CN112236152A - 使用人脐带组织来源的间充质基质细胞治疗脑性瘫痪和缺氧缺血性脑病的方法 - Google Patents

使用人脐带组织来源的间充质基质细胞治疗脑性瘫痪和缺氧缺血性脑病的方法 Download PDF

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CN112236152A
CN112236152A CN201980032411.XA CN201980032411A CN112236152A CN 112236152 A CN112236152 A CN 112236152A CN 201980032411 A CN201980032411 A CN 201980032411A CN 112236152 A CN112236152 A CN 112236152A
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study
infusion
msc
patient
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J·库茨贝格
J·孙
A·宋
C·M·科滕
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Duke University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Biotechnology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201980032411.XA 2018-04-04 2019-04-04 使用人脐带组织来源的间充质基质细胞治疗脑性瘫痪和缺氧缺血性脑病的方法 Pending CN112236152A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862652818P 2018-04-04 2018-04-04
US62/652,818 2018-04-04
PCT/US2019/025796 WO2019195554A1 (en) 2018-04-04 2019-04-04 Methods of treating cerebral palsy and hypoxic-ischemic encephalopathy using human umbilical cord tissue-derived mesenchymal stromal cells

Publications (1)

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CN112236152A true CN112236152A (zh) 2021-01-15

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CN201980032411.XA Pending CN112236152A (zh) 2018-04-04 2019-04-04 使用人脐带组织来源的间充质基质细胞治疗脑性瘫痪和缺氧缺血性脑病的方法

Country Status (11)

Country Link
US (1) US20210361716A1 (https=)
EP (1) EP3773624A4 (https=)
JP (1) JP2021520353A (https=)
KR (1) KR20210021946A (https=)
CN (1) CN112236152A (https=)
AU (1) AU2019247383B2 (https=)
BR (1) BR112020020288A2 (https=)
CA (1) CA3096037A1 (https=)
IL (1) IL277732A (https=)
SG (1) SG11202009800SA (https=)
WO (1) WO2019195554A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024075676A1 (ja) * 2022-10-03 2024-04-11 キッズウェル・バイオ株式会社 脳性まひの予防又は治療剤
WO2025100424A1 (ja) * 2023-11-10 2025-05-15 国立大学法人 東京大学 急性脳症治療剤及び急性脳症の治療方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1803193A (zh) * 2005-01-13 2006-07-19 中山大学 骨髓来源的间质干细胞用于制备治疗缺氧缺血性脑性瘫痪的制剂的用途
US20070128722A1 (en) * 2005-12-05 2007-06-07 Industrial Technology Research Institute Human mesenchymal stem cells and culturing methods thereof
WO2017204231A1 (ja) * 2016-05-24 2017-11-30 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
CN110461344A (zh) * 2017-01-16 2019-11-15 美迪因诺医疗创新科技有限公司 用于治疗新生儿hie的组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170042944A1 (en) * 2014-04-21 2017-02-16 Anthrogenesis Corporation Treatment of conditions and complications in infants
WO2016019332A1 (en) * 2014-07-29 2016-02-04 Ingeneron, Inc. Method and apparatus for recovery of umbilical cord tissue derived regenerative cells and uses thereof
WO2017144552A1 (en) * 2016-02-22 2017-08-31 Centauri Biotech. S.L. Pharmaceutical or veterinary cell compositions comprising mesenchymal stromal cells (mscs) and dimethyl sulfoxide (dmso)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1803193A (zh) * 2005-01-13 2006-07-19 中山大学 骨髓来源的间质干细胞用于制备治疗缺氧缺血性脑性瘫痪的制剂的用途
US20070128722A1 (en) * 2005-12-05 2007-06-07 Industrial Technology Research Institute Human mesenchymal stem cells and culturing methods thereof
WO2017204231A1 (ja) * 2016-05-24 2017-11-30 国立大学法人 東京大学 臍帯由来細胞を含む脳障害の治療剤
CN110461344A (zh) * 2017-01-16 2019-11-15 美迪因诺医疗创新科技有限公司 用于治疗新生儿hie的组合物

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHARLES MICHAEL COTTEN 等: "Feasibility of Autoiogous Cord Blood Cells for Infants with Hypoxic-Ischemic", 《THE JOURNAL OF PEDIATRICS》 *
HUAJIANG DONG 等: "Umbilical cord mesenchymal stem cell (UC-MSC) transplantations for cerebral", 《AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH》 *
JAMIE ARCHAMBAULT 等: "Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review and meta-analysis of preclinical studies", 《PLOS ONE》 *
LIMING WANG 等: "Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report", 《CASE REPORT》 *
TAKEO MUKAI 等: "INTRAVENOUS INJECTION OF UMBILICAL CORD-DERIVED MESENCHYMAL STROMAL CELLS ATTENUATES REACTIVE GLIOSIS AND HYPOMYELINATION IN A NEONATAL INTRAVENTRICULAR HEMORRHAGE MODEL", 《NEUROSCIENCE》 *

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Publication number Publication date
AU2019247383B2 (en) 2025-11-27
EP3773624A4 (en) 2022-01-12
WO2019195554A1 (en) 2019-10-10
AU2019247383A1 (en) 2020-10-29
KR20210021946A (ko) 2021-03-02
EP3773624A1 (en) 2021-02-17
BR112020020288A2 (pt) 2021-01-12
SG11202009800SA (en) 2020-11-27
IL277732A (en) 2020-11-30
US20210361716A1 (en) 2021-11-25
CA3096037A1 (en) 2019-10-10
JP2021520353A (ja) 2021-08-19

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