CN112352780B

CN112352780B - Isolated air purification disinfectant

Info

Publication number: CN112352780B
Application number: CN202011120775.4A
Authority: CN
Inventors: 黄祝华; 黄舒雯; 党增超
Original assignee: NANJING INSTITUTE OF PRODUCT QUALITY INSPECTION
Current assignee: NANJING INSTITUTE OF PRODUCT QUALITY INSPECTION
Priority date: 2020-10-19
Filing date: 2020-10-19
Publication date: 2022-03-08
Anticipated expiration: 2040-10-19
Also published as: CN112352780A

Abstract

The invention discloses an isolated air purification disinfectant, which comprises water-based resin, a diluent, a drying agent, a disinfectant, a propellant and water, wherein the water-based resin is selected from one or more of polyvinyl alcohol, polyacrylamide, water-based acrylic resin, water-based alkyd resin and water-based polyurethane resin. According to the invention, the water-based resin and the drying accelerator are adopted to spray and wrap substances such as bacteria, viruses and PM2.5 particles, so that the bacteria, the viruses and the PM2.5 particles are effectively prevented from directly contacting with a human body, and the transmission path of the bacteria and the viruses is blocked. The invention adopts the water-based resin which is easy to dissolve in water, the sprayed substance is easy to clean, and the adopted raw materials are all safe and nontoxic medical raw materials, thereby ensuring the environment and the human body safety.

Description

Isolated air purification disinfectant

Technical Field

The invention belongs to the technical field of air purification, and particularly relates to an isolated air purification disinfectant.

Background

With the acceleration of human industrialization process, population density is increasing, air pollution is serious, airborne infectious diseases are happening continuously, and substances such as bacteria, viruses and PM2.5 particles in the air seriously affect human health and even life safety. For example, the new coronavirus pneumonia that is prevalent worldwide is abusive in many regions worldwide. The virus is sensitive to heat, and can be killed in a short time by ultraviolet rays, lysuwater, 0.1% peroxyacetic acid, 1% of klealin and the like. The existing air bactericide is usually aqueous, and can kill bacteria and viruses by directly contacting with the bacteria and viruses. However, it usually takes a certain time to achieve the killing effect, and there is still a risk of infection when the bacteria and viruses are inhaled or contacted by human body before being killed.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides an isolated air purification disinfectant, which adopts water-based resin and a drying accelerator, so that a mist-like spray can be quickly fused with bacteria, viruses and PM2.5 particles in air/environment and can be naturally wrapped to fall, and even if a part of small-diameter spray floating in the air is inhaled by a person, the bacteria and the viruses cannot be directly contacted with the human body due to the wrapping of the resin and then are killed by the disinfectant in aerosol. The invention can block the transmission path of bacteria and virus and purify the environment.

The specific technical scheme of the invention is as follows:

an isolated air purification disinfectant comprises water-based resin, a diluent, a drying agent, a disinfectant, a propellant and water, wherein the water-based resin is selected from one or more of polyvinyl alcohol, polyacrylamide, water-based acrylic resin, water-based alkyd resin and water-based polyurethane resin, and preferably polyvinyl alcohol and/or polyacrylamide.

Preferably, the drying accelerator is selected from one or more of borax, cobalt salt and rare earth salt, and borax and/or rare earth are/is more preferred.

Preferably, the disinfectant is selected from aldehyde disinfectants (such as formaldehyde and glutaraldehyde), alkaline disinfectants (such as quicklime, sodium hydroxide and potassium hydroxide), halogen disinfectants including chlorine-containing disinfectants, iodine-containing disinfectants and bromine-containing disinfectants: the chlorine-containing disinfectant comprises inorganic chlorine-containing disinfectant (sodium hypochlorite, bleaching powder, chlorine dioxide, etc.) and organic chlorine-containing disinfectant (dichloroisocyanuric acid, sodium dichloroisocyanurate, trichloroisocyanuric acid, dichlorohydantoin), etc.; iodine-containing disinfectants such as iodine tincture, iodophor, compound iodine preparation, etc.; the disinfectant containing bromine includes dibromohydantoin, bromochlorohydantoin, isocyanuric acid containing bromine, etc. Oxidant disinfectant (peroxyacetic acid, potassium permanganate, hydrogen peroxide), phenol disinfectant (lysol, compound phenol, coal phenol soap solution, and klealin), quaternary ammonium salt disinfectant (benzalkonium chloride, double-long-chain quaternary ammonium salt disinfectant, domiphen bromide, chlorhexidine, and chlorfluazuron), and alcohol disinfectant (75% ethanol). More preferably, the disinfectant is one or more of formaldehyde with the final concentration of 0.5-5%, glutaraldehyde with the final concentration of 2-5%, sodium hydroxide or potassium hydroxide with the final concentration of 2-3%, bleaching powder with the final concentration of 1-5%, sodium hypochlorite with the final concentration of 0.05-1.5%, dichloroisocyanuric acid with the final concentration of 0.5-10%, sodium dichloroisocyanurate with the final concentration of 0.5-10%, chlorine dioxide with the final concentration of 0.5-2%, benzalkonium chloride with the final concentration of 0.01-1%, chlorobutanol with the final concentration of 1-5%, peracetic acid with the final concentration of 0.2-0.4%, potassium permanganate with the final concentration of 0.02-5%, hydrogen peroxide with the final concentration of 1-3%, lysol with the final concentration of 1-10%, complex phenol with the final concentration of 0.3-1%, clinoporin with the final concentration of 1-5%, neobrel with the final concentration of 0.05-2%, domiphen with the final concentration of 0.1-10%, potassium permanganate with the final concentration of 0.02-5%, hydrogen peroxide with the final concentration of 1%, and ethanol with the final concentration of 0.1-10%. The concentration is the final mass volume percentage concentration of the disinfectant contained in the air purification disinfectant.

The diluent is selected from one or more of C1-C6 monohydric or polyhydric alcohols, such as methanol, ethanol, ethylene glycol, propylene glycol, glycerol, isopropanol, butanol, pentanol, isobutanol, isoamyl alcohol and n-hexanol, preferably C1-C3 monohydric or polyhydric alcohols, such as methanol, ethanol, ethylene glycol, propylene glycol, glycerol and isopropanol, more preferably isopropanol.

The propellant is selected from one or more of cyclohexane, heptane, dichloromethane, dichloroethane, trichloroethylene and styrene, and more preferably dichloroethane and dichloromethane.

In a preferred embodiment of the present invention, the aqueous resin is polyvinyl alcohol, the drying promoter is borax and/or a rare earth salt, the diluent is isopropanol and/or glycerol, the propellant is dichloromethane and/or dichloroethane, and the disinfectant is benzalkonium bromide with a final concentration of 1% and/or chlorobutanol with a final concentration of 5%.

The air purification disinfectant disclosed by the invention comprises the following components in parts by weight except for a disinfectant for realizing the disinfectant dosage:

200 portions and 500 portions of aqueous resin;

2-5 parts of a drying promoter;

diluent 400-700 parts;

50-100 parts of a propellant;

30-80 parts of water.

Preferably, the weight parts of the components are as follows:

200 parts of water-based resin;

5 parts of a drying promoter;

600 parts of a diluent;

80 parts of propellant;

50 parts of water.

The invention relates to an air purification disinfectant, which has a specific technical scheme that: 200 parts of polyvinyl alcohol serving as water-based resin, and 5 parts of borax and/or rare earth salt serving as a drying accelerator; the diluent is isopropanol and/or glycerin, 600 portions; the propellant is dichloromethane and/or dichloroethane, 80 parts, the water is 50 parts, and the disinfectant is benzalkonium bromide with the final concentration of 1% and/or chlorobutanol with the final concentration of 5%.

Besides, the coating also comprises 6772 parts of a defoaming agent Haimaisi DF, 2802 parts of a wetting agent Tego and 750W 1 parts of a dispersing agent Tego.

The isolated air purification disinfectant can be prepared by the following method:

1. the aqueous resin is dissolved in a diluent (preferably 65 ℃), cooled and then added with the disinfectant until completely dissolved.

2. The drying agent is dissolved in water.

3. The solution of step 2 is added to the solution prepared in step 1.

4. And (4) slowly adding the defoaming agent, the wetting agent and the dispersing agent into the solution prepared in the step (3), and stirring and mixing uniformly.

5. And (4) adding a propellant into the solvent prepared in the step (4), and stirring and mixing uniformly to obtain the isolated air purification disinfectant solution.

Further, the solution can be filtered and filled into a spray can.

The viscosity of the air purification disinfectant is less than or equal to 800mPa & s, the particle size of the mist spray is more than or equal to 0.4mm, and the particle size after drying is more than or equal to 0.1 mm. The isolated air purification disinfectant is used in household and large environment, wherein the household is filled by a small-capacity aluminum metal tank, and the large environment can be packaged by a 50L steel iron drum. During casting, the spraying can be carried out from top to bottom at the height of 2m, and the spraying is uniform. The invention has the advantages that:

according to the invention, the water-based resin and the drying accelerator are adopted to spray and wrap substances such as bacteria, viruses and PM2.5 particles, so that the bacteria, the viruses and the PM2.5 particles are effectively prevented from directly contacting with a human body, and the transmission path of the bacteria and the viruses is blocked. Meanwhile, the disinfectant can kill bacteria and viruses more effectively and quickly due to the wrapping of the water-based drying promoting resin. The raw materials adopted by the invention are safe and nontoxic medical raw materials, thereby ensuring the safety of the environment and human body. In addition, the water-based resin adopted by the invention is easy to dissolve in water, and the sprayed object is easy to clean, thereby ensuring the cleanness of the sprayed object. It is also suitable for killing bacteria and viruses.

According to a specific embodiment of the invention, polyvinyl alcohol is used as a film forming substance, isopropanol is adopted to dissolve the polyvinyl alcohol at high temperature in a refluxing manner, the solid content of the polyvinyl alcohol is more than 20%, dichloromethane is used as a spraying agent, the diameter of a spray head is 0.5mm, the diameter of sprayed mist particles is 0.4mm, the particle size after drying is about 0.1mm, and the requirements of wrapping particles with the particle size of 2.5 microns, bacteria with the particle size of 5 microns and fungus threads with the particle size of 10 microns are met. Meanwhile, borax is used as a drying curing agent, and the surface drying time of polyvinyl alcohol is 30s and 5min is full, so that even if viruses, bacteria, fungi and spores have activity, the polyvinyl alcohol is wrapped, and after the polyvinyl alcohol contacts the surface of a human organ, the microorganisms are prevented from copying, the activity is greatly weakened, and the viruses cannot smoothly enter cells of the organ. Under the action of the halogen and quaternary ammonium salt composite disinfectant, viruses, bacteria, fungi and spores can be killed within 5 min.

Detailed Description

The following examples illustrate specific steps of the present invention, but are not intended to limit the invention.

Terms used in the present invention generally have meanings commonly understood by those of ordinary skill in the art, unless otherwise specified. The invention is described in further detail below with reference to specific examples and data, it being understood that these examples are intended to illustrate the invention and are not intended to limit the scope of the invention in any way.

In the following examples, various procedures and methods not described in detail are conventional methods well known in the art.

Example 1 formulation screening of isolated air purifying disinfectant

Firstly, a basic formula: totaling 1000kg

200kg of aqueous resin (medical grade);

600kg of diluent

80kg of propellant

A drying accelerator: borax 5kg

Defoaming agent: haimax DF677 (Haimax) 2kg

Wetting agent: tego 280 (digao) 2kg

Dispersing agent: tego 750W (Digao) 1kg

A disinfectant: benzalkonium bromide 10kg (medical grade), chlorobutanol 50kg (medical grade)

50kg of deionized water.

Second, preparation method

1. Adding 600kg of diluent into a 2-ton reaction kettle, heating to 65 ℃ at the speed of 5 ℃/min, stirring, refluxing at constant temperature, slowly adding 5kg/min of aqueous resin powder, stirring within 40 minutes, stirring for 5 hours, observing complete dissolution of the aqueous resin, and cooling to 40 ℃ at the speed of 5 ℃/min; quickly adding 10kg of benzalkonium bromide into a reaction kettle, stirring for 20 minutes at the speed of 30 r/min, refluxing isopropanol, and observing complete dissolution of the benzalkonium bromide; slowly adding the chlorobutanol into the reaction kettle, controlling the stirring speed at 80 r/min, refluxing the isopropanol, and observing the complete dissolution of the chlorobutanol.

2. 50kg of deionized water was heated to 85 ℃ and 10kg of borax was added with stirring until complete dissolution.

3. Slowly adding the borax solution obtained in the step 2 into the aqueous resin solution prepared in the step 1 under stirring, and keeping the temperature of the reaction kettle at 40 ℃.

4. And (4) slowly adding the defoaming agent, the wetting agent and the dispersing agent into the solution prepared in the step (3), and stirring for 10min at constant temperature.

5. And cooling the fully mixed liquid to room temperature, adding 80kg of propellant, and stirring and mixing uniformly.

6. And (3) filter-pressing the mixed solution into a storage tank by using a plate-frame filter, wherein the aperture of a plate-frame filter membrane is 200 meshes of polypropylene fabric, the pressure is 4-6 kg, and the speed is 20-40 kg/min.

7. And (3) filling by using an automatic filling machine, wherein the filling speed is 15-30L/min, the filling quantity is 750 ml/piece, and the sterile liquid is prevented from generating foam in the filling process, so that overflow is prevented.

8. The manual pressurized spraying pump head is put into a sterilization liquid tank, the spraying pump head (the aperture is 0.5mm) is screwed, and the fastening part of the spraying pump and the tank body is sealed by a metal aluminum sheet. The sealing and spraying properties were checked.

Third, performance investigation method

1. The method for measuring the surface dry time and the actual dry time comprises the following steps: taking 1 bottle of the product, detaching the spray head, sealing, spraying on a glass plate with the thickness of 100mm multiplied by 4mm, uniformly spraying with the thickness of 50 mu m +/-10 mu m, and judging according to the surface drying method, the actual drying method, the first method of GB/T1728 plus 1979 'determination method for drying time of lacquer film putty film'.

The surface drying time should be less than or equal to 1min, and the actual drying time should be less than or equal to 1 h. (actual drying does not affect the wrapping performance, only needs surface drying)

2. The method for measuring the spray particle size and the dried particle size comprises the following steps: taking 1 bottle of the product, opening the spray head, sealing, spraying onto 2 glass slides of 60mm × 60mm placed in advance according to the use method specified by the product or spraying from top to bottom at the height of 2m, wherein the spraying positions are not overlapped, the distance between every two spraying positions is about 10mm, the spraying frequency is determined according to the spraying area, immediately after spraying, the glass slides are moved to an objective microscope with scales for observation, 5 visual fields are observed, and the particle sizes of the aqueous resin wet film and the aqueous resin dry film formed in each visual field are measured.

The spraying particle size is more than or equal to 0.40mm, and the particle size is more than or equal to 0.1mm after drying.

PM2.5 elimination assay method: in a closed room with 2m × 2m × 2.5m (temperature 20 + -2 deg.C, RH30 + -5%), making PM2.5 silicon dioxide or other substances into 500 μ g/m with PM2.5 generator³The PM2.5 mass concentration detector is adopted to measure the initial PM2.5 concentration W of the PM₁Then 1 bottle of the product is taken apart from the spray head, the whole closed room is uniformly sprayed, and after one bottle is completely sprayed, a PM2.5 mass concentration detector is adopted to measure the concentration W of PM2.5 after the test is finished₂The removal rate X of PM2.5 is (W)₁-W₂)×100/W₁。

Fourthly, screening and optimizing the formula

1. Screening of aqueous resins

According to the requirements of environmental protection and health, the invention does not adopt oleoresin as a film forming agent, uses isopropanol as a solvent and borax as a drying promoter, and investigates the main performances of the spray adopting different water-based resins (note: carboxymethyl cellulose/carboxyethyl cellulose water is used as a solvent). The results are shown in table 1 below:

TABLE 1

The above results show that with polyacrylamide, after spraying, the film did not dry well after a tack-free time of 1 h. Because carboxymethyl cellulose and carboxyethyl cellulose are insoluble in organic substances, after water is used as a solvent, the viscosity is high, the stability is poor, the spraying process is linear, and an effective uniform mist cannot be formed, and through PM2.5 wrapping tests and spraying particle size tests, the particle size can reach 1mm at most, and small particles cannot wrap PM 2.5. The surface drying time of the formed film of the polyvinyl acetate is 30min, the surface drying time is extremely fast required by the design of the spray, so the product requirements are not met, and meanwhile, the bonding strength is high after the film is formed, the water resistance is high after the film is formed, the film is not easy to remove, and the environment and furniture are polluted. The polyvinyl alcohol is adopted, so that the spraying granule, the surface drying time and the actual drying time are good.

2. On the basis of the research, the cleaning capability (coating and settling capability) of spray particles formed by the spray agent prepared by using polyvinyl alcohol as aqueous resin, borax as a drying accelerator and different diluents and propellants on the particles is further considered, and the viscosity of the prepared solution is preferably less than or equal to 1.0 Pa.s, and more preferably less than or equal to 0.8 Pa.s. The results are shown in table 2 below:

TABLE 2

The results show that the clearance rate of PM2.5 can reach more than 90% by taking isopropanol as a diluent, the surface drying time is shortest, and dichloromethane is selected as a propellant.

Fifthly, the optimized microbial killing performance of the air purification disinfectant

The formula is as follows: 200kg (medical grade) of polyvinyl alcohol powder, 600kg of isopropanol, 50kg of deionized water, 80kg of dichloromethane, 5kg of borax, 2kg of Haimax DF677 antifoaming agent (Haimax), 2kg of Tego 280 base wetting agent (digao), 1kg of Tego 750W dispersing agent (digao), 10kg of benzalkonium bromide (medical grade) and 50kg of chlorobutanol (medical grade), and the total amount is 1000 kg.

1. When the spray method is adopted for disinfection under natural conditions, the dosage of the disinfectant is 25mL/m³When the composition is used for 5min, the sterilization rate of the composition on microorganisms, viruses and fungi, such as bacteria propagules (including mycobacteria), viruses, fungi and spores, bacterial spores and pathogenic spores thereof is more than or equal to 90 percent. The detection method is according to disinfectant technical Specification 2019.

The experimental results are as follows: (the dosage of the disinfectant adopted in the detection is 25mL/m³Act for 5 min).

The bacterial propagules and bacterial spores are inspected by a bacterial killing test method, and the live bacteria are not detected according to the results of the test; the killing bacteria log value is 4.12 through the test of the mycobacterium test method; through the test of a fungus killing test method, the killing log value of candida albicans and aspergillus niger is 4.52; through the test of a virus fire-extinguishing test method, the mean fire-extinguishing logarithm value of the viral pathogenic rate of the poliovirus and the HIV is 7.13; the air disinfection identification test method is adopted to test the liquid, the laboratory test killing rate is 100 percent, the simulation field test killing rate is 100 percent, and the field test natural bacteria elimination rate is 98 percent.

2. Antibacterial efficacy: the retention bacteriostasis effect identification test and the immersion test method test are adopted, the bacteriostasis rate is more than or equal to 90 percent, and the detection method is according to the disinfectant technical specification 2019 edition according to the detection method.

The experimental results are as follows:

1) after the detention bacteriostasis effect identification test, negative control bacteria grow aseptically in each test, and the bacteriostasis rate to staphylococcus aureus is 100 percent after 16 experiments.

2) After the test of the dipping test method: the "0" contact time control fabric had an average colony count of 3125 cfu/mL; the negative control bacteria grows aseptically, the number of the positive control bacteria is obviously increased than the number of the bacteria in the contact time of 0; the bacteriostasis rate of 3 tests is more than or equal to 96 percent.

Claims

1. An isolated air purification disinfectant is characterized by comprising aqueous resin, a diluent, a drying agent, a disinfectant, a propellant and water, wherein the aqueous resin is polyvinyl alcohol, the diluent is isopropanol, the propellant is dichloromethane, the drying agent is borax, and the disinfectant is formaldehyde with the final concentration of 0.5-5%, 2-5% of glutaraldehyde, 2-3% of sodium hydroxide or potassium hydroxide, 1-5% of bleaching powder, 0.05-1.5% of sodium hypochlorite, 0.5-10% of sodium dichloroisocyanurate, 0.5-2% of chlorine dioxide, 0.05-0.2% of sodium dichloroisocyanurate, 0.0005-0.2% of trichloroisocyanuric acid, 0.0005-0.003% of dichlorohydantoin, 0.0001-0.0003% of dibromohydantoin, 0.01-0.04% of bromochlorohydantoin, 1-5% of bromoisocyanuric acid, 0.01-1% of benzalkonium chloride, One or more of 1 percent of benzalkonium bromide, 1 to 5 percent of chlorobutanol, 0.2 to 0.4 percent of peroxyacetic acid, 0.02 to 5 percent of potassium permanganate, 1 to 3 percent of hydrogen peroxide, 1 to 10 percent of lysol, 0.3 to 1 percent of compound phenol, 3 to 5 percent of Keliaogin, 0.05 to 2 percent of benzalkonium bromide, 0.1 to 0.5 percent of domiphen bromide, 0.02 to 0.5 percent of chlorhexidine, 0.1 to 0.3 percent of Baidusha and 75 percent of ethanol, wherein,

200 portions and 500 portions of aqueous resin;

2-5 parts of a drying promoter;

diluent 400-700 parts;

50-100 parts of a propellant;

30-80 parts of water.

2. The air purifying disinfectant as claimed in claim 1, wherein the components are as follows in parts by weight:

200 parts of water-based resin;

5 parts of a drying promoter;

600 parts of a diluent;

80 parts of propellant;

50 parts of water.

3. An air purifying disinfectant according to claim 1, characterized by comprising the following components:

200 parts of polyvinyl alcohol serving as water-based resin and 5 parts of borax serving as a drying accelerator; the diluent is isopropanol, 600 shares; the propellant is dichloromethane, 80 parts, the water is 50 parts, and the disinfectant is benzalkonium bromide with the final concentration of 1% and/or chlorobutanol with the final concentration of 5%.

4. An air cleaning disinfectant according to any one of claims 1 to 3, wherein said air cleaning disinfectant further comprises one or more of a defoamer, a wetting agent, a dispersant, a film former, an emulsifier, an anti-skinning agent, a freeze-thaw stabilizer, an anti-sagging agent, a thickener, a flame retardant, an antistatic agent, and a mildewproofing agent.

5. An air cleaning disinfectant according to claim 4, further comprising 6772 parts of antifoaming agent Haimax DF, 2802 parts of wetting agent Tego, and 750W 1 parts of dispersant Tego.

6. The air purifying disinfectant as set forth in claim 1, wherein the viscosity of the air purifying disinfectant is not more than 800 mPa-s, the particle size of the mist spray is not less than 0.4mm, and the particle size after drying is not less than 0.1 mm.