CN112236447B - 具有mage-b2特异性的t细胞受体及其用途 - Google Patents

具有mage-b2特异性的t细胞受体及其用途 Download PDF

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CN112236447B
CN112236447B CN201980037254.1A CN201980037254A CN112236447B CN 112236447 B CN112236447 B CN 112236447B CN 201980037254 A CN201980037254 A CN 201980037254A CN 112236447 B CN112236447 B CN 112236447B
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tcr
mage
cells
hla
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CN112236447A (zh
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余嘉诚
潘科
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University of Texas System
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/32—T-cell receptors [TCR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/55—Lung
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201980037254.1A 2018-04-19 2019-04-19 具有mage-b2特异性的t细胞受体及其用途 Active CN112236447B (zh)

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US201862660083P 2018-04-19 2018-04-19
US62/660,083 2018-04-19
PCT/US2019/028239 WO2019204683A1 (en) 2018-04-19 2019-04-19 T cell receptors with mage-b2 specificity and uses thereof

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CN112236447B true CN112236447B (zh) 2023-10-20

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US (2) US12202877B2 (https=)
EP (1) EP3784255B1 (https=)
JP (2) JP7469807B2 (https=)
KR (1) KR102892744B1 (https=)
CN (1) CN112236447B (https=)
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CA3097399A1 (en) 2019-10-24
CN112236447A (zh) 2021-01-15
US20250101079A1 (en) 2025-03-27
JP7761293B2 (ja) 2025-10-28
WO2019204683A1 (en) 2019-10-24
KR20210003767A (ko) 2021-01-12
KR102892744B1 (ko) 2025-11-28
EP3784255A4 (en) 2022-06-22
US20210363215A1 (en) 2021-11-25
EP3784255B1 (en) 2025-09-17
EP3784255A1 (en) 2021-03-03
JP7469807B2 (ja) 2024-04-17
US12202877B2 (en) 2025-01-21
JP2021521776A (ja) 2021-08-30

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