CN112263662A - Chinese medicinal compound granule for treating apoplexy and preparation method thereof - Google Patents
Chinese medicinal compound granule for treating apoplexy and preparation method thereof Download PDFInfo
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- CN112263662A CN112263662A CN202011363977.1A CN202011363977A CN112263662A CN 112263662 A CN112263662 A CN 112263662A CN 202011363977 A CN202011363977 A CN 202011363977A CN 112263662 A CN112263662 A CN 112263662A
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Classifications
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention provides a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof, wherein the traditional Chinese medicine compound granule comprises the following components in parts by weight: 10-16 parts of radix curcumae, 15-20 parts of snakegourd fruit, 6-10 parts of rhizoma acori graminei, 6-7 parts of notopterygium root, 6-10 parts of arisaema cum bile, 15-17 parts of caulis spatholobi, 10-12 parts of immature bitter orange, 10-12 parts of mangnolia officinalis, 2-3 parts of mirabilite, 6-7 parts of earthworm, 3-4 parts of raw rhubarb and 5-6 parts of liquorice, and the preparation method comprises the steps of extracting volatile oil from the rhizoma acori graminei and the notopterygium root, adding the rest components such as the radix curcumae and the like into traditional Chinese medicine residues, adding drinking water, decocting, concentrating. The traditional Chinese medicine composition has the effects of opening and closing the channels, relaxing bowels, expelling toxin, regulating qi, promoting blood circulation, dispelling wind and reducing phlegm, is suitable for meridian or visceral patients in the acute stage of the apoplexy, can obviously improve the consciousness state of the patients in the acute stage of the apoplexy, relieve the trend of aggravation of the disease, relieve the damage degree of hemiplegia and reduce the incidence rate of infection complications; and the medicine has obvious curative effect and wide market, and is expected to become a suitable first-aid technology which is the best for treating the apoplexy in acute stage, venous thrombolysis and intravascular treatment.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof.
Background
Stroke is a general term of a sudden cerebrovascular disease, modern medicine is called as 'stroke', the stroke is divided into two main categories of ischemic and hemorrhagic (namely cerebral infarction and cerebral hemorrhage), has the characteristics of high morbidity, high recurrence rate, high disability rate and high lethality rate, is the first cause of death/disability of Chinese people, and is the first killer of human health. In the aspect of acute-stage treatment of apoplexy, western medicines and western medicine technology have certain curative effects, but the cost is extremely high, and the treatment is difficult for many families. The Chinese medicinal preparation has the characteristics of simplicity, convenience, cheapness and effectiveness, and is popular with Chinese people. However, most of the traditional Chinese medicine preparations on the market are of the type of promoting blood circulation to remove blood stasis, and are specially used in the recovery period of stroke. Therefore, the clinical need is to develop a traditional Chinese medicine preparation used for the acute stage of the apoplexy.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof, the traditional Chinese medicine compound granule is prepared from radix curcumae, snakegourd fruit, rhizoma acori graminei and the like, is a traditional Chinese medicine preparation used in the acute stage of apoplexy, can obviously improve mental disorder and nerve function defect states of patients in the acute stage of apoplexy (cerebral hemorrhage), reduces the incidence rate of cerebral infarction complications such as pulmonary infection and the like, and has the advantages of obvious curative effect, simplicity and easiness in preparation, wide market and the like.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine compound granule for treating apoplexy comprises the following components in parts by weight: 10-16 parts of radix curcumae, 15-20 parts of snakegourd fruit, 6-10 parts of rhizoma acori graminei, 6-7 parts of notopterygium root, 6-10 parts of arisaema cum bile, 15-17 parts of caulis spatholobi, 10-12 parts of immature bitter orange, 10-12 parts of mangnolia officinalis, 2-3 parts of mirabilite, 6-7 parts of earthworm, 3-4 parts of raw rhubarb and 5-6 parts of liquorice.
A preparation method of a traditional Chinese medicine compound granule for treating apoplexy comprises the following steps:
1) placing rhizoma Acori Graminei and Notopterygii rhizoma in volatile oil extractor, adding drinking water, and soaking at room temperature for 1 h;
2) decocting with low fire for 8 hr after boiling to generate vapor, condensing the vapor, collecting volatile oil, and keeping the residue of Chinese medicinal materials;
3) adding radix Curcumae, fructus Trichosanthis, rhizoma arisaematis cum bile, caulis Spatholobi, fructus Aurantii Immaturus, cortex Magnolia officinalis, Natrii sulfas, Lumbricus, radix et rhizoma Rhei, and Glycyrrhrizae radix into the Chinese medicinal residue;
4) adding drinking water, soaking at normal temperature for 0.5 hr, boiling, decocting with low fire for 0.5 hr, and filtering to obtain Chinese medicinal decoction;
5) repeating the step 4) for 2 times;
6) transferring the Chinese medicinal decoction obtained by filtering for 3 times to a concentrating device, and continuously concentrating to obtain extract;
7) adding dextrin into the extract, and preparing into traditional Chinese medicine granules by a granule preparation device;
8) uniformly spraying the volatile oil collected in the step 2) into the particles, and sealing for 24 hours at normal temperature so that the volatile oil is fully dissolved into the particles;
9) packaging the prepared Chinese medicinal granules, and sealing to obtain the final product.
According to the scheme, the adding amount of the drinking water in the step 1) is 1/2 of the sum of the mass of the rhizoma acori graminei and the mass of the notopterygium root.
According to the scheme, the adding amount of the drinking water in the step 4) is 8-10 times of the sum of the mass of all the components.
According to the scheme, the relative density of the extract reaches more than 1.15.
The stroke is a disease of deficiency in origin and excess in excess, and is marked by deficiency of qi and blood, disturbance of qi and blood, and intermingled wind-fire and phlegm-stasis. The pathogenesis and treatment of apoplexy are discussed in Huangdi's internal classic: "Qi is reversed, disease is in the upper part, and the lower part is taken. The therapeutic principle and the therapeutic method of 'upper disease lower treatment' lay the theoretical foundation for 'treating the brain disease and the intestines with the stroke disease' and 'reducing phlegm and dredging the abdomen'. The invention inherits the essence of the Xuanfu school, creates the Xuanfu theory of brain and the therapeutic rule of 'treating encephalopathy by opening the xuan', and organically combines two encephalopathy therapies of 'resolving phlegm and dredging abdomen' and 'treating encephalopathy by opening the xuan' on the basis of the 'treating encephalopathy by treating upper diseases by lower treatment' in traditional Chinese medicine and 'flora-intestine-brain axis' in western medicine.
The invention is composed of radix curcumae, trichosanthes kirilowii maxim, rhizoma acori graminei, notopterygium root, arisaema cum bile, caulis spatholobi, immature bitter orange, magnolia officinalis, mirabilite, earthworm, raw rhubarb and liquorice, wherein: raw rhubarb and mirabilite have the effects of clearing internal organs and purging heat, promoting qi and removing stagnation, snakegourd fruit and arisaema cum bile have the effects of clearing phlegm and heat, and notopterygium root has the effect of warming and dredging governor vessels so as to be beneficial to qi and blood circulation; turmeric root-tuber, grassleaved sweetflag rhizome, which is opened and closed to open the front; rhubarb and mirabilite, attacking the lower part and opening the front; fructus Trichosanthis and rhizoma arisaematis cum bile for resolving phlegm and dispelling the evil wetness; licorice and spatholobus stem, radix Glycyrrhizae to promote blood circulation and drive blood circulation; immature bitter orange, magnolia bark, regulating qi and relieving the evil wetness; earthworm, notopterygium root, expelling wind and opening the channels; the traditional Chinese medicine composition has the functions of regulating qi and activating blood circulation, inducing resuscitation and refreshing mind, dispelling wind and eliminating phlegm, and clearing hollow viscera and expelling toxin, is suitable for meridian and viscera patients in the acute stage of the apoplexy, can obviously improve the consciousness state of the patients in the acute stage of the apoplexy, relieve the trend of aggravation of the disease, relieve the damage degree of hemiplegia and reduce the incidence rate of infection complications.
The invention has the beneficial effects that:
1) the traditional Chinese medicine composition is prepared from radix curcumae, trichosanthes kirilowii maxim and other formulas, has the effects of regulating qi, activating blood, inducing resuscitation, dispelling wind, reducing phlegm, relaxing bowels and expelling toxin, is suitable for meridian and viscera patients in the acute stage of stroke, can obviously improve the consciousness state of the patients in the acute stage of stroke, relieve the tendency of aggravation of diseases, relieve the damage degree of hemiplegia and reduce the incidence rate of infection complications;
2) the invention has been used for more than ten years in clinic, treats tens of thousands of patients in the acute stage of the apoplexy, has obvious curative effect and wide market, and is expected to become a suitable first-aid technology which is the important treatment for the acute stage of the apoplexy, venous thrombolysis and intravascular treatment.
Detailed Description
The technical solution of the present invention will be described with reference to the following examples.
Example 1:
the invention provides a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof, wherein the traditional Chinese medicine compound granule comprises the following components by mass: 10g of radix curcumae, 15g of fructus trichosanthis, 6g of rhizoma acori graminei, 6g of notopterygium root, 6g of arisaema cum bile, 15g of caulis spatholobi, 10g of immature bitter orange, 10g of magnolia officinalis, 2g of mirabilite, 6g of earthworm, 3g of raw rhubarb and 5g of liquorice, and the traditional Chinese medicine is prepared by the following steps:
1) placing rhizoma Acori Graminei and Notopterygii rhizoma in volatile oil extractor, adding drinking water, and soaking at room temperature for 1 h;
2) decocting with low fire for 8 hr after boiling to generate vapor, condensing the vapor, collecting volatile oil, and keeping the residue of Chinese medicinal materials;
3) adding radix Curcumae, fructus Trichosanthis, rhizoma arisaematis cum bile, caulis Spatholobi, fructus Aurantii Immaturus, cortex Magnolia officinalis, Natrii sulfas, Lumbricus, radix et rhizoma Rhei, and Glycyrrhrizae radix into the Chinese medicinal residue;
4) adding drinking water, soaking at normal temperature for 0.5 hr, boiling, decocting with low fire for 0.5 hr, and filtering to obtain Chinese medicinal decoction;
5) repeating the step 4) for 2 times;
6) transferring the Chinese medicinal decoction obtained by filtering for 3 times to a concentrating device, and continuously concentrating to obtain extract;
7) adding dextrin into the extract, and preparing into traditional Chinese medicine granules by a granule preparation device;
8) uniformly spraying the volatile oil collected in the step 2) into the particles, and sealing for 24 hours at normal temperature so that the volatile oil is fully dissolved into the particles;
9) packaging the prepared Chinese medicinal granules, and sealing to obtain the final product.
Further, the adding amount of the drinking water in the step 1) is 1/2 of the sum of the mass of the rhizoma acori graminei and the mass of the notopterygium root; the adding amount of the drinking water in the step 4) is 10 times of the sum of the mass of all the components; the relative density of the extract reaches 1.15.
Example 2:
the invention provides a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof, wherein the traditional Chinese medicine compound granule comprises the following components by mass: 16g of radix curcumae, 15g of fructus trichosanthis, 10g of rhizoma acori graminei, 6g of notopterygium root, 6g of arisaema cum bile, 15g of caulis spatholobi, 10g of immature bitter orange, 10g of magnolia officinalis, 2g of mirabilite, 6g of earthworm, 3g of raw rhubarb and 5g of liquorice, and the preparation method is the same as that in example 1.
Example 3:
the invention provides a traditional Chinese medicine compound granule for treating apoplexy and a preparation method thereof, wherein the traditional Chinese medicine compound granule comprises the following components by mass: 16g of radix curcumae, 20g of fructus trichosanthis, 10g of rhizoma acori graminei, 6g of notopterygium root, 10g of arisaema cum bile, 15g of caulis spatholobi, 10g of immature bitter orange, 10g of magnolia officinalis, 2g of mirabilite, 6g of earthworm, 3g of raw rhubarb and 5g of liquorice, and the preparation method is the same as that in example 1.
The traditional Chinese medicine composition is mainly used for treating apoplexy or other diseases accompanied with phlegm-heat fu-organ excess disease, can improve the nerve function and consciousness state of a patient, relieve the aggravation trend of diseases, relieve the degree of hemiplegia lesion and reduce the incidence rate of infection complications. The application method comprises the following steps: the medicine is taken orally or through a gastric tube, three days are taken as a treatment course, one dose is taken every day, and three times are taken every day.
Application case 1:
some ju, 58 years old, male, "left limb weakness, speech unclear 23 hours" as the chief complaint, transfer to from subordinate hospital, admission to the disease see: lying in bed, abdominal distension and defecating for three days; lethargy, mental retardation, eye opening calling, following actions, no gaze, answering basic questions but with vague structure, central facial paralysis on the left, tongue stretching, deviation to the left, muscle strength of the upper left limb at level 2, muscle strength of the lower left limb at level 2, and pain attenuation on the left side. The mental state score GCS 14 (E4V 4M 6) and the neurological deficit degree score NIHSS 10. And (3) diagnosis: 1. apoplexy involving the meridians; 2. acute cerebral infarction of the right hemisphere; 3. coronary heart disease after stent implantation; 4. diabetes mellitus; 5. hypertension. After admission, the Chinese medicinal decoction prepared in the example 1 is orally taken, one dose/three times a day for three consecutive days. In the morning of the third day, the foul stool is released, and in the afternoon of the third day, the soft stool is discharged, so that the foul smell of the stool is reduced. After two weeks, the limb muscle was partially recovered: the muscle strength of the left upper limb is grade 3, and the muscle strength of the left lower limb is grade 4. After three weeks, the patient had clear mind, GCS 15 points (E4V 5M 6), left facial paralysis was recovered basically, speech was slightly less clear, muscle strength of the left upper limb was grade 4, muscle strength of the left lower limb was grade 5-and NIHSS 3 points, and was supported by another person and discharged from hospital.
Description of the drawings: the prescription can obviously improve the neurological dysfunction of patients with apoplexy (cerebral infarction) in the acute stage.
Application case 2:
zhangyi, 76 years old, male, "unclear consciousness, right limb weakness, unable to speak for 18 hours" as the chief complaint, transferred from subordinate hospitals, admission symptoms were: bed rest, right side forced head position, wheezy phlegm in the throat, moist rale of the lungs, and non-resolved stool for four days; coma, vomiting residue left in the corners of the mouth, inability to match physical examination, stabbing pain and opening eyes, left-handed gaze fixation of both eyes, mixed aphasia, stabbing pain without pronunciation, central facial paralysis on the right side, muscle strength of the right upper limb at level 0, muscle strength of the right lower limb at level 1, and partial feeling on the right side at the decreased level. The mental state score was GCS 8 (E2V 1M 5) and the neurological deficit degree score was NIHSS 23. And (3) diagnosis: 1. stroke, middle zang-fu organs; 2. acute cerebral infarction of the left hemisphere; 3. hypertension. After admission, a gastric tube is arranged, and the traditional Chinese medicine decoction prepared in the embodiment 2 is added from the gastric tube, one dose/three times a day for three consecutive days. And resolving the foul stool on the third day, and adding a decoction according to the original formula. In the afternoon of the fourth day, loose stool was discharged, and the foul smell of feces was reduced more than before. One week later, the patient's mental component recovered: lethargy, GCS 12 points (E4V 2M 6), calls for eyes open, mouth open, and follows the left hand lift (healthy side). After two weeks, the limb muscle was partially recovered: the muscle strength of the right upper limb is grade 1, and the muscle strength of the right lower limb is grade 3. Three weeks later, the patient is refreshed, the patient is basically matched with the others, and the patient loses speech due to exercise, suffers from slight central facial paralysis on the right side, 2 grades of muscle strength of the right upper limb, 4 grades of muscle strength of the right lower limb, 13 minutes from NIHSS and is discharged from the wheelchair.
The method is characterized in that: the patients in this embodiment can be treated with radix Curcumae and rhizoma Acori Graminei to achieve the effect of opening and closing to relieve the mysterious state of the patients.
Description of the drawings: the prescription can obviously improve the mental disorder and the neurological function defect state of a patient with apoplexy (cerebral infarction) in the acute stage and reduce the incidence rate of cerebral infarction complications such as pulmonary infection and the like.
Application case 3:
tan somewhere, 62 years old, women, "sudden coma 26 hours" as the chief complaint, transferred from subordinate hospitals, admission symptoms see: the traditional Chinese medicine composition is laid in bed, the body temperature is 38.9 ℃, the heart rate is 121 times/minute, vomiting, wheezy phlegm in the throat, moist and rale of the lung, and the stool is not decomposed; coma, vomit residue left in the corners of the mouth, incapability of matching physical examination, stabbing pain and eyes, no sound production, stabbing pain and limb positioning, right central facial paralysis, right upper limb muscle strength level 0, right lower limb muscle strength level 0, right pain neglect, right muscle tension increase, right paralysis positive, and weak neck. The mental state score was GCS 6 (E1V 1M 4) and the neurological deficit degree score was NIHSS 24. Admission chest CT show: sputum embolus in trachea and bronchus, high signal image of lobular macula in both lungs, and lung inflammation. White blood cell count (WBC) 14X 10^9/L, neutrophil (NEUT%) 81%. And (3) diagnosis: 1. stroke, middle zang-fu organs; 2. acute cerebral hemorrhage of left basal ganglia; 3. hypertension; 4. pulmonary infection. After admission, a gastric tube is arranged, and the traditional Chinese medicine decoction prepared in the embodiment 3 is added from the gastric tube, one dose/three times a day for three consecutive days. And resolving the foul stool on the third day, and adding a decoction according to the original formula. On the fourth day, loose stool was discharged, and the foul smell of feces was reduced more than before. After one week, the patient had improved inflammation: body temperature 37.3 ℃, white blood cell count (WBC) 9.4 x 10^9/L, neutrophil (NEUT%) 74%; the mind of the patient is improved: sleepiness, calling to open eyes, open mouth, following the advice of lifting the left hand (side health). Three weeks later, the patient was refreshed, the patient was basically matched, the patient was confused, the patient had right central facial paralysis, the muscle strength of the right upper limb was grade 2, the muscle strength of the right lower limb was grade 4, GCS 14 (E4V 4M 6), NIHSS 11, and the patient was discharged from the wheelchair.
The method is characterized in that: in the embodiment, radix curcumae and rhizoma acori graminei are used for opening and closing the opening of the scurrying channel so as to improve the situation that phlegm obstructs the clear orifices and promote the recovery of mind of patients; fructus Trichosanthis and rhizoma arisaematis cum bile are added for clearing heat and eliminating phlegm, so as to improve the phlegm-heat state and alleviate the lung infection.
Description of the drawings: the prescription can obviously improve the mental disorder and the neurological function defect state of patients with apoplexy (cerebral hemorrhage) in the acute stage, and reduce the incidence rate of cerebral infarction complications such as pulmonary infection and the like.
The above embodiments are only used for illustrating but not limiting the technical solutions of the present invention, and although the above embodiments describe the present invention in detail, those skilled in the art should understand that: modifications and equivalents may be made thereto without departing from the spirit and scope of the invention and any modifications and equivalents may fall within the scope of the claims.
Claims (5)
1. A traditional Chinese medicine compound granule for treating apoplexy is characterized by comprising the following components in parts by mass: 10-16 parts of radix curcumae, 15-20 parts of snakegourd fruit, 6-10 parts of rhizoma acori graminei, 6-7 parts of notopterygium root, 6-10 parts of arisaema cum bile, 15-17 parts of caulis spatholobi, 10-12 parts of immature bitter orange, 10-12 parts of mangnolia officinalis, 2-3 parts of mirabilite, 6-7 parts of earthworm, 3-4 parts of raw rhubarb and 5-6 parts of liquorice.
2. The preparation method of the compound traditional Chinese medicine granule for treating apoplexy according to claim 1, comprising the following steps:
1) placing rhizoma Acori Graminei and Notopterygii rhizoma in volatile oil extractor, adding drinking water, and soaking at room temperature for 1 h;
2) decocting with low fire for 8 hr after boiling to generate vapor, condensing the vapor, collecting volatile oil, and keeping the residue of Chinese medicinal materials;
3) adding radix Curcumae, fructus Trichosanthis, rhizoma arisaematis cum bile, caulis Spatholobi, fructus Aurantii Immaturus, cortex Magnolia officinalis, Natrii sulfas, Lumbricus, radix et rhizoma Rhei, and Glycyrrhrizae radix into the Chinese medicinal residue;
4) adding drinking water, soaking at normal temperature for 0.5 hr, boiling, decocting with low fire for 0.5 hr, and filtering to obtain Chinese medicinal decoction;
5) repeating the step 4) for 2 times;
6) transferring the Chinese medicinal decoction obtained by filtering for 3 times to a concentrating device, and continuously concentrating to obtain extract;
7) adding dextrin into the extract, and preparing into traditional Chinese medicine granules by a granule preparation device;
8) uniformly spraying the volatile oil collected in the step 2) into the particles, and sealing for 24 hours at normal temperature so that the volatile oil is fully dissolved into the particles;
9) packaging the prepared Chinese medicinal granules, and sealing to obtain the final product.
3. The method for preparing a compound Chinese medicinal granule for treating apoplexy according to claim 2, wherein the drinking water in step 1) is added in an amount of 1/2 which is the sum of the masses of rhizoma Acori Tatarinowii and rhizoma Et radix Notopterygii.
4. The preparation method of the compound traditional Chinese medicine granule for treating apoplexy according to claim 2, wherein the addition amount of drinking water in the step 4) is 8-10 times of the sum of the mass of all the components.
5. The preparation method of the compound traditional Chinese medicine granule for treating apoplexy according to claim 2, wherein the relative density of the extract is more than 1.15.
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| CN101134082A (en) * | 2007-09-14 | 2008-03-05 | 尹克华 | Traditional Chinese medicine for treating early hemorrhagic stroke |
| CN102935155A (en) * | 2012-11-21 | 2013-02-20 | 长春中医药大学附属医院 | Traditional Chinese medicine preparation for treating stroke and preparation process |
| CN110664884A (en) * | 2019-09-29 | 2020-01-10 | 安徽九华华源药业有限公司 | Improved three-component soup and preparation method thereof |
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