CN209961742U - Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer - Google Patents
Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer Download PDFInfo
- Publication number
- CN209961742U CN209961742U CN201920597862.5U CN201920597862U CN209961742U CN 209961742 U CN209961742 U CN 209961742U CN 201920597862 U CN201920597862 U CN 201920597862U CN 209961742 U CN209961742 U CN 209961742U
- Authority
- CN
- China
- Prior art keywords
- way valve
- interface
- gas chromatograph
- mass spectrometer
- gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The application relates to a time-sharing multiplexing interface device of a gas chromatograph-mass spectrometer. The interface device is provided with a first four-way valve and a second four-way valve component, and the second four-way valve component comprises one or more second four-way valves; the first interface of the first four-way valve is connected with a mass spectrometer, the third interface of the first four-way valve is connected with a gas chromatograph, and the second interface of the first four-way valve is connected with the first interface of the second four-way valve at the tail end of the second four-way valve component; in the second four-way valve assembly, a first interface and a second interface of adjacent second four-way valves are respectively connected, so that the plurality of second four-way valves are sequentially connected, and a third interface of each second four-way valve is connected with a gas chromatograph; and a second interface of a second four-way valve at the head end of the second four-way valve assembly is connected with the gas chromatograph. The time-sharing multiplexing of a plurality of gas chromatographs and a mass spectrometer can be realized.
Description
Technical Field
The utility model relates to a check out test set technical field, concretely relates to interface arrangement for connecting gas chromatograph and mass spectrograph.
Background
When the gas chromatography-mass spectrometry is used in combination, the gas chromatograph and the mass spectrometer are arranged in a one-to-one mode, the gas chromatograph separates samples, and the mass spectrometer analyzes the samples and collects signals. Generally, one chromatographic column can only be used for analyzing one type of substance, and one gas chromatograph is only provided with one chromatographic column. If various types of substance analysis work is to be finished, a plurality of chromatographs are required to be used for carrying out the work respectively, and the mass spectrometers with the same number are required to be arranged correspondingly. However, mass spectrometers are very expensive, far above the price of gas chromatographs.
Among the prior art, an intelligence automatic switch-over multichannel gas chromatography post connecting device is proposed, including fixed baseplate, a plurality of gas chromatography posts, still including the control panel who has the display screen and two have many fluid passage and through rotatory switching fluid passage make the fluid flow through the multichannel chromatographic column connecting device of different gas chromatography posts. In the technical scheme, when the gas chromatographic column is replaced, the gas chromatographic column does not need to be manually disassembled and reinstalled, and the sample can be automatically switched and controlled to be injected into different chromatographic columns by one key. However, this solution is used to simultaneously connect a plurality of chromatographic columns in one chromatograph, only one selected chromatographic column can operate, and both ends of the remaining chromatographic columns are sealed and are in a completely non-operating state.
SUMMERY OF THE UTILITY MODEL
In view of the technical problem that exists among the above-mentioned prior art, this application aims at providing a multiplexing interface arrangement of neotype gas chromatograph-mass spectrometer timesharing, and the interface arrangement of this application can connect many gas chromatographs and a mass spectrometer, utilizes the time difference of the different gas chromatographs separation different kinds of material for many gas chromatographs can divide a sharing mass spectrometer of period, thereby accomplish the detection achievement of multiple kinds of material, reduce device cost.
The application provides a time-sharing multiplexing interface device of a gas chromatograph-mass spectrometer, wherein a first four-way valve and a second four-way valve component are arranged in the interface device, and the second four-way valve component comprises one or more second four-way valves;
the first interface of the first four-way valve is connected with a mass spectrometer, the third interface of the first four-way valve is connected with a gas chromatograph, and the second interface of the first four-way valve is connected with the first interface of the second four-way valve at the tail end of the second four-way valve component;
in the second four-way valve assembly, a first interface and a second interface of adjacent second four-way valves are respectively connected, so that the plurality of second four-way valves are sequentially connected, and a third interface of each second four-way valve is connected with a gas chromatograph;
and a second interface of a second four-way valve at the head end of the second four-way valve assembly is connected with the gas chromatograph.
As an alternative embodiment of the present application, port four of the first four-way valve is used for evacuation.
As an alternative embodiment of the present application, the four ports of the second four-way valve are all used for evacuation.
As an optional implementation manner of the present application, the first four-way valve and the second four-way valve are both two-position four-way valves.
As an optional embodiment of the present application, the inner diameters of the first interface, the second interface, and the third interface of the first four-way valve are all the same as or similar to the inner diameter of a chromatographic column in a connected gas chromatograph.
In an optional embodiment of the present application, in the second four-way valve assembly, the inner diameters of the first port, the second port, and the third port of the plurality of second four-way valves are all the same as or similar to the inner diameter of a chromatographic column in a connected gas chromatograph.
The utility model provides a multiplexing interface arrangement of gas chromatograph-mass spectrometer timesharing can connect a plurality of gas chromatographs and a mass spectrometer, because the kind of the material that a plurality of gas chromatographs separated is different, separation time will have great difference to can guarantee that gas chromatograph can send the sample after the separation into the mass spectrometer in proper order in the time quantum of difference respectively, and then detect different kinds of material respectively.
Therefore, the gas chromatograph-mass spectrometer time-sharing multiplexing interface device can realize time-sharing multiplexing of a plurality of gas chromatographs and one mass spectrometer by utilizing the time difference of the substance separation process.
Drawings
Fig. 1 is a schematic structural diagram of a gas chromatograph-mass spectrometer time-sharing multiplexing interface device provided in the present application.
Fig. 2 is a schematic structural diagram of a time division multiplexing interface device according to an embodiment of the present application.
Detailed Description
The invention will be described in more detail with reference to the following figures and examples, so that the aspects of the invention and their advantages can be better understood. However, the specific embodiments and examples described below are for illustrative purposes only and are not intended to limit the present invention.
The terms "connected" and "connected" as used herein, unless otherwise expressly specified or limited, are to be construed broadly, as meaning either directly or through an intermediate. In the description of the present application, it is to be understood that the directions or positional relationships indicated by "upper", "lower", "front", "rear", "left", "right", "top", "bottom", and the like are based on the directions or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and thus, should not be construed as limiting the present application.
As shown in fig. 1, the gas chromatograph-mass spectrometer time division multiplexing interface apparatus proposed in the present application includes a first four-way valve 1 and a second four-way valve assembly, where the second four-way valve assembly includes one or more second four-way valves 2.
The gas chromatograph-mass spectrometer time-sharing multiplexing interface device provided in the application can enable a plurality of gas chromatographs to jointly use the same mass spectrometer, and the plurality of gas chromatographs can respectively use the mass spectrometer to perform detection and analysis of substances in different time periods, so that mutual interference among the substances at different separation times is avoided. Specifically, in the gas chromatograph separation technology, a gas is used as a mobile phase, and a multi-component mixture can be separated into single components. Wherein, because the distribution coefficients of different substances between the gas mobile phase and the stationary phase in the chromatographic column are different, the running speeds of the components in the mixture in the chromatographic column are different, and after passing through the chromatographic column with a certain column length, the components are separated and sequentially leave the chromatograph, thereby realizing the separation of the mixture. The mass spectrometer can ionize substance molecules, separate and analyze ions according to mass-to-charge ratio, and finally complete qualitative and quantitative analysis of substances.
In the time division multiplexing interface device of the present application, the first four-way valve 1 has a first interface 11, a second interface 12, a third interface 13, and a fourth interface 14. The second four-way valves 2 are respectively provided with a first interface 21, a second interface 22, a third interface 23 and a fourth interface 24.
As shown in fig. 1, in the second four-way valve assembly, when a plurality of second four-way valves 2 are included in the second four-way valve assembly, the plurality of second four-way valves 2 are connected in sequence. Moreover, the first port 21 and the second port 22 of every two adjacent second four-way valves 2 are respectively connected. And the third interfaces 23 of the second four-way valves 2 are all connected with the gas chromatograph 3. Optionally, port four 24 of the second four-way valve 2 is used for draining.
As shown in fig. 1, the first port 11 of the first four-way valve 1 is connected to the mass spectrometer 4. The third interface 13 of the first four-way valve 1 is connected with the gas chromatograph 3. The second port 12 of the first four-way valve 1 is connected with the first port 21 of the second four-way valve 2 at the end position of the second four-way valve assembly. Optionally, port four 14 of the first four-way valve 1 is used for evacuation.
Optionally, in the second four-way valve assembly, the gas chromatograph 3 is connected to the second port 22 of the second four-way valve 2 at the head end. In different embodiments of the present application, the gas chromatograph may also be connected to the second interface 22 of the second four-way valve 2 at other positions, and the connection manner of the corresponding other interfaces is changed, which is not described herein again.
When the time-sharing multiplexing interface device comprises a first four-way valve 1 and N second four-way valves 2, the time-sharing multiplexing interface device can comprise (N +2) gas chromatographs and a mass spectrometer, and the time-sharing multiplexing of the (N +2) gas chromatographs on the mass spectrometer is realized.
As an optional embodiment of the present application, the mass spectrometer and the gas chromatograph are both connected to corresponding interfaces through gas pipelines, and the interfaces are also connected through gas pipelines. And the inner diameter of each gas pipeline is the same as that of the interface connected with the two ends of the gas pipeline, so that the sample in the gas pipeline is prevented from being diffused. In the actual operation process, the inner diameter of each gas pipeline can be slightly smaller than the inner diameter of the interface connected with the two ends of the gas pipeline, or slightly larger than the inner diameter of the interface connected with the two ends of the gas pipeline.
Optionally, the gas pipeline in this application all adopts the passivation pipeline to take place adsorption effect, influence separation analysis when avoiding the sample of different grade type and pipeline contact.
In the drawings of the present application, the same reference numerals are used for the plurality of gas chromatographs for convenience of description.
As an alternative embodiment of the present application, the first four-way valve 1 and the second four-way valve 2 are both two-position four-way valves. In the application, the specific type of the used two-position four-way valve is not limited, and the selection can be performed according to the requirements of different working environments in different implementation modes.
Further, in the time division multiplexing interface device of the present application, the inner diameters of the first interface 11, the second interface 12, and the third interface 13 of the first four-way valve 1 are all the same as or close to the inner diameter of the chromatographic column in the gas chromatograph 3 connected to the third interface 13 of the first four-way valve 1, so that the interfaces can be tightly connected and sealed through a gas pipeline, and the influence of the diffusion of sample substances in the gas pipeline on the separation process can be avoided.
Further, in the second four-way valve assembly of the present application, the inner diameters of the first interface 21, the second interface 22, and the third interface 23 of the plurality of second four-way valves 2 are all the same as or close to the inner diameters of the chromatographic columns in the gas chromatographs 3 connected to each other, so that tight connection and sealing can be realized between the interfaces through the gas pipeline, and the influence on the separation process possibly caused by the diffusion of sample substances in the gas pipeline is avoided.
As an optional embodiment of the present application, the four interfaces of the first four-way valve 1 and the second four-way valve 2 are both used for evacuation, so that when one of the gas chromatographs 3 is connected with the mass spectrometer 4 for detecting a sample, the outlets of the remaining gas chromatographs 3 are not sealed, and it is ensured that all the gas chromatographs 3 can be in a working state.
As one embodiment of the present application, a first four-way valve 1 and a second four-way valve 2 are disposed in the time division multiplexing interface apparatus of the present application, as shown in fig. 2.
In the embodiment shown in fig. 2, the first port 11 of the first four-way valve 1 is connected to a mass spectrometer 4. A third interface 13 of the first four-way valve 1 is connected with a gas chromatograph 3. The No. four connection 14 of the first four-way valve 1 is used for draining.
The second interface 22 of the second four-way valve 2 is connected with a gas chromatograph 3. The third interface 23 of the second four-way valve 2 is connected with a gas chromatograph 3. Port four 24 of second four-way valve 2 is used for drain.
Further, the second port 12 of the first four-way valve 1 is connected to the first port 21 of the second four-way valve 2.
The time-sharing multiplexing interface device for the gas chromatograph-mass spectrometer can realize time-sharing multiplexing of three gas chromatographs and one mass spectrometer.
In the application, according to different working process needs, different numbers of gas chromatographs and mass spectrometers can be set.
The application also provides a method for detecting by using the gas chromatograph-mass spectrometer time-sharing multiplexing interface device. In the detection method provided by the application, the mass spectrometer is respectively connected with different gas chromatographs by controlling the change of the positions of the valve core of the first four-way valve 1 and the valve core of the second four-way valve 2, so that substances to be detected in the gas chromatographs can enter the mass spectrometer for qualitative and quantitative detection after separation.
In the detection method, the connection between the mass spectrometer and the gas chromatographs at different positions can be realized respectively through the following three modes:
(1) the second interface 12 and the first interface 11, the third interface 13 and the fourth interface 14 of the first four-way valve 1 are respectively communicated with each other.
The first port 21 and the second port 22 of the adjacent second four-way valve 2 are communicated with each other, so that the plurality of second four-way valves 2 are arranged in sequence.
The second port 12 of the first four-way valve 1 and the first port 21 of the second four-way valve 2 at the end position of the second four-way valve assembly are communicated.
For one of the second four-way valves 2, the first port 21 and the third port 23, the second port 22 and the fourth port 24 of the second four-way valve 2 are communicated respectively. In addition, the first port 21 and the second port 22, and the third port 23 and the fourth port 24 are communicated with the remaining second four-way valve 2 except the second four-way valve 2 in the second four-way valve assembly.
In this connection mode, the mass spectrometer 4 is connected to the gas chromatograph 3 connected to the third interface 23 of the one of the second four-way valves 2, and the substance to be detected in the gas chromatograph 3 can enter the mass spectrometer 4 for qualitative and quantitative detection after separation.
(2) The second interface 12 and the first interface 11, the third interface 13 and the fourth interface 14 of the first four-way valve 1 are respectively communicated with each other.
The first port 21 and the second port 22 of the adjacent second four-way valve 2 are communicated with each other, so that the plurality of second four-way valves 2 are arranged in sequence.
The second port 12 of the first four-way valve 1 and the first port 21 of the second four-way valve 2 at the end position of the second four-way valve assembly are communicated.
The first interface 21 and the second interface 22, the third interface 23 and the fourth interface 24 of the second four-way valve 2 at the head end position of the second four-way valve assembly are communicated.
In this kind of connected mode, mass spectrograph 4 is connected with the gas chromatograph 3 of No. two interfaces 22 departments of the second cross valve 2 of above-mentioned second cross valve subassembly head end position department, and the material that awaits measuring in this gas chromatograph 3 can get into in the mass spectrograph 4 after the separation and carry out qualitative and quantitative determination.
(3) The first port 21 and the second port 22 of the adjacent second four-way valve 2 are communicated with each other, so that the plurality of second four-way valves 2 are arranged in sequence.
The second port 12 of the first four-way valve 1 and the first port 21 of the second four-way valve 2 at the end position of the second four-way valve assembly are communicated.
The first interface 11 and the third interface 13, the second interface 12 and the fourth interface 14 of the first four-way valve 1 are respectively communicated with.
In this kind of connected mode, mass spectrograph 4 is connected with the gas chromatograph 3 of No. three interfaces 13 department of first cross valve 1, and the material to be measured in this gas chromatograph 3 can get into in the mass spectrograph 4 after the separation and carry out qualitative and quantitative determination.
The utility model provides a multiplexing interface arrangement of gas chromatograph-mass spectrometer timesharing can connect a plurality of gas chromatographs and a mass spectrometer, because the kind of the material that a plurality of gas chromatographs separated is different, separation time will have great difference to can guarantee that gas chromatograph can send the sample after the separation into the mass spectrometer in proper order in the time quantum of difference respectively, and then detect different kinds of material.
Furthermore, because the first four-way valve and the second four-way valve are provided with the interfaces for evacuation, when one of the gas chromatographs is connected to the mass spectrometer for operation, the outlets of the other gas chromatographs cannot be closed, and are also in an operating state, but the sample in the gas chromatographs is not separated from the gas chromatographs and flows out.
The time-sharing multiplexing interface device for the gas chromatograph-mass spectrometer can utilize the time difference of a substance separation process to realize time-sharing multiplexing of a plurality of gas chromatographs and a mass spectrometer.
Finally, it should be noted that: it should be understood that the above examples are only for clearly illustrating the present invention and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious changes and modifications may be made without departing from the scope of the present invention.
Claims (6)
1. A gas chromatograph-mass spectrometer time-sharing multiplexing interface device is characterized in that a first four-way valve and a second four-way valve component are arranged in the interface device, and the second four-way valve component comprises one or more second four-way valves;
the first interface of the first four-way valve is connected with a mass spectrometer, the third interface of the first four-way valve is connected with a gas chromatograph, and the second interface of the first four-way valve is connected with the first interface of the second four-way valve at the tail end of the second four-way valve component;
in the second four-way valve assembly, a first interface and a second interface of adjacent second four-way valves are respectively connected, so that the plurality of second four-way valves are sequentially connected, and a third interface of each second four-way valve is connected with a gas chromatograph;
and a second interface of a second four-way valve at the head end of the second four-way valve assembly is connected with the gas chromatograph.
2. The tdm interface device of claim 1, wherein the interface four of the first four-way valve is configured to drain.
3. The tdm interface device of claim 1, wherein the ports four of the second four-way valve are all used for draining.
4. The tdm interface device of claim 1, wherein the first four-way valve and the second four-way valve are both two-position four-way valves.
5. The interface device of claim 1, wherein the first, second and third ports of the first four-way valve have the same or similar inner diameter as the inner diameter of the connected chromatographic column of the gas chromatograph.
6. The interface apparatus according to claim 1, wherein the second four-way valve assembly has a first port, a second port, and a third port of the second four-way valve having the same or similar inner diameter as the inner diameter of the connected chromatographic column of the gas chromatograph.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920597862.5U CN209961742U (en) | 2019-04-28 | 2019-04-28 | Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920597862.5U CN209961742U (en) | 2019-04-28 | 2019-04-28 | Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209961742U true CN209961742U (en) | 2020-01-17 |
Family
ID=69243997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920597862.5U Active CN209961742U (en) | 2019-04-28 | 2019-04-28 | Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209961742U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110031563A (en) * | 2019-04-28 | 2019-07-19 | 北京雪迪龙科技股份有限公司 | A kind of gas chromatograph-mass spectrograph time-sharing multiplex interface arrangement and detection method |
-
2019
- 2019-04-28 CN CN201920597862.5U patent/CN209961742U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110031563A (en) * | 2019-04-28 | 2019-07-19 | 北京雪迪龙科技股份有限公司 | A kind of gas chromatograph-mass spectrograph time-sharing multiplex interface arrangement and detection method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6812458B2 (en) | Systems and methods for high-throughput microfluidic sample analysis | |
| US11331596B2 (en) | Multi-dimensional chromatographic system for analyzing multiple sample components | |
| US9599595B2 (en) | Comprehensive two-dimensional gas chromatograph and modulator for the chromatograph | |
| CN209961742U (en) | Time-sharing multiplexing interface device of gas chromatograph-mass spectrometer | |
| CA2975027A1 (en) | Means and methods for minimizing swept and dead volumes in chromatographic applications | |
| US20230366858A1 (en) | Fluidic configuration for a multidimensional liquid chromatography system | |
| CN208654099U (en) | Transformer oil gas analysis Special instrument | |
| CN205449910U (en) | Non -methane total hydrocarbon on -line measuring device | |
| Shintani et al. | Development of miniaturized multi-channel high-performance liquid chromatography for high-throughput analysis | |
| US7096886B2 (en) | Multiport switching valve for a liquid flow system | |
| CA2349777A1 (en) | Method and device for increasing efficiency of bioanalysis | |
| CN112180021B (en) | Liquid Chromatography System | |
| CN110031563A (en) | A kind of gas chromatograph-mass spectrograph time-sharing multiplex interface arrangement and detection method | |
| JP3179281U (en) | Valve converter for improving heart-cutting technology functions of gas chromatographs | |
| Wehr | Fast LC for high-throughput LC-MS.(Directions In Discovery). | |
| CN213398363U (en) | Multi-flow path parallel liquid chromatography equipment | |
| CN112595791B (en) | Gas chromatography device based on electromagnetic valve automatic sample injection and detection method | |
| Hinshaw | Valves for Gas Chromatography Part III: Fluidic Switching Applications | |
| JP2861336B2 (en) | Applied flow path of gas chromatograph | |
| JP2000266738A (en) | Liquid chromatograph mass spectroscope | |
| Wang et al. | Importance of mobile phase and injection solvent selection during rapid method development and sample analysis in drug discovery bioanalysis illustrated using convenient multiplexed LC-MS/MS | |
| CN116466002A (en) | Single TCD-based hydrogen and non-hydrogen component measurement device and method | |
| WO2022164627A1 (en) | Flow splitter for gas chromatography systems | |
| Stoll et al. | Effects of Buffer Capacity in LC, Part 2: Visualization of pH Changes Inside the Column | |
| JP2001249113A (en) | High-sensitivity separation structure analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |