CN112293748A - Eucommia health product capable of improving bone mineral density of astronaut and preparation method thereof - Google Patents

Eucommia health product capable of improving bone mineral density of astronaut and preparation method thereof Download PDF

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Publication number
CN112293748A
CN112293748A CN202011199522.0A CN202011199522A CN112293748A CN 112293748 A CN112293748 A CN 112293748A CN 202011199522 A CN202011199522 A CN 202011199522A CN 112293748 A CN112293748 A CN 112293748A
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parts
health product
vitamin
astronauts
eucommia
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潘淑勇
马晓暖
高瑞文
岳慧
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Shandong Beilong Duzhong Biological Engineering Co ltd
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Shandong Beilong Duzhong Biological Engineering Co ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract

The invention relates to a eucommia health product capable of improving the bone density of astronauts and a preparation method thereof, wherein the eucommia health product comprises the following raw materials: 1-7.5 parts of eucommia ulmoides, 1-15 parts of high-calcium food materials, 0.5-5 parts of mulberry leaves, 0.3-3 parts of ginseng and 0.1-10 parts of konjac flour; fructus Lycii and Cordyceps militarisAt least one of black beans, 1-6 parts of cordyceps militaris, 1-6 parts of wolfberry fruit and 10-30 parts of black beans; peach kernel, saffron, safflower, angelica, red peony root, rehmannia root or achyranthes root, 0.5-5 parts of peach kernel, 0.1-1 parts of saffron, 0.3-3 parts of safflower, 0.6-6 parts of angelica, 0.6-6 parts of red peony root, 1-10 parts of rehmannia root and 0.5-5 parts of achyranthes root; orange peel, at least one of fingered citron, allium macrostemon, platycodon grandiflorum, ligusticum wallichii or fructus aurantii, 0.3-3 parts of orange peel, 0.3-3 parts of fingered citron, 0.5-5 parts of allium macrostemon, 0.3-3 parts of platycodon grandiflorum, 0.3-3 parts of ligusticum wallichii, 0.3-3 parts of fructus aurantii and 0.2-2 parts of liquorice; at least one of vitamin D or vitamin K, vitamin D (1-50) x 10‑6Part of vitamin K (1-80) x 10‑6And (4) portions are obtained. The invention ensures the edible safety, reduces the risk caused by excessive calcium supplement, gives consideration to the pathogenesis of hepatic and renal yin deficiency, qi stagnation and blood stasis of astronauts, and obviously improves the bone density.

Description

Eucommia health product capable of improving bone mineral density of astronaut and preparation method thereof
Technical Field
The invention relates to the technical field of health products, belongs to the field of functional space food development, and particularly relates to an eucommia ulmoides health product capable of improving the bone density of astronauts and a preparation method thereof.
Background
When the astronaut executes the space mission, the astronaut can bring a lot of adverse effects to the physiological system of the astronaut due to the influence of environmental factors such as special environment weightlessness, noise, vibration, radiation, circadian rhythm change, narrow space and the like. 1-2% of bone calcium is mobilized and lost by astronauts every month on average; even if physical exercise is performed for 2-3 hours every day, bone calcium is still lost at the rate of 0.4% per month, the bone mass is reduced along with the prolonging of the space retention time, and the bone calcium still has irreversibility after returning to the ground, which can greatly hinder the rapid development of the aerospace industry. Therefore, effective prevention and treatment of bone loss in space environment are always important subjects for aerospace medical research.
There have been many attempts to combat bone loss caused by microgravity in space flight. The current major route of bone loss in the foreign fight space environment is to perform appropriate physical exercise, resistance training and to perform pharmacological interventions. Clinical practice proves that the intervention has poor prevention and treatment effects on bone loss caused by space environment, and serious side effects are accompanied after a large amount of medicine is taken. Therefore, the search for a nontoxic and significant health-care food with dual functions of bone loss prevention and health care becomes one of important ways for solving the problem of the adaptability of astronauts to microgravity environments.
Bone remodeling continues due to the synthesis of bone matrix by osteoblasts and resorption of bone by osteoclasts. Most of the drugs for osteoporosis mainly inhibit bone resorption and do not promote bone formation, so that it is difficult to promote bone regeneration in a space environment. Although some of the currently available drugs can treat bone loss to some extent, corresponding measures are still required to minimize potential side effects on other organs during treatment. Natural products of plant origin offer the potential for the treatment of bone-related diseases and studies conducted under different preclinical and clinical conditions can demonstrate the effectiveness of natural products in treating bone loss. The search and development of bone loss prevention medicines and health-care foods from natural products are an important direction for preventing the bone loss of astronauts in space environment.
Under the comprehensive effects of space microgravity, radiation, narrow isolation environment and the like, a series of physiological function changes of a human body can occur. Researchers believe that blood stasis and kidney deficiency can occur in both long-term retention and simulated weightlessness in an aerospace microgravity environment. The fatigue of the metabolism is analyzed by using the theory of traditional Chinese medicine, and the syndrome is distinguished that the early stage of the spaceflight is accompanied by syncope, abnormal ascending and descending and longer spaceflight time, the symptom of deficiency-excess is presented, and the syndrome is distinguished that liver-kidney yin deficiency is combined with qi stagnation and blood stasis. This provides theoretical guidance for finding astronaut food from natural products.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the eucommia health-care product capable of improving the bone density of astronauts and the preparation method thereof, so that the edible safety is ensured, the risk caused by excessive calcium supplement is reduced, the pathogenesis of liver-kidney yin deficiency, qi stagnation and blood stasis of the astronauts is considered, and the effect of improving the bone density is obvious.
The invention is realized by the following technical scheme:
the eucommia health-care product capable of improving the bone density of astronauts is provided, and comprises the following raw material components in parts by weight:
1-7.5 parts of eucommia ulmoides, 1-15 parts of high-calcium food materials, 0.5-5 parts of mulberry leaves, 0.3-3 parts of ginseng and 0.1-10 parts of konjac flour;
the feed also comprises at least one of medlar, cordyceps militaris and black bean, 1-6 parts of cordyceps militaris, 1-6 parts of medlar and 10-30 parts of black bean;
the medicine also comprises at least one of peach kernel, saffron, safflower, angelica, red peony root, radix rehmanniae or achyranthes bidentata, 0.5-5 parts of peach kernel, 0.1-1 part of saffron, 0.3-3 parts of safflower, 0.6-6 parts of angelica, 0.6-6 parts of red peony root, 1-10 parts of radix rehmanniae and 0.5-5 parts of achyranthes bidentata;
the food is characterized by also comprising at least one of orange peel, fingered citron, allium macrostemon, platycodon grandiflorum, ligusticum wallichii or fructus aurantii, 0.3-3 parts of orange peel, 0.3-3 parts of fingered citron, 0.5-5 parts of allium macrostemon, 0.3-3 parts of platycodon grandiflorum, 0.3-3 parts of ligusticum wallichii, 0.3-3 parts of fructus aurantii and 0.2-2 parts of liquorice;
further comprises at least one of vitamin D or vitamin K, vitamin D (1-50) x 10-6Part of vitamin K (1-80) x 10-6And (4) portions are obtained.
Eucommia bark, slightly pungent, warm in nature; entering liver and kidney meridians; tonify liver and kidney, strengthen tendons and bones; belongs to the top grade of traditional Chinese medicine. The root cause of the bad muscles and bones is the bad liver and kidney, and it has no effect to supplement calcium without tonifying liver and kidney.
Mulberry leaf, sweet, bitter and cold. Enter lung and liver meridians, dispel wind-heat, clear lung-heat, moisten dryness, clear liver and improve vision. The mulberry leaves can dredge the ascending and descending functions of lung qi. The mulberry leaf has rich calcium content: 1000-3000 mg/100g, which is far higher than common calcium-rich food such as milk, bean products, cheese and the like.
Ginseng is sweet, slightly bitter and warm. The channels of spleen, lung, heart and kidney belong to the homologous varieties of medicine and food, and have the effects of greatly reinforcing primordial qi, recovering pulse, relieving depletion, reinforcing spleen, benefiting lung and strengthening bones and muscles. Qi is the commander of blood, blood is the mother of qi, qi circulation is blood circulation, qi stagnation is blood stasis, and ginseng tonifies primordial qi greatly, dredges blood vessels and effectively improves symptoms of qi stagnation and blood stasis of astronauts.
The sticky property of the konjac flour endows the food with a gelatinous characteristic, so that the food is convenient for astronauts to eat in outer space. The compound of the konjac flour and the mulberry leaf powder can promote the normal growth of the thighbone of a mouse, increase the storage amount of calcium in the bone and improve the quality of the bone.
Fructus Lycii, Cordyceps militaris, and semen Sojae Atricolor can be used for tonifying kidney yin and liver yin.
The medlar has neutral nature and sweet taste, and has the functions of tonifying the kidney and nourishing the liver, replenishing vital essence and improving eyesight, strengthening bones and muscles, removing lumbago, prolonging life and the like after being taken for a long time. The book Ben Cao Jing Shu also says: medlar is the essential herb for fatigue, internal heat and invigoration due to deficiency of liver and kidney yin, and seven or eight of ten for the old with yin deficiency, so it is the top grade good for replenishing vital essence and improving eyesight to eat. "
Cordyceps militaris is warm in nature, sweet in taste, enters kidney and lung meridians, and is a rare medicinal material for balancing yin and yang.
Black bean, Li Shizhen, is recorded in Ben Cao gang mu (compendium of materia Medica); if the black beans are eaten frequently, the diseases can be cured. Used for treating kidney deficiency, yin deficiency, diabetes, polydipsia and frequent micturition; deficiency of liver-yin and kidney-yin, dizziness, blurred vision, or early white beard and hair.
Peach kernel, saffron, safflower, Chinese angelica root, red peony root, dried rehmannia root and achyranthes root are used for promoting blood circulation and removing blood stasis.
Tangerine peel, fingered citron, longstamen onion bulb, platycodon grandiflorum, ligusticum wallichii and bitter orange are used for promoting qi circulation.
Licorice root: harmonize the drugs.
Vitamin D promotes the absorption of calcium by the intestinal tract.
Vitamin K is an accessory factor formed by gamma-carboxyglutamic acid in protein, and the vitamin K in vivo mainly influences the carboxylation of bone-derived vitamin K-dependent protein osteocalcin so as to promote the deposition of bone mineral salt.
Further, the high calcium food material comprises one or more of milk mineral salt, bone meal, milk powder, sesame paste, dried small shrimps, crab apple and cucumber seed.
High-calcium food material: milk powder, sesame paste, dried small shrimps, cucumber seeds, crab apple, bone meal, milk mineral salt and the like. The calcium-rich food has balanced and comprehensive nutritional structure, is the highest-quality food source of calcium, and has lower possibility of causing calculus and angiosclerosis.
The content of calcium in milk powder is 1797mg/100 g.
The sesame paste has a calcium content of 1057mg/100g, and is a calcium king in pastes.
The calcium content of the dried small shrimps is up to 991mg/100g, and the dried small shrimps are the calcium king in aquatic products.
The calcium content of cucumber seeds is as follows: 89.9mg/100g, is the calcium king in the dry fruit. The snake gourd seed calcium supplement and bone strengthening health care product has the effects of supplementing calcium, setting a broken bone, strengthening bones and building a body, has rich calcium content and proper calcium-phosphorus proportion, is easy to be absorbed by a human body, has the effects of repairing bone damage necrosis and strain, and has a good improving effect on osteoporosis and bone necrosis by supplementing calcium and building a body all the time.
The malus micromalus makino contains various trace elements beneficial to human bodies, wherein the malus micromalus makino contains 66.59mg/100g of calcium, 2.16mg/100g of iron and 0.54mg/100g of zinc, the calcium is positioned at the head of fruits, and the malus micromalus makino is called as the fruit-in-calcium king.
The bone meal contains 20% of calcium and 10% of phosphorus, is a multipurpose bovine bone meal, has a calcium-phosphorus ratio close to that of a human body, contains a certain protein component, has an obvious calcium supplement effect, and has a higher absorption rate than that of a common calcium tablet.
A milk mineral salt is a new resource food, which is prepared from whey as raw material by removing protein and lactose. The calcium content is 23-28%, the phosphorus content is 10-14%, and the calcium-phosphorus composite material is natural, safe and non-irritant and can be effectively absorbed and utilized by a human body; the calcium supplement agent is close to the composition of human skeleton teeth, and has reasonable calcium-phosphorus ratio, so that the calcium supplement effect is better; and the calcium supplement effect is not reversed, and the increased bone density is still maintained even after the milk mineral salt supplement is stopped for three years.
Further, the eucommia bark comprises one or more of eucommia leaf, eucommia male flower and eucommia bark.
A preparation method of the eucommia ulmoides health product capable of improving the bone mineral density of astronauts is characterized in that high-calcium food materials are ground into powder and then are mixed with the rest raw materials after being ground into powder.
A preparation method of the eucommia ulmoides health product capable of improving the bone density of astronauts comprises the steps of extracting the raw materials except the high-calcium food materials, filtering to obtain a mixed extracting solution, and mixing and matching the mixed extracting solution with the high-calcium food materials.
A preparation method of the eucommia health product capable of improving the bone density of astronauts comprises the steps of extracting eucommia in component raw materials to obtain an extracting solution, concentrating, drying and crushing the eucommia fine powder, grinding mulberry leaves, ginseng, medlar, cordyceps militaris, black beans, peach kernels, saffron, safflower, angelica sinensis, red paeony roots, radix rehmanniae, achyranthes roots, orange peels, fingered citron, allium macrostemon, platycodon grandiflorum, ligusticum wallichii, bitter orange and liquorice, and matching the ground eucommia fine powder with crushed high-calcium food materials.
Further, in the process of compatibility, food additives are added, wherein the food additives comprise at least one of acidity regulator, sweetener, preservative, antioxidant, excipient and nutrition enhancer.
Wherein: the acidity regulator is selected from any one of citric acid, malic acid, tartaric acid, adipic acid, sodium carbonate, lactic acid, fumaric acid, succinic acid, citrate, and fruit vinegar;
the sweetener is at least one of white sugar, fructose, maltitol, isomalt, trehalose, erythritol, idacin, xylitol, fructo-oligosaccharide, sorbitol, stevioside, sucralose, mogroside, glucose, sucrose, maltose, lactose, sugar alcohol, licorice, disodium glycyrrhizinate, tripotassium glycyrrhizinate, trisodium glycyrrhizinate, aspartame and acesulfame potassium.
The preservative is selected from any one of benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, sodium propionate, nisin, calcium propionate and dehydroacetic acid;
the antioxidant is selected from any one of ascorbic acid, butyl hydroxy anisol, tea polyphenols, propyl gallate, phytic acid, dibutyl hydroxy toluene and propyl gallate;
the excipient is at least one selected from starch, maltodextrin, xanthan gum, carrageenan, konjac gum, konjac flour, sodium carboxymethylcellulose, sesbania gum, tamarind seed gum, gelatin, acacia, sodium caseinate, cyclodextrin, pectin, soybean milk powder, cocoa powder and magnesium stearate;
the nutrition enhancer is selected from: at least one of trace elements, vitamins, calcium lactate, ferrous lactate, and potassium gluconate.
Furthermore, the dosage form of the eucommia health care product prepared by compatibility is capsules, tablets, granules, paste, pills or oral liquid.
Compared with the prior art, the invention has the beneficial effects that:
based on eucommia ulmoides and high-calcium food materials, auxiliary medicinal materials are added. The compatibility principle is as follows: eucommia bark/eucommia leaf/eucommia male flower is used as a monarch drug, the raw material with high calcium content is used as a ministerial drug, the other materials (except liquorice) are used as adjuvant drugs, and the liquorice is used as a conductant drug. The edible safety is ensured, the risk caused by excessive calcium supplement is reduced, the pathogenesis of hepatic and renal yin deficiency, qi stagnation and blood stasis of astronauts is considered, and the effect of improving the bone density is obvious. Other food raw materials can be added on the basis of the formula to achieve similar effects or purposes.
Detailed Description
In order to clearly illustrate the technical features of the present solution, the present solution is explained below by way of specific embodiments.
Example 1:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 6g of male eucommia ulmoides flower, 10g of cucumber seed, 5g of milk mineral salt, 5g of peach kernel, 0.6g of saffron, 1g of Chinese angelica, 1g of orange peel, 3g of fingered citron, 3g of frosted mulberry leaf, 3g of platycodon grandiflorum, 3g of ginseng, 1g of liquorice, 6g of konjaku flour, 25g of black bean, 1g of cordyceps militaris, 6g of wolfberry fruit and 5 mu g of vitamin D.
The preparation method comprises the following steps: preparing raw materials according to the above quality, extracting eucommia male flowers to obtain an extracting solution, concentrating, drying and crushing, crushing cucumber seeds, peach kernels, saffron, angelica sinensis, orange peel, ginseng, fingered citron, frosted mulberry leaves, platycodon grandiflorum, liquorice, cordyceps militaris, wolfberry fruits and black beans, adding konjac powder, milk mineral salt and vitamin D, uniformly mixing, granulating and preparing the solid beverage.
Example 2:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 5g of eucommia male flower, 15g of milk powder, 5g of sesame paste, 3g of peach kernel, 0.8g of saffron, 3g of Chinese angelica, 2g of orange peel, 2g of fingered citron, 4g of frost mulberry leaf, 2g of platycodon grandiflorum, 2g of ginseng, 1.5g of liquorice, 5g of konjaku flour, 20g of black bean, 2g of cordyceps militaris, 6g of wolfberry fruit and 25 mu g of vitamin D.
The preparation method comprises the following steps: preparing raw materials according to the above quality, crushing eucommia male flower, peach kernel, saffron, angelica, orange peel, ginseng, fingered citron, frosted mulberry leaf, platycodon grandiflorum, liquorice, cordyceps militaris, medlar and black bean, adding konjac powder, milk powder, sesame paste and vitamin D, uniformly mixing, and preparing the tablet candy.
Example 3:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 4g of eucommia male flower, 15g of dried small shrimps, 2g of peach kernel, 1g of saffron, 2g of Chinese angelica, 3g of orange peel, 1g of fingered citron, 5g of frosted mulberry leaf, 1g of platycodon root, 1g of ginseng, 2g of liquorice, 4g of konjaku flour, 15g of black bean, 3g of cordyceps militaris, 6g of medlar and 10 mu g of vitamin D.
The preparation method comprises the following steps: preparing raw materials according to the above quality, extracting eucommia male flowers to obtain an extracting solution, concentrating, drying, crushing dried small shrimps, peach kernels, saffron, angelica sinensis, orange peel, ginseng, fingered citron, frosted mulberry leaves, platycodon grandiflorum, liquorice, cordyceps militaris, wolfberry fruits and black beans, adding konjac powder, milk mineral salt and vitamin D, uniformly mixing, granulating and preparing the solid beverage.
Example 4:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 6g of eucommia ulmoides, 10g of crab apple, 5g of bone meal, 4g of peach kernel, 2g of safflower, 4g of angelica, 4g of red peony root, 10g of radix rehmanniae, 1g of ligusticum wallichii, 3g of fructus aurantii, 1g of platycodon grandiflorum, 3g of ginseng, 3g of achyranthes bidentata, 2g of liquorice, 4g of cordyceps militaris, 6g of wolfberry fruit, 20 mu g of vitamin D and 50 mu g of vitamin K.
The preparation method comprises the following steps: preparing raw materials according to the above quality, extracting eucommia ulmoides, peach kernel, safflower, angelica, red paeony root, rehmannia root, ligusticum wallichii, fructus aurantii, platycodon grandiflorum, ginseng, achyranthes bidentata, cordyceps militaris, wolfberry fruit and liquorice to obtain an extracting solution, concentrating, drying and crushing; pulverizing Malus micromalus makino; adding Malus micromalus makino powder, bone meal, vitamin D, vitamin K and food additive, mixing, granulating, and tabletting to obtain hard capsule.
Example 5:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: preparing raw materials according to the mass, 4g of eucommia leaves, 10g of milk powder, 4g of milk mineral salt, 1g of peach kernels, 2.5g of safflower, 5g of angelica, 5g of red peony roots, 8g of dried rehmannia roots, 2g of ligusticum wallichii, 2g of fructus aurantii, 2g of platycodon grandiflorum, 2g of ginseng, 4g of achyranthes roots, 1.5g of liquorice, 5g of cordyceps militaris, 5g of wolfberry fruits and 30 mu g of vitamin K.
The preparation method comprises the following steps: extracting folium Eucommiae, semen Persicae, flos Carthami, radix Angelicae sinensis, radix Paeoniae Rubra, radix rehmanniae, rhizoma Chuanxiong, fructus Aurantii, radix Platycodonis, radix Ginseng, radix Achyranthis bidentatae, Cordyceps militaris, fructus Lycii, and radix Glycyrrhizae to obtain extractive solution, concentrating, drying, and pulverizing; adding milk powder, milk mineral salt, vitamin K, and food additive, mixing, and tabletting to obtain soft capsule.
Example 6:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 3g of eucommia ulmoides, 8g of milk powder, 3g of milk mineral salt, 5g of peach kernel, 3g of safflower, 6g of angelica, 6g of red peony root, 6g of radix rehmanniae, 3g of ligusticum wallichii, 1g of fructus aurantii, 3g of platycodon grandiflorum, 1g of ginseng, 5g of achyranthes bidentata, 1g of liquorice, 6g of cordyceps militaris, 4g of wolfberry fruit, 8g of konjac powder and 30 mu g of vitamin D.
The preparation method comprises the following steps: preparing the raw materials according to the mass, extracting eucommia ulmoides, peach kernel, safflower, angelica, red paeony root, rehmannia root, ligusticum wallichii, fructus aurantii, platycodon grandiflorum, ginseng, achyranthes bidentata, cordyceps militaris, wolfberry fruit and liquorice to obtain an extracting solution, and adding milk powder, milk mineral salt, konjac powder and vitamin D to be completely dissolved to obtain the liquid beverage.
Example 7:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 15g of milk powder, 5g of sesame paste, 3g of peach kernel, 0.8g of saffron, 3g of Chinese angelica, 2g of orange peel, 2g of fingered citron, 4g of frosted mulberry leaf, 2g of platycodon root, 2g of ginseng, 1.5g of liquorice, 5g of konjaku flour, 20g of black bean, 2g of cordyceps militaris, 6g of wolfberry fruit and 25 mu g of vitamin D.
The preparation method comprises the following steps: preparing the raw materials according to the mass, crushing peach kernels, saffron, angelica sinensis, orange peel, ginseng, fingered citron, frosted mulberry leaves, platycodon grandiflorum, liquorice, cordyceps militaris, wolfberry fruits and black beans, adding konjac powder, milk powder, sesame paste and vitamin D, uniformly mixing, and preparing the tablet candy.
Example 8:
a eucommia health product capable of improving the bone density of astronauts comprises the following raw material components in parts by weight: 8g of milk powder, 3g of milk mineral salt, 5g of peach kernel, 3g of safflower, 6g of angelica, 6g of red peony root, 6g of radix rehmanniae, 3g of ligusticum wallichii, 1g of fructus aurantii, 3g of platycodon grandiflorum, 1g of ginseng, 5g of achyranthes bidentata, 1g of liquorice, 6g of cordyceps militaris, 4g of wolfberry fruit, 8g of konjac powder and 30 mu g of vitamin D.
The preparation method comprises the following steps: preparing the raw materials according to the mass, extracting peach kernel, safflower, angelica, red peony root, rehmannia root, ligusticum wallichii, bitter orange, platycodon grandiflorum, ginseng, achyranthes root, cordyceps militaris, medlar and liquorice to obtain an extracting solution, and adding milk powder, milk mineral salt, konjac powder and vitamin D to be completely dissolved to obtain the liquid beverage.
The above 8 examples were validated for efficacy:
the rat tail suspension can better simulate the body fluid head distribution and the load shedding phenomenon of the bearing bone during weightlessness, and is a recognized animal model for simulating the bone loss in space at present. The influence of tail suspension simulated weightlessness on rat bone metabolism is mainly shown in that the reduction of bone formation capability is consistent with the change of space flight bone metabolism, and the model is also a NASA classic model.
Experiment one:
90 male Wistar rats of 5 weeks of age were selected and randomly divided into 13 groups:
free-moving group, suspension group, examples 1-6 groups, control group, each group was 10.
Wherein:
the free activity group only carries out single-cage feeding, and the rat can freely move;
the rats in the other groups were suspended with their tails suspended and their hind limbs off the ground for 21 days, and the stomach was perfused with 0.15g/kg of sample per day. And detecting the content of bone minerals and the elastic deflection.
Experiment two:
90 male Wistar rats of 5 weeks of age were selected and randomly divided into 13 groups:
free-moving group, suspension group, examples 1-6 groups, control group, each group was 10.
Intragastric administration of stone-inducing agent (containing 0.75% ethylene glycol, 0.75% ammonium chloride, 1 mL/time, 3 times/d) was given to each group;
wherein:
the free activity group only carries out single-cage feeding, and the rat can freely move;
the rats in the other groups were suspended with their tails suspended and their hind limbs off the ground for 21 days, and the stomach was perfused with 0.15g/kg of sample per day. Detecting the oxalic acid content and the calcium content of urine, and comparing the probability of forming kidney stones.
Control group: the preparation method comprises the following steps of taking 21g of pine polyphenol extract as a main component, and mixing 12g of morinda officinalis extract, 12g of rhizoma drynariae extract, 12g of epimedium extract, 8g of prepared rehmannia root extract, 12g of fructus psoraleae extract, 3g of eucommia ulmoides extract, 4g of radix achyranthis bidentatae extract, 5g of astragalus mongholicus extract, 5g of polygonum multiflorum extract, 1g of radix puerariae extract and 1g of salvia miltiorrhiza extract uniformly.
The experiment for increasing bone density by suspending the tail of the rat is shown in the following table:
group of Bone mineral salt content Elastic deflection (mm)
Free moving group 0.528±0.008 0.43±0.15
Suspension set 0.440±0.008 0.33±0.14
Control group 0.469±0.003 0.36±0.15
Example 1 0.483±0.002 0.39±0.16
Example 2 0.490±0.005 0.40±0.11
Example 3 0.475±0.004 0.38±0.17
Example 4 0.486±0.005 0.39±0.18
Example 5 0.493±0.006 0.40±0.14
Example 6 0.501±0.004 0.40±0.15
Example 7 0.470±0.004 0.36±0.14
Example 8 0.469±0.003 0.37±0.16
And (4) conclusion:
1. the groups of the embodiments have the obvious effect of improving the content of bone mineral salt and the elastic flexibility.
2. The effects of improving the bone mineral salt content and the elastic deflection of the groups of examples 1-6 are better than those of the control group.
3. The efficacy of the groups 7 and 8 in increasing the bone mineral salt content and the elastic deflection is equivalent to that of the control group. The example 7 group is lower than the example 2 group, and the example 8 group is lower than the example 6 group, which shows that the eucommia bark plays a role in multiplying the efficacies.
The results of the experiment for reducing the risk of renal calculus by suspending the tail of the rat are shown in the following table:
Figure RE-GDA0002849974170000131
and (4) conclusion:
1. the groups of examples had significant efficacy in reducing uric acid and urinary calcium levels, with lower levels indicating a lower risk of kidney stone formation.
2. The effect of reducing the uric acid content and the urinary calcium content of the groups of examples 1-6 is better than that of the control group.
3. The efficacy of reducing uric acid content and urinary calcium content in the groups of examples 7 and 8 is equivalent to that of the control group. The example 2 group is lower than the example 7 group, and the example 6 group is lower than the example 8 group, which shows that the eucommia bark plays a role in multiplying the efficacies.
Of course, the above description is not limited to the above examples, and the undescribed technical features of the present invention can be implemented by or using the prior art, and will not be described herein again; the above embodiments are merely for illustrating the technical solutions of the present invention and not for limiting the present invention, and the present invention has been described in detail with reference to the preferred embodiments, and those skilled in the art should understand that changes, modifications, additions or substitutions which are made by those skilled in the art within the spirit of the present invention are also within the scope of the claims of the present invention.

Claims (9)

1. A eucommia bark health product capable of improving the bone mineral density of astronauts is characterized in that: comprises the following raw material components in parts by weight:
1-7.5 parts of eucommia ulmoides, 1-15 parts of high-calcium food materials, 0.5-5 parts of mulberry leaves, 0.3-3 parts of ginseng and 0.1-10 parts of konjac flour;
the feed also comprises at least one of medlar, cordyceps militaris and black bean, 1-6 parts of cordyceps militaris, 1-6 parts of medlar and 10-30 parts of black bean;
the medicine also comprises at least one of peach kernel, saffron, safflower, angelica, red peony root, radix rehmanniae or achyranthes bidentata, 0.5-5 parts of peach kernel, 0.1-1 part of saffron, 0.3-3 parts of safflower, 0.6-6 parts of angelica, 0.6-6 parts of red peony root, 1-10 parts of radix rehmanniae and 0.5-5 parts of achyranthes bidentata;
the food is characterized by also comprising at least one of orange peel, fingered citron, allium macrostemon, platycodon grandiflorum, ligusticum wallichii or fructus aurantii, 0.3-3 parts of orange peel, 0.3-3 parts of fingered citron, 0.5-5 parts of allium macrostemon, 0.3-3 parts of platycodon grandiflorum, 0.3-3 parts of ligusticum wallichii, 0.3-3 parts of fructus aurantii and 0.2-2 parts of liquorice;
further comprises at least one of vitamin D or vitamin K, vitamin D (1-50) x 10-6Part of vitamin K (1-80) x 10-6And (4) portions are obtained.
2. The eucommia ulmoides oliv health product for increasing bone density of astronauts as claimed in claim 1, wherein: 4.5-7.5 parts of eucommia bark, 5-15 parts of high-calcium food material, 2-3 parts of mulberry leaf, 1-3 parts of ginseng, 1-9 parts of konjac flour, 3-5 parts of peach kernel, 0.5-1 part of saffron, 1-3 parts of safflower, 3-6 parts of angelica, 3-6 parts of red peony root, 5-10 parts of radix rehmanniae, 2-5 parts of achyranthes root, 1-3 parts of orange peel, 1-3 parts of fingered citron, 3-5 parts of allium macrostemon, 1-3 parts of platycodon grandiflorum, 1-3 parts of ligusticum wallichii, 1-3 parts of fructus aurantii, 1-2 parts of liquorice, and vitamin D (10-30) x 10-6Part of vitamin K (10-60) x 10-6And (4) portions are obtained.
3. The eucommia ulmoides oliv health product for increasing bone density of astronauts as claimed in claim 1 or 2, wherein: the high calcium food material comprises one or more of milk mineral salt, bone meal, milk powder, sesame paste, dried small shrimp, crab apple and cucumber seed.
4. The eucommia ulmoides oliv health product for increasing bone density of astronauts as claimed in claim 1 or 2, wherein: the Eucommiae cortex comprises one or more of folium Eucommiae, male flower of Eucommiae cortex and cortex Eucommiae.
5. The preparation method of the eucommia ulmoides health product capable of improving the bone density of astronauts as claimed in claim 1, wherein the preparation method comprises the following steps: grinding high calcium food material, mixing with the rest materials, and mixing.
6. The preparation method of the eucommia ulmoides health product capable of improving the bone density of astronauts as claimed in claim 1, wherein the preparation method comprises the following steps: extracting the other raw materials except the high-calcium food material, filtering to obtain mixed extract, and mixing with the high-calcium food material.
7. The preparation method of the eucommia ulmoides health product capable of improving the bone density of astronauts as claimed in claim 1, wherein the preparation method comprises the following steps: extracting eucommia ulmoides in the component raw materials to obtain an extracting solution, concentrating, drying and crushing the eucommia ulmoides fine powder, grinding mulberry leaves, ginseng, medlar, cordyceps militaris, black beans, peach kernels, saffron, safflower, angelica sinensis, red paeony roots, radix rehmanniae, achyranthes bidentata, orange peels, fingered citron, allium macrostemon, platycodon grandiflorum, ligusticum wallichii, bitter orange and liquorice, and matching with crushed high-calcium food materials to obtain the eucommia ulmoides extract.
8. The method for preparing eucommia ulmoides oliv health product for increasing bone density of astronauts as claimed in any one of claims 5, 6 or 7, wherein the eucommia ulmoides oliv health product comprises the following steps: during the compatibility, food additives are added, wherein the food additives comprise at least one of acidity regulator, sweetener, preservative, antioxidant, excipient and nutrition enhancer.
9. The method for preparing eucommia ulmoides oliv health product for increasing bone density of astronauts as claimed in any one of claims 5, 6 or 7, wherein the eucommia ulmoides oliv health product comprises the following steps: the preparation formulation of the eucommia health product prepared by compatibility is capsule, tablet, granule, paste, pill or oral liquid.
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