CN112245818A - Ultrasonic nerve regulation and control device - Google Patents
Ultrasonic nerve regulation and control device Download PDFInfo
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- CN112245818A CN112245818A CN202010942814.2A CN202010942814A CN112245818A CN 112245818 A CN112245818 A CN 112245818A CN 202010942814 A CN202010942814 A CN 202010942814A CN 112245818 A CN112245818 A CN 112245818A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N2007/0004—Applications of ultrasound therapy
- A61N2007/0021—Neural system treatment
- A61N2007/0026—Stimulation of nerve tissue
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Abstract
The invention relates to the field of ultrasonic nerve regulation, in particular to an ultrasonic nerve regulation device which comprises a planar ultrasonic transducer (100), an acoustic lens (200) and a sound wave collimator (300), wherein the planar ultrasonic transducer (100), the acoustic lens (200) and the sound wave collimator (300) are sequentially arranged, the acoustic lens (200) is used for regulating and controlling the inclined focusing of planar ultrasonic waves, is in a shape formed by a major arc line and a straight line connected with two ends of the major arc line, and comprises a plurality of concentrically arranged split rings (110). The planar ultrasonic transducer (100) emits planar ultrasonic waves, the planar ultrasonic waves form inclined focusing through the acoustic lens (200), and therefore the focusing can be adjusted to a preset position through adjusting the inclined angle, and nerve stimulation can be conducted without fixing an animal.
Description
Technical Field
The invention relates to the field of ultrasonic nerve regulation and control, in particular to an ultrasonic nerve regulation and control device.
Background
In recent years, the clinical application of ultrasound is no longer limited to image diagnosis, and the therapeutic effect of ultrasound in tumor and brain diseases is gradually a hot spot in modern medical research. For example, HIFU therapy is used for thermal tumor therapy by inducing transient hyperthermia using high intensity focused ultrasound to cause very rapid coagulation necrosis of tumor tissue; the focused sound field in the nerve regulation research can accurately stimulate the nerve nucleus, effectively regulate the nerve loop, and provide an important means for researching the pathogenesis and treatment of brain functions such as senile dementia, Parkinson, epilepsy, depression and the like.
Ultrasound neuromodulation utilizes ultrasound waves that propagate in tissue in pulses or continuous waves, thereby affecting the acoustic activity of the tissue through the mechanical or thermal effects of the ultrasound waves. The nerve of the stimulation part generates stimulation or inhibition effect by changing the ultrasonic frequency, pulse width, duration and ultrasonic intensity, thereby regulating the nerve function reversely and bidirectionally.
Currently, the ultrasonic neural regulation and control mainly utilizes a single-array element focused ultrasonic transducer to stimulate a corresponding nuclear mass for brain disease treatment. However, there is a certain challenge to the stimulation of the heminucleus of the animal brain, mainly because the animal needs to be fixed or cannot be effectively stimulated when the heminucleus stimulation is performed by using the single-array focused ultrasound transducer, so that the freedom of movement of the animal is limited.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an ultrasonic nerve regulation and control device, which aims to solve the problem that when the hemilateral nucleus is stimulated, an animal needs to be fixed, otherwise the stimulation cannot be effectively carried out, and the action freedom of the animal is limited.
The invention is realized by the following steps:
an ultrasonic nerve regulation and control device comprises a planar ultrasonic transducer and an acoustic lens, wherein the planar ultrasonic transducer is used for emitting planar ultrasonic waves, the acoustic lens is used for regulating and controlling the planar ultrasonic waves to be obliquely focused and comprises a plurality of concentrically arranged split rings.
Optionally, the phase distribution formula of the acoustic lens modulation plane ultrasonic wave tilt is as follows: :
wherein the content of the first and second substances,
is the intermediate position (x, y) of the acoustic lensPhase equation, k is 2 pi/lambda is the wavelength of the plane ultrasonic wave, and lambda is 2 pi f/c0Is the wavelength of the planar ultrasonic waves in water, c0The sound velocity of the plane ultrasonic wave in the air is shown as f, the position of the focus of the acoustic lens is (x)0,y0,z0)。
Optionally, the relationship between the acoustic lens thickness and phase is as follows:
wherein the content of the first and second substances,
is the phase equation of the acoustic lens material as a function of thickness t, c1Is the speed of sound of the acoustic lens material.
Optionally, the planar ultrasonic transducer has a sound emitting plane, the planar ultrasonic transducer emits the planar ultrasonic wave from the sound emitting plane, and the acoustic lens is disposed on the sound emitting plane.
Optionally, the ultrasonic transducer can adjust the frequency range of the sound waves to be 0.5-5 MHz.
Optionally, the ultrasonic transducer is a planar piezoelectric ceramic.
Optionally, the acoustic lens is made of photosensitive resin, acrylic material or medical silicone rubber.
Optionally, the inner cylinder diameter of the acoustic wave collimator is arranged in a tapered manner in a direction away from the planar ultrasonic transducer.
Based on the invention, the plane ultrasonic transducer emits plane ultrasonic waves, the plane ultrasonic waves form inclined focusing through the acoustic lens, and thus the focusing can be adjusted to a preset position by adjusting the inclined angle, so that nerve stimulation can be carried out without fixing an animal.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic diagram of the overall structure of an ultrasonic neuromodulation device provided by an embodiment of the invention;
fig. 2 is an acoustic path diagram of an ultrasonic neuromodulation device provided by an embodiment of the invention.
FIG. 3 is a top view of an acoustic lens of an ultrasonic neuromodulation device according to an embodiment of the present invention.
The reference numbers illustrate:
| reference numerals | Name (R) | Reference numerals | Name (R) |
| 100 | Planar |
110 | |
| 200 | |
210 | |
| 300 | Acoustic wave collimator |
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The embodiment of the invention provides an ultrasonic nerve regulation and control device, which utilizes ultrasonic waves to stimulate the central nerve of a part in a pulse or continuous wave mode to generate a stimulation or inhibition effect so as to reversely and bidirectionally regulate the nerve function.
Referring to fig. 1 to 3, the ultrasound nerve modulation device includes a planar ultrasound transducer 100, an acoustic lens 200 and an acoustic collimator 300, the planar ultrasound transducer 100, the acoustic lens 200 and the acoustic collimator 300 are sequentially disposed, the acoustic lens 200 is used for modulating the inclined focusing of the planar ultrasound, is in a shape formed by a major arc line and a straight line connecting two ends of the major arc line, and includes a plurality of open rings 210 concentrically disposed.
Based on the ultrasonic nerve regulation and control device provided by the embodiment of the invention, the plane ultrasonic transducer 100 emits plane ultrasonic waves, the plane ultrasonic waves form inclined focusing through the acoustic lens 200, and thus, the focusing can be adjusted to a preset position by adjusting the inclined angle, so that nerve stimulation can be performed without fixing an animal.
In the embodiment of the present invention, the acoustic lens 200 may be made of photosensitive resin, acrylic material, or medical silicone rubber. In the present embodiment, the thickness of each split ring 210 is the same.
Specifically, in the present embodiment, the formula of the phase distribution of the acoustic lens 200 for adjusting the tilt of the planar ultrasonic wave is as follows:
wherein the content of the first and second substances,
is a phase equation of the middle position (x, y) of the acoustic lens 200, k 2 pi/lambda is the wavelength of the plane ultrasonic wave, and lambda 2 pi f/c0Is the wavelength of the plane ultrasonic waves in water, c0The sound velocity of the planar ultrasonic wave in air, f is the frequency of the planar ultrasonic wave, and the position of the focal point of the acoustic lens 200 is (x)0,y0,z0)。
In the present embodiment, the relationship between the thickness and the phase of the acoustic lens 200 is as follows:
wherein the content of the first and second substances,
is the phase equation of the material of the acoustic lens 200 as a function of the thickness t, c1Is the speed of sound of the material of the acoustic lens 200.
In the embodiment of the invention, the planar ultrasonic frequency f is 3MHz, the wavelength λ is 0.5mm, and the focusing position is (x, y, z) is (2mm,0mm,8 mm); the width w of each unit of the lens is 0.5mm, and the material of the lens in this embodiment is photosensitive resin, the sound velocity c of which is1When 2700m/s, the unit height h of the lens is calculated according to the above two formulas from left to right: 1.12mm, 1.59mm, 0.98mm, 1.53mm, 1mm, 1.65mm, 1.22mm, 0.86mm, 1.68mm, 1.44mm, 1.26mm, 1.16mm, 1.12 mm.
Referring to fig. 1, in an embodiment of the present invention, the planar ultrasonic transducer 100 has a sound emitting plane 110, the planar ultrasonic transducer 100 emits a planar ultrasonic wave from the sound emitting plane 110, and the acoustic lens 200 is disposed on the sound emitting plane 110, that is, the acoustic lens 200 is directly attached to the sound emitting plane 110. Thus, compared with the arrangement of the acoustic lens 200 and the planar ultrasonic transduction interval, the reduction of the regulation effect of the acoustic lens 200 caused by the mutual interference in the planar ultrasonic transmission process can be reduced, wherein the structural design of the acoustic lens 200 is usually set according to a specific formula, for example, the mutual interference in the planar ultrasonic transmission process seriously affects the regulation effect of the acoustic lens 200.
In the embodiment of the present invention, the planar ultrasonic transducer 100 can adjust the frequency range of the sound wave to be 0.5-5 MHz. For example, 0.6MHz, 0.7MHz, 0.8MHz, 1MHz, 1.2MHz, 1.5MHz, 1.8MHz, 2MHz, 3MHz, 4 MHz.
In the embodiment of the present invention, the planar ultrasonic transducer 100 is a planar piezoelectric ceramic, which has a relatively simple structure, is convenient for production and manufacture, and is beneficial to reducing the production and manufacturing cost of the ultrasonic nerve modulation and control device.
In the embodiment of the present invention, the ultrasound nerve modulation device further includes an acoustic wave collimator 300, the acoustic wave collimator 300 is cylindrical and abuts against the planar ultrasound transducer 100, and accommodates the acoustic lens 200, and the acoustic wave collimator 300 can further adjust the focused high-frequency ultrasound waves, that is, change the ultrasound focusing depth.
Specifically, in the present embodiment, the inner cylindrical diameter of the acoustic wave collimator 300 is tapered in a direction away from the planar ultrasonic transducer 100.
The present invention is not limited to the above preferred embodiments, and any modification, equivalent replacement or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. An ultrasonic nerve regulation and control device is characterized by comprising a planar ultrasonic transducer, a Fresnel lens and a sound wave collimator, wherein the planar ultrasonic transducer, the Fresnel lens and the sound wave collimator are sequentially arranged, the transmitting end of the planar ultrasonic transducer is used for transmitting a planar ultrasonic signal, the sound lens is used for regulating and controlling the planar ultrasonic to be obliquely focused, is in a shape formed by a major arc line and a straight line connected with the two ends of the major arc line, and comprises a plurality of concentrically arranged split rings.
2. The ultrasonic neuromodulation device as in claim 1, wherein the phase profile of the acoustic lens modulation planar ultrasonic tilt is formulated as follows:
wherein the content of the first and second substances,
is a phase equation of the intermediate position (x, y) of the acoustic lens, k 2 pi/lambda is the wavelength of the planar ultrasonic wave, and lambda 2 pi f/c0Is the wavelength of the planar ultrasonic waves in water, c0The sound velocity of the plane ultrasonic wave in the air is shown as f, the position of the focus of the acoustic lens is (x)0，y0，z0)。
3. The ultrasonic neuromodulation device as in claim 2, wherein the relationship between the acoustic lens thickness and phase is as follows:
wherein the content of the first and second substances,
is the phase equation of the acoustic lens material as a function of thickness t, c1Is the speed of sound of the acoustic lens material.
4. The ultrasonic neuromodulation device of claim 1 wherein the planar ultrasound transducer has an acoustic exit plane, the planar ultrasound transducer emitting the planar ultrasound waves out of the acoustic exit plane, the acoustic lens being disposed in the acoustic exit plane.
5. The ultrasonic neuromodulation device of claim 1 wherein the ultrasonic transducer is capable of adjusting the frequency of the acoustic wave to a range of 0.5-5 MHz.
6. The ultrasonic neuromodulation device of claim 1 wherein the ultrasonic transducer is a planar piezoelectric ceramic.
7. The ultrasonic neuromodulation device of claim 1 wherein the acoustic lens is made of a photosensitive resin, an acrylic material, or a medical silicone rubber.
8. The ultrasonic neuromodulation device of claim 8 wherein the inner cylindrical diameter of the acoustic collimator tapers away from the planar ultrasound transducer.
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| CN202010942814.2A CN112245818B (en) | 2020-09-09 | 2020-09-09 | Ultrasonic nerve regulation and control device |
| PCT/CN2020/117718 WO2022052179A1 (en) | 2020-09-09 | 2020-09-25 | Ultrasonic nerve regulating device |
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| CN202010942814.2A CN112245818B (en) | 2020-09-09 | 2020-09-09 | Ultrasonic nerve regulation and control device |
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| CN112245818B CN112245818B (en) | 2022-05-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114101018A (en) * | 2021-11-25 | 2022-03-01 | 福州大学 | Metamaterial acoustic lens phased array transducer and method for improving focus sound pressure |
| WO2022052179A1 (en) * | 2020-09-09 | 2022-03-17 | 深圳先进技术研究院 | Ultrasonic nerve regulating device |
| CN114308156A (en) * | 2021-12-23 | 2022-04-12 | 深圳先进技术研究院 | Ultrasonic liquid transfer device and method |
| WO2023169021A1 (en) * | 2022-03-09 | 2023-09-14 | 深圳先进技术研究院 | Acoustic holographic lens for multi-point transcranial ultrasound focusing |
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| Publication number | Publication date |
|---|---|
| CN112245818B (en) | 2022-05-17 |
| WO2022052179A1 (en) | 2022-03-17 |
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