CN112262944A - Technology for extracting nitric oxide donor product by plants - Google Patents
Technology for extracting nitric oxide donor product by plants Download PDFInfo
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- CN112262944A CN112262944A CN202011175970.7A CN202011175970A CN112262944A CN 112262944 A CN112262944 A CN 112262944A CN 202011175970 A CN202011175970 A CN 202011175970A CN 112262944 A CN112262944 A CN 112262944A
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- 239000002840 nitric oxide donor Substances 0.000 title claims abstract description 68
- 235000013361 beverage Nutrition 0.000 claims abstract description 12
- 238000000605 extraction Methods 0.000 claims abstract description 11
- 238000000227 grinding Methods 0.000 claims abstract description 11
- 235000013311 vegetables Nutrition 0.000 claims abstract description 10
- 239000011259 mixed solution Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000005119 centrifugation Methods 0.000 claims abstract description 4
- 230000001376 precipitating effect Effects 0.000 claims abstract description 4
- 238000012216 screening Methods 0.000 claims abstract description 4
- 239000007787 solid Substances 0.000 claims abstract description 4
- 238000001694 spray drying Methods 0.000 claims abstract description 4
- 241000196324 Embryophyta Species 0.000 claims description 29
- 240000007087 Apium graveolens Species 0.000 claims description 6
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 claims description 6
- 235000010591 Appio Nutrition 0.000 claims description 6
- 244000046738 asparagus lettuce Species 0.000 claims description 6
- 235000006705 asparagus lettuce Nutrition 0.000 claims description 6
- 240000000031 Achyranthes bidentata Species 0.000 claims description 3
- 235000021537 Beetroot Nutrition 0.000 claims description 3
- 240000006509 Gynostemma pentaphyllum Species 0.000 claims description 3
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 claims description 3
- 241000408747 Lepomis gibbosus Species 0.000 claims description 3
- 244000300264 Spinacia oleracea Species 0.000 claims description 3
- 235000009337 Spinacia oleracea Nutrition 0.000 claims description 3
- 240000008042 Zea mays Species 0.000 claims description 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 235000020236 pumpkin seed Nutrition 0.000 claims description 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract description 51
- 239000000047 product Substances 0.000 abstract description 13
- 239000013589 supplement Substances 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 7
- 206010020772 Hypertension Diseases 0.000 abstract description 6
- 238000001727 in vivo Methods 0.000 abstract description 6
- 229930014626 natural product Natural products 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 5
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 4
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 206010002383 Angina Pectoris Diseases 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 150000002828 nitro derivatives Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 206010003225 Arteriospasm coronary Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- 239000000006 Nitroglycerin Substances 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- -1 chronic diseases Chemical compound 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000035777 life prolongation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a technology for extracting a nitric oxide donor product by a plant, which comprises the following steps of: detecting the content of the nitric oxide donor in vegetables of known varieties, and screening out the vegetables with high content of the nitric oxide donor to obtain nitric oxide donor plants; ② extracting nitric oxide donor: crushing the rhizome of the nitric oxide donor plant obtained in the step I, then putting the crushed rhizome into a grinding tank, grinding the crushed rhizome to form a crushed object, then putting the crushed object into a centrifugal machine, adding an extraction liquid into the crushed object for centrifugal extraction, and collecting an upper-layer mixed liquid after the centrifugation is finished; thirdly, preparing a nitric oxide donor product: precipitating the mixed solution obtained in the step (II) to obtain nitric oxide donor beverage; and (3) carrying out spray drying treatment on the nitric oxide donor beverage at room temperature to obtain the nitric oxide donor active solid beverage. The invention has no toxic and side effect, safely supplements nitric oxide in vivo, reduces hypertension, is completely made of natural products, and has lower cost.
Description
Technical Field
The invention relates to the technical field of preparation of a nitric oxide donor product extracted by a plant, in particular to a technology for extracting the nitric oxide donor product by the plant.
Background
The key to the project is the application of natural nitric oxide donor transformation in vivo to supplement nitric oxide to prevent and treat cardiovascular diseases including hypertension, the nitric oxide exists widely in vivo, but due to short half-life (only a few milliseconds) and extreme instability, continuous supplement is needed to meet the normal physiological needs of the body and maintain health, and the nitric oxide is sourced from endogenous synthesis and exogenous supplement.
Endogenous synthesis takes arginine, oxygen and NADPH as substrates, and nitric oxide and citrulline are catalytically generated by Nitric Oxide Synthase (NOS). Although a healthy human body has sufficient nitric oxide synthase to produce nitric oxide, the total activity of nitric oxide synthase in the human body is reduced with age due to various factors such as the reduction of gene expression in cell aging, and the production of nitric oxide in the human body is also reduced accordingly. For example, by the age of forty, nitric oxide is generated in healthy people, which is half or less than that of twenty years old, and causes dysfunction of vascular endothelial cells, and white blood cells and platelets are gathered on the vascular wall to cause atherosclerosis of the vascular wall. This may also explain why blood pressure rises with age. More importantly, the modern life has many factors to influence the nitric oxide, such as chronic diseases, smoking, air pollution, unhealthy diet, bad living habits, over-pressure and the like, which can directly or indirectly cause the reduction of the nitric oxide in the body.
Exogenous supplementation can be converted to nitric oxide in vivo by ingestion of food and drug nitric oxide donors. Clinically, commonly used nitrate-based drugs for treating angina pectoris and heart failure, such as nitroglycerin and Xiaocardia pain, expand blood vessels by supplying exogenous nitric oxide to vascular smooth muscle, relieve coronary spasm, increase blood volume in ischemic region, and reduce oxygen consumption of myocardium, so as to relieve symptoms of angina pectoris and heart failure. Nitrate drugs such as glycerol trinitrate can only temporarily relieve angina pectoris symptoms of coronary heart disease, cannot delay the progress of the disease course, and have no improvement effect on prognosis. Meanwhile, the medicine for supplementing nitric oxide is usually only used for emergency due to large dosage, quick response and short duration
The nitric oxide donors are quick to absorb (1-2 minutes of action), short in drug effect (the half-life period is only 7 minutes), and capable of effectively relieving cardiovascular pressure, but because nitric oxide is quickly released in a large amount to cause vascular irritation and relaxation, the common clinical side effects such as headache, palpitation, hypotension, syncope and the like are caused, drug resistance is generated after long-term large-amount administration, and therefore, the drug supplementing nitric oxide cannot be used as a conventional nitric oxide supplementing way.
Disclosure of Invention
The invention aims to provide a technology for extracting a nitric oxide donor product by a plant.
The above object of the present invention is achieved by the following technical solutions: a technology for extracting nitric oxide donor products by plants comprises the following steps:
firstly, content detection: detecting the content of the nitric oxide donor in vegetables of known varieties, and screening out the vegetables with high content of the nitric oxide donor to obtain nitric oxide donor plants;
② extracting nitric oxide donor: crushing the rhizome of the nitric oxide donor plant obtained in the step I, then putting the crushed rhizome into a grinding tank, grinding for 60-90min to form a crushed object, then putting the crushed object into a centrifugal machine, adding an extraction liquid into the crushed object for centrifugal extraction, and collecting an upper-layer mixed solution after the centrifugation is finished;
thirdly, preparing a nitric oxide donor product: precipitating the mixed solution obtained in the step (II) to obtain nitric oxide donor beverage; and (3) carrying out spray drying treatment on the nitric oxide donor beverage at room temperature to obtain the nitric oxide donor active solid beverage.
Preferably, the nitric oxide donor plant is achyranthes bidentata, gynostemma pentaphylla, red beet, celery, radix cyathulae or asparagus lettuce.
Preferably, the nitric oxide donor plant is spinach rhizome, asparagus lettuce rhizome, western celery rhizome, pumpkin seed and corn stigma.
Preferably, the extract in the second step is juice obtained by crushing the nitric oxide donor plant in a grinding tank.
Preferably, the centrifugal extraction process in the step (II) is centrifuged for 15-20min at a relative centrifugal force of below 6000 g.
In conclusion, the beneficial technical effects of the invention are as follows:
1. the natural products comprise traditional Chinese medicines, vegetables, fruits and the like which contain rich nitric oxide donors, can safely and effectively supplement nitric oxide for human bodies, and provides a brand new and effective method for treating hypertension and preventing and treating and recovering cardiovascular and cerebrovascular diseases;
2. different from medicinal organic nitro compounds, the plant nitric oxide donor has the main characteristics of no toxic or side effect, safety supplement of nitric oxide in vivo, reduction of hypertension and no reduction of normal blood pressure, and in addition, the material is completely derived from natural products and is more easily accepted by people, so that the product has wide market space;
3. provides a green nitric oxide donor for human body, achieves the aims of health care, life quality improvement and life prolongation;
4. the nitric oxide donor can safely supplement physiological dosage of nitric oxide, improve endothelial cell function and relax blood vessels, and the effective nitric oxide supplement achieves the aims of reducing blood pressure and protecting cardiovascular system.
Detailed Description
The present invention will be described in further detail with reference to examples.
The invention discloses a technology for extracting a nitric oxide donor product by a plant, which comprises the following steps:
firstly, content detection: detecting the content of the nitric oxide donor in vegetables of known varieties, and screening out the vegetables with high content of the nitric oxide donor to obtain nitric oxide donor plants;
② extracting nitric oxide donor: crushing the rhizome of the nitric oxide donor plant obtained in the step I, then putting the crushed rhizome into a grinding tank, grinding for 60-90min to form a crushed object, then putting the crushed object into a centrifugal machine, adding an extraction liquid into the crushed object for centrifugal extraction, and collecting an upper-layer mixed solution after the centrifugation is finished;
thirdly, preparing a nitric oxide donor product: precipitating the mixed solution obtained in the step (II) to obtain nitric oxide donor beverage; and (3) carrying out spray drying treatment on the nitric oxide donor beverage at room temperature to obtain the nitric oxide donor active solid beverage.
The nitric oxide donor plant is achyranthes bidentata, gynostemma pentaphylla, red beet, celery, radix cyathulae or asparagus lettuce.
The nitric oxide donor plant is spinach rhizome, asparagus lettuce rhizome, western celery rhizome, pumpkin seed and corn stigma.
The extract in the second step is juice obtained by crushing the nitric oxide donor plant in a grinding tank.
And in the step II, the centrifugal extraction process is carried out for 15-20min by using a relative centrifugal force below 6000 g.
The implementation principle of the embodiment is as follows: the natural products comprise traditional Chinese medicines, vegetables, fruits and the like which contain rich nitric oxide donors, can safely and effectively supplement nitric oxide for human bodies, provides a brand new and effective method for treating hypertension and preventing and recovering cardiovascular and cerebrovascular diseases, has great health-care potential for healthy and sub-healthy people, and does not have the effective and nontoxic plant nitric oxide supplement in the current Chinese market. Different from medicinal organic nitro compounds, the plant nitric oxide donor has the main characteristics of no toxic or side effect, safe supplement of nitric oxide in vivo, and capability of reducing hypertension without reducing normal blood pressure. In addition, the materials are completely derived from natural products and are more easily accepted by people, so that the products have wide market space, and with the development of the technology, people can produce diversified products, provide green nitric oxide donors for human bodies, and achieve the purposes of health care, improvement of life quality and prolonging of service life.
The embodiments of the present invention are preferred embodiments of the present invention, and the scope of the present invention is not limited by these embodiments, so: all equivalent changes made according to the structure, shape and principle of the invention are covered by the protection scope of the invention.
Claims (5)
1. A technology for extracting nitric oxide donor products from plants is characterized by comprising the following steps:
firstly, content detection: detecting the content of the nitric oxide donor in vegetables of known varieties, and screening out the vegetables with high content of the nitric oxide donor to obtain nitric oxide donor plants;
② extracting nitric oxide donor: crushing the rhizome of the nitric oxide donor plant obtained in the step I, then putting the crushed rhizome into a grinding tank, grinding for 60-90min to form a crushed object, then putting the crushed object into a centrifugal machine, adding an extraction liquid into the crushed object for centrifugal extraction, and collecting an upper-layer mixed solution after the centrifugation is finished;
thirdly, preparing a nitric oxide donor product: precipitating the mixed solution obtained in the step (II) to obtain nitric oxide donor beverage; and (3) carrying out spray drying treatment on the nitric oxide donor beverage at room temperature to obtain the nitric oxide donor active solid beverage.
2. The plant technology for extracting nitric oxide donor products according to claim 1, wherein: the nitric oxide donor plant is achyranthes bidentata, gynostemma pentaphylla, red beet, celery, radix cyathulae or asparagus lettuce.
3. The plant technology for extracting nitric oxide donor products according to claim 1, wherein: the nitric oxide donor plant is spinach rhizome, asparagus lettuce rhizome, western celery rhizome, pumpkin seed and corn stigma.
4. The plant technology for extracting nitric oxide donor products according to claim 1, wherein: the extract in the second step is juice obtained by crushing the nitric oxide donor plant in a grinding tank.
5. The plant technology for extracting nitric oxide donor products according to claim 1, wherein: and in the step II, the centrifugal extraction process is carried out for 15-20min by using a relative centrifugal force below 6000 g.
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| CN202011175970.7A CN112262944A (en) | 2020-10-28 | 2020-10-28 | Technology for extracting nitric oxide donor product by plants |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108936667A (en) * | 2018-08-29 | 2018-12-07 | 福建千叶百肽生物科技有限公司 | A kind of multi-functional compound fruit and vegetable nitric oxide donors nutrient and preparation method thereof |
| CN109043539A (en) * | 2018-08-29 | 2018-12-21 | 福建千叶百肽生物科技有限公司 | A kind of Dietotherapy health compound fruit and vegetable nitric oxide donors nutrient and preparation method |
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2020
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108936667A (en) * | 2018-08-29 | 2018-12-07 | 福建千叶百肽生物科技有限公司 | A kind of multi-functional compound fruit and vegetable nitric oxide donors nutrient and preparation method thereof |
| CN109043539A (en) * | 2018-08-29 | 2018-12-21 | 福建千叶百肽生物科技有限公司 | A kind of Dietotherapy health compound fruit and vegetable nitric oxide donors nutrient and preparation method |
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