CN112236454B - 新型抗pd-1抗体 - Google Patents

新型抗pd-1抗体 Download PDF

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Publication number
CN112236454B
CN112236454B CN201980020380.6A CN201980020380A CN112236454B CN 112236454 B CN112236454 B CN 112236454B CN 201980020380 A CN201980020380 A CN 201980020380A CN 112236454 B CN112236454 B CN 112236454B
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seq
amino acid
acid sequence
antibody
vhh
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CN201980020380.6A
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Chinese (zh)
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CN112236454A (zh
Inventor
陈蕴颖
李竞
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Wuxi Biologics Shanghai Co Ltd
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Wuxi Biologics Shanghai Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980020380.6A 2018-03-20 2019-03-18 新型抗pd-1抗体 Active CN112236454B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211052114.1A CN116333126A (zh) 2018-03-20 2019-03-18 新型抗pd-1抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2018102555703 2018-03-20
CN201810255570 2018-03-20
CN2018079631 2018-03-20
CNPCT/CN2018/079631 2018-03-20
PCT/CN2019/078515 WO2019179396A1 (en) 2018-03-20 2019-03-18 Novel anti-pd-1 antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202211052114.1A Division CN116333126A (zh) 2018-03-20 2019-03-18 新型抗pd-1抗体

Publications (2)

Publication Number Publication Date
CN112236454A CN112236454A (zh) 2021-01-15
CN112236454B true CN112236454B (zh) 2022-09-13

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CN201980020380.6A Active CN112236454B (zh) 2018-03-20 2019-03-18 新型抗pd-1抗体
CN202211052114.1A Pending CN116333126A (zh) 2018-03-20 2019-03-18 新型抗pd-1抗体

Family Applications After (1)

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CN202211052114.1A Pending CN116333126A (zh) 2018-03-20 2019-03-18 新型抗pd-1抗体

Country Status (7)

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US (2) US12030941B2 (enExample)
EP (1) EP3768724A4 (enExample)
JP (2) JP7482031B2 (enExample)
CN (2) CN112236454B (enExample)
CA (1) CA3093992A1 (enExample)
TW (1) TWI829677B (enExample)
WO (1) WO2019179396A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112236454B (zh) * 2018-03-20 2022-09-13 上海药明生物技术有限公司 新型抗pd-1抗体
CN112442122B (zh) * 2019-09-04 2021-09-21 上海洛启生物医药技术有限公司 阻断型pd-1纳米抗体及其编码序列和用途
WO2021057836A1 (en) * 2019-09-25 2021-04-01 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
CN114206931B (zh) * 2019-09-30 2024-06-04 四川科伦博泰生物医药股份有限公司 抗pd-1抗体及其用途
CA3181776A1 (en) 2020-05-26 2021-12-02 Boehringer Ingelheim International Gmbh Anti-pd-1 antibodies
CN114685655B (zh) * 2020-12-28 2024-04-12 浙江纳米抗体技术中心有限公司 Pd-1结合分子及其应用
CN116829584B (zh) * 2020-12-31 2026-02-06 浙江道尔生物科技有限公司 一种抗pd-1的单域抗体
EP4286520A4 (en) * 2021-01-29 2025-04-16 Minghui Pharmaceutical (Hangzhou) Limited Antigen-binding protein and use thereof
WO2026132542A2 (en) * 2024-12-20 2026-06-25 Ablynx Nv Immunoglobulin single variable domains targeting pd-1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3530736A3 (en) * 2005-05-09 2019-11-06 ONO Pharmaceutical Co., Ltd. Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics
US8168757B2 (en) * 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
CN105061597B (zh) * 2015-06-09 2016-04-27 北京东方百泰生物科技有限公司 一种抗pd-1的单克隆抗体及其获得方法
CN106432494B9 (zh) * 2015-08-11 2022-02-15 广州誉衡生物科技有限公司 新型抗-pd-1抗体
IL300122A (en) * 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc Substances that bind to PD1 and/or LAG3
CN106046162B (zh) * 2016-06-21 2019-04-02 大庆东竺明生物技术有限公司 抗人程序性死亡因子1（pd-1）单克隆抗体的制备及应用
CN107474135B (zh) * 2017-02-17 2020-08-18 广西医科大学 抗PD-1的纳米抗体PD-1/Nb20及其制备方法与应用
TWI708787B (zh) * 2018-03-02 2020-11-01 美商美國禮來大藥廠 Pd-1促效劑抗體及其用途
CN112236454B (zh) * 2018-03-20 2022-09-13 上海药明生物技术有限公司 新型抗pd-1抗体

Also Published As

Publication number Publication date
JP2024029261A (ja) 2024-03-05
JP2021518137A (ja) 2021-08-02
US20210061912A1 (en) 2021-03-04
WO2019179396A1 (en) 2019-09-26
CA3093992A1 (en) 2019-09-26
EP3768724A1 (en) 2021-01-27
CN112236454A (zh) 2021-01-15
US12030941B2 (en) 2024-07-09
TWI829677B (zh) 2024-01-21
JP7482031B2 (ja) 2024-05-13
US20240301067A1 (en) 2024-09-12
CN116333126A (zh) 2023-06-27
EP3768724A4 (en) 2022-04-13
TW202003563A (zh) 2020-01-16

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