CN112255358A - Multicomponent detecting system based on single column - Google Patents
Multicomponent detecting system based on single column Download PDFInfo
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- CN112255358A CN112255358A CN202010991332.6A CN202010991332A CN112255358A CN 112255358 A CN112255358 A CN 112255358A CN 202010991332 A CN202010991332 A CN 202010991332A CN 112255358 A CN112255358 A CN 112255358A
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- channel
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- detection system
- column
- component detection
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- 238000001514 detection method Methods 0.000 claims abstract description 16
- 230000005526 G1 to G0 transition Effects 0.000 claims abstract description 4
- 238000011002 quantification Methods 0.000 claims abstract description 3
- 239000012530 fluid Substances 0.000 claims description 7
- 238000000926 separation method Methods 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 3
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 18
- 239000007789 gas Substances 0.000 description 11
- 229930195733 hydrocarbon Natural products 0.000 description 9
- 150000002430 hydrocarbons Chemical class 0.000 description 9
- 238000004587 chromatography analysis Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000007547 defect Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The invention provides a single-column based multi-component detection system, which comprises a quantification unit; two ends of the quantitative unit are respectively communicated with the ports of the multi-way valve; two ends of only one chromatographic column are respectively communicated with the ports of the multi-way valve; the chromatographic column comprises; a plurality of channels are arranged in parallel; the stationary phase is arranged in the channel; the air resistance is arranged at the output end of the channel, so that when the gas to be detected is introduced into the channels, the pressure intensity of the input ends of the channels is the same. The invention has the advantages of simple structure, low cost, short separation time, simultaneous separation of various components, good separation effect and the like.
Description
Technical Field
The invention relates to a chromatographic technology, in particular to a multi-component detection system based on a single column.
Background
Chromatograph is a commonly used high-end precision analytical instrument. In a chromatograph, a chromatographic column is a key device for separating substances, and chromatographic columns with different physicochemical properties have limited separating capacity for different substances, so that a multi-valve multi-column parallel blowback chromatographic separation technology is adopted when the traditional chromatograph is used for analyzing various substances: a plurality of multi-way valves are assigned to the chromatography columns. Taking a non-methane total hydrocarbon gas chromatograph as an example, the principle schematic diagram of the chromatograph is shown as 1, a double-valve double-chromatographic column is adopted to analyze methane and total hydrocarbons respectively, and the content of the non-methane total hydrocarbons is calculated by the difference value of the total hydrocarbons and the methane content, and the method has the following defects:
1. the double-valve double-column gas circuit is complicated, the valve box space is crowded, and the installation and the maintenance are not facilitated;
2. double valves and double columns, double valves are selected, and the cost is high.
Based on the above principle, when the species to be analyzed are more, such as methane, total hydrocarbons and benzene series, the valves, chromatographic columns and gas circuits are more complicated.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides the single-column-based multi-component detection system which is simple in structure, low in cost, short in separation time and good in separation effect and can be used for simultaneously separating multiple components.
The purpose of the invention is realized by the following technical scheme:
a single-column based multi-component detection system comprising a quantification unit; the multi-component detection system further comprises:
two ends of the quantitative unit are respectively communicated with the ports of the multi-way valve;
two ends of only one chromatographic column are respectively communicated with the ports of the multi-way valves; the chromatographic column comprises;
a plurality of channels arranged in parallel; the stationary phase is arranged in the channel;
and the air resistor is arranged at the output end of the channel, so that when the gas to be detected is introduced into the channels, the pressure intensities of the input ends of the channels are the same.
Compared with the prior art, the invention has the beneficial effects that:
1. the structure is simple;
the device is provided with a plurality of parallel channels, and each channel is internally provided with a fixed phase matched with a component to be separated, so that various components can be separated by only one chromatographic column (single column), such as total hydrocarbon and methane, the number of valves and gas circuits is reduced, the structural complexity is reduced, and the space is saved;
the setting of the air resistance ensures that the pressure intensity at the inlet of each channel is the same, thereby conveniently calculating the flow speed and the flow in each channel;
2. the cost is low;
the separation of multiple components is realized by only using one chromatographic column, the number of core devices such as a rotary valve, an EPC and the like is reduced, the cost is reduced, and the maintenance amount is reduced;
3. the separation time is short;
the simultaneous separation of a plurality of components is realized by utilizing one chromatographic column, and the separation time is reduced;
4. the separation effect is good;
the separation of various components is realized by using one chromatographic column, the system error is reduced, and the components such as non-methane total hydrocarbon and the like can be more accurately detected.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only for illustrating the technical solutions of the present invention and are not intended to limit the scope of the present invention. In the figure:
FIG. 1 is a schematic diagram of a single column based multicomponent detection system according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view of a chromatography column according to an embodiment of the invention;
FIG. 3 is a cross-sectional view of a chromatography column according to an embodiment of the invention.
Detailed Description
Fig. 1-3 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and use the invention. Some conventional aspects have been simplified or omitted for the purpose of teaching the present invention. Those skilled in the art will appreciate that variations or substitutions from these embodiments will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Thus, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
FIG. 1 schematically shows a schematic diagram of a single-column based multi-component detection system according to an embodiment of the present invention, as shown in FIG. 1, the single-column based multi-component detection system comprising:
a fixed-displacement ring 81, only one of the multi-way valves 71 to which only one fixed-displacement ring 81 is directly connected;
two ends of the quantitative ring 81 are respectively communicated with the ports of the multi-way valve 71;
a sample gas inlet 41, a standard gas inlet 42, a carrier gas inlet 43, a hydrogen inlet 44, an oxygen inlet 45 and a standard gas outlet 46, wherein a filter is arranged at the downstream of each gas inlet;
the two ends of only one chromatographic column 61 are respectively communicated with the ports of the multi-way valve 71;
fig. 1 schematically shows a schematic structural diagram of a chromatography column according to an embodiment of the present invention, which, as shown in fig. 1, includes:
the device comprises a plurality of channels 11-13, wherein the channels 11-13 are arranged in parallel, and a stationary phase matched with a component to be separated is arranged in each channel;
the air resistors 21-23 are arranged at the output ends of the channels, so that when the gas to be detected is introduced into the channels, the pressure intensities of the input ends of the channels are the same, and the flow rate of the fluid in each channel is obtained by using the pressure intensities.
In order to reduce the difficulty of implementation and improve the reliability, further, the structure of the plurality of channels is:
the cross section in the direction perpendicular to the inner fluid flow velocity of the channel is in a concentric structure, and a plurality of channels 11-13 which are isolated from each other are arranged from the inside to the outside, as shown in figure 1; alternatively, the plurality of channels are separate and independent channels 11-13, as shown in FIG. 2.
In order to reduce the processing and assembling difficulty, the cross section of the channel perpendicular to the flow velocity direction of the fluid inside the channel is a separated circle or a nested circle.
In order to reduce the difficulty of processing and assembling, the air resistors 21-23 are further cylindrical structures, are arranged in each channel and are connected with the inner wall of the channel.
Example 2:
an example of the use of the single column based multicomponent detection system according to example 1 of the present invention in the detection of non-methane total hydrocarbons.
In this application, as shown in fig. 1, only one multi-way valve, only one dosing ring and a gas circuit employ the prior art;
as shown in fig. 2, the chromatographic column in the present application example adopts a dual-channel concentric composite chromatographic column, the center of which is a first channel, and the first channel is an inerting empty column for separating total hydrocarbons; a second concentric channel is arranged outside the first channel and is filled with PQ filler for separating methane; the section of the first channel perpendicular to the flow velocity direction of the fluid inside the first channel is circular, the section of the second channel perpendicular to the flow velocity direction of the fluid inside the second channel is circular, and the output ends of the first channel and the second channel are internally provided with air resistors with tubular structures.
Claims (5)
1. A single-column based multi-component detection system comprising a quantification unit; characterized in that the multicomponent detection system further comprises:
two ends of the quantitative unit are respectively communicated with the ports of the multi-way valve;
two ends of only one chromatographic column are respectively communicated with the ports of the multi-way valves; the chromatographic column comprises;
a plurality of channels arranged in parallel; the stationary phase is arranged in the channel;
and the air resistor is arranged at the output end of the channel, so that when the gas to be detected is introduced into the channels, the pressure intensities of the input ends of the channels are the same.
2. The single column-based multi-component detection system of claim 1, wherein: the quantitative unit is only provided with one multi-way valve which is directly connected with the quantitative unit.
3. The single column-based multi-component detection system of claim 1, wherein: the structure of the plurality of channels is:
the cross section in the direction perpendicular to the flow velocity of the internal fluid of the channel is of a concentric structure, and a plurality of channels which are isolated from each other are arranged from inside to outside; or,
the plurality of channels are separate and independent channels.
4. The single column-based multi-component detection system of claim 1, wherein: the cross section of the channel perpendicular to the flow velocity direction of the fluid in the channel is in a separated circular shape or a nested circular ring shape.
5. The single column-based multi-component detection system of claim 4, wherein: the air resistance is of a cylindrical structure, is arranged in each channel and is connected with the inner wall of each channel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010991332.6A CN112255358A (en) | 2020-09-20 | 2020-09-20 | Multicomponent detecting system based on single column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010991332.6A CN112255358A (en) | 2020-09-20 | 2020-09-20 | Multicomponent detecting system based on single column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112255358A true CN112255358A (en) | 2021-01-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010991332.6A Pending CN112255358A (en) | 2020-09-20 | 2020-09-20 | Multicomponent detecting system based on single column |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935040A (en) * | 1989-03-29 | 1990-06-19 | The Perkin-Elmer Corporation | Miniature devices useful for gas chromatography |
| CN1419123A (en) * | 2002-12-05 | 2003-05-21 | 清华大学 | Miniature gas chromatographic column, gas chromatographic system and method for analysizing composition in sample |
| CN105572257A (en) * | 2015-12-31 | 2016-05-11 | 杭州谱育科技发展有限公司 | Methane-free total hydrocarbon and benzene series online detection device and method |
| CN106501399A (en) * | 2016-10-21 | 2017-03-15 | 苏州冷杉精密仪器有限公司 | A kind of methane and NMHC detection method of content |
| CN108490104A (en) * | 2018-03-05 | 2018-09-04 | 苏州感闻环境科技有限公司 | A kind of micro-scale gas chromatograph column chip and preparation method thereof |
-
2020
- 2020-09-20 CN CN202010991332.6A patent/CN112255358A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4935040A (en) * | 1989-03-29 | 1990-06-19 | The Perkin-Elmer Corporation | Miniature devices useful for gas chromatography |
| CN1419123A (en) * | 2002-12-05 | 2003-05-21 | 清华大学 | Miniature gas chromatographic column, gas chromatographic system and method for analysizing composition in sample |
| CN105572257A (en) * | 2015-12-31 | 2016-05-11 | 杭州谱育科技发展有限公司 | Methane-free total hydrocarbon and benzene series online detection device and method |
| CN106501399A (en) * | 2016-10-21 | 2017-03-15 | 苏州冷杉精密仪器有限公司 | A kind of methane and NMHC detection method of content |
| CN108490104A (en) * | 2018-03-05 | 2018-09-04 | 苏州感闻环境科技有限公司 | A kind of micro-scale gas chromatograph column chip and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 詹益兴等: "《实用气相色谱分析》", 30 June 1983, 湖南科学技术出版社 * |
| 郝军等: "多维气相色谱法快速分析裂解气的组成", 《甘肃科技》 * |
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Application publication date: 20210122 |