CN112326604A - System and method for detecting bubbles in liquid path of full-automatic chemiluminescence immunoassay analyzer - Google Patents
System and method for detecting bubbles in liquid path of full-automatic chemiluminescence immunoassay analyzer Download PDFInfo
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- CN112326604A CN112326604A CN202011201482.9A CN202011201482A CN112326604A CN 112326604 A CN112326604 A CN 112326604A CN 202011201482 A CN202011201482 A CN 202011201482A CN 112326604 A CN112326604 A CN 112326604A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
Abstract
The utility model relates to a bubble detecting system and method in full-automatic chemiluminescence immunoassay appearance liquid way sets up sealed mount pad on the liquid way pipeline, and sealed mount pad plays the effect of installing other parts, simultaneously forms a "darkroom" part on the liquid way pipeline again, and infrared generator sends infrared ray, and infrared inductor receives the infrared ray that infrared generator sent and passed the liquid way pipeline, when having the bubble in the liquid way pipeline, its whole light transmissivity will strengthen, also the infrared inductor can sense more infrared rays, and its current signal is also stronger, and microprocessor just can calculate the bubble size by current signal.
Description
Technical Field
The application belongs to the technical field of medical equipment and equipment, and particularly relates to a system and a method for detecting bubbles in a liquid path of a full-automatic chemiluminescence immunoassay analyzer.
Background
The full-automatic chemiluminescence immune analyzer is a medical inspection instrument for carrying out immune analysis on a human body by detecting serum of a patient, quantitatively analyzes the concentration of molecules to be detected in a sample according to a mathematical model established by a standard substance, and finally prints a data report to assist clinical diagnosis.
The sample and various actual sample adding quantities in the full-automatic chemiluminescence immunoassay analyzer have different liquid quantity precision requirements, and when the liquid quantity is too high or too low, the test result can be influenced, so that how to effectively absorb the sample and the reagent with accurate liquid quantity is a key problem; however, this method may be affected by up-and-down movement errors of the motor, liquid level changes of the reagent or the sample during the movement process, reagent bottle condensed water and other factors, and deviation occurs during the detection process, so that the needle does not really contact the liquid level, the sample needle or the reagent needle is empty, the test result is inaccurate, and when the sample needle or the reagent needle is empty, air bubbles are formed in the pipeline, and therefore, a method for detecting whether air bubbles exist in the pipeline is required.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: in order to solve the defects in the prior art, the system and the method for detecting the bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer are provided.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a bubble detecting system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer,
the liquid path pipeline is made of a light-transmitting material;
the sealing installation seat is sleeved on the liquid pipeline;
the infrared generator is arranged in the sealed mounting seat and positioned on one side of the liquid path pipeline and used for emitting infrared rays;
the infrared inductor is arranged in the sealed mounting seat and positioned on the other side of the liquid path pipeline and used for receiving infrared rays emitted by the infrared generator and penetrating through the liquid path pipeline and outputting a current signal;
and the microprocessor is used for receiving the current signal of the infrared sensor, matching the current signal with a set relational expression of the bubble size and the current signal and outputting the bubble size.
Preferably, in the bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer, the current signal output by the infrared sensor is amplified by the amplifier and then is connected with the microprocessor.
Preferably, in the detection system for bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer, the liquid path pipeline comprises a pipeline body, and light refracting bodies which are distributed in the space surrounded by the sealed mounting seat and are made of glass and positioned on two sides of the infrared generator, wherein the light refracting bodies are concave lenses.
Preferably, in the detection system for bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer, both sides of the refractometer are concave surfaces.
Preferably, in the system for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer, the liquid path pipeline comprises a pipeline body, and glass-made refraction bodies which are distributed in the space surrounded by the sealed mounting seat and positioned at two sides of the infrared generator, wherein the refraction bodies are convex lenses, and the intersection point positions of the two convex lenses for infrared rays are positioned outside the receiving range of the infrared inductor.
The invention also provides a method for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer, which uses the bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer;
the method comprises the following steps:
s1: establishing a relation curve between an output current signal of the infrared sensor and the size of the bubbles;
s2: and monitoring the current signal output by the infrared inductor in real time, and calculating the amount of the liquid passing through according to the magnitude of the output current signal.
Preferably, the method for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer,
the current signal output by the infrared inductor is amplified by a certain multiple through an amplifier;
s1, establishing a relation curve between the amplified output current signal of the infrared sensor and the size of the bubble; and S2, monitoring the amplified output current signal of the infrared inductor in real time.
Preferably, the method for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer is further provided with a temperature sensor before the sealing mounting seat, and the temperature sensor can sense the temperature of liquid flowing through the liquid path pipeline.
Preferably, the infrared generator emits at a frequency of the flow rate of the liquid divided by the width of the seal mount.
The invention has the beneficial effects that:
the invention relates to a bubble detection system and a method in a liquid path of a full-automatic chemiluminescence immunoassay analyzer.A sealing installation seat is arranged on a liquid path pipeline, the sealing installation seat plays a role of installing other components, meanwhile, a 'darkroom' part is formed on the liquid path pipeline, an infrared generator emits infrared rays, an infrared sensor receives the infrared rays emitted by the infrared generator and penetrating through the liquid path pipeline, when bubbles exist in the liquid path pipeline, the integral light transmittance of the liquid path pipeline is enhanced, namely the infrared sensor senses more infrared rays, the current signal of the liquid path pipeline is stronger, and a microprocessor can calculate the size of the bubbles by the current signal.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
FIG. 1 is a schematic diagram of a bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer according to an embodiment of the application;
FIG. 2 is a schematic structural diagram of a refractometer in a bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer in example 1 of the present application;
FIG. 3 is a schematic diagram showing another refractile body in a bubble detection system in a liquid path of the full-automatic chemiluminescence immunoassay analyzer in example 1 of the present application;
the reference numbers in the figures are:
1, a liquid pipeline;
2, sealing the mounting seat;
3 an infrared generator;
4 infrared inductor;
5 a microprocessor;
6 infrared inductor;
10 a pipe body;
11 a refractive body.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific situations.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Example 1
The present embodiment provides a bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer, as shown in fig. 1, including:
the liquid pipeline 1 is made of light-transmitting materials, such as common medical transparent plastics;
the sealing installation seat 2 is sleeved on the liquid pipeline 1;
the infrared generator 3 is arranged at one side of the liquid pipeline 1 in the seal mounting seat 2 and used for emitting infrared rays;
the infrared inductor 4 is arranged in the sealing installation seat 2 and positioned on the other side of the liquid path pipeline 1, and is used for receiving infrared rays which are emitted by the infrared generator 3 and penetrate through the liquid path pipeline 1 and outputting a current signal;
and the microprocessor 5 is used for receiving the current signal of the infrared sensor, matching the current signal with a set relational expression between the size of the bubble and the current signal, and outputting the size of the bubble.
The bubble detecting system in the liquid way of the full-automatic chemiluminescence immunoassay analyzer of the embodiment is characterized in that a sealing installation seat 2 is arranged on a liquid way pipeline 1, the sealing installation seat 2 plays a role in installing other components, meanwhile, a 'darkroom' part is formed on the liquid way pipeline 1, an infrared ray is emitted by an infrared ray generator 3, an infrared ray sensor 4 receives the infrared ray emitted by the infrared ray generator 3 and penetrates through the liquid way pipeline 1, when bubbles exist in the liquid way pipeline 1, the whole light transmission performance of the infrared ray sensor is enhanced, namely the infrared ray sensor 4 senses more infrared rays, the current signal of the infrared ray sensor is stronger, a micro processor 5 can also give an alarm according to an overlarge current signal, and reminds a user that the bubbles exist in liquid passing through the micro processor, so that the detection of the bubbles in the liquid way is realized.
It should be noted that the darkroom is only for a completely darkroom which generally blocks most of the light, and it is not possible nor necessary to have a completely darkroom without any light.
Preferably, the current signal output by the infrared sensor 6 is amplified by an amplifier and then connected with the microprocessor 5. The amplifier is a common circuit, and can amplify the output current of the infrared sensor 6, thereby improving the sensitivity.
Example 2
The present embodiment provides a bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer, as shown in fig. 2, including:
the liquid pipeline 1 is made of light-transmitting materials, such as common medical transparent plastics;
the sealing installation seat 2 is sleeved on the liquid pipeline 1 to form an infrared darkroom space;
the infrared generator 3 is arranged at one side of the liquid pipeline 1 in the seal mounting seat 2 and used for emitting infrared rays;
the infrared inductor 4 is arranged in the sealing installation seat 2 and positioned on the other side of the liquid path pipeline 1, and is used for receiving infrared rays which are emitted by the infrared generator 3 and penetrate through the liquid path pipeline 1 and outputting a current signal;
and the microprocessor 5 is used for receiving the current signal of the infrared sensor, matching the current signal with a set relational expression between the size of the bubble and the current signal, and outputting the size of the bubble.
The microprocessor 5 can also be connected to an alarm to notify the person when the current signal is too high (presence of air bubbles).
The liquid path pipeline 1 comprises a pipeline body 10 and light refracting bodies 11 which are distributed in a space surrounded by the seal mounting seat 2 and are made of glass and positioned on two sides of the infrared generator 3, wherein the light refracting bodies 11 are concave lenses (the light refracting bodies 11 are integrally concave lenses, but a flow channel for liquid to pass through is formed in the center, and the diameter of the flow channel is equal to that of the flow channel of the pipeline body 10). Also embedded one section refraction body 11 in the sealed mount pad 2 of liquid way pipeline 1, through concave lens with light divergence to make sealed mount pad 2 outside along the infrared ray in the environment that liquid way pipeline 1 penetrated (outside light inevitably jets into sealed mount pad 2 from both sides), can be dispersed by concave lens, and can't reach infrared inductor 4 district, thereby overcome infrared inductor 4 and received the infrared ray in the environment, reduce the influence of infrared ray to testing result in the environment.
Both sides of the refraction body 11 are concave surfaces, or one side facing outwards can be a concave surface, and the other side is a plane.
As an alternative embodiment, as shown in fig. 3, the liquid path pipe 1 includes a pipe body 10, and glass-made light refracting bodies 11 distributed in the space surrounded by the seal mounting seat 2 and located on both sides of the infrared ray generator 3, wherein the light refracting bodies 11 are convex lenses, and the intersection point positions of the two convex lenses with respect to the infrared ray are located outside the receiving range of the infrared ray sensor 4.
That is, through adjusting the focus and the setting position of the refraction body 11, the infrared ray in the environment injected along the liquid channel pipeline 1 outside the seal installation seat 2 can be converged outside the receiving range of the infrared inductor 4, so that the infrared ray in the environment is prevented from being injected into the infrared inductor 4, and the influence of the infrared ray on the detection result in the environment is reduced.
Example 3
The embodiment provides a method for detecting bubbles in a liquid path of a full-automatic chemiluminescence immunoassay analyzer, which uses the bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer;
the method comprises the following steps:
s1: establishing a relation curve between an output current signal of the infrared sensor and the size of the bubbles;
s2: and monitoring the current signal output by the infrared inductor in real time, and calculating the amount of the liquid passing through according to the magnitude of the output current signal.
By passingWherein t is the time of the liquid flowing through the pipeline, R is the radius of the pipeline, v is the liquid flow rate, k is a coefficient, and i is an output current signal of the infrared inductor;
and k represents a proportionality coefficient of the area occupied by the bubbles and the output current signal of the infrared sensor in a cross section of the pipeline in a relation curve of the output current signal of the infrared sensor and the size of the bubbles.
The infrared generator 3 emits at a frequency that is the flow rate of the liquid divided by the width of the seal mount 2. The liquid just runs the width of the sealing mount 2 in the emission interval of the infrared generator 3. In order to ensure that the values are matched, a flow rate sensor may be provided, by means of which the emission frequency of the infrared generator 3 is adjusted.
Preferably, the method for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer of the embodiment,
the current signal output by the infrared inductor is amplified by a certain multiple through an amplifier;
s1, establishing a relation curve between the amplified output current signal of the infrared sensor and the size of the bubble; and S2, monitoring the amplified output current signal of the infrared inductor in real time. A filter circuit may also be provided to filter out spurs in the signal.
Preferably, in the method for detecting bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer of the embodiment, a temperature sensor is further arranged in front of the sealed mounting seat, and the temperature sensor can sense the temperature of liquid flowing through the liquid path pipeline.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (9)
1. A bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer is characterized in that,
the liquid path pipeline (1) is made of a light-transmitting material;
the sealing installation seat (2) is sleeved on the liquid pipeline (1);
the infrared generator (3) is arranged on one side of the liquid pipeline (1) in the sealing installation seat (2) and is used for emitting infrared rays;
the infrared inductor (4) is arranged in the sealed mounting seat (2) and positioned on the other side of the liquid path pipeline (1), and is used for receiving infrared rays which are emitted by the infrared generator (3) and penetrate through the liquid path pipeline (1) and outputting a current signal;
and the microprocessor (5) is used for receiving the current signal of the infrared sensor (4), matching the current signal with a set relational expression between the bubble size and the current signal and outputting the bubble size.
2. The bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer according to claim 1, wherein the current signal output by the infrared sensor (6) is amplified by an amplifier and then connected to the microprocessor (5).
3. The bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer according to claim 1 or 2, wherein the liquid path pipeline (1) comprises a pipeline body (10), and light refracting bodies (11) which are distributed in the space surrounded by the seal mounting seat (2) and are made of glass and positioned at two sides of the infrared generator (3), wherein the light refracting bodies (11) are concave lenses.
4. The bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer according to claim 3, wherein both sides of the refractor (11) are concave.
5. The bubble detection system in the liquid path of the full-automatic chemiluminescence immunoassay analyzer according to claim 1 or 2, wherein the liquid path pipe (1) comprises a pipe body (10), and glass-made refractors (11) which are distributed in the space surrounded by the seal mounting seat (2) and are positioned at both sides of the infrared ray generator (3), the refractors (11) are convex lenses, and the intersection point positions of the two convex lenses for infrared rays are positioned outside the receiving range of the infrared ray sensor (4).
6. A method for detecting bubbles in a liquid path of a full-automatic chemiluminescence immunoassay analyzer, which is characterized in that a bubble detection system in a liquid path of a full-automatic chemiluminescence immunoassay analyzer according to any one of claims 1 to 5 is used;
the method comprises the following steps:
s1: establishing a relation curve between an output current signal of the infrared sensor (4) and the size of the bubbles;
s2: the current signal output by the infrared sensor (4) is monitored in real time, and the amount of the liquid passing through is calculated according to the magnitude of the output current signal.
7. The method for detecting air bubbles in a liquid path of a full-automatic chemiluminescence immunoassay analyzer according to claim 6,
the current signal output by the infrared inductor (4) is amplified by a certain multiple through an amplifier;
s1, establishing a relation curve between the amplified output current signal of the infrared sensor (4) and the size of the bubbles; and S2, monitoring the amplified output current signal of the infrared inductor (4) in real time.
8. The method for detecting the bubbles in the liquid path of the full-automatic chemiluminescence immunoassay analyzer according to claim 6, wherein a temperature sensor is further provided before the seal mounting seat (2), and the temperature sensor can sense the temperature of the liquid flowing in the liquid path pipeline (1).
9. The method for detecting bubbles in the liquid path of a full-automatic chemiluminescence immunoassay analyzer according to claim 6, wherein the emission frequency of the infrared generator (3) is the flow rate of the liquid divided by the width of the seal mount (2).
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CN202011201482.9A CN112326604A (en) | 2020-11-02 | 2020-11-02 | System and method for detecting bubbles in liquid path of full-automatic chemiluminescence immunoassay analyzer |
PCT/CN2021/081006 WO2022088586A1 (en) | 2020-11-02 | 2021-03-16 | System and method for detecting bubbles in liquid path of fully automatic chemiluminescence immunoassay analyzer |
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CN202011201482.9A CN112326604A (en) | 2020-11-02 | 2020-11-02 | System and method for detecting bubbles in liquid path of full-automatic chemiluminescence immunoassay analyzer |
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WO2022088586A1 (en) * | 2020-11-02 | 2022-05-05 | 苏州长光华医生物医学工程有限公司 | System and method for detecting bubbles in liquid path of fully automatic chemiluminescence immunoassay analyzer |
CN115479627A (en) * | 2022-07-27 | 2022-12-16 | 谭万龙 | Method, system, device and storage medium for counting liquid drops and measuring flow |
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