CN110897786A - Detect flexible intelligent bandage device with treatment integration - Google Patents
Detect flexible intelligent bandage device with treatment integration Download PDFInfo
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- CN110897786A CN110897786A CN201911166337.9A CN201911166337A CN110897786A CN 110897786 A CN110897786 A CN 110897786A CN 201911166337 A CN201911166337 A CN 201911166337A CN 110897786 A CN110897786 A CN 110897786A
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Abstract
The invention discloses a flexible intelligent bandage device integrating detection and treatment, which adopts an integrated sensor to acquire biological information of the skin of a patient in real time, judges a wound infected area of the patient through the biological information, treats a wound by using an LED phototherapy module, solves the problems that the existing wound nursing bandage cannot provide information of wound change in real time and cannot treat the wound autonomously, and can realize the effects of detecting the state of the wound in real time, sterilizing the wound and promoting the growth of wound tissues. Ultimately providing patients and physicians with accurate and reliable wound conditions for better treatment and management of wounds.
Description
Technical Field
The invention belongs to the technical field of medical treatment, and particularly relates to a flexible intelligent bandage device based on detection and treatment integration.
Background
Chronic wounds are of diverse etiology and therefore of diverse character. Despite molecular and clinical heterogeneity, chronic wounds can be divided into three major categories: venous Leg Ulcers (VLUs), Diabetic Foot Ulcers (DFUs) and Pressure Ulcers (PUs). Chronic venous ulcers of the lower limb are a manifestation of severe and intractable chronic venous insufficiency of the lower limb. The prevalence rate of the population is as high as 1.1% -1.8%. The most important pathogenesis is considered at present to be venous hypertension caused by abnormal venous blood flow, and the pathophysiological basis of venous ulcer is venous hypertension of lower limbs. Therefore, correction of venous hemodynamic abnormalities in the lower extremities is a critical issue for the treatment of venous ulcers. The diabetic foot is foot ischemic, nervous and neuroischemic lesion caused by diabetes, can cause foot infection, ulcer and gangrene in different degrees, increases amputation risk, and is one of the common complications of diabetes. Diabetic foot can lead to limited walking and lifelong disability of the patient, and seriously affect physical and mental health and quality of life. Pressure ulcers, also known as pressure sores and bedsores, are caused by tissue ulceration and necrosis due to persistent ischemia, hypoxia and malnutrition caused by long-term local tissue compression. Skin pressure sores are a common problem in rehabilitation and care. Many smart bandages have been developed for specific types of chronic wounds, depending on the wound condition, such as dryness or exudation, superficial or deep, cleansing or infection.
The conventional bandage has a limitation in that a doctor must detach the bandage to check the wound condition, which is very disadvantageous in the healing of the wound and increases the possibility of secondary infection. Current wound bandages are primarily intended to maintain the seal and protection of the wound site. Some of these release drugs or compounds that can prevent infection and help with faster healing. One key limitation of these bandages is that they do not provide information about the healing status of the wound and the wound environment, including its ph, blood glucose, lactate, bacterial load, tissue blood oxygen content and inflammation levels, in real time.
The existing intelligent bandage has the limitation that the nursing to the wound is passive, the medicine is uniformly released for uniform treatment, and the wound is not targeted. Yet another important limitation of passive wound care products is their inability to identify differences between different stages of wound healing. In general, the rate of physiological events that occur throughout the healing process varies from patient to patient due to differences in the physical condition of each individual, and thus, passively releasing the drug results in either an excessively rapid release of the drug or an early release of the drug. Moreover, the concentration of the desired pharmaceutical agent and drug may vary over time to the extent that accurate treatment is not achieved. In summary, one of the major limitations of current wound care bandage products is: no information about the state of the wound, the rate of healing, etc. is provided and the treatment is personalized. This drawback not only increases the cost of treatment and the number of visits to the patient, but also increases the risk of secondary infection of the patient's wound.
Disclosure of Invention
In order to overcome the technical defects, the invention provides a flexible intelligent bandage device integrating detection and treatment, which solves the limitations that the existing wound nursing bandage cannot provide information of wound change in real time and cannot perform personalized treatment, and can realize the effects of detecting the state of a wound in real time, sterilizing the wound and promoting the growth of wound tissues. Ultimately providing patients and physicians with accurate and reliable wound conditions for better treatment and management of wounds.
In order to solve the problems, the invention is realized according to the following technical scheme:
a flexible intelligent bandage device that detects and treats integration, includes:
the sensor detection module is arranged on one surface of the bandage facing the human epidermis and comprises a plurality of integrated sensors; the integrated sensors are arranged in an array and used for acquiring biological information of human epidermis at corresponding positions; the biological information comprises one or more of noninvasive blood glucose and blood oxygen information, pH value information, temperature information, humidity information, potassium ion concentration value information, sodium ion concentration value information, calcium ion concentration value information and glucose/lactic acid concentration value information;
the signal processing module is used for receiving the biological information, judging a wound infection area on the human body epidermis and sending an LED phototherapy instruction;
LED phototherapy module sets up on the one side of bandage orientation human epidermis, including the LED banks of a plurality of different wavelength of launchs, is used for receiving LED phototherapy instruction is in order to be treated on the human epidermis wound infection region.
The invention is further improved in that the integrated sensors include a non-invasive blood glucose and blood oxygen detecting sensor, a pH value detecting sensor, a temperature detecting sensor, a humidity sensor, a potassium ion concentration detecting sensor, a sodium ion concentration detecting sensor, a calcium ion concentration detecting sensor and a glucose/lactic acid concentration value detecting sensor.
The invention is further improved in that the non-invasive blood sugar and blood oxygen detection sensor comprises a photoelectric emission unit and a photoelectric detection unit;
the photoelectric emission unit is used for emitting light to blood vessels of human epidermis;
the photoelectric detection unit is used for detecting the light returned by the blood vessel and analyzing to obtain the blood glucose concentration information and the blood oxygen information of the human epidermis.
The invention is further improved in that the pH value detection sensor comprises a pH detection electrode modified by polyaniline material, and is used for detecting human epidermis and obtaining the pH value information.
A further improvement of the present invention resides in that the temperature detection sensor includes a flexible substrate and a thermistor;
the flexible substrate is a nanofiber substrate, and the thermistor is arranged on the flexible substrate; the thermistor is used for acquiring the temperature information of the human epidermis.
In a further development of the invention, the humidity detection sensor comprises a flexible substrate and interdigital electrodes;
the flexible substrate is a nanofiber substrate, and the interdigital electrodes are arranged on the flexible substrate; the interdigital electrode is used for acquiring the humidity information of the human epidermis. The invention has the further improvement that the potassium ion concentration detection sensor, the sodium ion concentration detection sensor and the calcium ion concentration sensor respectively comprise a reference electrode and a working electrode which is modified by ion selection through a membrane and is used for acquiring the potassium ion concentration value information or the sodium ion concentration value information and the calcium ion concentration value information of the human epidermis.
The invention is further improved in that the glucose/lactic acid concentration value detection sensor comprises a reference electrode and a working electrode modified by glucose oxidase or lactate oxidase, and is used for acquiring the glucose/lactic acid concentration value information in human blood.
The invention is further improved in that the signal processing module judges whether the biological information of different positions on the human epidermis exceeds a preset biological information threshold value, and judges the position on the human epidermis corresponding to the biological information exceeding the biological information threshold value as the wound infection area.
In a further improvement of the invention, the plurality of LED lamp groups include one or more of blue LED lamps, ultraviolet LED lamps and infrared LED lamps.
The invention is further improved in that the sensor detection module is connected to the signal processing module through a signal filtering and amplifying circuit.
Compared with the prior art, the invention has the beneficial effects that:
the invention discloses a flexible intelligent bandage device integrating detection and treatment, which adopts an integrated sensor to acquire biological information of the skin of a patient in real time, judges a wound infected area of the patient through the biological information, treats a wound by using an LED phototherapy module, solves the problems that the existing wound nursing bandage cannot provide information of wound change in real time and cannot treat the wound autonomously, and can realize the effects of detecting the state of the wound in real time, sterilizing the wound and promoting the growth of wound tissues. Ultimately providing patients and physicians with accurate and reliable wound conditions for better treatment and management of wounds.
Drawings
Fig. 1 is a functional block diagram of a flexible intelligent bandage device according to embodiment 1 of the present invention.
Fig. 2 is a schematic structural view of an integrated sensor described in embodiment 2 of the present invention.
Fig. 3 is a schematic structural diagram of an LED matrix described in embodiment 2 of the present invention.
Fig. 4 is a schematic structural view of an integrated matrix of a treatment part and a detection part described in embodiment 2 of the present invention.
Fig. 5 is a schematic diagram of data transmission and a structure of the signal processing section according to embodiment 2 of the present invention.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Example 1
Fig. 1 shows an embodiment of the invention, and discloses a flexible intelligent bandage device integrating detection and treatment, which comprises a sensor detection module, a signal processing module and an LED phototherapy module. The sensor detection module is arranged on one surface of the bandage facing the human epidermis and is used for acquiring biological information of the human epidermis at a corresponding position; the signal processing module is used for receiving the biological information, judging a wound infection area on the human body epidermis and sending an LED phototherapy instruction; the LED phototherapy module sets up on the one side of bandage orientation human epidermis, including the LED lamp of a plurality of different wavelength of launchs for receive LED phototherapy instruction and treat with the wound infection region on the human epidermis.
Specifically, the sensor detection module is arranged on one surface of the bandage facing the human epidermis and comprises a plurality of integrated sensors; specifically, a plurality of integrated sensors are arranged in an array and used for acquiring biological information of human epidermis at corresponding positions; the biological information comprises one or more of noninvasive blood glucose and blood oxygen information, pH value information, temperature information, humidity information, potassium ion concentration value information, sodium ion concentration value information, calcium ion concentration value information and glucose/lactic acid concentration value information;
specifically, each integrated sensor comprises a non-invasive blood sugar and blood oxygen detection sensor, a pH value detection sensor, a temperature detection sensor, a humidity detection sensor, a potassium ion concentration detection sensor, a sodium ion concentration detection sensor, a calcium ion sensor and a glucose/lactate concentration value detection sensor.
Specifically, the noninvasive blood glucose and blood oxygen detection sensor comprises a photoelectric emission unit and a photoelectric detection unit; the photoelectric emission unit is used for emitting light to blood vessels on the epidermis of a human body; the photoelectric detection unit is used for detecting the light returned by the blood vessel and analyzing to obtain the blood glucose concentration information and the blood oxygen information of the epidermis of the human body.
Specifically, the pH detection sensor comprises a pH detection electrode modified by polyaniline material and is used for detecting human epidermis and obtaining pH information.
Specifically, the temperature detection sensor comprises a flexible substrate and a thermistor; the flexible substrate adopts a nanofiber substrate, and a thermistor is arranged on the flexible substrate; the thermistor is used for acquiring temperature information of the human epidermis.
Specifically, the humidity detection sensor comprises a flexible substrate and interdigital electrodes; the flexible substrate adopts a nanofiber substrate, and interdigital electrodes are arranged on the nanofiber substrate; the interdigital electrode is used for acquiring humidity information of human epidermis.
Specifically, the potassium ion concentration detection sensor, the sodium ion concentration detection sensor and the calcium ion concentration sensor respectively comprise a reference electrode and a working electrode which is modified by ion selection through a membrane and is used for obtaining potassium ion concentration value information or sodium ion concentration value information and calcium ion concentration value information of human epidermis.
Specifically, the glucose/lactate concentration value detection sensor comprises a reference electrode and a working electrode modified by glucose oxidase or lactate oxidase, and is used for acquiring the glucose/lactate concentration value information in human blood.
The signal processing module is used for receiving the biological information, judging a wound infection area on the human body epidermis and sending an LED phototherapy instruction; specifically, the signal processing module judges whether biological information of different positions on the human epidermis exceeds a preset biological information threshold value, and judges the position on the human epidermis corresponding to the biological information exceeding the biological information threshold value as a wound infection area.
LED phototherapy module sets up on the one side of bandage orientation human epidermis, including the LED lamp of a plurality of different wavelength of launchs for receive LED phototherapy instruction and treat with the wound infection region on the human epidermis. Specifically, the plurality of LED lamps includes one or more of a blue LED lamp, an ultraviolet LED lamp, and an infrared LED lamp.
Specifically, the sensor detection module is connected to the signal processing module through a signal filtering and amplifying circuit so as to transmit the filtered and amplified signal to the signal processing module.
Example 2
The above-mentioned intelligent bandage device solution will be described more specifically by taking an actually implemented intelligent matrix bandage product integrating detection and treatment as an example, and specifically, the intelligent matrix bandage product includes three parts, namely a detection part, a signal transmission and processing part and a treatment part.
Specifically, the detection part is a sensor matrix consisting of n × m integrated sensors, each integrated sensor comprises 7 biosensors, and 7 groups of data including noninvasive blood glucose and blood oxygen, pH value, temperature, humidity, potassium ions (sodium ions and calcium ions) and blood glucose value (lactic acid value) can be obtained. Once the 7 data of each integrated sensor are obtained in the form of a matrix, the healing conditions of different parts of the wound can be preliminarily obtained according to the values of the sensors.
Specifically, the schematic structure diagram of each integrated sensor is shown in fig. 2, and includes a temperature sensor, a humidity sensor, a potassium ion sensor, a pH sensor, a sodium ion sensor, a calcium ion sensor, a blood glucose/lactate sensor, a noninvasive blood glucose and blood oxygen sensor, and an AgCl/Ag reference electrode.
Specifically, the treatment part adopts a plurality of LEDs with different wavelengths to form an LED matrix, a plurality of LED matrixes are arranged on one surface of the bandage facing the wound of the patient, and the treatment part utilizes red light, ultraviolet light, blue light and the like to perform auxiliary treatment. Specifically, an LED matrix composed of three LED lamps as shown in fig. 3 may be made to emit red light, ultraviolet light, and blue light, respectively, for adjuvant therapy. Ultraviolet rays can kill bacteria, reduce inflammation and facilitate wound healing; the red light can heat local tissues, promote blood circulation, increase the supply of oxygen and nutrients required for wound healing, and promote the production of collagen. Blue light can inhibit pain, it can stimulate the body to produce nitric oxide, dilate blood vessels, increase blood flow to the area, and increase the supply of analgesic molecules. More specifically, the LED matrix is coupled to the processor and is capable of receiving signals from the processor to determine where to treat a wound of the patient.
Specifically, the wavelength of the ultraviolet LED lamp is 250-280nm, the wavelength of the infrared LED lamp is larger than 780nm, the wavelength of the blue LED lamp is 400-500 nm, and the on-off of the LEDs is controlled by the processor through the amplifying circuit.
In particular, the treatment portion and the detection portion may also be integrated together to form a matrix as shown in FIG. 4, each module of the matrix including the LED matrix and integrated sensors described above, thereby reducing the complexity and bulk of the layout of the devices on the bandage.
Specifically, the signal processing portion includes a plurality of signal amplification filter circuits, a central processing unit, a wireless transmission module and a battery, and data transmission thereof is as shown in fig. 5, specifically, the signal processing portion may also be partially integrated on the wearable electronic device, and since 7 sets of data are not interfered with each other, n × m × 7 data obtained sequentially enter the external independent wearable electronic device for processing. The external electronic device has the characteristics of miniaturization and flexibility. The device has the functions of receiving, processing, analyzing, controlling and transmitting signals. The electric signal transmitted by the bandage detection part can realize the transmission, amplification, filtration and analysis of the signal after being processed by the silicon integrated circuit integrated on the flexible circuit board. Preferably, the wearable electronic device may further comprise a screen for displaying a healing image of the wound local area. Further, after processing the complex signals, it can be determined which part of the wound is deteriorated, for example, a corresponding biological information threshold value can be set for each biological information, for example, PH exceeds 7.4, oxygen pressure is lower than 20mmHg, blood glucose value exceeds 7.0mmol/dL, etc., the wound deterioration or infection in the area can be determined, and real-time monitoring can be performed for a long time, and drugs can be actively released or the phototherapy LED matrix can be used for targeted irradiation according to the wound healing condition. The wearable electronic device is used for releasing the electric signal to control the corresponding treatment module to release the medicine or irradiate the LED. Certainly, these data also can be through transmitting to high in the clouds or electronic terminal on the wireless transmission module (for example bluetooth, wifi etc.), and the doctor and patient of being convenient for look over data information these continuous and real-time monitoring data can help patient and doctor better aassessment wound's physiological state, and this platform can realize extensive personalized diagnosis and physiological monitoring and use.
Specifically, the principle of the temperature sensor is to use the resistance change of the thermistor along with the temperature change, and specifically, the micromachined metal resistance sensor shown in fig. 2 is used as a flexible temperature sensor, which can be used for skin temperature mapping of skin wounds. The conductive lines are stretchable and are fabricated on a flexible substrate. A flexible sensor based on silver ink was fabricated using a nanofiber substrate to have a relatively linear response to temperature changes in the range of 25-31 degrees. The temperature information of the wound of the patient is obtained by obtaining the voltage difference between two ends of the resistor and converting the voltage difference into the temperature.
Specifically, the principle of the humidity sensor is to utilize capacitance change of the interdigital electrode along with humidity change, and specifically, the micromachined interdigital electrode sensor shown in fig. 2 is used as a flexible temperature sensor, which can be used for skin humidity mapping of skin wounds. The conductive lines are stretchable and are fabricated on a flexible substrate. The nanofiber substrate was used to fabricate a silver ink based flexible sensor with a relatively linear response to humidity changes in the range of 40% -70% relative humidity. And the humidity information of the wound of the patient is obtained by converting the capacitance at the two ends of the interdigital electrode into the humidity.
Specifically, the potassium ion sensor, the sodium ion sensor and the calcium ion sensor all adopt a working electrode modified by an ion selective permeable membrane, the reference electrode is used for detecting concentration by electrochemically generating voltage difference, and a dual-channel voltage amplifier is adopted for amplifying the voltage of 100-300mV to the voltage of 0-3.3V level.
Specifically, the principle of the pH sensor is similar to that of a sodium ion sensor, a potassium ion sensor or a calcium ion sensor, but the difference is that a working electrode modified by polyaniline and the reference electrode are used, and a dual-channel voltage amplifier is adopted to amplify the voltage of 100-300mV to the voltage of 0-3.3V level.
Specifically, the blood glucose/lactate sensor is used for preparing an enzyme-based glucose (lactate) electrochemical sensor, a working electrode modified by Gox (glucose oxidase) or Lox (lactate oxidase) is adopted, glucose (lactate) can accelerate oxidation reaction under the action of glucose (lactate) oxidase, electrons generated by two electrodes can be detected through a current potential method, so that current is generated, and the generation amount of glucose is reversely deduced, specifically, a transimpedance amplifier circuit is also used, and under the control of adding a tiny voltage, the current of 100 nA-300 nA can be amplified into a voltage of 0-3.3V level for further data analysis.
Specifically, the noninvasive blood glucose and blood oxygen sensor comprises 2 1550nm patch LEDs, 1 600nm-800nm patch LED, an 800nm-1000nm patch LED and a photoelectric detector, a transimpedance amplifier circuit is used for amplifying an electric signal collected by the photoelectric detector, and a current signal within 0-100 nA level can be amplified into a voltage signal of 0-3.3V level. The blood glucose detection principle is to detect the blood glucose concentration in blood by using the absorption of blood glucose to 1550nm wavelength, and the blood oxygen detection principle is to detect the content of oxyhemoglobin HbO2 and hemoglobin Hb in blood vessels by using the reflection change of light in the blood vessels.
Alternatively, the detecting portion and the treating portion may be located directly below the bandage (applied to the wound) and the signal processing portion may be located above the bandage (exposed to air). First, the wound is detected by the detection section by regions, and the infected region and the uninfected region are determined. The obtained data is transmitted to a signal processing part on the upper layer of the bandage through signals, then judgment is carried out, and treatment is carried out through releasing the signals to an LED lamp matrix at a specific position (such as an infected area).
The intelligent bandage product in this embodiment combines a conventional bandage with electronics, biosensors. The product is used for continuous wound detection, on one hand, the wound healing conditions of different areas are provided, and the patient and a doctor can better know the wound condition; on the other hand, the detection of the wounds in different areas can be targeted to actively release the medicine, so that secondary damage to the wounds caused by excessive or insufficient medicine release is avoided. According to the invention, through continuous matrix detection of the wound, the problem that the bandage needs to be repeatedly taken off and observed is avoided, the possibility of wound infection is reduced, and on the basis of the original intelligent bandage, the pain of a patient is better relieved, and the recovery is quicker. Aiming at patients with different trauma degrees, the design has good practicability, and the burden of the patients is greatly reduced.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention are within the scope of the technical solution of the present invention.
Claims (10)
1. The utility model provides a detect and treat flexible intelligent bandage device of integration which characterized in that includes:
the sensor detection module is arranged on one surface of the bandage facing the human epidermis and comprises a plurality of integrated sensors; the integrated sensors are arranged in an array and used for acquiring biological information of human epidermis at corresponding positions; the biological information comprises one or more of noninvasive blood glucose and blood oxygen information, pH value information, temperature information, humidity information, potassium ion concentration value information, sodium ion concentration value information, calcium ion concentration value information and glucose/lactic acid concentration value information;
the signal processing module is used for receiving the biological information, judging a wound infection area on the human body epidermis and sending an LED phototherapy instruction;
LED phototherapy module sets up on the one side of bandage orientation human epidermis, including the LED banks of a plurality of different wavelength of launchs, is used for receiving LED phototherapy instruction is in order to be treated on the human epidermis wound infection region.
2. A detection and therapy integrated flexible smart bandage device as recited in claim 1, wherein said integrated sensors include non-invasive blood glucose and blood oxygen detection sensors, pH detection sensors, temperature detection sensors, humidity sensors, potassium concentration detection sensors, sodium concentration detection sensors, and glucose/lactate concentration value detection sensors.
3. The detection and therapy integrated flexible intelligent bandage device of claim 2 wherein said non-invasive blood glucose and blood oxygen detection sensor comprises a photo-emission unit and a photo-detection unit;
the photoelectric emission unit is used for emitting light to blood vessels of human epidermis;
the photoelectric detection unit is used for detecting the light returned by the blood vessel and analyzing to obtain the blood glucose concentration information and the blood oxygen information of the human epidermis.
4. The detection and treatment integrated flexible intelligent bandage device of claim 2, wherein the pH detection sensor comprises pH detection electrodes modified by polyaniline material for detecting human epidermis and obtaining the pH information.
5. The detection and therapy integrated flexible smart bandage device of claim 2 wherein said temperature detection sensor comprises a flexible substrate and a thermistor;
the flexible substrate is a nanofiber substrate, and the thermistor is arranged on the flexible substrate; the thermistor is used for acquiring the temperature information of the human epidermis.
6. The detection and therapy integrated flexible smart bandage device of claim 2 wherein said moisture detection sensor comprises a flexible substrate and interdigitated electrodes;
the flexible substrate is a nanofiber substrate, and the interdigital electrodes are arranged on the flexible substrate; the interdigital electrode is used for acquiring the humidity information of the human epidermis.
7. The integrated detection and treatment flexible intelligent bandage device of claim 2, wherein the potassium ion concentration detection sensor and the sodium ion concentration detection sensor each comprise a reference electrode and a working electrode modified by ion selection through a membrane, and are used for obtaining the potassium ion concentration value information, the sodium ion concentration value information or the calcium ion concentration value information of the human epidermis.
8. The integrated detection and treatment flexible intelligent bandage device of claim 2, wherein the glucose/lactate concentration value detection sensor comprises a reference electrode and a working electrode modified by glucose oxidase or lactate oxidase, and is used for obtaining the glucose/lactate concentration value information in human blood.
9. The detection and treatment integrated flexible intelligent bandage device as claimed in claim 1, wherein the signal processing module determines whether the biological information at different positions on the human epidermis exceeds a preset biological information threshold value, and determines the position on the human epidermis corresponding to the biological information exceeding the biological information threshold value as the wound infection area.
10. The detection and therapy integrated flexible smart bandage device of claim 1 wherein said plurality of LED light groups comprise one or more of blue LED lights, ultraviolet LED lights, and infrared LED lights.
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