CN1122700A - 一种治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法 - Google Patents
一种治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法，将藤黄、雄黄、乳香、没药、一枝蒿、松香、马钱子、明矾经前处理→粉碎→过筛→混合→成品包装制得该散剂。本发明主要治疗各种乳腺疾病，包括乳痈和乳痨，同时对各种疮毒，痈疽以及肿瘤等症也有显著疗效，治愈率为总有效率的97％。
Description
本发明涉及一种用中草药制备的治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法，属于纯中草药制成的中成药及其制造工艺。
乳腺疾病是外科临床上较常见的疾病，由于女子生理特点不同，故发病率高于男子。乳腺疾病与肝脾郁结，胃热壅滞有关。乳腺疾病包括乳痈、乳痨等症。据《中医外伤科学》(江苏科学技术出版社1982年3月第3次印刷)记载，乳痈是发于乳房部的痈，相当于开代医学的急性乳腺炎，致病菌多为金黄色葡萄球菌，分为外吹乳痈，内吹乳痈，非哺乳期乳痈，临床上以外吹乳痈多见，本病成因为由于乳儿吮时含乳而睡，口、鼻中熏热之气与乳头接触，乳汁积滞不得外泄，情绪波动，暴怒忧郁，肝失条达，以致气滞血凝，饮食不节，脾胃运化失职，厚味蕴酿，湿热浊气蕴结，产后血虚，外感风寒热邪壅滞而成；或胎气旺盛，胸满气上，气机失于疏泄，邪热壅蒸阳明，以致结块成痈，或挤伤染毒而成。乳痨相当于现代医学的乳房结核，为结核杆菌所致，本病不限年龄大小，好发于乳房偏内上方，它多由身体虚弱，肝气郁滞，胃经痰浊凝结，失于调治而成；西医在治疗乳痈时选用广普抗菌素口服，中医在治疗该病时采用括萎牛蒡汤加蒲公英，或透脓散，八珍汤或十全大补汤内服，外敷可用金黄散或冲和膏，但效果均不理想，治疗后复发率较高且治疗期较长。西医治疗乳痨时可选用抗痨天冬素片及消核片西药，中医治疗时可用透脓散、归脾汤、六味地黄汤，兼内服、金丹，或用解凝膏掺桂麝散外敷，但其效果也同样不理想，不仅治疗期长且复发率高。
肿瘤包括乳腺癌和恶性淋巴瘤等等，据《中国中医秘方大金》(下卷)(文汇出版社1994年1月第10次印刷)，乳腺癌是指发生于乳腺的小叶和导管上皮的恶性肿瘤，以女性为多，男性仅占1％，中医认为它是由于情志失调，肝气郁结或因冲任失调，气血运行不畅，气滞血凝，经络阻塞，结滞于乳中所致。西医治疗该病主要采用手术切除，化疗、放疗及激素、免疫治疗，中医则用公英汤、牛黄消肿方等治疗，治疗18例，其中6例痊愈，6例显效(肿块体积缩小1/2以上)。恶性淋巴瘤是原发于淋巴结和淋巴组织较为常见的恶性肿瘤，中医认为邪毒内结，或风热血燥，寒痰凝滞；内因忧思善怒，肝郁气结，生痰化火及气滞血瘀，积而成结，日久脏腑内虚，肝肾亏损，气血两亏。西医治疗该病主要采用化疗为主的综合治疗，中医治疗该病多以扶正祛邪，正虚明显，以扶正为主；邪实甚，正气未衰或正衰不明显，可以攻邪为主；用慈菇海藻汤，枯草昆布汤治疗，治疗7例，肿块消失3例，基本消失1例，缩小1/2以上者2例，肿块保持不变1例。显然，治疗效果并不理想。
疮毒包括各种痈和疽等，据《中医外伤科学》(江苏科学技术出版社1982年3月第3次印刷)记载，范围多在2-3寸左右，发病迅速、易种、易脓、易溃、易敛的一种发于皮肉之间的急性化脓性疾患，称作痈。痈是气血为毒邪壅塞不通的意思，属阳证，相当于现代医学的蜂窝组织炎。病原菌为链球菌或金黄色葡萄球菌。疽是气血为毒邪阻滞不行的意思，疽一般分为二种型类，一种是初起有头，称为有头疽，多发于颈，背肌肉坚厚之处，初起即有脓头，局部红肿热痛，易向周围及深部扩散，并有明显的全身症状，属于阳证范围，相当于现代医学的“痈”，病原菌为金黄色葡萄球菌；另一种是初起无头的，起病缓慢，局部不红不热，疼痛及全身症状不明显，溃脓很慢，溃后难敛，称为无头疽，属于阳证范围。西医治疗痈用磺胺噻唑、青霉素、链霉素、土霉素、四环素等药，中医治疗痈用牛蒡解肌肠，透脓散等，西医治疗疽用磺胺类药物和抗菌素等，中医治疗疽用金黄散和冲和膏外敷，可选用生肌玉红膏掺生肌散，但治疗效果均不理想且治疗期较长。
本发明的目的在于克服现有技术存在的不足，提供一种疗程短且有较高疗效的治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法，本药不仅能治疗各种乳腺疾病，尤其是乳痈和乳痨等症，而且还可治疗各种疮毒、痈疽以及肿瘤等症，对人体无任何副作用，且可达到标本兼治的目的。
本发明的目的是这样实现的：治疗乳腺疾病、肿瘤疮毒的散剂包括以下重量百分比的药味组成成份：
滕黄 5-6％
雄黄 55-60％
乳香 14-15％
没药 14-15％
一枝蒿 2-3％
松香 2-3％
马钱子 1-2％
明凡 1-2％
本方案中最佳的重量百分比的药味组成成份为：
滕黄 5.7％
雄黄 57.14％
乳香 14.29％
没药 14.29％
一枝蒿 2.86％
松香 2.86％
马钱子 1.43％
明凡 1.43％
本发明的制备方法是：药材前处理→粉碎→过筛→混合→成品包装。
本发明的具体制备方法是：
(1)药材前处理：
a.取一枝蒿去污，洗净后，晒干；
b.取马钱子沙炒去毛；
c.取乳香和没药分别于50-150℃加热30分钟去油，然后回收去油后的乳香和没药，冷却；
(2)粉碎和过筛：
a.将按上述重量百分比配置好的滕黄、雄黄以及经前处理后的一枝蒿和马钱子混合粉碎，然后过100目的筛；
b.将松香和明凡分别单独粉碎，然后分别过100目的筛；
c.将经前处理后的乳香和没药分别单独粉碎，然后分别过100目的筛；
(3)混合：按上述重量百分比将各种过筛后的药粉混合均匀；
(4)成品包装：将上述混匀后的药粉装入包装袋，即得治疗乳腺疾病、肿瘤疮毒的散剂。
本发明在使用时先将该散剂放于白沙布或纸上，然后滴浸浓度为75％的酒精(每100g散剂加入2-3毫升酒精)，滴浸成膏状物，贴敷于乳房、肿瘤疮毒病灶处，三日更换一次，每次3-5g，并根据病灶面积而考虑药量。
本发明的配方是根据活血化瘀、消炎、消肿、解毒止痛、软坚散结的配伍形式，采用滕黄、雄黄能消肿排浓，散瘀解毒，杀虫止痒，用马钱子通络止痛，散结消肿，用乳香和没药活血止痛，生肌；用一枝蒿祛毒止痛、活血、消肿；用松香生肌止痛，燥湿杀虫；用明凡燥湿止痒，诸药和方共奏，有活血化瘀，消肿软坚，解毒止痛，消炎杀虫的作用，并对皮肤有保护作用。
本药主治各种乳腺疾病，包括乳痈和乳痨等症，对各种疮毒，痈疽以及肿瘤有显著疗效。
本药经临床试验308例，年龄为18-24岁，平均年龄30岁，病程为2-4年，平均3年，疗程为15天6个月，平均4个月，该药具有疗效高，见效快，适用范围广的特点，治疗上述各症的总有效率达100％，其临床观察结果如下：
疗效 例数 百分率
治愈 300 97.40％
有效 6 1.95％
显效 2 0.65％
无效 0 0
本药具有肯定的无毒、副作用，适用各种乳腺疾病和疮毒，痈疽，肿瘤等症，具有标本兼治且易制作，成本低的特点。
实施例：
(1)药材前处理
A.取一枝蒿去污，洗净后，晒干；
B.取马钱子沙炒去毛；
C.取乳香和没药分别在100℃加热30分钟，去油，然后回收去油的乳香和没药，冷却；
(2)粉碎和过筛
A.将200g滕黄，2000g雄黄以及经前处理后的100g一枝蒿和50g马钱子混合粉碎，然后过100目的筛；
B.将100g松香和50g明凡分别单独粉碎，然后分别过100目的筛；
C.将经前处理后的500g乳香和500g没药分别单独粉碎，然后分别过100目的筛；
(3)混合：将上述过筛后的药粉混合均匀；
(4)成品包装：将上述混匀后的药粉装入包装袋，即得治疗乳腺疾病、肿瘤疮毒的散剂。
该治疗乳腺疾病、肿瘤疮毒的散剂主治各种乳腺疾病，包括乳痈和乳痨等症，对各种疮毒、痈疽以及肿瘤均有显著疗效。其用法和用量是：使用时先将该散剂放于白沙布或纸上，然后滴浸浓度为75％的酒精(每100g散剂加入2-3毫升酒精)，滴浸成膏状物，贴敷于乳房肿瘤疮毒病灶处，三日更换一次，每次3-5g。
Claims (3)
1.一种治疗乳腺疾病、肿瘤疮毒的散剂，其特征在于包括以下重量百分比的药味组成成份：
滕黄 5-6％
雄黄 55-60％
乳香 14-15％
没药 14-15％
一枝蒿 2-3％
松香 2-3％
马钱子 1-2％
明凡 1-2％。
2.根据权利要求1所述的一种治疗乳腺疾病、肿瘤疮毒的散剂，其特征在于包括以下重量百分比的药味组成成份：
滕黄 5.7％
雄黄 57.14％
乳香 14.29％
没药 14.29％
一枝蒿 2.86％
松香 2.86％
马钱子 1.43％
明凡 1.43％。
3.根据权利要求1、2所述的一种治疗乳腺疾病、肿瘤疮毒的散剂的制备方法，其特征在于按以下几个步骤进行：
(1)药物前处理：
a.取一枝蒿去污，洗净后，晒干；
b.取马钱子沙炒去毛；
c.取乳香和没药分别于50-150℃加热30分钟去油，然后回收去油后的乳香和没药，冷却；
(2)粉碎和过筛：
a.将按上述重量百分比配置好的滕黄、雄黄以及经前处理后的一枝蒿和马钱子混合粉碎，然后过100目的筛；
b.将松香和明凡分别单独粉碎，然后分别过100目的筛；
c.将经前处理后的乳香和没药分别单独粉碎，然后分别过100目的筛；
(3)混合：按上述重量百分比将各种过筛后的药粉混合均匀；
(4)成品包装，将上述混匀后的药粉装入包装袋，即得治疗乳腺疾病、肿瘤疮毒的散剂。
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| CN 94111970 CN1122700A (zh) | 1994-11-08 | 1994-11-08 | 一种治疗乳腺疾病、肿瘤疮毒的散剂及其制备方法 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6723351B2 (en) | 1997-11-10 | 2004-04-20 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6733792B1 (en) | 1998-04-24 | 2004-05-11 | Daopei Lu | Arsenic sulfide compounds and derivatives thereof for the treatment of malignancies |
| US6875451B2 (en) | 1997-10-15 | 2005-04-05 | Polarx Biopharmaceuticals Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
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1994
- 1994-11-08 CN CN 94111970 patent/CN1122700A/zh active Pending
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| US6875451B2 (en) | 1997-10-15 | 2005-04-05 | Polarx Biopharmaceuticals Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| US7205001B2 (en) | 1997-10-15 | 2007-04-17 | Polarx Biopharmaceuticals, Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| US7179493B2 (en) | 1997-10-15 | 2007-02-20 | Polarx Biopharmaceuticals, Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| US7163703B2 (en) | 1997-10-15 | 2007-01-16 | Polarx Biopharmaceuticals, Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| US7132116B2 (en) | 1997-10-15 | 2006-11-07 | Polarx Biopharmaceuticals Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| US6884439B2 (en) | 1997-11-10 | 2005-04-26 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6723351B2 (en) | 1997-11-10 | 2004-04-20 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6982096B2 (en) | 1997-11-10 | 2006-01-03 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6861076B2 (en) | 1997-11-10 | 2005-03-01 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6855339B2 (en) | 1997-11-10 | 2005-02-15 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US6770304B2 (en) | 1997-11-10 | 2004-08-03 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US7879364B2 (en) | 1997-11-10 | 2011-02-01 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US8273379B2 (en) | 1997-11-10 | 2012-09-25 | Memorial Sloan-Kettering Cancer Center | Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol |
| US7138147B2 (en) | 1998-04-24 | 2006-11-21 | Daopei Lu | Arsenic sulfide compounds and derivatives thereof for the treatment of malignancies |
| US6733792B1 (en) | 1998-04-24 | 2004-05-11 | Daopei Lu | Arsenic sulfide compounds and derivatives thereof for the treatment of malignancies |
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