carried out on the workpiece obtained in the S222 so as to open a plurality of end face holes corresponding to the distribution through holes;
s224, rough turning the workpiece obtained in the S223 into an outer arc surface of the rear plate 3;
s225, repeatedly performing finish turning on the inner arc surface on the workpiece obtained in the S224;
s226, repeatedly performing finish turning on the outer arc surface on the workpiece obtained in the S225;
s227, repeatedly performing finish turning on the end face holes on the workpiece obtained in the S226 so as to process the end face holes into the distribution through holes;
s228, drilling the workpiece obtained in S227, thereby machining a first rough machining center hole corresponding to the first center through hole 31;
s229 of boring the first rough machining center hole on the workpiece obtained in S228, thereby machining a first finish machining center hole corresponding to the first center through hole 31;
s2210, chamfering an inner hole groove cutter on the first finish machining center hole on the workpiece obtained in S229, so as to machine the first center through hole 31;
s2211, the workpiece obtained in S2210 is cut, thereby obtaining the rear plate 3.
The process sequence of steps S221 to S2211 ensures the processing precision of the back plate 3, and simultaneously improves the production efficiency of the back plate 3, and the processed fine structure of the back plate 3 meets the requirements of ophthalmic biocompatibility and postoperative visual definition.
Further, as shown in fig. 1, 2 and 5, the collar 4 is ring-shaped and provided with a second central through hole 41; in S2, the third machining program executes a third machining process by the second numerically controlled lathe or the third numerically controlled lathe, the third machining process including the steps of:
s231, positioning a machining zero point of the numerical control lathe;
s232, drilling the third machining blank 400 according to the outline dimension of the clamping ring 4, so as to machine a second rough machining center hole corresponding to the second center through hole 41;
s233, performing primary boring on the second rough machining center hole machined in S232, thereby machining a second finish machining center hole corresponding to the second center through hole 41;
s234, performing inner hole slotting cutter chamfering on the second finish machining center hole processed in the S233, so as to process a third finish machining center hole corresponding to the second center through hole 41;
s235, rough turning is carried out on the end face of the workpiece obtained in the S234 according to the outline dimension of the clamping ring 4;
s236, repeatedly boring the third finish machining center hole of the workpiece obtained in S235 according to the external dimension of the clamping ring 4, so as to form a fourth finish machining center hole corresponding to the second center through hole 41;
s237, performing a hole grooving tool chamfering on the fourth finish machining center hole machined in S236, thereby machining the second center through hole 41;
s238, turning the end face of the workpiece obtained in S237 according to the external dimension of the clamping ring 4, and chamfering the included angle between the end face and the outer side face of the workpiece, so as to process a rear chamfer;
s239, chamfering the workpiece obtained in the S238 according to the outline dimension of the clamping ring 4, so as to process a front chamfer; the front chamfer and the rear chamfer are respectively positioned at the peripheral edges of the two end faces of the clamping ring 4;
s2310, repeatedly finish turning the end face of the workpiece obtained in the S239 according to the outline dimension of the clamping ring 4;
s2311, cutting the workpiece obtained in S2310.
The process sequence of steps S231 to S2311 ensures the processing precision of the collar 4, and simultaneously improves the production efficiency of the collar 4, and the processed artificial cornea fine structure meets the ophthalmic biocompatibility.
Further, as shown in fig. 1 and 2, between S2 and S3, the method further includes:
s2201, measuring or detecting the lens column 1, the rear plate 3 and the clamping ring 4 simultaneously or respectively; specifically, the external dimensions of the lens column 1, the back plate 3 and the clamping ring 4 are measured, and the optical resolution of the lens column 1 is detected to remove unqualified products;
s2202, repeatedly cleaning the lens post 1, the back plate 3 and the collar 4 by using an ultrasonic cleaner at the same time or separately.
Further, as shown in fig. 1 and 2, the following steps are further included between S2201 and S2202:
s2203, performing sand blasting treatment and cleaning on the rear plate 3; the natural color of pure titanium is silver with metal reflection, if the surface of the material is not processed, strong reflection can be generated under the irradiation of an operating lamp during implantation so as to cause great discomfort to an operator, and in addition, the appearance of a silver titanium back plate after implantation into an eye is greatly different from that of a normal Chinese brown eye bead; the surface of the titanium back plate is subjected to sand blasting treatment, so that the problem of strong reflection under the irradiation of an operating lamp is solved; the sand blasting treatment can also improve the biocompatibility of the rear plate 3;
s2204, oxidizing the rear plate 3 and the clamping ring 4 simultaneously or respectively; coloring contrast is required after oxidation treatment; the surface of the back plate is oxidized to be similar to the iris of the Chinese, so that the difference between the postoperative appearance of the patient and normal human eyes is reduced, and the confidence of the patient in adapting to society after operation is increased.
Further, as shown in fig. 2, in S5, the collar-clip type keratoprosthesis pre-operative package is sterilized using ethylene oxide and an oversterilization method; specifically, ethylene oxide is used for sterilizing the lens column 1, the rear plate 3 and the clamping ring 4 through the dialysis paper of the collar buckle type artificial cornea preoperative package kit, and the lens column 1 can be prevented from aging in the sterilization process by using the ethylene oxide.
Further, the first numerical control lathe uses air flow to remove scraps and cool a processed workpiece in the processing process; and the second numerical control lathe and/or the third numerical control lathe uses an emulsifying agent to remove scraps and cool a processed workpiece in the processing process.
Further, as shown in fig. 2 and 4, in S1, a titanium alloy or titanium metal is used as the metal bar of the second processing blank 300; the metal bar is subjected to secondary annealing treatment and secondary cryogenic treatment and then is subjected to machining by a numerical control lathe;
the annealing temperature of the first annealing treatment is more than or equal to 255 ℃ and less than or equal to 265 ℃, and the annealing temperature of the second annealing treatment is more than or equal to 700 ℃ and less than or equal to 800 ℃; the cold treatment temperature of the first sub-cooling treatment is more than or equal to-180 and less than or equal to-100 ℃, and the cold treatment temperature of the second sub-cooling treatment is more than or equal to-230 and less than or equal to-200 ℃; the stress relieving requirements of the titanium metal rear plate are met through twice annealing treatment, the mechanical property and toughness of the titanium metal rear plate are improved through twice cryogenic treatment, and the titanium metal rear plate treated through the temperature range meets the requirements of high precision, high biocompatibility and strong assembly adaptability.
Further, as shown in fig. 2, in S2, the numerically controlled lathe uses the air flow to remove scraps from the first machined blank 100 during the machining process; because the vitrification temperature of PMMA material is about 105 degrees, the material is harder and is easy to break, in order to cut the skirt edge (shown in the white mark ring at the upper left corner of figure 6) with the thickness of only 0.02mm of the artificial cornea mirror column, on the basis of the original numerical control lathe, an on-line cooling system is additionally arranged, and the cutting speed of the feeding of the numerical control lathe can be further accelerated by carrying out the instant cooling from a specific position at the key moment point of cutting through the programming control, so that the PMMA bar is not required to be melted due to the excessively high temperature, the artificial cornea mirror column with high fitting degree with the eyeball surface is produced, the long-term bit rate after the artificial cornea operation is directly improved, and the discomfort of the ocular surface of a patient after the implantation operation is relieved.
As shown in fig. 6 and 7, by comparing fig. 6 and 7, the advantages of the invention in processing precision are obviously reflected, and the ultra-thin mirror column skirt can be processed; the mirror post skirt structure indicated by the white arrow at the upper left corner of fig. 7 is produced by a conventional process, and the mirror post skirt is thick and lacks fineness.
The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (10)
1. The preparation method of the collar buckle type artificial cornea is applied to the production process of the collar buckle type artificial cornea comprising a lens column, a back plate and a clamping ring, and is characterized by comprising the following steps of:
s1, preparing a processed blank, and inputting the processed blank into a numerical control lathe; a first processing blank with a transparent bar as a mirror column, a second processing blank with a metal bar as a rear plate, and a third processing blank with another metal bar as a clamping ring;
s2, machining the corresponding first machining blank into a lens column by using a first numerical control lathe according to a set first machining program, and then cleaning the machined lens column; machining the corresponding second machining blank into a rear plate by using a second numerical control lathe according to a set second machining program, and then deburring and cleaning the machined rear plate; machining the corresponding third machining blank into a collar by using a second numerical control lathe or a third numerical control lathe according to a set third machining program, and then deburring and cleaning the machined collar;
s3, drying the lens column, the rear plate and the clamping ring simultaneously or respectively;
s4, combining and packaging the lens column, the back plate and the clamping ring by using packaging materials to form a collar buckle type artificial cornea preoperative packaging kit;
s5, sterilizing a collar buckle type artificial cornea preoperative packaging kit provided with a lens column, a rear plate and a collar;
the cutting speed related parameters of the first numerical control lathe are specifically as follows: cutting speed is 15-80 mm/min, feeding amount is 0.1-0.25 mm/r, and cutting depth is 0.15-0.2 mm;
the lens column is mushroom-shaped and comprises an optical umbrella body part and an optical column body part which are sequentially arranged, and an annular groove for clamping a clamping ring is formed in the outer side face of the optical column body part; in S2, the first machining program executes a first machining process by a first numerically controlled lathe, the first machining process including the steps of:
s211, positioning a machining zero point of the numerical control lathe;
s212, carrying out outer diameter rough turning on the first processing blank according to the outline dimension of the lens column;
s213, repeatedly finish turning the end face of the workpiece obtained in the S212;
s214, carrying out slot rough turning on the workpiece obtained in the S213, so as to process a rough machining groove structure corresponding to the position of the annular groove;
s215, performing external diameter finish turning on the workpiece obtained in S213 according to the external dimension of the lens column;
s216, carrying out slot repeated finish turning on the rough machining groove structure processed in the S215, so as to process the rough machining groove structure into the annular groove;
s217, repeatedly finish turning is carried out on the contour cambered surface of the inner umbrella surface of the optical umbrella body corresponding to the workpiece obtained in the S216;
s218, turning the contour cambered surface of the outer umbrella surface of the corresponding optical umbrella body of the workpiece obtained in S217;
s219, cutting the workpiece obtained in S218, thereby obtaining a mirror post.
2. The method according to claim 1, wherein in S1, the dried PMMA particles are injection molded using an injection molding machine, thereby obtaining a plurality of transparent bars as a first processed blank.
3. The method for preparing the collar buckle type artificial cornea according to claim 1, wherein the back plate is arc-dish-shaped and is provided with a first central through hole, and the back plate is provided with a plurality of distribution through holes along the first central through hole; in S2, the second machining program executes a second machining process by a second numerically controlled lathe, the second machining process including the steps of:
s221, positioning a machining zero point of a numerical control lathe;
s222, roughly turning the second processed blank to obtain an inner arc surface of the rear plate;
s223, rough turning is carried out on the workpiece obtained in the S222 so as to open a plurality of end face holes corresponding to the distribution through holes;
s224, performing rough turning on the workpiece obtained in the S223 to form an outer arc surface of a rear plate;
s225, repeatedly performing finish turning on the inner arc surface on the workpiece obtained in the S224;
s226, repeatedly performing finish turning on the outer arc surface on the workpiece obtained in the S225;
s227, repeatedly performing finish turning on the end face holes on the workpiece obtained in the S226 so as to process the end face holes into the distribution through holes;
s228, drilling the workpiece obtained in the S227, so as to process a first rough machining center hole corresponding to the first center through hole;
s229, boring the first rough machining center hole on the workpiece obtained in the S228, so as to machine a first finish machining center hole corresponding to the first center through hole;
s2210, chamfering an inner hole groove cutter on the first finish machining center hole on the workpiece obtained in the S229, so as to machine the first center through hole;
s2211, cutting the workpiece obtained in S2210, thereby obtaining the rear plate.
4. The method of claim 1, wherein the collar is annular and has a second central through hole; in S2, the third machining program executes a third machining process through a second numerically controlled lathe or a third numerically controlled lathe, and the third machining process includes the following steps:
s231, positioning a machining zero point of the numerical control lathe;
s232, drilling the third machining blank according to the outline dimension of the clamping ring, so as to machine a second rough machining center hole corresponding to the second center through hole;
s233, performing primary boring on the second rough machining center hole machined in the S232, so as to machine a second finish machining center hole corresponding to the second center through hole;
s234, performing inner hole slotting cutter chamfering on the second finish machining center hole processed in the S233, so as to process a third finish machining center hole corresponding to the second center through hole;
s235, rough turning is carried out on the end face of the workpiece obtained in the S234 according to the outline dimension of the clamping ring;
s236, repeatedly boring the third finish machining center hole of the workpiece obtained in S235 according to the outline dimension of the clamping ring, so as to machine a fourth finish machining center hole corresponding to the second center through hole;
s237, chamfering an inner hole cutter on the fourth finish machining center hole machined in the S236, so as to machine the second center through hole;
s238, turning the end face of the workpiece obtained in the step S237 according to the outline dimension of the clamping ring, and chamfering the included angle between the end face and the outer side face of the workpiece, so as to process a rear chamfer;
s239, chamfering the workpiece obtained in the S238 according to the outline dimension of the clamping ring, so as to process a front chamfer; the front chamfer and the rear chamfer are respectively positioned at the peripheral edges of the two end faces of the clamping ring;
s2310, repeatedly finish turning the end face of the workpiece obtained in the S239 according to the outline dimension of the clamping ring;
s2311, cutting the workpiece obtained in S2310.
5. The method for preparing a collarband type artificial cornea according to claim 1, further comprising between S2 and S3:
s2201, measuring or detecting the lens column, the rear plate and the clamping ring simultaneously or respectively;
s2202, repeatedly cleaning the lens column, the rear plate and the clamping ring by using an ultrasonic cleaner at the same time or respectively.
6. The method of claim 5, further comprising the steps of:
s2203, carrying out sand blasting treatment and cleaning again on the rear plate;
s2204, oxidizing the rear plate and the clamping ring simultaneously or respectively.
7. The method of claim 1, wherein in S5, the collar-clip type keratoprosthesis packaging set is sterilized by ethylene oxide and oversterilization.
8. The method of claim 1, wherein the first numerically controlled lathe uses air flow to remove the scraps from the machined workpiece during machining; and the second numerical control lathe and/or the third numerical control lathe uses an emulsifying agent to remove scraps of a processed workpiece in the processing process.
9. The method according to claim 1, wherein in S1, the metal bar as the second processing blank is made of titanium alloy or titanium metal, and the metal bar is machined by a numerically controlled lathe after the second annealing treatment and the second cryogenic treatment.
10. The method for producing a collar-buckle type artificial cornea according to claim 9, wherein an annealing temperature of the first annealing treatment is 255 ℃ or higher and 265 ℃ or lower in the second annealing treatment, and an annealing temperature of the second annealing treatment is 700 ℃ or higher and 800 ℃ or lower; the cold treatment temperature of the first cryogenic treatment is greater than or equal to-180 and less than or equal to-100 ℃, and the cold treatment temperature of the second cryogenic treatment is greater than or equal to-230 and less than or equal to-200 ℃.
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| CN113786268A (en) * | 2021-08-27 | 2021-12-14 | 广东佳悦美视生物科技有限公司 | II-type collar button type artificial cornea |
| CN114010370A (en) * | 2021-12-02 | 2022-02-08 | 北京米赫医疗器械有限责任公司 | Artificial cornea based on umbrella-shaped lens column and preparation process thereof |
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