CN112345764B - Specific protein instrument control method - Google Patents
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- CN112345764B CN112345764B CN202011092584.1A CN202011092584A CN112345764B CN 112345764 B CN112345764 B CN 112345764B CN 202011092584 A CN202011092584 A CN 202011092584A CN 112345764 B CN112345764 B CN 112345764B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Abstract
The invention discloses a control method of a specific protein instrument, which comprises the steps of obtaining a sample to be detected; then, equally dividing the sample to be detected into X1 parts, and selecting one part of the sample to be detected; then putting the protein into a specific protein instrument for specific protein content determination to obtain content information of all specific proteins, and marking the content information as Hij; wherein n is a positive integer and represents content information corresponding to a specific protein; then, selecting the next sample to be detected, repeating the steps to obtain new content information II, and marking the new content information II as Hij; iterating the previous steps again to obtain all content information groups Hij; then, data correction is carried out on the content information group Hij by means of an equipment checking system; the accuracy of the data and whether the information acquired by the current instrument has the credibility are judged by carrying out the calculation of the relevant proportion among the transverse data; and different reactions are carried out according to the credibility.
Description
Technical Field
The invention belongs to the field of specific protein instruments, and relates to a specific protein instrument control technology, in particular to a specific protein instrument control method.
Background
The patent with publication number CN106970226A specifically discloses a kit for measuring the concentration level of epidermal growth factor receptor 2 extracellular region protein in human serum, and aims to solve the technical problem of providing a kit for measuring the concentration level of human serum suitable for a full-automatic biochemical analyzer and a specific protein analyzer, wherein the kit comprises three parts which are related to each other: the reagent R1, the reagent R2 and the calibrator Cal are combined on a specific instrument for calibration and then a clinical serum sample is directly tested, and the obtained result is the concentration level of the protein in human serum. Compared with a chemiluminescence method, the kit has higher consistency of results, is lower in cost and is more suitable for application and popularization of clinical detection.
The patent with publication number CN111398006A also discloses a whole blood sample preprocessing device, and it is including preliminary treatment pipe and preliminary treatment diluent, and the preliminary treatment diluent holds in the preliminary treatment pipe, is equipped with a plurality of nonrust steel ball in the body, accelerates the speed of the intraductal liquid misce bene of preliminary treatment through adding nonrust steel ball, the component of preliminary treatment diluent include buffer solution, surfactant agent, inorganic salt, stabilizer and antiseptic, the preliminary treatment pipe includes body and pipe cap, and the body is cylindrical pipe, and the bottom of body is equipped with the arc concave surface, and the pipe cap is established at the open-top of body, pipe cap and body sealing connection. The whole blood sample pretreatment device can pretreat the collected whole blood sample without separating serum or plasma, the pretreated whole blood sample can be widely applied to detection of a full-automatic biochemical analyzer and a specific protein analyzer, the detection efficiency is higher, and the stability is good; the stabilizing agent component in the pretreated diluent is beneficial to the preservation of the object to be detected in the sample, the detection accuracy is improved, and the repeatability is good.
These are also relevant detection principles and pretreatment steps for detecting by a specific protein instrument, but the current specific protein instrument cannot carry out reasonable self-check, and whether the measured data is accurate or not is also lack of a corresponding mode for checking; to address this technical deficiency, a solution is now provided.
Disclosure of Invention
The invention aims to provide a specific protein instrument control method.
The purpose of the invention can be realized by the following technical scheme:
the control method of the specific protein instrument comprises the specific protein instrument and a corresponding equipment checking system;
the method specifically comprises the following steps:
the method comprises the following steps: obtaining a sample to be detected;
step two: equally dividing a sample to be detected into X1 parts, wherein X1 is a preset value;
step three: optionally selecting a sample to be tested;
step four: putting the protein into a specific protein instrument for measuring the content of specific protein to obtain the content information of all specific proteins, and marking the content information as Hij, i-1.. n, j-1; wherein n is a positive integer and represents content information corresponding to a specific protein;
step five: optionally selecting the next sample to be detected, repeating the step four to obtain new content information II, and marking the content information II as Hij, i is 1.. n, j is 2;
step six: repeating the fifth step to obtain all content information groups Hij, i-1.. n, j-1.. X1;
step seven: correcting data by means of an equipment checking system;
the equipment checking system comprises a data intercepting unit, a self-judging unit, a management unit, a controller, a display unit, a storage unit and a data analysis unit;
the data interception unit is used for acquiring all content information groups Hij and transmitting the content information groups Hij to the self-judgment unit, the self-judgment unit receives the content information groups Hij transmitted by the data interception unit, performs self-judgment analysis on the content information groups Hij, and generates error signals and permission signals according to results;
the self-judging unit is used for transmitting an error signal and a permission signal to the controller; the controller is used for transmitting an error signal and a permission signal to the data analysis unit;
the data interception unit is used for transmitting the content information group Hij to the data analysis unit, and the data analysis unit is used for automatically solving the average value of each specific protein at j ═ 1.. X1 when receiving an admission signal transmitted by the controller to obtain the result content of all specific proteins; the data analysis unit is used for returning the result content to the controller; the data analysis unit does not perform any processing when receiving the error signal transmitted by the controller;
the management unit is in communication connection with the controller.
Further, the specific analysis process of the self-judgment analysis is as follows:
s1: acquiring all content information Hij;
s2: obtaining all content information H1j by changing i to 1;
s3: calculating an average value of the content information H1j, and marking the corresponding average value as P;
s4: when j is equal to 1, removing the corresponding content information H11, then calculating an average value, and marking the average value as P1;
s5: repeating the step S4 to obtain an average value P2 by making j equal to j + 1;
s6: repeating the step S5 until all the content information H1j is processed; obtaining the average value group Pj, wherein the Pj corresponds to H1j one by one;
s7: calculating to obtain an influence difference value Cj by using a formula, wherein the specific calculation formula is that Cj is P-Pj; marking the error content of the Cj exceeding X2 to obtain the proportion of the error content in all content information, and marking the proportion as difference proportion Z1; x2 is a predetermined value;
s8: let i equal i + 1; acquiring corresponding content information; repeating the steps S3-S8 to obtain all corresponding difference ratios Zi;
s9: acquiring the ratio of the number of Zi values exceeding X3 to the total number and marking the ratio as an evaluation ratio, when the evaluation ratio exceeds X4; x3 and X4 are both preset values; generating an error signal; otherwise a grant signal is generated.
Further, the controller is used for transmitting the result content to the display unit for real-time display; and the controller is used for transmitting the result content to the storage unit for real-time storage.
Further, the controller drives the display unit to display that the current specific protein instrument has a possible error and please check the word eye when receiving the error signal transmitted from the judging unit.
Further, the management unit is configured to record all preset values.
The invention has the beneficial effects that:
the method comprises the steps of obtaining a sample to be detected; then, equally dividing the sample to be detected into X1 parts, and selecting one part of the sample to be detected; then putting the protein into a specific protein instrument for specific protein content determination to obtain content information of all specific proteins, and marking the content information as Hij; wherein n is a positive integer and represents content information corresponding to a specific protein; then, selecting the next sample to be tested, repeating the steps to obtain new content information II, and marking the new content information II as Hij; iterating the previous steps again to obtain all content information groups Hij;
then, data correction is carried out on the content information group Hij by means of an equipment checking system; the accuracy of the data and whether the information acquired by the current instrument has the credibility are judged by carrying out the calculation of the relevant proportion among the transverse data; and carrying out different reactions according to the credibility; the invention is simple, effective and easy to use.
Drawings
In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a system block diagram of the device verification system of the present invention.
Detailed Description
As shown in fig. 1, the control method of the specific protein instrument comprises the specific protein instrument and a corresponding equipment checking system;
the method specifically comprises the following steps:
the method comprises the following steps: obtaining a sample to be detected;
step two: equally dividing a sample to be detected into X1 parts, wherein X1 is a preset value; the specific examples can be three or five, and are specifically distributed according to the situation;
step three: optionally selecting a sample to be tested;
step four: putting the protein into a specific protein instrument for measuring the content of specific protein to obtain the content information of all specific proteins, and marking the content information as Hij, i-1.. n, j-1; wherein n is a positive integer and represents content information corresponding to a specific protein;
step five: optionally selecting the next sample to be tested, repeating the step four to obtain new content information II, and marking the content information II as Hij, i-1.. n, j-2;
step six: repeating the fifth step to obtain all content information groups Hij, i-1.. n, j-1.. X1;
step seven: correcting data by means of an equipment checking system;
the equipment checking system comprises a data intercepting unit, a self-judging unit, a management unit, a controller, a display unit, a storage unit and a data analysis unit;
the data interception unit is used for acquiring all content information sets Hij and transmitting the content information sets Hij to the self-judgment unit, the self-judgment unit receives the content information sets Hij transmitted by the data interception unit and performs self-judgment analysis on the content information sets Hij, and the specific analysis process is as follows:
s1: acquiring all content information Hij;
s2: obtaining all content information H1j by changing i to 1;
s3: calculating an average value of the content information H1j, and marking the corresponding average value as P;
s4: let j equal to 1, remove the corresponding content information H11, find the average value, mark it as P1;
s5: repeating the step S4 to obtain an average value P2;
s6: repeating the step S5 until all the content information H1j is processed; obtaining the one-to-one correspondence of the average value groups Pj and Pj to H1 j;
s7: calculating to obtain an image difference value Cj by using a formula, wherein the specific calculation formula is that Cj is equal to P-Pj; marking the error content of the Cj exceeding X2 to obtain the proportion of the error content in all content information, and marking the proportion as difference proportion Z1; x2 is a preset value;
s8: let i equal i + 1; acquiring corresponding content information; repeating the steps S3-S8 to obtain all corresponding difference ratios Zi;
s9: acquiring the ratio of the number of Zi values exceeding X3 to the total number and marking the ratio as an evaluation ratio, and when the evaluation ratio exceeds X4; x3 and X4 are both preset values; generating an error signal; otherwise, generating a permission signal;
the self-judging unit is used for transmitting an error signal and a permission signal to the controller; the controller is used for transmitting an error signal and a permission signal to the data analysis unit;
the data interception unit is used for transmitting the content information group Hij to the data analysis unit, and the data analysis unit is used for automatically calculating the average value of each specific protein at j 1.. X1 when receiving the permission signal transmitted by the controller to obtain the result content of all specific proteins; the data analysis unit is used for returning the result content to the controller; the data analysis unit does not perform any processing when receiving the error signal transmitted by the controller;
the controller is used for transmitting the result content to the display unit for real-time display; the controller is used for transmitting the result content to the storage unit for real-time storage.
The controller drives the display unit to display that the current specific protein instrument has errors and please check the word eye when receiving the error signal transmitted by the self-judging unit.
The management unit is in communication connection with the controller and is used for recording all preset values.
The control method of the specific protein instrument comprises the specific protein instrument and a corresponding equipment checking system; the method specifically comprises the following steps of firstly obtaining a sample to be detected; then, equally dividing the sample to be detected into X1 parts, and selecting one part of the sample to be detected; then putting the protein into a specific protein instrument for specific protein content determination to obtain content information of all specific proteins, and marking the content information as Hij; wherein n is a positive integer and represents content information corresponding to a specific protein; then, selecting the next sample to be tested, repeating the steps to obtain new content information II, and marking the new content information II as Hij; iterating the previous steps again to obtain all content information groups Hij;
then, data correction is carried out on the content information group Hij by means of an equipment checking system; the accuracy of the data and whether the information acquired by the current instrument has the credibility are judged by carrying out the calculation of the relevant proportion among the transverse data; carrying out different reactions according to the credibility; the invention is simple, effective and easy to use.
The foregoing is merely exemplary and illustrative of the present invention and various modifications, additions and substitutions may be made by those skilled in the art to the specific embodiments described without departing from the scope of the invention as defined in the following claims.
Claims (4)
1. The control method of the specific protein instrument is characterized by comprising the specific protein instrument and a corresponding equipment checking system;
the method specifically comprises the following steps:
the method comprises the following steps: obtaining a sample to be detected;
step two: equally dividing a sample to be detected into X1 parts, wherein X1 is a preset value;
step three: optionally selecting a sample to be tested;
step four: putting the protein into a specific protein instrument for specific protein content measurement to obtain content information of all specific proteins, and marking the content information as Hij, i =1.. n, j = 1; wherein n is a positive integer and represents content information corresponding to a specific protein;
step five: optionally selecting the next sample to be detected, repeating the step four to obtain new content information II, and marking the content information II as Hij, i =1.. n, j = 2;
step six: repeating the fifth step to obtain all content information groups Hij, i =1.. n, j =1.. X1;
step seven: correcting data by means of an equipment checking system;
the equipment checking system comprises a data intercepting unit, a self-judging unit, a management unit, a controller, a display unit, a storage unit and a data analysis unit;
the data interception unit is used for acquiring all content information groups Hij and transmitting the content information groups Hij to the self-judgment unit, the self-judgment unit receives the content information groups Hij transmitted by the data interception unit, performs self-judgment analysis on the content information groups Hij, and generates error signals and permission signals according to results;
the self-judging unit is used for transmitting an error signal and a permission signal to the controller; the controller is used for transmitting an error signal and a permission signal to the data analysis unit;
the data interception unit is used for transmitting the content information group Hij to the data analysis unit, and the data analysis unit is used for automatically calculating the average value of each specific protein at j =1.. X1 when receiving a permission signal transmitted by the controller to obtain the result content of all specific proteins; the data analysis unit is used for returning the result content to the controller; the data analysis unit does not perform any processing when receiving the error signal transmitted by the controller;
the management unit is in communication connection with the controller;
the specific analysis process of the self-judgment analysis is as follows:
s1: acquiring all content information Hij;
s2: letting i =1, and acquiring all content information H1 j;
s3: calculating an average value of the content information H1j, and marking the corresponding average value as P;
s4: let j =1, remove the corresponding content information H11, find the average value, mark it as P1;
s5: let j = j +1, repeat step S4, get average value P2;
s6: repeating the step S5 until all the content information H1j is processed; obtaining the one-to-one correspondence of the average value groups Pj and Pj to H1 j;
s7: calculating to obtain a shadow difference value Cj by using a formula, wherein the specific calculation formula is Cj = P-Pj; marking the error content of the Cj exceeding X2 to obtain the proportion of the error content in all content information, and marking the proportion as difference proportion Z1; x2 is a preset value;
s8: let i = i + 1; acquiring corresponding content information; repeating the steps S3-S8 to obtain all corresponding difference ratios Zi;
s9: acquiring the ratio of the number of Zi values exceeding X3 to the total number and marking the ratio as an evaluation ratio, and when the evaluation ratio exceeds X4; x3 and X4 are both preset values; generating an error signal; otherwise a permission signal is generated.
2. The method for controlling a specific protein instrument according to claim 1, wherein the controller is configured to transmit the content of the result to a display unit for real-time display; the controller is used for transmitting the result content to the storage unit for real-time storage.
3. The method as claimed in claim 1, wherein the controller drives the display unit to display that the specific protein instrument may have an error and please check the word when receiving the error signal transmitted from the determining unit.
4. The method for controlling a specific protein instrument according to claim 1, wherein said management unit is configured to enter all preset values.
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| JP2006064568A (en) * | 2004-08-27 | 2006-03-09 | Denka Seiken Co Ltd | Automatic external precision control system and method |
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| WO2008090941A1 (en) * | 2007-01-24 | 2008-07-31 | Ajinomoto Co., Inc. | Method of evaluating ibd, amino acid data processor, amino acid data processing method, amino acid data processing system, amino acid data processing program and recording medium |
| US9659146B2 (en) * | 2011-05-02 | 2017-05-23 | Tyler Stuart Bray | Method for quantitative analysis of complex proteomic data |
| JP6683111B2 (en) * | 2016-11-28 | 2020-04-15 | 株式会社島津製作所 | Sample analysis system |
| CN109725133B (en) * | 2019-03-06 | 2022-01-21 | 河北谱尼测试科技有限公司 | Soil moisture real-time monitoring system and monitoring method thereof |
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| CN110823838A (en) * | 2019-11-26 | 2020-02-21 | 安徽九陆生物科技有限公司 | Optical detection device of specific protein immunoassay analyzer and use method thereof |
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