CN112220869A - Composition, preparation method and application thereof in burn and scald medicines - Google Patents
Composition, preparation method and application thereof in burn and scald medicines Download PDFInfo
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- CN112220869A CN112220869A CN201910564144.2A CN201910564144A CN112220869A CN 112220869 A CN112220869 A CN 112220869A CN 201910564144 A CN201910564144 A CN 201910564144A CN 112220869 A CN112220869 A CN 112220869A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The invention belongs to the technical field of drug research and development, and particularly relates to a composition, a preparation method and application thereof in burn and scald drugs. The invention provides a composition, which comprises the following raw materials: brine, pork, white sugar, edible salt, aloe, mint and honey. The invention also provides a preparation method of the composition, and application of the composition or a product obtained by the preparation method in burn and scald medicines. The product prepared by the invention can be directly applied to an affected part after burns and scalds, can achieve the effects of defervescence and analgesia at the first time, and effectively inhibits the development of injury; meanwhile, the blisters can disappear automatically without leaving scars, and the use of extra scar-removing medicines is not needed. The composition, the preparation method and the application of the composition in the burn and scald medicine provided by the invention solve the technical defects that the burn and scald medicine cannot be timely treated after the burn and scald, the development of the wound condition is inhibited, and the effects of removing scars and removing scars are poor in the prior art.
Description
Technical Field
The invention belongs to the technical field of drug research and development, and particularly relates to a composition, a preparation method and application thereof in burn and scald drugs.
Background
Burn, which generally refers to thermal injury, includes tissue damage caused by hot liquid (water, soup, oil, etc.), steam, high temperature gas, flame, hot metal liquid or solid (such as molten steel, steel ingot), and the like, mainly refers to skin and/or mucous membrane, and serious people can also injure subcutaneous or/and submucosal tissues, such as muscle, bone, joint and even viscera. Scalding is the damage of tissue caused by flameless high temperature liquids (boiling water, hot oil, molten steel), high temperature solids (burning hot metals, etc.) or high temperature steam, etc.
In the prior art, burn and scald medicines are used for diminishing inflammation and detoxifying and preventing erosion, are not used for treating severe pain and blister stage when burns and scalds just happen, and cannot treat and inhibit wound development in time after the burns and scalds happen; moreover, the burn and scald medicine has poor effect on removing scars, and needs to be matched with a special scar-removing medicine or even skin grafting.
Therefore, the development of a composition, a preparation method and an application thereof in burn and scald medicines is developed for solving the technical defects that the burn and scald medicines cannot be timely treated after burns and scalds, the development of wounds is inhibited, and the effects of removing scars and scars are poor in the prior art, and the problems to be solved by the technical staff in the field are urgently needed.
Disclosure of Invention
In view of the above, the invention provides a composition, a preparation method and an application thereof in burn and scald medicines, and aims to solve the technical defects that burn and scald medicines cannot be timely treated after burns and scalds, the development of wounds is inhibited, and the effects of removing scars and removing scars are poor in the prior art.
The invention provides a composition, which comprises the following raw materials: brine, pork, white sugar, edible salt, aloe, mint and honey.
Preferably, the raw materials of the composition comprise, by mass: 1-10 parts of brine, 1-5 parts of pork, 10-80 parts of white sugar, 10-80 parts of edible salt, 1-10 parts of aloe, 1-10 parts of mint and 1-10 parts of honey.
Preferably, the bittern is an aqueous solution of mineral salt, and the concentration of the aqueous solution of mineral salt is 30%.
The invention also provides a preparation method of the composition, which comprises the following steps:
step one, mixing brine, white sugar and pork, and sealing and fermenting to obtain a first product;
step two, boiling the pork in the first product into oil, and collecting the boiled lard as a second product;
step three, peeling aloe, mixing with mint, and stirring to obtain a third product;
and step four, mixing the honey, the second product, the brine in the first product and the third product, stirring for the first time to form paste, mixing the paste with sugar and salt, and stirring for the second time to form paste to obtain the product.
Preferably, in the step one, the temperature of the sealed fermentation is 10-20 ℃, and the time of the sealed fermentation is 360-1080 days.
Preferably, in the second step, the oil boiling temperature is 30-180 ℃, and the oil boiling time is 0.2-0.7 h.
Preferably, in the third step, the rotation speed of the stirring is 60-100 rpm, and the stirring time is 10-30 min.
Preferably, the method is characterized in that in the fourth step, the rotating speed of the first stirring is 60-100 rpm, and the time of the first stirring is 10-30 min;
in the fourth step, the rotation speed of the second stirring is 60-100 rpm, and the time of the second stirring is 10-30 min.
Preferably, in the fourth step, the particle size of the salt is 200-300 meshes, and the particle size of the sugar is 200-300 meshes.
The invention also provides application of the composition or the product obtained by the preparation method in preparing a burn and scald medicine.
In summary, the present invention provides a composition, which comprises the following raw materials: brine, pork, white sugar, edible salt, aloe, mint and honey. The invention also provides a preparation method of the composition, and application of the composition or a product obtained by the preparation method in burn and scald medicines. The product prepared by the technical scheme can be directly applied to an affected part after burns and scalds, can achieve the effects of defervescence and analgesia at the first time, and effectively inhibits the development of injury; meanwhile, the blisters can disappear automatically without leaving scars, and the use of extra scar-removing medicines is not needed. The composition, the preparation method and the application of the composition in the burn and scald medicine provided by the invention solve the technical defects that the burn and scald medicine cannot be timely treated after the burn and scald, the development of the wound condition is inhibited, and the effects of removing scars and removing scars are poor in the prior art.
Detailed Description
The invention provides a composition, a preparation method and application thereof in burn and scald medicines, which are used for solving the technical defects that the burn and scald medicines cannot be timely treated after burns and scalds, inhibit wound development and have poor effects of removing scars and removing scars in the prior art.
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to illustrate the invention in more detail, the following embodiment is used to specifically describe a composition, a preparation method and an application thereof in the medicine for treating burns and scalds.
Example 1
The invention relates to a specific embodiment for preparing a burn and scald medicine product 1.
Mixing 100kg of brine, 10kg of white sugar and 50kg of pork, and fermenting in a sealed environment at 20 ℃ for 360 days in a shady, dry and ventilated environment to obtain a first product 1; in this example, the brine is a 30% aqueous solution of mineral salts.
Fishing out the pork in the first product 1, reserving the residual brine for later use, heating the fished pork at 180 ℃ for 0.2h to decoct, and collecting the decocted lard as a second product 1.
Peeling 1kg of Aloe Vera, mixing with 5kg of herba Menthae, and stirring at 100rpm for 15min to obtain a third product 1.
1kg of honey, brine in the first product 1, the second product 1 and the third product 1 are mixed and stirred for 15min at the speed of 60rpm to form paste, and the obtained paste is mixed with 30kg of sugar and 10kg of salt and stirred for 30min at the speed of 30rpm to form paste, so that the product 1 is obtained; in this embodiment, the particle size of the salt is 200 to 300 mesh, and the particle size of the sugar is 200 to 300 mesh.
Example 2
The invention relates to a specific embodiment for preparing a burn and scald medicine product 2.
Mixing 100kg of bittern, 10kg of white sugar and 50kg of pork, and fermenting in a shady, dry and ventilated environment at 10 deg.C for 1080 days in a sealed manner to obtain a first product 2; in this example, the brine is a 30% aqueous solution of mineral salts.
Fishing out the pork in the first product 2, reserving the residual brine for later use, heating the fished pork at 100 ℃ for 0.7h to decoct, and collecting the decocted lard as a second product 2.
Peeling 6kg Aloe vera, mixing with 10kg herba Menthae, and stirring at 80rpm for 10min to obtain third product 2.
Mixing 10kg of honey, the brine in the first product 2, the second product 2 and the third product 2, stirring at 30rpm for 30min to form paste, mixing the obtained paste with 20kg of sugar and 60kg of salt, and stirring at 100rpm for 20min to form paste to obtain a product 2; in this embodiment, the salt has a particle size of 200 to 300 mesh, and the sugar has a particle size of 200 to 300 mesh
Example 3
The invention relates to a specific embodiment for preparing a burn and scald medicine product 3.
Mixing 100kg of bittern, 10kg of white sugar and 50kg of pork, and fermenting in a shady, dry and ventilated environment at 15 deg.C for 600 days under sealed condition to obtain a first product 3; in this example, the brine is a 30% aqueous solution of mineral salts.
Fishing out the pork in the first product 3, reserving the residual brine for later use, heating the fished pork at 30 ℃ for 0.6h to boil, and collecting the boiled lard as a second product 3.
10kg of aloe is peeled and mixed with 1kg of mint, and stirred at 60rpm for 30min to obtain a third product 3.
Mixing 3kg of honey, brine in the first product 3, the second product 3 and the third product 3, stirring at 100rpm for 10min to form paste, mixing the obtained paste with 5kg of sugar and 80kg of salt, and stirring at 70rpm for 10min to form paste to obtain a product 3; in this embodiment, the particle size of the salt is 200 to 300 mesh, and the particle size of the sugar is 200 to 300 mesh.
Example 4
This example is a specific example of the measurement of the products 1 to 3 obtained in examples 1 to 3 for burn and scald treatment.
50 tested volunteers of clinical burn and scald patients are collected, any one of the products 1 to 3 is directly externally applied to the patients in emergency treatment, the pain relieving time, the red and swollen eliminating time, the blister removing time and the skin scar and scab tissue softening time of each tested volunteer are collected, and the average value of each time is collected.
Data collection and statistics show that the medicine can be applied to the burn and scald wound, pain can be achieved within 3-5 min, redness disappears within 3-5 h, water bubbles disappear automatically within 10-12 h, and scar and crust tissues of the skin can be softened within 20-48 h.
Long-term monitoring shows that the scar can be effectively removed by insisting on applying the product prepared by the embodiment of the invention, and extra medicines such as scar removing cream and the like are not needed.
The product prepared by the technical scheme provided by the embodiment of the invention can be directly coated without treating the wound surface after burns and scalds, so that the development of the wound can be inhibited in time, scars can be lightened, an additional scar-removing medicine is not required, and the use is more convenient.
In summary, the present invention provides a composition, which comprises the following raw materials: brine, pork, white sugar, edible salt, aloe, mint and honey. The invention also provides a preparation method of the composition, and application of the composition or a product obtained by the preparation method in burn and scald medicines. The product prepared by the technical scheme can be directly applied to an affected part after burns and scalds, can achieve the effects of defervescence and analgesia at the first time, and effectively inhibits the development of injury; meanwhile, the blisters can disappear automatically without leaving scars, and the use of extra scar-removing medicines is not needed. The composition, the preparation method and the application of the composition in the burn and scald medicine provided by the invention solve the technical defects that the burn and scald medicine cannot be timely treated after the burn and scald, the development of the wound condition is inhibited, and the effects of removing scars and removing scars are poor in the prior art.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A composition characterized in that the raw materials of said composition comprise: brine, pork, white sugar, edible salt, aloe, mint and honey.
2. The composition according to claim 1, wherein the composition comprises the following raw materials in parts by mass: 1-10 parts of brine, 1-5 parts of pork, 10-80 parts of white sugar, 10-80 parts of edible salt, 1-10 parts of aloe, 1-10 parts of mint and 1-10 parts of honey.
3. The composition of claim 1, wherein the brine is an aqueous mineral salt solution having a concentration of 30%.
4. A process for the preparation of a composition comprising any one of claims 1 to 3, wherein the process comprises:
step one, mixing brine, white sugar and pork, and sealing and fermenting to obtain a first product;
step two, boiling the pork in the first product into oil, and collecting the boiled lard as a second product;
step three, peeling aloe, mixing with mint, and stirring to obtain a third product;
and step four, mixing the honey, the second product, the brine in the first product and the third product, stirring for the first time to form paste, mixing the paste with sugar and salt, and stirring for the second time to form paste to obtain the product.
5. The preparation method according to claim 4, wherein in the first step, the temperature of the sealed fermentation is 10-20 ℃, and the time of the sealed fermentation is 360-1080 days.
6. The preparation method according to claim 4, wherein in the second step, the oil boiling temperature is 30-180 ℃, and the oil boiling time is 0.2-0.7 h.
7. The preparation method according to claim 4, wherein in the third step, the rotation speed of the stirring is 60-100 rpm, and the stirring time is 10-30 min.
8. The preparation method according to claim 4, wherein in the fourth step, the rotation speed of the first stirring is 60-100 rpm, and the time of the first stirring is 10-30 min;
in the fourth step, the rotation speed of the second stirring is 60-100 rpm, and the time of the second stirring is 10-30 min.
9. The method according to claim 4, wherein in the fourth step, the particle size of the salt is 200 to 300 mesh, and the particle size of the sugar is 200 to 300 mesh.
10. Use of a composition according to any one of claims 1 to 3 or a product obtained by the process according to any one of claims 4 to 9 in the preparation of a medicament for treating burns and scalds.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910564144.2A CN112220869A (en) | 2019-06-26 | 2019-06-26 | Composition, preparation method and application thereof in burn and scald medicines |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910564144.2A CN112220869A (en) | 2019-06-26 | 2019-06-26 | Composition, preparation method and application thereof in burn and scald medicines |
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| CN112220869A true CN112220869A (en) | 2021-01-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910564144.2A Pending CN112220869A (en) | 2019-06-26 | 2019-06-26 | Composition, preparation method and application thereof in burn and scald medicines |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679640A (en) * | 2005-01-25 | 2005-10-12 | 刘述余 | Medicine for treating burn and scald |
| CN1977943A (en) * | 2005-12-09 | 2007-06-13 | 方昌阁 | Topical burn composition |
| CN101601799A (en) * | 2009-07-17 | 2009-12-16 | 梁小松 | A kind of medicine that is used for the treatment of scald |
-
2019
- 2019-06-26 CN CN201910564144.2A patent/CN112220869A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679640A (en) * | 2005-01-25 | 2005-10-12 | 刘述余 | Medicine for treating burn and scald |
| CN1977943A (en) * | 2005-12-09 | 2007-06-13 | 方昌阁 | Topical burn composition |
| CN101601799A (en) * | 2009-07-17 | 2009-12-16 | 梁小松 | A kind of medicine that is used for the treatment of scald |
Non-Patent Citations (3)
| Title |
|---|
| 唐世华，刘文银，马艳红主编: "《家用小验方》", 28 February 2014, 人民军医出版社 * |
| 永城县革命委员会文教卫生局: "《土单验方中草药汇编》", 31 December 1970 * |
| 盛华海主编: "《德医博集》", 30 June 2017, 天津科学技术出版社 * |
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Application publication date: 20210115 |