CN112299724A - Bioactive glass material for orthopedic repair and preparation method thereof - Google Patents
Bioactive glass material for orthopedic repair and preparation method thereof Download PDFInfo
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- CN112299724A CN112299724A CN202011149163.8A CN202011149163A CN112299724A CN 112299724 A CN112299724 A CN 112299724A CN 202011149163 A CN202011149163 A CN 202011149163A CN 112299724 A CN112299724 A CN 112299724A
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C14/00—Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
- C03B19/00—Other methods of shaping glass
- C03B19/02—Other methods of shaping glass by casting molten glass, e.g. injection moulding
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/062—Glass compositions containing silica with less than 40% silica by weight
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
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Abstract
The invention belongs to the technical field of bioactive glass, and particularly relates to a bioactive glass material for orthopedic repair and a preparation method thereof, wherein the bioactive glass material comprises the following raw materials in parts by weight: 30-50 parts of silicon dioxide, 10-15 parts of sodium oxide, 40-50 parts of calcium oxide, 15-25 parts of phosphorus pentoxide, 10-15 parts of aluminum oxide, 8-12 parts of zirconium oxide, 1-3 parts of stabilizer, 6-9 parts of titanium dioxide, 10-15 parts of zinc oxide, 8-12 parts of magnesium oxide, 6-8 parts of molybdenum dioxide, 12-15 parts of tungsten oxide, 10-15 parts of silver oxide, 3-6 parts of yttrium phosphate, 5-7 parts of cerium silica powder, 12-16 parts of calcium citrate and 3-8 parts of ceramic powder. The invention can obviously improve the compression resistance and the wear resistance of the bioactive glass, has good antibacterial property, and has the advantages of fine and simple preparation method and lower cost.
Description
Technical Field
The invention relates to the technical field of bioactive glass, in particular to a bioactive glass material for orthopedic repair and a preparation method thereof.
Background
Bioactive glass (BAG) is a material which can repair, replace and regenerate body tissues and can enable the tissues and the materials to form bonding. BAG was discovered in 1969 by Hench as a silicate glass consisting of the basic components SiO2, Na2O, CaO and P2O 5. The degradation product of the bioactive glass can promote the generation of growth factors, promote the multiplication of cells, and enhance the gene expression of osteoblasts and the growth of bone tissues. Is the only artificial biomaterial which can be bonded with bone tissue and connected with soft tissue.
The bioactive glass material for orthopedic repair in the prior art has low strength, can only be used for parts with low stress, has poor compression resistance and no good wear resistance, reduces the service life of the bioactive glass material for orthopedic repair, has no good antibacterial property, and is rough in preparation method.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a bioactive glass material for orthopedic repair and a preparation method thereof, and solves the problems that the bioactive glass material for orthopedic repair in the prior art is poor in compression resistance and wear resistance and does not have good antibacterial performance.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: the bioactive glass material for the orthopedic repair comprises the following raw materials in parts by weight: 30-50 parts of silicon dioxide, 10-15 parts of sodium oxide, 40-50 parts of calcium oxide, 15-25 parts of phosphorus pentoxide, 10-15 parts of aluminum oxide, 8-12 parts of zirconium oxide, 1-3 parts of stabilizer, 6-9 parts of titanium dioxide, 10-15 parts of zinc oxide, 8-12 parts of magnesium oxide, 6-8 parts of molybdenum dioxide, 12-15 parts of tungsten oxide, 10-15 parts of silver oxide, 3-6 parts of yttrium phosphate, 5-7 parts of cerium silica powder, 12-16 parts of calcium citrate and 3-8 parts of ceramic powder.
As a preferred technical scheme of the invention, the bioactive glass material for orthopedic repair comprises the following raw materials in parts by weight: 40 parts of silicon dioxide, 13 parts of sodium oxide, 45 parts of calcium oxide, 20 parts of phosphorus pentoxide, 12 parts of aluminum oxide, 10 parts of zirconium oxide, 2 parts of stabilizer, 8 parts of titanium dioxide, 14 parts of zinc oxide, 10 parts of magnesium oxide, 7 parts of molybdenum dioxide, 13 parts of tungsten oxide, 13 parts of silver oxide, 5 parts of yttrium phosphate, 6 parts of cerium silica powder, 15 parts of calcium citrate and 7 parts of ceramic powder.
As a preferable technical scheme of the invention, the stabilizer is boron trioxide.
As a preferable technical scheme of the invention, the silicon dioxide is nano silicon dioxide, and the calcium oxide is nano calcium oxide.
As a preferable technical scheme of the invention, the alumina is nano alumina.
As a preferable technical scheme of the invention, the particle size of the molybdenum dioxide is 300-900 microns.
A preparation method of a bioactive glass material for orthopedic repair comprises the following steps:
s1: weighing corresponding parts by weight of silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, aluminum oxide, zirconium oxide, a stabilizer, titanium dioxide, zinc oxide, magnesium oxide, molybdenum dioxide, tungsten oxide, silver oxide, yttrium phosphate, cerium silica powder, calcium citrate and ceramic powder according to the proportion.
S2: the raw materials of each component are added into a mixer to be mixed together, then are put into a grinder to be ground for 30-60min, and are sieved by a 300-mesh 800-mesh sieve to obtain the raw materials.
S3: adding the screened raw materials into a reaction kettle for melting treatment at 1300-1500 ℃ for 90-120min to obtain the glass mixed solution.
S4: preheating the glass mold, injecting the glass mixed solution into the glass mold, placing the glass mold into an annealing furnace, preserving heat for 2-3h, and cooling to room temperature to obtain the ground glass.
S5: and (3) putting the cooled ground glass into a heating box for heating, taking out the heated ground glass, and cooling to room temperature.
S6: and polishing the cooled glass, and cleaning the polished glass to obtain the bioactive glass material.
(III) advantageous effects
Compared with the prior art, the invention provides a bioactive glass material for orthopedic repair and a preparation method thereof, and the bioactive glass material has the following beneficial effects:
1. according to the preparation method of the bioactive glass material for orthopedic repair, the yttrium phosphate, the cerium silica and the calcium citrate are used, so that the bioactive glass material has ideal biocompatibility, the mechanical property of the bioactive glass is improved, the compression resistance of the bioactive glass is obviously improved, the bioactive glass can be suitable for positions with large stress, the application range of the bioactive glass is improved, and the strength of the bioactive glass material can be further improved through the calcium citrate.
2. According to the preparation method of the bioactive glass material for the orthopedic repair, the wear resistance of the bioactive glass can be improved and the service life of the bioactive glass can be prolonged through the zirconium oxide, the tungsten oxide and the silver oxide, the bioactive glass has good antibacterial performance and the functional characteristics of the bioactive glass are improved, and the preparation method is fine and simple and has low cost.
Drawings
Fig. 1 is a flow chart of a preparation method of the bioactive glass material for orthopedic repair according to the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples
Referring to fig. 1, the present invention provides the following technical solutions: the bioactive glass material for the orthopedic repair comprises the following raw materials in parts by weight: 30-50 parts of silicon dioxide, 10-15 parts of sodium oxide, 40-50 parts of calcium oxide, 15-25 parts of phosphorus pentoxide, 10-15 parts of aluminum oxide, 8-12 parts of zirconium oxide, 1-3 parts of stabilizer, 6-9 parts of titanium dioxide, 10-15 parts of zinc oxide, 8-12 parts of magnesium oxide, 6-8 parts of molybdenum dioxide, 12-15 parts of tungsten oxide, 10-15 parts of silver oxide, 3-6 parts of yttrium phosphate, 5-7 parts of cerium silica powder, 12-16 parts of calcium citrate and 3-8 parts of ceramic powder.
In the embodiment, the silicate glass composed of basic components such as silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide and the like, the degradation product of the bioactive glass can promote the generation of growth factors, promote the proliferation of cells, enhance the gene expression of osteoblasts and the growth of bone tissues, the alumina can improve the hardness of the bioactive glass, so that the compression resistance of the bioactive glass can be improved, the zirconia has inactive chemical properties and has the properties of high melting point, high resistivity, high refractive index and low thermal expansion coefficient, so that the wear resistance of the bioactive glass can be improved, the stabilizing agent can ensure that the bioactive glass is conveniently and stably fused and is convenient to prepare, the titanium dioxide has strong adhesion capacity, the raw materials of each component can be conveniently mixed, the energy band gap and exciton constraint of the zinc oxide are large, the transparency is high, and the zinc oxide also has certain bactericidal capacity, the wear-resisting property of the bioactive glass can be obviously improved by the molybdenum dioxide and the tungsten oxide, so that the service life of the bioactive glass can be prolonged, the bioactive glass has good bactericidal capacity by the silver oxide, the mechanical property of the bioactive glass can be improved by the yttrium phosphate and the cerium silica powder, the compression resistance of the bioactive glass can be obviously improved, the strength of calcium can be enhanced by the calcium citrate, so that the service life of the bioactive glass can be prolonged, the ceramic powder has good stability, good plasticity, high heat-resisting temperature, small density, low loss on ignition, good light scattering property, good insulativity and wide source, and the production cost is reduced.
Specifically, the bioactive glass material for orthopedic repair comprises the following raw materials in parts by weight: 40 parts of silicon dioxide, 13 parts of sodium oxide, 45 parts of calcium oxide, 20 parts of phosphorus pentoxide, 12 parts of aluminum oxide, 10 parts of zirconium oxide, 2 parts of stabilizer, 8 parts of titanium dioxide, 14 parts of zinc oxide, 10 parts of magnesium oxide, 7 parts of molybdenum dioxide, 13 parts of tungsten oxide, 13 parts of silver oxide, 5 parts of yttrium phosphate, 6 parts of cerium silica powder, 15 parts of calcium citrate and 7 parts of ceramic powder.
In this embodiment, silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, aluminum oxide, zirconium oxide, a stabilizer, titanium dioxide, zinc oxide, magnesium oxide, molybdenum dioxide, tungsten oxide, silver oxide, yttrium phosphate, cerium silica powder, calcium citrate, and ceramic powder are precisely weighed and proportioned, so that the prepared bioactive glass has better performance, and the application range of the bioactive glass is improved.
Specifically, the stabilizer is boron trioxide.
In this example, diboron trioxide was used as a flux in the decomposition of silicate. The raw materials of each component can be conveniently mixed, the stability among the components can be realized, the preparation of the bioactive glass is convenient, the operation is simple, and the cost is low.
Specifically, the silicon dioxide is nano silicon dioxide, and the calcium oxide is nano calcium oxide.
In the embodiment, the particles of the nano silicon dioxide and the nano calcium oxide are smaller, so that the fusion is convenient, the preparation of the bioactive glass is tighter, and the gaps among the components are shortened, so that the compression resistance of the bioactive glass can be improved, and the wear resistance of the bioactive glass can be improved.
Specifically, the alumina is nano alumina.
In the embodiment, the nano-alumina is finer, so that the properties of the prepared bioactive glass are closer to the bones of a human body, and the adaptation degree of the bioactive glass to the human body is improved.
Specifically, the particle size of the molybdenum dioxide is 300-900 microns.
In this embodiment, the molybdenum dioxide is a transition metal oxide having high conductivity, high melting point, and high chemical stability, which can make the chemical properties of the bioactive glass more stable, improve the application range of the bioactive glass, and increase the functional characteristics of the bioactive glass.
A preparation method of a bioactive glass material for orthopedic repair comprises the following steps:
s1: weighing corresponding parts by weight of silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, aluminum oxide, zirconium oxide, a stabilizer, titanium dioxide, zinc oxide, magnesium oxide, molybdenum dioxide, tungsten oxide, silver oxide, yttrium phosphate, cerium silica powder, calcium citrate and ceramic powder according to the proportion.
S2: the raw materials of each component are added into a mixer to be mixed together, then are put into a grinder to be ground for 30-60min, and are sieved by a 300-mesh 800-mesh sieve to obtain the raw materials.
S3: adding the screened raw materials into a reaction kettle for melting treatment at 1300-1500 ℃ for 90-120min to obtain the glass mixed solution.
S4: preheating the glass mold, injecting the glass mixed solution into the glass mold, placing the glass mold into an annealing furnace, preserving heat for 2-3h, and cooling to room temperature to obtain the ground glass.
S5: and (3) putting the cooled ground glass into a heating box for heating, taking out the heated ground glass, and cooling to room temperature.
S6: and polishing the cooled glass, and cleaning the polished glass to obtain the bioactive glass material.
The working principle and the using process of the invention are as follows: firstly, respectively weighing corresponding parts by weight of silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, aluminum oxide, zirconium oxide, a stabilizer, titanium dioxide, zinc oxide, magnesium oxide, molybdenum dioxide, tungsten oxide, silver oxide, yttrium phosphate, cerium silica powder, calcium citrate and ceramic powder according to a proportion, adding the raw materials of the components into a mixer to mix together, then putting the mixture into a grinder to grind for 30-60min, then sieving through a sieve with 800 meshes of 300 meshes to obtain raw materials, adding the sieved raw materials into a reaction kettle to carry out melting treatment at the temperature of 1300 meshes and 1500 ℃ for reaction time of 90-120min to obtain a glass mixed solution, preheating a glass mold, injecting the glass mixed solution into the glass mold, then putting the glass mold into an annealing furnace to preserve heat for 2-3h, then cooling to room temperature to obtain ground glass, putting the cooled ground glass into a heating box to heat, and taking out the heated ground glass, cooling to room temperature, polishing the cooled glass, and cleaning the polished glass to obtain the bioactive glass material.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. A bioactive glass material for orthopedic repair, characterized in that: the bioactive glass material for orthopedic repair comprises the following raw materials in parts by weight: 30-50 parts of silicon dioxide, 10-15 parts of sodium oxide, 40-50 parts of calcium oxide, 15-25 parts of phosphorus pentoxide, 10-15 parts of aluminum oxide, 8-12 parts of zirconium oxide, 1-3 parts of stabilizer, 6-9 parts of titanium dioxide, 10-15 parts of zinc oxide, 8-12 parts of magnesium oxide, 6-8 parts of molybdenum dioxide, 12-15 parts of tungsten oxide, 10-15 parts of silver oxide, 3-6 parts of yttrium phosphate, 5-7 parts of cerium silica powder, 12-16 parts of calcium citrate and 3-8 parts of ceramic powder.
2. The bioactive glass material for orthopedic repair of claim 1, wherein: the bioactive glass material for orthopedic repair comprises the following raw materials in parts by weight: 40 parts of silicon dioxide, 13 parts of sodium oxide, 45 parts of calcium oxide, 20 parts of phosphorus pentoxide, 12 parts of aluminum oxide, 10 parts of zirconium oxide, 2 parts of stabilizer, 8 parts of titanium dioxide, 14 parts of zinc oxide, 10 parts of magnesium oxide, 7 parts of molybdenum dioxide, 13 parts of tungsten oxide, 13 parts of silver oxide, 5 parts of yttrium phosphate, 6 parts of cerium silica powder, 15 parts of calcium citrate and 7 parts of ceramic powder.
3. The bioactive glass material for orthopedic repair of claim 1, wherein: the stabilizer is boron trioxide.
4. The bioactive glass material for orthopedic repair of claim 1, wherein: the silicon dioxide is nano silicon dioxide, and the calcium oxide is nano calcium oxide.
5. The bioactive glass material for orthopedic repair according to claim 1, characterized in that: the alumina is nano alumina.
6. The bioactive glass material for orthopedic repair of claim 1, wherein: the particle size of the molybdenum dioxide is 300-900 microns.
7. The method for preparing a bioactive glass material for orthopedic repair according to any of claims 1-6, characterized by comprising the following steps:
s1: respectively weighing corresponding parts by weight of silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, aluminum oxide, zirconium oxide, a stabilizer, titanium dioxide, zinc oxide, magnesium oxide, molybdenum dioxide, tungsten oxide, silver oxide, yttrium phosphate, cerium silica powder, calcium citrate and ceramic powder according to the proportion;
s2: adding the raw materials of all the components into a mixer, mixing together, then placing the mixture into a grinder to grind for 30-60min, and then sieving the mixture through a 300-mesh and 800-mesh sieve to obtain the raw materials;
s3: adding the screened raw materials into a reaction kettle for melting treatment, wherein the temperature is 1300 ℃ and 1500 ℃, and the reaction time is 90-120min, so as to obtain a glass mixed solution;
s4: preheating a glass mold, injecting the glass mixed solution into the glass mold, putting the glass mold into an annealing furnace, preserving heat for 2-3h, and cooling to room temperature to obtain ground glass;
s5: putting the cooled ground glass into a heating box for heating, taking out the heated ground glass, and cooling to room temperature;
s6: and polishing the cooled glass, and cleaning the polished glass to obtain the bioactive glass material.
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Citations (8)
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|---|---|---|---|---|
| GB1234043A (en) * | 1967-06-01 | 1971-06-03 | ||
| US4897370A (en) * | 1987-06-30 | 1990-01-30 | Lion Corporation | Process for preparing ceramics composite sintered bodies |
| CN102757182A (en) * | 2012-08-06 | 2012-10-31 | 西安创联宏晟电子有限公司 | Low-temperature low expansion coefficient high-rigidity lead-free electronic glass powder and preparation method thereof |
| US20130102684A1 (en) * | 2010-07-01 | 2013-04-25 | Joseph F. Bringley | Bioactive compositions |
| CN105217960A (en) * | 2015-09-30 | 2016-01-06 | 苏州蔻美新材料有限公司 | A kind of rear-earth-doped biological active glass ceramic and preparation method thereof |
| CN108863059A (en) * | 2018-07-31 | 2018-11-23 | 合肥利裕泰玻璃制品有限公司 | A kind of Wear-resistant, high-temperature resistant glass and preparation method thereof |
| CN110407474A (en) * | 2018-04-26 | 2019-11-05 | 佛山市嘉懿行农业科技有限公司 | A kind of high-performance glass fiber |
| CN110436778A (en) * | 2019-07-26 | 2019-11-12 | 深圳阳光环球玻璃有限公司 | A kind of orthopaedics reparation bioactive glass material preparation method |
-
2020
- 2020-10-23 CN CN202011149163.8A patent/CN112299724A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1234043A (en) * | 1967-06-01 | 1971-06-03 | ||
| US4897370A (en) * | 1987-06-30 | 1990-01-30 | Lion Corporation | Process for preparing ceramics composite sintered bodies |
| US20130102684A1 (en) * | 2010-07-01 | 2013-04-25 | Joseph F. Bringley | Bioactive compositions |
| CN102757182A (en) * | 2012-08-06 | 2012-10-31 | 西安创联宏晟电子有限公司 | Low-temperature low expansion coefficient high-rigidity lead-free electronic glass powder and preparation method thereof |
| CN105217960A (en) * | 2015-09-30 | 2016-01-06 | 苏州蔻美新材料有限公司 | A kind of rear-earth-doped biological active glass ceramic and preparation method thereof |
| CN110407474A (en) * | 2018-04-26 | 2019-11-05 | 佛山市嘉懿行农业科技有限公司 | A kind of high-performance glass fiber |
| CN108863059A (en) * | 2018-07-31 | 2018-11-23 | 合肥利裕泰玻璃制品有限公司 | A kind of Wear-resistant, high-temperature resistant glass and preparation method thereof |
| CN110436778A (en) * | 2019-07-26 | 2019-11-12 | 深圳阳光环球玻璃有限公司 | A kind of orthopaedics reparation bioactive glass material preparation method |
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Application publication date: 20210202 |