CN112284818A

CN112284818A - Sampling device for biological pharmacy and extraction method thereof

Info

Publication number: CN112284818A
Application number: CN202011132957.3A
Authority: CN
Inventors: 不公告发明人
Original assignee: Zhaoqing Yueneng Technology Co Ltd
Current assignee: Zhaoqing Yueneng Technology Co Ltd
Priority date: 2020-10-21
Filing date: 2020-10-21
Publication date: 2021-01-29

Abstract

The invention relates to the technical field of pharmaceutical extraction equipment and discloses a sampling device for bio-pharmaceuticals and an extraction method thereof. Through annular piece and connecting device's setting, only need to install the sampling tube, then rotatory annular piece, make the fixed block rotate to the position with spacing tooth contact, the inside medium of pharmacy pipe gets into the sampling tube automatically this moment, when the sample reaches required quantity, the annular piece of reversal to fixed block recovery normal position, the sprue seals with the through-hole laminating this moment, take off the sampling tube again and accomplish the sample promptly, can realize quick sealed sample through the positive and negative rotation that uses the annular piece, whole process operation is simple, and the sampling medium is in the state of not having any contact with the external world always, the sample can not appear and be polluted, the condition such as reveal appears in the sampling process.

Description

Sampling device for biological pharmacy and extraction method thereof

Technical Field

The invention relates to the technical field of pharmaceutical extraction equipment, in particular to a sampling device for bio-pharmaceuticals and an extraction method thereof.

Background

Biopharmaceuticals refer to the study of organisms, biological tissues, cells, organs, body fluids, etc., using microbiological, biological, medical, biochemical, etc., results. The medical industry is an important component of national economy, and is closely related to vital interests such as life health and quality of life of people, at present, China has become the world's largest drug preparation producing country, and half of the worldwide pharmaceuticals are biosynthesized, and particularly when synthesizing a drug with a complex molecular structure, the sampling device is not only simpler and more convenient than a chemical synthesis method, but also has higher economic benefit, and is an indispensable process for sampling and detecting in the biopharmaceutical process, so the sampling device for the biopharmaceutical is particularly important in the biopharmaceutical process.

Most of the existing liquid sampling devices for bio-pharmaceuticals are sampling by holding a sampling rod by a sampling worker, the sampling process is complex, a professional person who needs to be trained professionally can sample, artificial deviation can occur inevitably in artificial sampling, and meanwhile, aseptic sampling cannot be guaranteed in the process of artificial sampling, so that pollution can be caused to products and production requirements cannot be met, therefore, people generally use a sampling valve to sample, the sampling valve is arranged on a medium conveying pipeline to sample, detect and analyze media, an online sampling valve is used for directly arranging a sampling valve body on the medium conveying pipeline, and the media in the pipeline are sampled under the condition of normal fluid of the medium conveying pipeline, but a residual dead angle exists between the valve body and the medium pipeline of the existing sampling valve, so that the sampling valve is difficult to clean and easy to pollute the media in the pipeline, and the quantitative precision of sampling is poor, and the detection quality is difficult to ensure.

Disclosure of Invention

Aiming at the defects of the background technology, the invention provides the sampling device for the bio-pharmaceuticals and the extraction method thereof, which have the advantages of simple and quick sampling, no need of sterile treatment, no dead angle in the sampling channel and easy cleaning, and solve the problems in the background technology.

The invention provides the following technical scheme: the utility model provides a sampling device for bio-pharmaceuticals, includes the pharmacy pipe, the annular piece has been cup jointed in the outside activity of pharmacy pipe, the through-hole that circumference such as a plurality of groups was arranged is seted up to the side of pharmacy pipe, the inside of annular piece is provided with the sampling tube, the one end of sampling tube is provided with connecting device, one side sample passageway that is located connecting device is seted up to the inside of annular piece, a plurality of groups installation cavity have been seted up to the inner wall of annular piece, the inside fixedly connected with reset spring of installation cavity, reset spring's other end fixedly connected with sprue.

Preferably, the connecting device comprises a connecting pipe fixedly connected with the sampling pipe, one side of the connecting pipe is fixedly connected with a rubber ring, and a limiting block is fixedly connected with the middle part of the connecting pipe.

Preferably, one side fixedly connected with fixed block of annular piece, the outside fixedly connected with spacing tooth of pharmacy pipe, the pivoted distance equals with adjacent through-hole and sampling channel rotation distance between spacing tooth and the fixed block.

Preferably, the size of the plugging block is matched with the through hole, and the bottom surface of the plugging block is an arc surface with the same diameter as the inner wall of the pharmaceutical catheter.

Preferably, the inside of connecting pipe one end open-ended is provided with the ejector pin, the one end that sampling channel is close to the sampling tube is provided with contact check valve.

Preferably, the rubber ring is an annular sealing line rubber ring.

The invention also provides a sampling method of the sampling device for the bio-pharmaceuticals, which comprises the following steps:

s1, installing a sampling tube and ensuring that the contact type one-way valve is opened;

s2, rotating the ring-shaped block to a fixed block to contact with the limit teeth;

s3, sampling, and observing the sampling tube until the sampling amount is reached;

s4, rotating the ring-shaped block to the fixed block to restore the original position, taking down the sampling tube and completing sampling.

The invention has the following beneficial effects:

1. through the arrangement of the annular block and the connecting device, when the medium in the pharmaceutical conduit is sampled, the sampling tube is only needed to be installed in the annular block, then the annular block is rotated, the fixed block at one end of the annular block is rotated to the position contacted with the limiting teeth, at the moment, the lower opening of the sampling channel is just aligned with the through hole, the medium in the pharmaceutical conduit automatically enters the sampling tube under the self pressure, when a worker observes that the sampling reaches the required dosage, the annular block is reversely rotated to the fixed block to recover the original position, at the moment, the blocking block extends out under the elastic action of the reset spring and is attached and sealed with the through hole, then the sampling tube is taken down to finish the sampling, the rapid sealed sampling can be realized by using the forward and reverse rotation of the annular block, the operation of the whole process is simple, the sampling medium is always in a state without any contact with the outside, and the sample, leakage and the like occur in the sampling process.

2. Through the arc surface that is the same radian with pharmaceutical pipe with a lateral surface terminal surface of sprue orientation medium, when not the state of sampling, the arc surface of sprue constitutes complete round hole with the through-hole on the pharmaceutical pipe, can prevent that the medium from long-pending causing the sample to pollute, can not cause the interference to the flow of the inside medium of pharmaceutical pipe moreover.

Drawings

FIG. 1 is a schematic view of the overall appearance of the structure of the present invention;

FIG. 2 is a front cross-sectional view of the structure of the present invention;

FIG. 3 is an enlarged view of the structure A of the present invention;

FIG. 4 is a schematic structural view of the present invention;

fig. 5 is a schematic view of the installation of the limiting teeth of the structure of the present invention.

In the figure: 1. a pharmaceutical conduit; 101. limiting teeth; 2. a ring block; 201. a fixed block; 3. a through hole; 4. a sampling tube; 5. a connecting device; 51. a connecting pipe; 52. a rubber ring; 53. a limiting block; 6. a sampling channel; 7. a mounting cavity; 8. a return spring; 9. and (7) blocking.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Please refer to fig. 1-5, a sampling device for bio-pharmaceuticals, including pharmaceutical pipe 1, annular block 2 has been cup jointed in pharmaceutical pipe 1's the outside activity, pharmaceutical pipe 1's side is seted up a plurality of groups of through-holes 3 of arranging of circumference such as, annular block 2's inside is provided with sampling tube 4, sampling tube 4's one end is provided with connecting device 5, connecting device 5 includes connecting pipe 51 with sampling tube 4 fixed connection, one side fixedly connected with rubber circle 52 of connecting pipe 51, the middle part fixedly connected with stopper 53 of connecting pipe 51, one side sample passage 6 that is located connecting device 5 is seted up to annular block 2's inside, a plurality of groups of installation cavity 7 have been seted up to annular block 2's inner wall, the inside fixedly connected with reset spring 8 of installation cavity 7, reset spring 8's other end fixedly connected with sprue 9.

Wherein, one side of the ring block 2 is fixedly connected with a fixed block 201, the outer side of the pharmaceutical conduit 1 is fixedly connected with a limit tooth 101, the rotating distance between the limit tooth 101 and the fixed block 201 is equal to the rotating distance between the adjacent through hole 3 and the sampling channel 6, when the media in the pharmaceutical conduit 1 is sampled, firstly, the sampling tube 4 is installed in the ring block 2, so that the connecting device 5 is connected and sealed with the sampling channel 6, then the ring block 2 is rotated, so that the fixed block 201 at one end of the ring block 2 is rotated to the position contacted with the limit tooth 101, in the rotating process of the ring block 2, the block 9 gradually overcomes the elastic force of the reset spring 8 under the action of the rotating moment, contracts backwards and rotates synchronously along with the ring block 2, when the fixed block 201 is contacted with the limit tooth 101, the lower opening of the sampling channel 6 is just aligned with the through hole 3, the media in the pharmaceutical conduit 1 automatically enters the sampling tube 4 under the self pressure, when observing that the sample reaches required quantity, the staff begins to reverse the annular block 2 until the fixed block 201 recovers the original position, at the moment, the block 9 extends out under the elastic force action of the return spring 8 and is attached and sealed with the through hole 3, and then the sampling tube 4 is taken down to finish sampling.

Wherein, the size and the through-hole 3 looks adaptation of sprue 9, and the bottom surface of sprue 9 is the arc surface the same with the pharmacy pipe 1 inner wall diameter, when not taking a sample, sprue 9 is sealed with the laminating of through-hole 3, and sprue 9 is the arc surface of the same radian towards a side end face of medium and pharmacy pipe 1, and when the state of not taking a sample, the arc surface of sprue 9 constitutes complete round hole with through-hole 3 on the pharmacy pipe 1, can prevent that the medium is long-pending to be left and cause the sample pollution.

Wherein, connecting pipe 51 one end open-ended inside is provided with the ejector pin, sampling channel 6 is close to the one end of sampling tube 4 and is provided with the contact check valve, when taking a sample and preparing the during operation, sampling tube 4 is installed in 2 inside in-process on the annular piece, if sampling tube 4 installs preset position, the inside contact check valve of sampling channel 6 is touched to the ejector pin this moment, can open the contact check valve, take a sample, can prevent that the staff is because of carelessness, lead to sampling tube 4 just to begin the sample for installing in place, cause the medium to reveal and lose.

Wherein, rubber circle 52 is the sealed line rubber ring of annular, and rubber circle 52 can seal the 4 front ends of sampling tubes, prevents that impurities such as bacterium in the air from getting into sampling tube 4 in, causes the pollution to the sample, influences subsequent testing result.

The sampling method comprises the following steps:

s1, installing the sampling tube 4 and ensuring that the contact type one-way valve is opened;

s2, rotating the ring-shaped block 2 to the fixed block 201 to contact with the limit teeth 101;

s3, sampling, and observing the sampling tube 4 until the sampling amount is reached;

s4, rotating the ring-shaped block 2 to the fixed block 201 to restore the original position, taking down the sampling tube 4 and completing sampling.

The working principle is that when a medium in the pharmaceutical catheter 1 is sampled, firstly, the sampling tube 4 is installed in the annular block 2, the connecting device 5 is connected and sealed with the sampling channel 6, then the annular block 2 is rotated, the fixed block 201 at one end of the annular block 2 is rotated to the position contacted with the limiting teeth 101, in the rotating process of the annular block 2, the blocking block 9 gradually overcomes the elastic force of the return spring 8 under the action of the rotating moment, contracts backwards and rotates synchronously along with the annular block 2, when the fixed block 201 is contacted with the limiting teeth 101, namely, the lower opening of the sampling channel 6 is just aligned with the through hole 3, the medium in the pharmaceutical catheter 1 automatically enters the sampling tube 4 under the self pressure, when a worker observes that the sampling reaches the required dosage, the annular block 2 starts to be reversed until the fixed block 201 recovers to the original position, at the moment, the blocking block 9 stretches out under the elastic force of the return spring 8, and is jointed and sealed with the through hole 3, and then the sampling tube 4 is taken down to finish sampling.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a sampling device for bio-pharmaceuticals, includes pharmaceutical pipe (1), annular piece (2) have been cup jointed in the outside activity of pharmaceutical pipe (1), through-hole (3) that a plurality of groups equalled circumference were arranged are seted up to the side of pharmaceutical pipe (1), the inside of annular piece (2) is provided with sampling tube (4), its characterized in that: the one end of sampling tube (4) is provided with connecting device (5), one side sample passageway (6) that are located connecting device (5) are seted up to the inside of annular piece (2), a plurality of groups installation cavity (7) have been seted up to the inner wall of annular piece (2), the inside fixedly connected with reset spring (8) of installation cavity (7), the other end fixedly connected with sprue (9) of reset spring (8).

2. A sampling device for biopharmaceuticals according to claim 1, wherein: connecting device (5) include with sampling tube (4) fixed connection's connecting pipe (51), one side fixedly connected with rubber circle (52) of connecting pipe (51), the middle part fixedly connected with stopper (53) of connecting pipe (51).

3. A sampling device for biopharmaceuticals according to claim 1, wherein: one side fixedly connected with fixed block (201) of annular piece (2), the outside fixedly connected with spacing tooth (101) of pharmacy pipe (1), pivoted distance equals with adjacent through-hole (3) and sampling channel (6) rotation distance between spacing tooth (101) and fixed block (201).

4. A sampling device for biopharmaceuticals according to claim 1, wherein: the size of the plugging block (9) is matched with the through hole (3), and the bottom surface of the plugging block (9) is an arc surface with the same diameter as the inner wall of the pharmaceutical catheter (1).

5. A sampling device for biopharmaceuticals according to claim 2, wherein: an ejector rod is arranged in the opening at one end of the connecting pipe (51), and a contact type check valve is arranged at one end, close to the sampling pipe (4), of the sampling channel (6).

6. A sampling device for biopharmaceuticals according to claim 2, wherein: the rubber ring (52) is an annular sealing wire rubber ring.

7. A method of sampling a biopharmaceutical sampling device as claimed in any of claims 1-3:

s1, installing a sampling tube (4) and ensuring that the contact type one-way valve is opened;

s2, rotating the annular block (2) until the fixed block (201) is contacted with the limiting teeth (101);

s3, sampling, and observing the sampling tube (4) until the sampling amount is reached;

s4, rotating the annular block (2) to the fixed block (201) to restore the original position, and taking down the sampling tube (4) to finish sampling.