CN112274785A - Optical medical device and using method thereof - Google Patents

Optical medical device and using method thereof Download PDF

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Publication number
CN112274785A
CN112274785A CN202011224599.9A CN202011224599A CN112274785A CN 112274785 A CN112274785 A CN 112274785A CN 202011224599 A CN202011224599 A CN 202011224599A CN 112274785 A CN112274785 A CN 112274785A
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layer
light
treatment
treated
light emitting
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于倩倩
谢静
许显斌
胡永岚
李栋栋
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Guan Yeolight Technology Co Ltd
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Guan Yeolight Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02Compresses or poultices for effecting heating or cooling
    • A61F2007/0203Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
    • A61F2007/0215Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing liquids other than water
    • A61F2007/0219Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0626Monitoring, verifying, controlling systems and methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/065Light sources therefor
    • A61N2005/0651Diodes
    • A61N2005/0653Organic light emitting diodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662Visible light
    • A61N2005/0663Coloured light

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  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Physics & Mathematics (AREA)
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Abstract

The invention discloses a photomedical device and a method of use thereof, wherein the device comprises: the OLED device comprises an OLED light source, a sensing module and a control module. The OLED light source is used for providing a treatment light source and comprises a plurality of light emitting areas which independently emit light; the sensing module is used for sensing the skin or tissue state of the treatment area and comprises a plurality of sensors distributed on the working surface of the optical medical equipment; the control module is configured to receive the state signal sensed by the sensor, determine the region to be treated according to the state signal, and light the light emitting region corresponding to the region to be treated with the brightness corresponding to the state signal. This application sets up the response module through the surface at light medical device, and the sensor and the skin direct contact of response module respond to the state signal of skin to can judge treatment area accurately, with open the luminous region that corresponds with treatment area, realize accurate treatment, avoid "being forced to the treatment" to normal skin tissue, protect normal skin tissue, promote treatment.

Description

Optical medical device and using method thereof
Technical Field
The invention relates to the technical field of medical devices, in particular to an optical medical device and a using method thereof.
Background
In recent years, phototherapy has achieved significant clinical effects in treating diseases, and has become one of the main methods for treating diseases, and photodynamic therapy is a method for treating diseases by directly using light or using light and drugs in combination, and is currently applied to clinical medicine. There are two main ways of photodynamic therapy, one is direct light therapy, and the other is light therapy and drug (also called photosensitizer) synergistic therapy. The direct light therapy is to directly irradiate the affected part with one or more kinds of light, and has the effects of sterilizing, disinfecting, promoting cell metabolism, promoting cell regeneration, promoting cell secretion of chemical substances (such as serotonin) and promoting blood circulation. The medical process of the synergistic effect of light and medicine is that the laser irradiation with specific wavelength excites the photosensitizer absorbed by the tissue, and the excited photosensitizer transfers the energy to the surrounding oxygen to generate singlet oxygen with strong activity, and the singlet oxygen and the adjacent biological macromolecules generate oxidation reaction to generate cytotoxicity effect, thereby causing cell damage and even death. At present, the phototherapeutic treatment can treat skin diseases such as herpes zoster, alopecia areata, phlebitis, erysipelas, acne, paronychia, chilblain and the like, surgical diseases such as wound infection, abscess, ulcer and the like, gynecological diseases such as chronic pelvic inflammatory disease, adnexitis, cervical erosion, leukoplakia vulvae and the like, internal diseases such as infantile diarrhea, ischemic heart disease, chronic gastritis and the like, and other diseases such as otorhinolaryngology department, burn department and the like.
In the existing optical medical device, because the irradiation area and the area of the light source are fixed, the irradiation area is often larger than the treatment area during treatment, so that normal skin tissues are forced to receive treatment, which is not favorable for the treatment of patients; in the prior art, some technical schemes adopt an image recognition method to recognize a treatment area, and a light source selectively treats the recognized area to be treated, so that the method can seemingly solve the problem of forced treatment, but in the actual use process, the difference between the treatment area and normal skin tissues on image development is not obvious, and the treatment area and the normal skin tissues can be observed only by careful observation, so that the recognition accuracy of the image recognition method is poor, sometimes even false recognition occurs, and the problem of forced treatment cannot be fundamentally solved.
The light sources used for the optical medical device at present are a strong light source and a weak light source, and the strong light source is mainly 10000mW/cm2The low-light source is mainly 100mW/cm2The light source inside the medical device can be an OLED or an LED, the medical device with the strong light source is not convenient to wear, most of the medical devices can only be used in hospitals, and a patient needs to be kept still for a long time in the illumination time, so that a lot of inconvenience is brought to the patient, and the treatment cost of the patient is increased. In addition, general patients avoid diseases of genital organs and private parts, but in addition, the strong light source damages normal tissues due to too strong power when treating diseases, and in addition, the laser light source and the LED have poor uniformity of light emission, which is not favorable for treatment of affected parts with large areas.
Disclosure of Invention
In view of the above-mentioned deficiencies or inadequacies in the prior art, it would be desirable to provide a photomedical device that precisely locates the treatment area and is convenient to carry and use, and a method of using the same.
In a first aspect the present application provides a photomedical device comprising:
the OLED light source is used for providing a treatment light source and comprises a plurality of light emitting areas which independently emit light;
the sensing module is used for sensing the skin or tissue state of a treatment area and comprises a plurality of sensors distributed on the working surface of the optical medical device;
and the control module is configured to receive the state signal sensed by the sensor, analyze the state signal to determine a region to be treated, light a light emitting region corresponding to the region to be treated, and control the light emitting brightness or wavelength of different light emitting regions according to the state signal.
According to the technical scheme provided by the embodiment of the application, the control module is specifically configured to:
setting position information of each sensor;
receiving state signals of each sensor;
setting a threshold value of the state signal or determining a peak value in all the state signals;
determining the position information to be treated according to the difference value between the state signal and the threshold value or the peak value, and determining the region to be treated according to the position information to be treated;
lighting a light emitting area corresponding to the area to be treated;
the illumination intensity of the lighted luminescent region is controlled according to the difference between the state signal and the threshold or peak value.
According to the technical scheme provided by the embodiment of the application, a skin-friendly cooling layer is arranged on any one side of the OLED light source; the skin-friendly cooling layer consists of a hydrogel layer or consists of a hydrogel layer and a temperature regulating layer; the temperature adjusting layer consists of a semiconductor patch or a micro resistor; the control module is configured to control the temperature of the temperature regulation layer by controlling the working current of the temperature regulation layer.
According to the technical scheme provided by the embodiment of the application, each light emitting region of the OLED light source comprises at least one first light color light emitting layer and at least one second light color light emitting layer; the control module is configured to selectively control the first light-color light-emitting layer or the second light-color light-emitting layer of each light-emitting region to work according to treatment stages;
the OLED light source comprises a substrate and at least one first photochromic functional structure and at least one second photochromic functional structure which are stacked on the substrate;
the first photochromic functional structure sequentially comprises a first electrode, a hole transport functional layer, a first photochromic light-emitting layer, an electron transport functional layer and a second electrode;
the second photochromic functional structure sequentially comprises a third electrode, a hole transport functional layer, a second photochromic light-emitting layer, an electron transport functional layer and a fourth electrode; wherein two electrodes are adjacently disposed: a power source is connected in common, or a charge generation layer is formed in common.
According to the technical scheme provided by the embodiment of the application, the surface of the photomedical device is provided with a skin-friendly medicine layer; the drug layer contains a skin-friendly photosensitizer; the surface of the optical medical device is provided with a temperature sensor for detecting a temperature signal of a treatment area; the control module is provided with a wireless communication unit for communicating with the terminal device; the surface of the medical device is also provided with a first distance sensor for detecting the distance between the surface of the medical device and the area to be treated;
the control module is powered by a power supply module, and the power supply module realizes wireless charging by a pair of wireless charging receiving units and a wireless charging transmitting device; a second distance sensor is arranged in the optical medical device and used for detecting the charging distance and the deviation angle between the wireless charging receiving unit and the wireless charging transmitting device; the control module is configured to adjust the brightness of the OLED light source according to the charging distance and the deviation angle or control the sound-light alarm module to give an alarm.
According to the technical scheme provided by the embodiment of the application, the OLED light source, the induction module and the control module form a flexible sheet structure; the flexible sheet structure is attached to the support body in a curled manner.
According to the technical scheme provided by the embodiment of the application, the OLED light source, the induction module and the control module form a flexible sheet structure; the adhesive layer is arranged on the whole side or the periphery of one side of the flexible sheet structure in a surrounding manner, wherein the adhesive layer positioned on the light emergent side of the flexible sheet structure is made of a transparent or semitransparent material; or holes for suturing tissues, skin, clothes or medical supplies are arranged around the flexible sheet structure.
In a second aspect, the present application provides a method of using a photomedical device, comprising the steps of:
receiving state signals sensed by each sensor in the sensing module;
determining the area to be treated according to the state signal;
and lighting a light emitting area corresponding to the area to be treated in the OLED light source, and controlling the light emitting brightness or wavelength of different light emitting areas according to the state signal.
According to the technical scheme provided by the embodiment of the application, the lighting of the light emitting area corresponding to the area to be treated comprises the following steps:
starting a red light treatment mode: according to the set treatment intensity signal, a second light color luminescent layer in a luminescent region corresponding to the region to be treated is lightened, so that the illumination intensity of the second light color luminescent layer corresponds to the set treatment intensity signal; the second light color luminescent layer is a red luminescent layer;
starting a protection mode: when the treatment time of the red light treatment mode is judged to be larger than a limited treatment time threshold, or a distance signal sensed by the first distance sensor is larger than a set distance threshold, or a temperature signal sensed by the temperature sensor is larger than or equal to a set temperature threshold, controlling the sound-light alarm module to give an alarm, or reducing the luminous intensity of a red luminous layer of the OLED light source, or adjusting the luminous wavelength of the OLED light source, or controlling the working current of the temperature adjusting layer to reduce the temperature of the temperature adjusting layer, or closing the red light treatment mode;
the setting of the treatment intensity signal, the limiting of the treatment time threshold, the setting of the distance threshold and the setting of the temperature threshold are set by the input module or the terminal equipment.
According to the technical scheme provided by the embodiment of the application, before lighting the light emitting area corresponding to the area to be treated, the method further comprises the following steps:
starting a cold compress mode:
waiting for a first set time to allow the hydrogel layer to be cold-compressed on the area to be treated so as to assist the photosensitizer in the drug layer to diffuse on the area to be treated;
the method also comprises the following steps after the red light treatment mode is finished:
initiating a cold compress analgesia mode: and lighting a first light color luminescent layer in a luminescent region corresponding to the region to be treated within a second set time, wherein the first light color luminescent layer is a blue light luminescent layer.
Compared with the prior art, the invention has the beneficial effects that: by providing a sensing module on the surface of the photomedical device, the sensing module includes a sensor, such as a pressure sensor, a humidity sensor, or a pH sensor; through sensor and skin direct contact, the unsmooth state of response skin or humidity or pH value these can respond the state signal of the regional skin of treatment directly perceivedly to can judge the treatment area accurately, with open the luminous region that corresponds with the treatment area, realize accurate treatment, avoid "being forced the treatment" to normal skin tissue, not only can promote treatment, can also protect normal skin tissue.
According to the technical scheme provided by the embodiment of the application, the first distance sensor is arranged, so that misoperation such as displacement or detachment of the optical medical device can be detected in time in the treatment process, and sound and light alarm can be given out or the work can be stopped in time, so that on one hand, a user can be reminded to correct in time, and in addition, the user is protected; by arranging the second distance sensor, the distance and the angle between the wireless charging transmitting device and the wireless charging receiving device are detected in time and transmitted to the control system to calculate and feed back whether enough electric quantity can be received or not, and further the luminous brightness or the luminous acousto-optic alarm of the OLED light source is adjusted in time, so that the constant output of the electric quantity of the optical medical equipment can be controlled, the continuous supply of the light source in the treatment process is realized, and a user can be reminded to correct in time.
According to the technical scheme provided by the embodiment of the application, by designing the cooling layer and the medicine layer, before red light treatment is carried out, the photosensitizer in the medicine layer can be diffused in the treated tissue through a cold compress mode, so that the coupling rate of the photosensitizer is reduced, the proportion of the photosensitizer in the treated tissue is increased, and the subsequent red light treatment effect can be improved; simultaneously, the cooling layer is arranged, and the blue light emitting layer in the OLED light source can be combined after treatment is finished, so that cooling and pain easing can be performed after phototherapy, and the side effect of phototherapy is relieved.
According to the technical scheme that this application embodiment provided, through the temperature of designing temperature sensor real-time ground response treatment in-process, adjust illumination intensity or in time suspend the treatment or start the cold compress cooling or reduce illumination intensity when the high temperature according to this temperature, guaranteed the security in the phototherapy.
According to the technical scheme provided by the embodiment of the application, the safety of the treated area in the using process is ensured and the user experience of the optical medical device is improved by designing the skin-friendly drug layer and the skin-friendly photosensitizer.
According to the technical scheme provided by the embodiment of the application, the device is convenient to carry by using the structural form of the flexible patch, and can be attached to products such as underwear, a protection pad, underpants, a paper diaper, a sanitary towel and the like; on one hand, the use is convenient, and in addition, the privacy of the user is also protected.
According to the technical scheme provided by the embodiment of the application, the patch can be attached to the support body and used for in-vivo treatment.
It should be understood that the statements herein reciting aspects are not intended to limit the critical or essential features of any embodiment of the invention, nor are they intended to limit the scope of the invention. Other features of the present invention will become apparent from the following description.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments made with reference to the following drawings:
fig. 1 is a schematic top view of a photomedical device provided in embodiment 1 of the invention;
FIG. 2 is a schematic cross-sectional view of an OLED light source in the photomedical device provided by embodiment 1 of the invention;
FIG. 3 is a schematic cross-sectional view of a photomedical device provided in example 1 of the invention;
fig. 4 is a functional block diagram of a photomedical device provided in embodiment 1 of the invention;
FIG. 5 is a schematic structural diagram of one embodiment of a sensor 21 according to example 1 of the present invention;
FIG. 6 is a schematic structural diagram of another embodiment of a sensor 21 according to example 1 of the present invention;
fig. 7a is a schematic top view of a first photomedical device according to embodiment 1 of the invention that illuminates a light-emitting area corresponding to an area to be treated;
fig. 7b is a schematic top view of a second photomedical device according to embodiment 1 of the invention that illuminates a light-emitting area corresponding to an area to be treated;
fig. 7c is a schematic top view of a light emitting region corresponding to a region to be treated and illuminated by a third photomedical device provided in embodiment 1 of the invention;
FIG. 8a is a schematic cross-sectional view of an OLED light source with a dual light-emitting layer in an optical medical device provided in example 1 of the present invention;
FIG. 8b is a schematic cross-sectional view of an OLED light source with a dual light-emitting layer in an optical medical device provided in example 1 of the present invention;
FIG. 8c is a schematic cross-sectional view of an OLED light source with a dual light-emitting layer and a switching circuit in the photomedical device provided in example 1 of the invention;
FIG. 9 is a graph of a first square wave of voltage provided by a control module to an OLED light source in the photomedical device of embodiment 1 of the invention;
FIG. 10 is a diagram of a second square wave voltage provided by the control module to the OLED light source in the photomedical device of embodiment 1 of the invention;
FIG. 11 is a wavelength diagram of the light source of the OLED corresponding to FIG. 9 in the light medical device provided by embodiment 1 of the present invention;
FIG. 12 is a wavelength diagram of the light source of the OLED corresponding to FIG. 10 in the light medical device provided by embodiment 1 of the present invention;
FIG. 13 is a schematic cross-sectional view of a first example of a photomedical device of the present invention in example 2;
FIG. 14 is a schematic cross-sectional view of a second example of the photomedical device of the invention according to example 2;
FIG. 15 is a schematic cross-sectional view of a third example of the photomedical device of the invention according to example 2;
FIG. 16 is a schematic diagram showing a fourth cross-sectional structure of the photomedical device provided in example 2 of the invention;
FIG. 17 is a schematic block diagram of a photomedical device provided in embodiment 2 of the invention;
FIG. 18 is a schematic view of the structure of a photomedical device provided by example 3 of the invention;
fig. 19-21 are flow charts of example 5 in the present application.
Reference numbers in the figures:
10. an OLED light source; 20. a sensing module; 30. a control module; 11. a light emitting region; 12. a substrate; 13 an anode; 13a, a fourth electrode; 13b, a first electrode; 14. a hole transport functional layer; 15. a light emitting layer; 16. an electron transport functional layer; 17. a cathode; 17a, a third electrode; 17b, a second electrode; 40. a protective layer; 50. an adhesive layer; 60. a control layer; 70. a connecting layer; 21. a sensor; 22. a connecting wire; 80. a cooling layer; 81. a hydrogel layer; 82. a temperature adjusting layer; 90. a drug layer; 31. a temperature sensor; 32. a wireless communication unit; 100. a terminal device; 33. a first distance sensor; 34. an audible and visual alarm; 35. an input module; 36. a power supply module; 37. a second distance sensor; 110. a support body; 120. a flexible sheet structure.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.
Example 1:
the present embodiments provide a photomedical device, including:
an OLED light source 10 for providing a therapeutic light source, including a plurality of light emitting areas that independently emit light;
a sensing module 20 for sensing the skin or tissue condition of the treatment area, comprising a plurality of sensors 21 distributed on the working surface of the photomedical device;
the control module 30 is configured to receive the state signal sensed by the sensor, perform operation analysis on the state signal to determine the region to be treated, light the light emitting region corresponding to the region to be treated, and control the light emitting brightness or wavelength of different regions according to the state signal.
The OLED light source 10 is a flexible OLED screen body, which is uniformly provided with independent light emitting regions 11, and the shape of the light emitting regions 11 may be arbitrary, for example, a square as shown in fig. 1, or other polygons or irregular patterns; each light emitting region 11 is controlled by a separate electrode; for example, as shown in fig. 2, the OLED light source is sequentially provided with a substrate 12, an anode 13, a hole transport functional layer 14, a light emitting layer 15, an electron transport functional layer 16, and a cathode 17; the independent light-emitting regions 11 are formed in the light-emitting layer 15, the different light-emitting regions 11 are lighted by respectively controlling the anodes 13, different working voltages are provided for the anodes of the different light-emitting regions 11 to control the light-emitting brightness of the different light-emitting regions, or the different light-emitting layers in the different light-emitting regions work by adjusting the duty ratio of the circuit and the working voltages, so that the light-emitting wavelengths of the different light-emitting regions are adjusted.
The photomedical device in the present embodiment has a basic structure as shown in fig. 3, and sequentially includes a control layer 60, a connection layer 70, and an OLED light source 10; the control layer 60 uses a flexible circuit board as a carrier, and each chip and device of the control module are welded on the flexible circuit board, the control module can be a circuit structure which uses a microprocessor as a main body and consists of some peripheral circuits, and the microprocessor can be a single chip microcomputer or an ARM, for example; the connection layer 70 is used for connecting the control layer 60 and the OLED light source 10, and is preferably an adhesive layer disposed at the edge between the control layer 60 and the OLED light source 10; the basic structure described above allows the present medical device to form a substantially flexible sheet structure 120 that can be attached and secured to different shaped wearing articles or carriers. Wherein, one side of the control layer 60 is also provided with an adhesive layer 50 and a protective layer 40, and in the using process, the protective layer 40 can be uncovered from the adhesive layer 50 and attached to organisms, clothes or other medical appliances, thereby being convenient for the device to use; the protective layer 40 may be, for example, a sheet or box-like structure having a release surface to facilitate re-insertion after use of the device.
In addition, the adhesive layer 50 may be formed on the whole surface or the periphery of any side of the flexible sheet-like structure 120, and the adhesive layer 50 located on the light-emitting surface side of the flexible sheet-like structure 120 is made of a transparent material or a semi-transparent material, preferably a skin-friendly material; in other embodiments, holes are provided around the flexible sheet structure 120 for suturing tissue or skin or clothing or medical supplies; the device may thus be secured to the tissue being treated by suturing or by the use of materials which adhere to the mucosa of the tissue.
As shown in fig. 4, a basic schematic block diagram of the optical medical apparatus provided in this embodiment is provided, and as can be understood by those skilled in the art, as the optical medical apparatus, the apparatus has a basic input module 35, the input module 35 may include a start button and a signal input panel, the signal input panel may be, for example, a display screen with a touch screen, and a user may input control information such as treatment time, treatment intensity, etc. through the input panel; the control module 30 is a core control device of the apparatus, and controls the OLED light source 10 by receiving signals from the input module or the sensing module.
Wherein, as shown in fig. 1, the sensors 21 of the sensing module 20 are uniformly distributed on the surface of the device, for example, when corresponding to the device structure shown in fig. 3, the sensors 21 are uniformly distributed on the working surface of the photomedical device; as shown in fig. 5, each sensor 21 is attached to a narrow strip of connecting wires 22, and each connecting wire 22 is glued to the surface of the OLED light source 10; the connection line 22 is in signal connection with the control layer 10 from the side across the OLED light source 10; the connection line 22 may be FPC, and is adhered to the OLED light source 10 by a skin-friendly adhesive DOPA-substituted polyethylene glycol polymer, fibrin glue, or alkyl- α -cyanoacrylate glue, or may be directly a skin-friendly conductive pressure-sensitive adhesive, which may realize electrical connection between the sensor 21 and the control layer 60, and may be adhered to the surface of the OLED light source 10. This is just one embodiment of the specific distribution of the sensors, and in other embodiments, for example, as shown in fig. 6, the OLED light source 10 may be composed of a plurality of independent light sources, or may be provided with upper and lower through holes, and the sensors 21 disposed on the control layer may be passed out to the surface of the device from the gaps between the independent light sources or through holes.
Wherein, the sensor 21 can be any one or more of a pressure sensor, a humidity sensor or a pH sensor;
a pressure sensor: the device is suitable for being used in disease areas with the skin surface being uneven, such as epithelioma, pimples and acnes, the pressure sensor can detect the pressure between the device and the area to be treated at the time, and the area with the disease is judged according to the pressure difference value existing at different positions; in this case, various pressure sensors of suitable size are used, such as those disclosed by Manik Dautta et al, Multi-Functional Hydrogel-Interlayer RF/NFC detectors as a Versatile Platform for Passive and Wireless Biosensing, adv. Electron. Mater.2020, 1901311.
A humidity sensor: the humidity sensor is suitable for the condition that the diseases can cause the obvious humidity increase, and various humidity sensors with proper dimensions are adopted, such as the sensors disclosed by Li-Chia Tai and the like, Drug-ports Silicon double luminescence System for Monitoring and Inhibition of round Infection, adv.
pH sensors, suitable for use in conditions where the condition causes a significant change in pH, may be referred to as the sensors disclosed in Chen X, Wo F, Jin Y, et al, drug-port Silicon Dual luminescence System for Monitoring and Inhibition of round Infection [ J ] Acs Nano,2017: acsano.7 b02471.
The above are only some of the sensors applicable to the present application, and in other embodiments, the sensors may also be sensible human body signals [ human body signals include but are not limited to: signals of heat, sound, light, electricity, force, biochemistry, myoelectricity, body temperature, blood pressure, blood oxygen, biochemical indexes (glucose, lactic acid, uric acid) and the like); the size and the range of the area to be treated are accurately determined through the preparation identification of the state signal of the treatment area.
Wherein the control module 30 is specifically configured to:
setting position information of each sensor;
receiving state signals of each sensor;
setting a threshold value of the state signal or determining a peak value in all the state signals;
determining the position information to be treated according to the difference value between the state signal and the threshold value or the peak value, and determining the region to be treated according to the position information to be treated;
lighting a light emitting area corresponding to the area to be treated;
the illumination intensity or wavelength of the lighted luminescent region is controlled according to the difference between the state signal and the threshold or peak value.
The threshold and peak values are two parameters used in the determination of the area to be treated, optionally:
method 1, when a peak is used, the area to be treated is determined by the following steps:
determining an edge state signal, wherein the edge state signal is a state signal of which the difference value with the peak value is within a first set difference value range;
determining the position information of the sensor corresponding to each edge state signal as edge position information;
and determining the edge position information and the position information in the surrounding area thereof as the position information to be treated, wherein the area formed by all the position information to be treated is the area to be treated.
Method 2, when threshold values are used, the treatment position information is determined by the following steps:
determining a treatment state signal, wherein the treatment state signal is a state signal with a difference value with the threshold value larger than or equal to a second set difference value;
and determining the position information of the sensor corresponding to each treatment state signal as the position information to be treated, wherein the region formed by all the treatment position information is the region to be treated.
For example, taking the sensor distribution shown in fig. 1 as an example, assuming that the sensors are pressure sensors, at this time, one pressure sensor is correspondingly arranged in each light emitting area, and at this time, the control module stores the position information of the corresponding respective sensors, for example, as shown in the following table 1, as the array positions in the array arrangement:
(1,1) (1,2) (1,3) (1,4) (1,5) (1,6) (1,7) (1,8) (1,9) (1,10)
(2,1) (2,2) (2,3) (2,4) (2,5) (2,6) (2,7) (2,8) (2,9) (2,10)
(3,1) (3,2) (3,3) (3,4) (3,5) (3,6) (3,7) (3,8) (3,9) (3,10)
(4,1) (4,2) (4,3) (4,4) (4,5) (4,6) (4,7) (4,8) (4,9) (4,10)
(5,1) (5,2) (5,3) (5,4) (5,5) (5,6) (5,7) (5,8) (5,9) (5,10)
(6,1) (6,2) (6,3) (6,4) (6,5) (6,6) (6,7) (6,8) (6,9) (6,10)
(7,1) (7,2) (7,3) (7,4) (7,5) (7,6) (7,7) (7,8) (7,9) (7,10)
(8,1) (8,2) (8,3) (8,4) (8,5) (8,6) (8,7) (8,8) (8,9) (8,10)
(9,1) (9,2) (9,3) (9,4) (9,5) (9,6) (9,7) (9,8) (9,9) (9,10)
(10,1) (10,2) (10,3) (10,4) (10,5) (10,6) (10,7) (10,8) (10,9) (10,10)
TABLE 1
When the area to be treated is a pimple-shaped area, the pressure sensors at the respective positions detect the values as shown in table 2 below:
Figure BDA0002763230950000101
Figure BDA0002763230950000111
TABLE 2
When the above method 1 is adopted, then the peak value in all status signals is determined to be the status signal value 0.55 detected by the pressure sensor at the array position (6, 4); the first set difference range is, for example, 0.2 to 0.25, and the edge status signal ranges from 0.35 to 0.3, so that the edge position signals can be determined to be (3,2), (4,2), (5,2), (6,2), (7,2), (8,3), (8,4), (8,5), (8,6), (8,7), (7,9), (6,9), (5,9), (4,8), (4,7), (3,7), (2,6), (2,5), (2,4), (3, 3); therefore, the edge position information and the position information in the surrounding area thereof are determined as the treatment position information, and the light emitting area corresponding to the treatment position information is lit, so that the light emitting area to be lit is determined as the shaded area shown in fig. 7a in the present example.
In the embodiment, the severe region and the mild region can be judged according to the magnitude of the pressure difference value, and different irradiation intensities are adopted for treating the severe region and the mild region, so that the targeted and adaptive treatment on different degrees of disease regions is realized; for example, a severe signal region is defined where the status signal value is 0.4 or more, and the corresponding light-emitting region is shown as a dark shaded region in fig. 7b, which has stronger illumination intensity; defining the status signal value below 0.4 is a light signal area, and the corresponding light emitting area is shown as the light shaded area in fig. 7b, and the light intensity is weaker.
When the above method 2 is adopted, for example, the threshold value is set to 0.25, and the light emitting region to be lit is determined to be a shaded region as shown in fig. 7c in this example.
In this embodiment, because the regional area of powder thorn form is less, and irregular, compresses tightly the back on skin through this device, utilizes the protruding characteristic in acne district, gathers the different status signal of the pressure sensor in different positions, has confirmed the position in acne district according to these status signals accurately to can realize accurate treatment, avoid the treatment of being forced to normal skin.
In other embodiments, when a humidity sensor or a pH sensor is employed, the determination of the irradiation region and the light emitting region may also be similar to the above determination method in the present embodiment.
In this embodiment, each light emitting region of the OLED light source 10 includes at least one first light emitting layer and at least one second light emitting layer; the control module is configured to selectively control the first light-color light-emitting layer or the second light-color light-emitting layer of each light-emitting region to work according to the treatment stage;
by arranging the plurality of light color light-emitting layers, a plurality of treatment modes can be realized, each light-emitting area is independently controlled, and the light-emitting color of each light-emitting area can be different; meanwhile, when the first distance sensor 33 detects that the photomedical device is displaced in use, the treatment can be adjusted by selectively changing the light-emitting wavelength of each light-emitting area after displacement, so as to adjust the light-emitting color of different light-emitting areas.
The OLED light source comprises a substrate and at least one first photochromic functional structure and at least one second photochromic functional structure which are stacked on the substrate;
the first photochromic functional structure sequentially comprises a first electrode, a hole transport functional layer, a first photochromic light-emitting layer, an electron transport functional layer and a second electrode;
the second photochromic functional structure sequentially comprises a third electrode, a hole transport functional layer, a second photochromic light-emitting layer, an electron transport functional layer and a fourth electrode; wherein two electrodes are adjacently disposed: a power source is connected in common, or a charge generation layer is formed in common. Wherein the first electrode and the fourth electrode are semitransparent metal electrodes, and the thickness of the electrodes is in the range of 1-20 nm.
In this embodiment, each light emitting region of the OLED light source 10 includes at least one blue light emitting layer and at least one red light emitting layer; the control module is configured to selectively control the blue light-emitting layer or the red light-emitting layer of each light-emitting region to work according to the treatment stage, so as to realize the adjustment of the wavelength of the OLED light source. The treatment phases in this embodiment include at least two phases: the control module controls the red light emitting layer to work in the red light treatment stage and controls the blue light emitting layer to work in the blue light analgesia stage.
As shown in fig. 8a, the present embodiment is provided with a first light emitting layer and a second light emitting layer; the first light color light-emitting layer is a blue light-emitting layer, and the second light color light-emitting layer is a red light-emitting layer; as shown in the layered structure of the OLED light source 10 in this embodiment, the OLED light source sequentially includes, from bottom to top, a substrate 12, a third electrode 17a, a hole transport functional layer 14, a blue light emitting layer 15a, an electron transport functional layer 16, a fourth electrode 13a, a first electrode 13b, a hole transport functional layer 14, a red light emitting layer 15b, an electron transport functional layer 16, and a second electrode 17 b; wherein the third electrode 17a and the first electrode 13b are both anodes and the fourth electrode 13a and the second electrode 17b are both cathodes.
As shown in fig. 8b, the present embodiment is provided with a first light emitting layer and a second light emitting layer; the first light color light-emitting layer is a blue light-emitting layer, and the second light color light-emitting layer is a red light-emitting layer; as shown in the layered structure of the OLED light source 10 in this embodiment, the OLED light source sequentially includes, from bottom to top, a substrate 12, a third electrode 17a, a hole transport functional layer 14, a blue light emitting layer 15a, an electron transport functional layer 16, a fourth electrode 13a, a first electrode 13b, a hole transport functional layer 14, a red light emitting layer 15b, an electron transport functional layer 16, and a second electrode 17 b; the fourth electrode 13a and the first electrode 13b are vacant to form a charge generation layer together, the third electrode 17a is an anode, the second electrode 17b is a cathode, the blue light emitting layer 15a and the red light emitting layer 15b can work simultaneously to form yellow-green light, and the irradiation depth of the yellow-green light with the wave band of 510 nm-590 nm is between that of the blue light and the red light, so that the dredging and expansion of capillary vessels with the skin depth can be promoted, the resistance of cells is enhanced, and the treatment effect of affected parts is accelerated.
The two operation modes shown in fig. 8a and fig. 8b can be realized by providing a switching circuit to switch the power connection mode of the OLED light source.
The implementation of the switching circuit may alternatively use the approach shown in fig. 8c, i.e. using three switches S1, S2, S3; when S1, S3 are closed and S2 is opened, the working mode is the corresponding working mode of FIG. 8 a; when S1, S3 are turned off and S2 is turned on, the operation mode corresponding to fig. 8b is set. In the present application, the wavelength of the light-emitting regions can be adjusted by adjusting the light-emitting regions, so as to adapt to different status signals corresponding to different light-emitting regions, for example, for the light-emitting regions in which the value of the sensor in the region to be treated in table 2 is above 0.4, the operating mode corresponding to fig. 8a is adopted, so that red light treatment can be performed on the light-emitting regions; for the light emitting areas with the sensor values below 0.4 in the area to be treated of table 2, the corresponding mode of operation of fig. 8b is used, so that these light emitting areas can be treated with yellow-green light.
Therefore, the structure of the OLED light source provided by this embodiment increases the light emitting color of the photomedical device, thereby increasing the treatment function of the photomedical device, providing more treatment selectivity, and providing more comprehensive treatment possibilities.
The OLED light source is made into the structure, and the control module 30 is used for adjusting the duty ratio of input current or voltage so as to carry out red light phototherapy in treatment and blue light analgesia after treatment. Red light with a waveband of 590-810 nm can enable mitochondria to release cytochrome c oxidase, increase adenosine triphosphate, and enable cells to provide energy by utilizing the adenosine triphosphate, so that the metabolism of the cells is promoted; meanwhile, the red light irradiation heats molecules in the blood vessel, so as to adjust the blood vessel expansion and improve the blood circulation; the blue light irradiation of the 440-510 nm wave band can be used for relieving pain and swelling caused by inflammation.
The wavelength adjustment of the control module 30 can be specifically shown in fig. 9 and 10, when the control module controls the operating voltage of the OLED light source as shown in fig. 9, the operating wavelength of the OLED light source is blue light as shown in fig. 11; when the control module controls the operating voltage of the OLED light source as shown in fig. 10, the operating wavelength of the OLED light source is red as shown in fig. 12.
The first electrode and the fourth electrode are thin semi-transparent metal, the thickness is 1-20nm, and the first electrode and the fourth electrode can be one or more metals such as Ag, Al, Au, Mg and the like; the hole transmission function layer is at least one of a hole injection layer, a hole transmission layer and an exciton blocking layer; the electron transmission function layer is at least one of an electron injection layer, an electron transmission layer and an exciton blocking layer;
the specific structure can be ITO/MoO3(5nm)/NPB(30nm)/m-MTDATA(10nm)/MADN:5%DSA-PH(30nm)/BAlq(10nm)/Bphen(30nm)/BPhen:2%Yb(5nm)/Al(10nm)/Ag(2nm)/NPB:2%NDP-9(5nm)/NPB(30nm)/TCTA(10nm)/CBP:5%DCJTB(30nm)/BCP(10nm)/Bphen(30nm)/LiF(1nm)/Al(1500nm);
Wherein MoO3And NPB 2% NDP-9 as hole injection layer; NPB is a hole transport layer; m-MTDATA, TCTA, BALq, BCP are exciton blocking layers; bphen is an electron transport layer; BPhen: 2% Yb and LiF are electron injection layers.
The above is only an example of the wavelength adjustment, the structure is not limited to only two layers, and other wavelengths can be selected for adjustment and conversion according to different diseases.
The wavelength range of the OLED light source is 260-1018 nm; the red light of 590-810 nm band and the blue light of 440-510 nm band are only the band ranges applied in this embodiment. In other embodiments, the irradiation depth of yellow-green light with a wave band of 510 nm-590 nm can be selected to be between blue light and red light, so that the dredging and expansion of capillary vessels in the skin depth can be promoted, the resistance of cells can be enhanced, and the treatment effect of affected parts can be accelerated; or the infrared ray with the wave band of 810 nm-1018 nm can heat the deep part of the skin to promote the blood circulation.
Example 2:
this embodiment is based on embodiment 1, and as shown in fig. 13 and 14, a cooling layer 80 is provided on either side of the OLED light source. The cooling layer 80 consists of a hydrogel layer 81 or consists of a hydrogel layer 81 and a temperature adjusting layer 82; the temperature adjusting layer 82 is composed of a semiconductor patch or a micro resistor; the control module 30 is configured to control the temperature of the temperature adjusting layer 82 by controlling the operating current of the semiconductor patch or micro resistor.
At this time, the cooling layer 80 can be started in the blue light analgesia stage, and performs cooling and analgesia effects after red light treatment. Wherein the adjustable temperature range of the temperature adjusting layer is 5-35 ℃, and preferably 15-25 ℃; the temperature control layer 82 can also be started in the red light treatment stage for temperature reduction when the temperature is too high in the treatment process.
Preferably, as shown in fig. 15 and 16, a skin-friendly drug layer 90 is disposed on the surface of the photomedical device, and a skin-friendly photosensitizer is contained in the drug layer 90, and the photosensitizer has the characteristics of high target selectivity and high cellular absorption rate;
the photosensitizer generally consists of a carrier and photosensitive particles, and in order to ensure the biosafety performance in the using process, the photosensitizer carrier with skin-friendly property is adopted, and specifically comprises one or more of the following materials: nano metal particles NMOFs @ BSA/SDs, Prussian blue nano particles, polyhedral oligomeric silsesquioxane (POSS), sugar-containing polymer, chitosan oligosaccharide, chitosan or derivatives thereof, nano particle polymer Poly (HDDA-co-DBPA) -PEG, ionic viologen compounds, multi-layer capsule wall of natural polymer glycan (CHI) or glucan, platinum @ polydopamine-chlorin nanocomposite, Fe3O4@Bi2WO6MoS2-AuNPs-Ce6, polyacrylic acid, polyethylene glycol, polycaprolactone, erlotinib with alkoxy long chain, and hydroxyl phosphorusLimestone, degradable antimony nanostructures, polyvinylpyrrolidone, pyrimidinyloxy groups with long alkoxy chains, Mn3O4@ mSiO2@ CuS, multifunctional PLGA nanoparticles, polyethylene oxide-polypropylene oxide, N-vinyl pyrrolidone, acrylamide, ethyl acrylate, polyethylene oxide, polyethylene glycol, polybutadiene, poly (ethyl-ethylene), poly (methyl-ethylene), methyl acrylate, poly (epsilon-caprolactone), poly (gamma-methyl), polypeptide, glycan, pullulan, hyaluronic acid or hyaluronic acid derivative, polylactide, curdlan, pectin, starch, dextran, chitosan, poly-L-lysine, polyaspartic acid, polyethylene, polypropylene, polytetrafluoroethylene, polystyrene, polyurethane, silicone resin, polylactic acid, polyglycolic acid, gelatin hydrogel, polyethylene glycol, Collagen, cellulose ether, carbopol, polyvinyl pyrrole, and polyvinyl alcohol.
Also for the photosensitive particles we can use the following materials to make up the photosensitizer with the above carrier, for example: a plurality of fused ring azo and diazo compounds, aminolevulinic acid, indocyanine green, methylene blue, hypocrellin A and derivatives thereof, hypocrellin B and derivatives thereof, melittin, gold-carbon nanospheres, carbon nanotubes, phosphines, fullerenes, chlorins, bacteriochlorins and modified compositions thereof, pyrroles and modified compositions thereof, porphyrins and modified compositions thereof, phthalocyanines and modified compositions thereof, chlorine e6, monochloro, chlorine or benzotetrahydroxyphenyl chloride.
Of course, photosensitizer materials with skin-friendly properties can be used directly, for example: BPNs/chitosan/PRP temperature-sensitive hydrogel, G @ TiO2@ PS nano composite material, ruthenium dioxide composite ovalbumin nano material, catalase-photosensitive molecular composite, HSA- (PpIX)2, glutathione response type Berlin green nano particles, Prussian blue nano particles, BPQDs, hydrogen bond organic framework material constructed based on fused ring ligands, tellurium doped carbon quantum dots of precursor tellurocystine, Au38S2(SAdm)20, PEOH Poby DE A (pheophorbide a), bacteriophage phenol bacteria, YbPO4: Er-MC540 composite micro particles and CuS @ mSiO 2-TD/ICG.
The medicinal layer may also contain antibiotic, analgesic, antipyretic, antimicrobial, antibacterial, antiallergic, acne medicine, antiinflammatory, hemostatic, vitamin, anti-irritant, antipruritic, emollient, photosensitizer, etc., preferably photosensitizer.
The form of the medicine can be paste, cream, gel, powder, liquid, film, or patch.
The carrier for placing the drug on the drug layer is also a material with skin-friendly property, such as silica gel, Polydimethylsiloxane (PDMS), silica gel, Collagen (Collagen), Silicone Hydrogel (Hydrogel), Hydrogel (hydrocoloid), Polyurethane (PU), polymethyl methacrylate (PMMA), polymethylpentene polymer (PMP), Polyethylene (PE), polycarbonate, polystyrene, acrylonitrile butadiene styrene, polyolefin, polyamide, polyvinyl chloride, polyethylene, polypropylene, nylon, polyester, Silicone, polyimide, polytetrafluoroethylene, polyethersulfone, polysulfone, polyetheretherketone, chitosan, pectin, gelatin, nylon, fiber, and the like.
The drug layer 90 may be attached to the adjacent layer by selection of skin-friendly adhesives such as DOPA-substituted polyethylene glycol polymers, fibrin glue, and alkyl-alpha-cyanoacrylate glue.
Due to the drug layer 90, the photomedical device provided by the present embodiment may provide a cold compress preparation phase prior to the red treatment phase; this stage allows the photosensitizer to diffuse in the target tissue within a period of 30-180 min; meanwhile, the coupling rate of the photosensitizer in the skin tissue to be treated can be reduced through the cooling layer 80, so that the proportion of the photosensitizer in the skin tissue is increased, and the subsequent phototherapy effect is facilitated.
Wherein the drug layer is removably disposed on a surface of the photomedical device, the drug layer containing the corresponding drug may be selected when the photomedical device is used to treat a variety of conditions. The medicine layer can also be divided into a plurality of areas or modules, and the modules with different medicine contents are arranged corresponding to the areas with different pathological changes, so that the medicine content is adaptive, and the treatment effect is better.
Meanwhile, the drug layer can be combined with the sensing module to be adjusted in the treatment process; the relevant parameters of the light source or the relevant medicines can be further formulated and/or changed according to the status signals; for example, during treatment, a lower drug content drug layer may be replaced as symptoms improve; or directly removing the medicine layer and directly changing into low light therapy.
Preferably, as shown in the schematic block diagram of the present photomedical device of fig. 17, the surface of the photomedical device is provided with a temperature sensor 31 for detecting a temperature signal of the treatment area; the temperature signal can be detected to detect the temperature on the surface of the optical medical device in time, and the working intensity and time of red light in the OLED light source or the temperature of the cooling layer can be adjusted according to the temperature so as to avoid the skin from being burnt by overhigh temperature, protect a user and provide basis for adjusting the illumination intensity.
Preferably, as shown in the schematic block diagram of the present photomedical apparatus of fig. 17, the control module is provided with a wireless communication unit 32 for communicating with a terminal device. The wireless communication unit may be, for example, a bluetooth module or an NFC module, and the terminal device 100 may be, for example, a computer, a PAD, or a mobile phone. The wireless communication unit enables the use of the device to be controlled through the terminal equipment, and the use is convenient.
Preferably, as shown in the schematic block diagram of the present photomedical device of fig. 17, the surface of the photomedical device is further provided with a first distance sensor 33 for detecting the distance between the surface of the medical device and the area to be treated; at this time, the control module 30 is also connected with an audible and visual alarm 34; the setting of first distance sensor 33 can in time detect light medical treatment device and treat that maloperation such as aversion or dismantlement in treatment region, when the user dresses light medical treatment device and when affirmatively starting, can acquire distance sensor 33's initial distance signal, at ruddiness treatment stage, when the difference of the distance signal that acquires in real time and initial distance signal is more than or equal to and sets for the distance difference, control module 30 starts audible-visual annunciator 34 and reports to the police in order to remind the user to the security of using has been guaranteed.
The control module 30 is powered by a power module 36, and the power module realizes wireless charging by a pair of wireless charging receiving units and wireless charging transmitting devices; a second distance sensor 37 is arranged in the optical medical device and used for detecting the charging distance and the deviation angle between the wireless charging receiving unit and the wireless charging transmitting device; the control module is configured to adjust the luminance of the OLED light source according to the charging distance and the deviation angle.
When the photomedical device is located internally and is not convenient to take out in a short time, charging needs to be completed internally, the charging distance and the deviation angle between the wireless charging receiving unit and the wireless charging transmitting device are determined by the position and the angle between the human body and the wireless charging transmitting device, and when the second distance sensor detects that the charging distance between the wireless charging receiving unit and the wireless charging transmitting device is greater than the set charging distance or the deviation angle is greater than the set deviation angle, the audible and visual alarm 34 can be started to alarm to remind a user of adjusting the position.
Meanwhile, when the therapy and the charging are performed simultaneously, the control module 30 is configured to adjust the luminance of the OLED light source according to the charging distance and the deviation angle, so that the constant output of the phototherapy device can be controlled no matter how much the luminance can be received. For example, the longer the charging distance between the wireless charging receiving unit and the wireless charging transmitting device is detected, or the larger the deviation angle is, the lower the light emitting brightness of the OLED light source is controlled, so that the OLED screen body can keep constant output.
Taking NFC charging as an example, the wireless charging receiving unit is provided with a receiving coil, the wireless charging transmitting unit is provided with a transmitting coil, a coordinate system established by taking a center point of the receiving coil of the wireless charging receiving unit as an origin point and a plane where the coil of the receiving coil passes through the origin point as an XY plane is a reference, a distance from the center point of the transmitting coil to the origin point is a charging distance, and an included angle between the plane where the coil of the transmitting coil is located and a Z axis is a deviation angle. The charging distance and the charging angle affect the magnitude and direction of the magnetic field intensity received by the charging receiving unit, thereby affecting the charging efficiency.
Preferably, the control module is powered by a power supply module, and is provided with a wireless charging unit; the power module is charged by the wireless charging unit. In addition, the power module can also adopt a paper battery or a button battery to supply power.
Example 3
As shown in fig. 18, the present embodiment provides a photomedical device based on embodiment 2, in which the OLED light source 10, the sensing module 20, and the control module 30 form a flexible sheet structure 120; the flexible sheet structure is crimped onto the outer surface of a support, such as cylindrical support 110.
The diameter of the whole optical medical device ranges from 1mm to 50 mm; the material of the cylindrical support may be, for example, rubber, resin, or TPU, and in this case, the present apparatus can be used for in vivo therapy. The OLED light source 10 wound on the cylindrical support 110 is then sealed, PU glue of AB component is selected as glue, the AB component is mixed according to the proportion of 1:1, packaging is carried out through a pulling method, curing is carried out for 12 hours at room temperature, the waterproof purpose can be realized, and in order to ensure the biological safety performance in the using process, skin-friendly materials such as polymer system sugar, amino acid, dextrin or solid lipid materials can be coated on the surface of the PU glue.
The embodiment enables the photomedical device to achieve not only treatment of the external skin but also treatment of the internal skin.
Example 4
The photomedical device provided by the present embodiment is based on embodiment 2, wherein the OLED light source 10, the sensing module 20 and the control module 30 form a flexible sheet structure 120; the flexible sheet structure is fixed on underwear, a protection pad, underpants, a paper diaper or a sanitary towel carrier. In this case, the support may not have its own function, for example, the pad may not have an adsorption function, but a pad-shaped support is provided so that the photomedical device can be attached to the support after the protective layer is removed.
In other embodiments, the flexible sheet structure has the shape of a pad, panty, diaper or sanitary napkin, such as a photomedical device shaped directly into a pad, and the pad may be further attached to the panty to effect treatment of the genital area.
Example 5
As shown in fig. 19, the present embodiment provides a method of using the photomedical device described in embodiment 1, including the steps of:
s10, receiving state signals sensed by each sensor in the sensing module;
s20, determining a region to be treated according to the state signal;
and S30, lighting a light emitting area corresponding to the area to be treated in the OLED light source, and controlling the light emitting brightness or wavelength of different areas according to the state signal.
Wherein the step S30 of lighting the light emitting region corresponding to the region to be treated includes:
according to the technical scheme provided by the embodiment of the application, before lighting the light emitting area corresponding to the area to be treated, the method further comprises the following steps:
starting a cold compress mode:
waiting for a first set time to allow the hydrogel layer to be cold-compressed on the area to be treated so as to assist the photosensitizer in the drug layer to diffuse on the area to be treated;
the method also comprises the following steps after the red light treatment mode is finished:
initiating a cold compress analgesia mode: and lighting a first light color luminescent layer in a luminescent region corresponding to the region to be treated within a second set time, wherein the first light color luminescent layer is a blue light luminescent layer.
The default subject in the above steps is the control module 30; as described in embodiment 1 and shown in fig. 20, the step S20 specifically includes the following steps:
s21, setting the position information of each sensor;
s22, receiving state signals of each sensor;
s23, setting a threshold value of the state signal or determining a peak value in all the state signals;
s24, determining treatment position information according to the difference value of the state signal and the threshold value or the peak value;
s25, lighting a light emitting region corresponding to the treatment position information;
and S26, controlling the irradiation intensity or the light-emitting wavelength of the lighted light-emitting region according to the difference between the state signal and the threshold value or the peak value.
The specific determination example of the light emitting region is the same as that of embodiment 1, and is not described again.
Preferably, corresponding to embodiment 2, as shown in fig. 21, the method of using the photomedical device further comprises the steps of: before lighting the light emitting area corresponding to the area to be treated, the method further comprises the following steps:
s40, starting a cold compress mode: waiting for a first set time to allow the hydrogel layer to be cold-compressed on the area to be treated to assist the photosensitizer in the drug layer to diffuse on the area to be treated.
The first set time is within the range of 0.5-6h, and when the cooling layer 80 only has the hydrogel layer 81, the cooling layer directly waits for the first set time; when the cooling layer 80 has both the hydrogel layer 81 and the temperature adjustment layer 82, the temperature of the temperature adjustment layer 82 is adjusted by the control module 30. So that the temperature of the surface of the photomedical device is not lower than 18 ℃ and not higher than 40 ℃;
preferably, the step S25 of lighting the light emitting region corresponding to the region to be treated is specifically:
receiving a treatment setting intensity signal and a treatment setting time signal sent by an input module or terminal equipment; starting a red light treatment mode:
according to the set treatment intensity signal, a red light emitting layer in a light emitting region corresponding to the region to be treated is lightened, so that the illumination intensity of the red light emitting layer corresponds to the set treatment intensity signal; or, determining a set treatment intensity signal according to the status signal;
when the set treatment time signal is less than or equal to the limited treatment time, the red light treatment mode is closed when the duration time of the red light treatment mode reaches the set treatment time signal;
when the set treatment time signal is greater than the limited treatment time, the red light treatment mode is closed when the duration time of the red light treatment mode reaches the limited treatment time;
the limited treatment time is the safe treatment time corresponding to the set treatment intensity signal.
For example, the input module or the terminal device may select to input the light therapy intensity in the following gears: 20000nit, 13000nit, 8000nit, 5000nit, 2000 nit; the limited treatment time of the phototherapy intensity corresponding to the above gears is 1h, 2h, 4h, 6h, 10 h.
For example, the treatment intensity signal currently input by the user is 13000nit, and the treatment time is 1 h; then at the moment, the set treatment time is less than the limited treatment time 2h corresponding to the gear; stopping the treatment when the treatment time reaches the set treatment time of 1 h;
for example, the treatment intensity signal currently input by the user is 13000nit, and the treatment time is 3 h; then at the moment, the set treatment time is more than the limited treatment time 2h corresponding to the gear; stopping the treatment when the treatment time reaches the limited treatment time of 2 h;
in the red light treatment, the brightness of the red light is not higher than 20000nit, and because the treatment process can generate uncomfortable feelings such as pain, itching, burning and the like, the intensity and the time of irradiation are controlled to ensure the comfort degree and the treatment effect in the treatment process.
The determination of the set treatment intensity signal may also be that the control module determines according to the status signal detected by the sensing module, for example, for a specific skin disease, such as abscess, the lesion level of abscess may be determined by the humidity signal detected by the humidity sensor, and the stronger the humidity signal, the stronger the treatment intensity required;
the protection mode is started simultaneously when the red light treatment mode is started: when the treatment time of the red light treatment mode is judged to be larger than a limited treatment time threshold, or a distance signal sensed by the first distance sensor is larger than a set distance threshold, or a temperature signal sensed by the temperature sensor is larger than or equal to a set temperature threshold, controlling the sound-light alarm module to give an alarm, or reducing the luminous intensity of a red luminous layer of the OLED light source, or adjusting the luminous wavelength of the OLED light source, or controlling the working current of the temperature adjusting layer to reduce the temperature of the temperature adjusting layer, or closing the red light treatment mode;
the setting of the treatment intensity signal, the limiting of the treatment time threshold, the setting of the distance threshold and the setting of the temperature threshold are set by the input module or the terminal equipment.
In the red light treatment stage, the temperature of the surface of the optical medical device is detected by the temperature sensor in real time, and when the real-time temperature exceeds the set temperature by 40 ℃, measures are taken in time to protect a user.
Preferably, corresponding to embodiment 2, the method further comprises the following steps after the red light treatment mode is ended:
s50, starting a cold compress analgesia mode: and lighting the blue light-emitting layer in the light-emitting area corresponding to the area to be treated within a second set time. The second set time is 10h or less, and the temperature control layer 82 is controlled so that the temperature of the surface of the photomedical device is not lower than 18 ℃ and not higher than 40 ℃.
In the description of the present specification, the terms "connect", "mount", "fix", and the like are to be understood in a broad sense, for example, "connect" may be a fixed connection, a detachable connection, or an integral connection; may be directly connected or indirectly connected through an intermediate. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
In the description of the present application, the description of the terms "one embodiment," "some embodiments," etc. means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims (10)

1. An photomedical device, comprising:
the OLED light source is used for providing a treatment light source and comprises a plurality of light emitting areas which independently emit light;
the sensing module is used for sensing the skin or tissue state of a treatment area and comprises a plurality of sensors distributed on the working surface of the optical medical device;
and the control module is configured to receive the state signal sensed by the sensor, analyze the state signal to determine a region to be treated, light a light emitting region corresponding to the region to be treated, and control the light emitting brightness or wavelength of different light emitting regions according to the state signal.
2. The photomedical device of claim 1, wherein the control module is specifically configured to:
setting position information of each sensor;
receiving state signals of each sensor;
setting a threshold value of the state signal or determining a peak value in all the state signals;
determining the position information to be treated according to the difference value between the state signal and the threshold value or the peak value, and determining the region to be treated according to the position information to be treated;
lighting a light emitting area corresponding to the area to be treated;
the illumination intensity or wavelength of the lighted luminescent region is controlled according to the difference between the state signal and the threshold or peak value.
3. The photomedical device of claim 1 or 2, wherein either side of the OLED light source is provided with a skin-friendly cooling layer; the cooling layer consists of a hydrogel layer or consists of a hydrogel layer and a temperature regulating layer; the temperature adjusting layer consists of a semiconductor patch or a micro resistor; the control module is configured to control the temperature of the temperature regulation layer by controlling the working current of the temperature regulation layer.
4. The photomedical device of claim 1 or 2, wherein each light emitting area of the OLED light source comprises at least one first photochromic light emitting layer and at least one second photochromic light emitting layer; the control module is configured to control the first light color light emitting layer or the second light color light emitting layer of each light emitting region to work according to the treatment stage;
the OLED light source comprises a substrate and at least one first photochromic functional structure and at least one second photochromic functional structure which are stacked on the substrate;
the first photochromic functional structure sequentially comprises a first electrode, a hole transport functional layer, a first photochromic light-emitting layer, an electron transport functional layer and a second electrode;
the second photochromic functional structure sequentially comprises a third electrode, a hole transport functional layer, a second photochromic light-emitting layer, an electron transport functional layer and a fourth electrode;
wherein two electrodes are adjacently disposed: a power source is connected in common, or a charge generation layer is formed in common.
5. The photomedical device of claim 1 or 2, wherein the surface of the photomedical device is provided with a skin-friendly drug layer; the medicine layer contains skin-friendly photosensitizer; the surface of the optical medical device is provided with a temperature sensor for detecting a temperature signal of a treatment area; the control module is provided with a wireless communication unit for communicating with the terminal equipment; the surface of the optical medical device is also provided with a first distance sensor for detecting the distance between the surface of the medical device and the area to be treated;
the control module is powered by a power supply module, and the power supply module is matched with a pair of wireless charging receiving units and a wireless charging transmitting device to realize wireless charging; a second distance sensor is arranged in the optical medical device and used for detecting the charging distance and the deviation angle between the wireless charging receiving unit and the wireless charging transmitting device; the control module is configured to adjust the brightness of the OLED light source according to the charging distance and the deviation angle or control the sound-light alarm module to give an alarm.
6. The photomedical device of claim 1 or 2, wherein the OLED light source, sensing module, and control module form a flexible sheet-like structure; the flexible sheet structure is attached to the support body in a curled manner.
7. The photomedical device of claim 1 or 2, wherein the OLED light source, sensing module, and control module form a flexible sheet-like structure; one side of the flexible sheet structure is provided with an adhesive layer in a whole surface or surrounding shape, wherein the adhesive layer positioned on the light emergent side of the flexible sheet structure is made of transparent or semitransparent materials; or holes for suturing tissues, skin, clothes or medical supplies are arranged around the flexible sheet structure.
8. A method of using a photomedical device, using the photomedical device of any of claims 1-2, comprising the steps of:
receiving state signals sensed by each sensor in the sensing module;
determining the area to be treated according to the state signal;
and lighting a light emitting area corresponding to the area to be treated in the OLED light source, and controlling the light emitting brightness or wavelength of different light emitting areas according to the state signal.
9. The method of using a photomedical device of claim 8, wherein illuminating a light emitting area corresponding to the area to be treated comprises:
starting a red light treatment mode: according to the set treatment intensity signal, a second light color luminescent layer in a luminescent region corresponding to the region to be treated is lightened, so that the illumination intensity of the second light color luminescent layer corresponds to the set treatment intensity signal; the second light color luminescent layer is a red luminescent layer;
starting a protection mode: when the treatment time of the red light treatment mode is judged to be larger than a limited treatment time threshold, or a distance signal sensed by the first distance sensor is larger than a set distance threshold, or a temperature signal sensed by the temperature sensor is larger than or equal to a set temperature threshold, controlling the sound-light alarm module to give an alarm, or reducing the luminous intensity of a red luminous layer of the OLED light source, or adjusting the luminous wavelength of the OLED light source, or controlling the working current of the temperature adjusting layer to reduce the temperature of the temperature adjusting layer, or closing the red light treatment mode;
the setting of the treatment intensity signal, the limiting of the treatment time threshold, the setting of the distance threshold and the setting of the temperature threshold are set by the input module or the terminal equipment.
10. The method of using a photomedical device of claim 9,
before the lighting of the light emitting area corresponding to the area to be treated, the method further comprises the following steps:
starting a cold compress mode:
waiting for a first set time to allow the hydrogel layer to be cold-compressed on the area to be treated so as to assist the photosensitizer in the drug layer to diffuse on the area to be treated;
the method also comprises the following steps after the red light treatment mode is finished:
initiating a cold compress analgesia mode: and lighting a first light color luminescent layer in a luminescent region corresponding to the region to be treated within a second set time, wherein the first light color luminescent layer is a blue light luminescent layer.
CN202011224599.9A 2020-11-05 2020-11-05 Optical medical device and using method thereof Pending CN112274785A (en)

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