CN112222436A - Preparation method of artificial corneal mirror column - Google Patents

Preparation method of artificial corneal mirror column Download PDF

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Publication number
CN112222436A
CN112222436A CN202011059307.0A CN202011059307A CN112222436A CN 112222436 A CN112222436 A CN 112222436A CN 202011059307 A CN202011059307 A CN 202011059307A CN 112222436 A CN112222436 A CN 112222436A
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China
Prior art keywords
column
processing
mirror
artificial
mirror column
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CN202011059307.0A
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Chinese (zh)
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CN112222436B (en
Inventor
史伟云
翟舒平
翟嘉洁
梁成新
杨秉尧
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Guangdong Jiayue Meishi Biotechnology Co ltd
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Guangdong Jiayue Meishi Biotechnology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23B—TURNING; BORING
    • B23B25/00—Accessories or auxiliary equipment for turning-machines
    • B23B25/06—Measuring, gauging, or adjusting equipment on turning-machines for setting-on, feeding, controlling, or monitoring the cutting tools or work
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/04—Cleaning involving contact with liquid
    • B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
    • B08B3/12—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration by sonic or ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23B—TURNING; BORING
    • B23B25/00—Accessories or auxiliary equipment for turning-machines
    • B23B25/02—Arrangements for chip-breaking in turning-machines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23Q—DETAILS, COMPONENTS, OR ACCESSORIES FOR MACHINE TOOLS, e.g. ARRANGEMENTS FOR COPYING OR CONTROLLING; MACHINE TOOLS IN GENERAL CHARACTERISED BY THE CONSTRUCTION OF PARTICULAR DETAILS OR COMPONENTS; COMBINATIONS OR ASSOCIATIONS OF METAL-WORKING MACHINES, NOT DIRECTED TO A PARTICULAR RESULT
    • B23Q11/00—Accessories fitted to machine tools for keeping tools or parts of the machine in good working condition or for cooling work; Safety devices specially combined with or arranged in, or specially adapted for use in connection with, machine tools
    • B23Q11/0042—Devices for removing chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
    • B23Q—DETAILS, COMPONENTS, OR ACCESSORIES FOR MACHINE TOOLS, e.g. ARRANGEMENTS FOR COPYING OR CONTROLLING; MACHINE TOOLS IN GENERAL CHARACTERISED BY THE CONSTRUCTION OF PARTICULAR DETAILS OR COMPONENTS; COMBINATIONS OR ASSOCIATIONS OF METAL-WORKING MACHINES, NOT DIRECTED TO A PARTICULAR RESULT
    • B23Q11/00—Accessories fitted to machine tools for keeping tools or parts of the machine in good working condition or for cooling work; Safety devices specially combined with or arranged in, or specially adapted for use in connection with, machine tools
    • B23Q11/10—Arrangements for cooling or lubricating tools or work

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Prostheses (AREA)
  • Eyeglasses (AREA)

Abstract

The invention specifically discloses a preparation method of an artificial corneal mirror column, which is applied to the production process of a collar button type artificial corneal mirror column and comprises the following steps: s1, preparing a processing blank, inputting the processing blank into a numerical control lathe, and taking a transparent bar as the processing blank of the mirror column; s2, processing the processing blank into a mirror column by using a numerical control lathe according to a set processing program; s3, cleaning and drying the lens column; and S4, packaging and sterilizing the lens column. The invention improves the precision and the definition of the collar button type artificial keratoscope column, realizes the batch and standardized production of the collar button type artificial keratoscope column, greatly improves the production efficiency and the qualification rate of finished products, and reduces the risk of pollution of the collar button type artificial keratoscope column in the preparation process.

Description

Preparation method of artificial corneal mirror column
Technical Field
The invention relates to the technical field of biomedical engineering and artificial cornea production, in particular to a preparation method of an artificial corneal microscope column.
Background
In 7 months in 2019, according to the media reports of multiple families such as people network and southern city newspaper: "China independently develops the first collar button type artificial cornea clinical test successfully". This means that the medical application of the domestic collar button type artificial cornea takes an important step and is primarily suitable for clinical application, but the optimization of the structure and the industrialized production of the artificial cornea are still in the process of exploration. As shown in fig. 1 and 6, the neckline keratoprosthesis includes a lens column 1, a back plate 3 as a mounting frame of the lens column 1, and a retainer ring 4 (reference numeral 2 in fig. 1 is a corneal implant) which is fastened to the outer side of one end of the lens column 1. The lens column is made of transparent material with excellent optical characteristics and stable physicochemical properties, and is used for replacing turbid cornea which obstructs an optical pathway of an eyeball after pathological changes, so that good optical resolution is required. The back plate is made of a hard material with good biocompatibility, and a central through hole for mounting the mirror column is formed in the back plate. At present, the common preparation method of the artificial cornea is 3D printing forming or mold injection molding integral forming, the preparation process is relatively complicated and is difficult to adapt to batch and standardized production, the preparation process is easy to be polluted, and the product precision is low, so that the recovery difficulty is increased and the visual definition is reduced.
Disclosure of Invention
In view of the above, there is a need to provide a method for manufacturing a collar button type artificial keratoscope column, which can improve the precision and definition of the collar button type artificial keratoscope column, and can realize batch and standardized production of the collar button type artificial keratoscope column, thereby greatly improving the production efficiency and the qualification rate of finished products, and reducing the risk of contamination of the collar button type artificial keratoscope column during the manufacturing process.
In order to achieve the purpose, the invention adopts the following technical scheme:
a preparation method of an artificial corneal mirror column is applied to the production process of a collar button type artificial corneal mirror column, and comprises the following steps:
s1, preparing a processing blank, and inputting the processing blank into a numerical control lathe; taking a transparent bar as a processing blank of the mirror column;
s2, processing the processing blank into a mirror column by using a numerical control lathe according to a set processing program;
s3, cleaning and drying the formed mirror column;
and S4, packaging and sterilizing the lens column.
Further, in S1, the PMMA particles after the drying process are injection molded using an injection molding machine, thereby obtaining a plurality of transparent rods as a processing blank.
Furthermore, the lens column is mushroom-shaped and comprises an optical umbrella body part and an optical column body part which are sequentially arranged, and an annular groove for clamping a clamping ring is annularly arranged on the outer side surface of the optical column body part; in S2, the machining program forms a machining process by a numerically controlled lathe, the machining process including the steps of:
s212, carrying out outer diameter rough turning on the processed blank according to the outline dimension of the mirror column;
s213, repeatedly finish-turning the end face of the workpiece obtained in the S212;
s214, roughly turning the slots of the workpiece obtained in the step S213 to form a roughly-machined groove structure corresponding to the annular groove;
s215, performing outer diameter finish turning on the workpiece obtained in the S213 according to the outer dimension of the mirror column;
s216, performing slot repeated finish turning on the rough machining groove structure machined in the S215 so as to machine the groove;
s217, performing repeated finish turning on the contour cambered surface of the inner umbrella surface of the optical umbrella body corresponding to the workpiece obtained in the S216;
s218, turning the contour cambered surface of the outer umbrella surface of the optical umbrella body part corresponding to the workpiece obtained in the S217;
and S219, cutting the workpiece obtained in the S218 to obtain a mirror column.
Further, before S212, a step S211 is further provided: and (5) carrying out zero point positioning on the numerical control lathe.
Further, in S3, the processed mirror post is cleaned by an ultrasonic cleaner.
Further, in S2, the nc lathe uses an air flow to remove chips from the workpiece during the machining process.
Further, in S4, the column and its package are sterilized by ethylene oxide and over-sterilization.
Further, in S1, the transparent rod enters the nc lathe through an automatic feeding device.
Further, between S2 and S3, the method further comprises:
s231, cleaning the lens column;
s232, the lens column is detected to remove unqualified products.
The invention has the beneficial effects that:
the invention realizes the automatic feed and tool change processing process of the processing blank by the numerical control lathe according to the processing program, ensures that the processed workpiece meets the clean requirement of the ophthalmic surgery through the cleaning process, and ensures that the cleaned artificial corneal mirror post reaches the E0 grade medical sanitation requirement through the drying treatment, the packaging treatment and the sterilization treatment, thereby realizing the batch and standardized production of the artificial corneal mirror post, greatly improving the production efficiency and the qualification rate of finished products and reducing the risk of pollution of the artificial corneal mirror post in the preparation process. The invention can improve the precision and the definition of the artificial corneal mirror column; the high-precision machining process of the numerical control lathe enables the optical eccentricity of the produced mirror column to be kept within 10 mu m, under high-speed cutting, the surface finish and the resolution of the artificial cornea mirror column meet requirements when the cutting of the numerical control lathe is finished, the later polishing process is omitted, and the optical eccentricity of the mirror column is prevented from being influenced by the change of the curvature of the artificial cornea front plate caused by the polishing process; the numerical control lathe automatically executes the machining process, so that the process that the clamp needs to be mounted again and the tool needs to be changed is omitted, and the production efficiency is improved; the invention improves the biocompatibility, the eccentricity of the high-precision lens column conforms to the eye structure of a human body, and the comfort of a patient after the implantation can be influenced.
Drawings
FIG. 1 is an exploded view of a neckline keratoprosthesis according to the present invention;
FIG. 2 is a flow chart of the operation of a method for manufacturing an artificial corneal mirror cylinder according to the present invention;
FIG. 3 is a feed path and a process diagram of a machining process of the present invention;
FIG. 4 is a microscopic structural view of a keratoprosthesis cylinder produced by the present invention;
FIG. 5 is a microscopic structure view of an artificial keratoscope column produced by a conventional process;
FIG. 6 is a perspective view of a neckline keratoprosthesis according to the present invention with respect to an eyeball;
description of reference numerals:
a lens barrel 1; a corneal implant 2; a rear plate 3; a collar 4; an optical umbrella body portion 11; an optical cylindrical portion 12; an annular groove 121; the blank 100 is processed.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be further clearly and completely described below with reference to the embodiments of the present invention. It should be noted that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", and the like, are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus are not to be construed as limiting the present invention.
Examples
As shown in fig. 1 and 2, a method for manufacturing an artificial keratoscope column is applied to a production process of a collar button type artificial keratoscope column 1, and the method comprises the following steps:
s1, preparing a processing blank, and inputting the processing blank into a numerical control lathe; using a transparent bar as a processing blank 100 of the mirror column 1;
s2, processing the processing blank 100 into the mirror column 1 by using a numerical control lathe according to a set processing program;
s3, cleaning, disinfecting and drying the formed mirror column;
and S4, packaging and sterilizing the lens column.
Specifically, drying treatment is carried out by using a centrifugal drying mode and a plasma fan drying mode;
specifically, under high-speed cutting, the cutting speed related parameters of the numerically controlled lathe are as follows: the cutting speed is 15-80 mm/min, the feed rate is 0.1-0.25 mm/r, and the cutting depth is 0.15-0.2 mm, under the combined condition, the surface smoothness and resolution of the artificial cornea meet the requirements when the cutting of a numerical control lathe is finished, the post-polishing process is omitted, and the optical eccentricity of a lens column is prevented from being influenced due to the change of the curvature of a front plate of the artificial cornea caused by the polishing process.
Further, in S1, the PMMA particles subjected to the drying process are injection molded using an injection molding machine, thereby obtaining a plurality of transparent rods as the processing blank 100.
As shown in fig. 1-3, further, the mirror column 1 is mushroom-shaped, and includes an optical umbrella body 11 and an optical column body 12 that are sequentially arranged, and an annular groove 121 for clamping a collar is annularly arranged on an outer side surface of the optical column body 12; in S2, the machining program forms a machining process by a numerically controlled lathe, the machining process including the steps of:
s212, carrying out outer diameter rough turning on the processed blank 100 according to the external dimension of the mirror column 1;
s213, repeatedly finish-turning the end face of the workpiece obtained in the S212;
s214, roughly turning the insertion grooves of the workpiece obtained in the step S213 to form a roughly-machined groove structure corresponding to the annular groove 121;
s215, performing outer diameter finish turning on the workpiece obtained in the S213 according to the external dimension of the mirror column 1;
s216, performing slot repeated finish turning on the rough-machined groove structure machined in S215, thereby machining the annular groove 121;
s217, performing repeated finish turning on the contour arc surface of the inner umbrella surface of the optical umbrella body part 11 corresponding to the workpiece obtained in the S216;
s218, turning the contour arc surface of the outer umbrella surface of the optical umbrella body part 11 corresponding to the workpiece obtained in the S217;
s219, the workpiece obtained in S218 is cut, and the mirror column 1 is obtained.
Further, before S212, a step S211 is further provided: and (5) carrying out zero point positioning on the numerical control lathe.
The process sequence of the steps S211 to S219 ensures the processing precision of the lens column 1 and improves the production efficiency of the lens column 1, and the fine structure of the processed lens column 1 meets the requirements of ophthalmological biocompatibility and postoperative visual definition.
Further, in S3, the finished lens barrel 1 is cleaned by an ultrasonic cleaning machine.
Further, in S2, the numerically controlled lathe uses an air flow to remove chips and cool the workpiece during the machining process; because the vitrification temperature of PMMA material is about 105 degrees, the material is hard and easy to break, in order to cut the skirt edge of the artificial keratoscope column with the thickness of only 0.02mm (as shown in the white color mark circle at the upper left corner of figure 4), an online cooling system is additionally arranged on the basis of the original numerical control lathe, and the instantaneous cooling is carried out from a specific position at the key cutting time point through programming control, so the cutting speed of the feed of the numerical control lathe can be further accelerated, the PMMA bar material is not required to be fused by worrying about generating overhigh temperature, the artificial keratoscope column with high degree of attachment with the surface of an eyeball is produced, the long-term on-site rate after the artificial keratoscope operation is directly improved, and the discomfort of the ocular surface of a patient after implantation is relieved.
Further, in S4, the column 1 and its package are sterilized by ethylene oxide and over-sterilization; specifically, ethylene oxide is used to sterilize the lens 1 through the packed dialysis paper, and the use of ethylene oxide can prevent the lens 1 from aging during sterilization.
Further, in S1, the transparent rod enters the nc lathe through an automatic feeding device.
Further, between S2 and S3, the method further comprises:
s231, cleaning the mirror column 1;
s232, detecting the lens column 1 to remove unqualified products; the detection process comprises measurement links of size, appearance, optical resolution and the like.
As shown in fig. 4 and 5, by comparing fig. 4 and 5, the advantages of the present invention in terms of processing precision are clearly reflected, and an ultra-thin mirror column skirt can be processed; the lens barrel skirt construction indicated by the white arrow at the top left corner of fig. 5 is produced by conventional techniques and is relatively thick and lacks fineness.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (9)

1. A preparation method of an artificial corneal mirror column is applied to the production process of a collar button type artificial corneal mirror column, and is characterized by comprising the following steps:
s1, preparing a processing blank, and inputting the processing blank into a numerical control lathe; taking a transparent bar as a processing blank of the mirror column;
s2, processing the processing blank into a mirror column by using a numerical control lathe according to a set processing program;
s3, cleaning and drying the formed mirror column;
and S4, packaging and sterilizing the lens column.
2. The method of claim 1, wherein in S1, the dried PMMA particles are injection molded by an injection molding machine to obtain a plurality of transparent rods as a processing blank.
3. The method for preparing the artificial keratoscope column as claimed in claim 1, wherein the column is mushroom-shaped and comprises an optical umbrella body part and an optical cylinder body part which are arranged in sequence, and an annular groove for clamping a clamping ring is annularly arranged on the outer side surface of the optical cylinder body part; in S2, the machining program forms a machining process by a numerically controlled lathe, the machining process including the steps of:
s212, carrying out outer diameter rough turning on the processed blank according to the outline dimension of the mirror column;
s213, repeatedly finish-turning the end face of the workpiece obtained in the S212;
s214, roughly turning the slots of the workpiece obtained in the step S213 to form a roughly-machined groove structure corresponding to the annular groove;
s215, performing outer diameter finish turning on the workpiece obtained in the S213 according to the outer dimension of the mirror column;
s216, performing slot repeated finish turning on the rough machining groove structure machined in the S215 so as to machine the groove;
s217, performing repeated finish turning on the contour cambered surface of the inner umbrella surface of the optical umbrella body corresponding to the workpiece obtained in the S216;
s218, turning the contour cambered surface of the outer umbrella surface of the optical umbrella body part corresponding to the workpiece obtained in the S217;
and S219, cutting the workpiece obtained in the S218 to obtain a mirror column.
4. The method for preparing an artificial keratoscope post according to claim 3, further comprising a step S211 before S212: and (5) carrying out zero point positioning on the numerical control lathe.
5. The method for producing a keratoprosthesis cylinder according to claim 1, wherein in S3, the post-processing cylinder is cleaned with an ultrasonic cleaning machine.
6. The method for producing a keratoprosthesis cylinder as claimed in claim 1, wherein in S2, the numerical control lathe uses an air flow to remove chips from the work piece during the machining process.
7. The method of claim 1, wherein in step S4, the lens and its package are sterilized by ethylene oxide and over-sterilization.
8. The method for preparing a keratoprosthesis cylinder according to claim 1, wherein in S1, the transparent rod is fed into a numerically controlled lathe by an automatic feeding device.
9. The method for preparing an artificial keratoscope post as claimed in claim 1, further comprising between S2 and S3:
s231, cleaning the lens column;
s232, the lens column is detected to remove unqualified products.
CN202011059307.0A 2020-04-13 2020-09-30 Preparation method of artificial corneal mirror column Active CN112222436B (en)

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CN202010286647 2020-04-13

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772283A (en) * 1986-05-16 1988-09-20 White Thomas C Corneal implant
US20100168849A1 (en) * 2007-05-24 2010-07-01 The Board Of Trustees Of The University Of Iiiinois Transcorneal vision assistance device
CN103722182A (en) * 2013-12-12 2014-04-16 郑丽萍 Method for turning germanium lens
CN204379849U (en) * 2014-12-02 2015-06-10 浙江大学 The collapsible artificial cornea of the front and rear surfaces difference modification that a kind of Nano ultrathin biomembrane is modified
US20170156925A1 (en) * 2006-07-11 2017-06-08 Refocus Group, Inc. Apparatus and method for securing ocular tissue
US20180279876A1 (en) * 2015-10-05 2018-10-04 Massachusetts Eye And Ear Infirmary Measurement of intraocular pressure
CN109069265A (en) * 2016-04-08 2018-12-21 马萨诸塞眼科耳科诊所 artificial cornea device, system and method
CN110123520A (en) * 2019-05-21 2019-08-16 广东普洛宇飞生物科技有限公司 A kind of amnion stealth contact lense, preparation method and application
CN110613862A (en) * 2019-09-19 2019-12-27 清华大学深圳国际研究生院 Tissue engineering cornea and preparation method thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772283A (en) * 1986-05-16 1988-09-20 White Thomas C Corneal implant
US20170156925A1 (en) * 2006-07-11 2017-06-08 Refocus Group, Inc. Apparatus and method for securing ocular tissue
US20100168849A1 (en) * 2007-05-24 2010-07-01 The Board Of Trustees Of The University Of Iiiinois Transcorneal vision assistance device
CN103722182A (en) * 2013-12-12 2014-04-16 郑丽萍 Method for turning germanium lens
CN204379849U (en) * 2014-12-02 2015-06-10 浙江大学 The collapsible artificial cornea of the front and rear surfaces difference modification that a kind of Nano ultrathin biomembrane is modified
US20180279876A1 (en) * 2015-10-05 2018-10-04 Massachusetts Eye And Ear Infirmary Measurement of intraocular pressure
CN109069265A (en) * 2016-04-08 2018-12-21 马萨诸塞眼科耳科诊所 artificial cornea device, system and method
CN110123520A (en) * 2019-05-21 2019-08-16 广东普洛宇飞生物科技有限公司 A kind of amnion stealth contact lense, preparation method and application
CN110613862A (en) * 2019-09-19 2019-12-27 清华大学深圳国际研究生院 Tissue engineering cornea and preparation method thereof

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