CN112213454A - Pharmaceutical chemical intermediate production process gas analysis pretreatment system - Google Patents
Pharmaceutical chemical intermediate production process gas analysis pretreatment system Download PDFInfo
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- CN112213454A CN112213454A CN202011193418.0A CN202011193418A CN112213454A CN 112213454 A CN112213454 A CN 112213454A CN 202011193418 A CN202011193418 A CN 202011193418A CN 112213454 A CN112213454 A CN 112213454A
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- 239000000126 substance Substances 0.000 title claims abstract description 32
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 26
- 238000004868 gas analysis Methods 0.000 title claims abstract description 18
- 238000005070 sampling Methods 0.000 claims abstract description 63
- 239000007788 liquid Substances 0.000 claims abstract description 45
- 239000012535 impurity Substances 0.000 claims abstract description 40
- 238000007791 dehumidification Methods 0.000 claims abstract description 26
- 238000000926 separation method Methods 0.000 claims abstract description 22
- 238000001914 filtration Methods 0.000 claims abstract description 12
- 239000003960 organic solvent Substances 0.000 claims abstract description 12
- 239000000428 dust Substances 0.000 claims abstract description 8
- 239000011859 microparticle Substances 0.000 claims abstract description 4
- 239000007789 gas Substances 0.000 claims description 100
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000009833 condensation Methods 0.000 claims description 17
- 230000005494 condensation Effects 0.000 claims description 17
- 239000000543 intermediate Substances 0.000 claims description 17
- 238000011010 flushing procedure Methods 0.000 claims description 15
- 238000005406 washing Methods 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 9
- 239000007924 injection Substances 0.000 claims description 9
- 230000000087 stabilizing effect Effects 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 238000005086 pumping Methods 0.000 claims description 8
- 239000012450 pharmaceutical intermediate Substances 0.000 claims description 5
- 238000011282 treatment Methods 0.000 abstract description 10
- 238000001816 cooling Methods 0.000 abstract description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- 150000002632 lipids Chemical class 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000007664 blowing Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000001471 micro-filtration Methods 0.000 description 3
- 238000005057 refrigeration Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/007—Arrangements to check the analyser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/007—Arrangements to check the analyser
- G01N33/0072—Arrangements to check the analyser by generating a test gas
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- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses a gas analysis pretreatment system in a pharmaceutical and chemical intermediate production process, which comprises an impurity removal unit, a dehumidification unit, a separation unit, a precise filtration unit, a gas sensor and a sampling unit, wherein the impurity removal unit, the dehumidification unit, the separation unit, the precise filtration unit, the gas sensor and the sampling unit are sequentially communicated through a pipeline; the impurity removal unit is used for removing organic solvent and dust in the gas to be detected; the separation unit is used for separating a gaseous substance and a liquid substance; the precise filtering unit is used for removing micro-particles and micro-droplet components in the gas to be detected; the gas sensor is used for detecting the gas content in the gas to be detected. The system integrally carries out a series of treatments of impurity removal, dehumidification and cooling on the gas to be detected through a plurality of equipment units, provides stable and safe gas to be detected for the gas analysis instrument, ensures that the instrument runs reliably for a long time, and simultaneously, the highly reliable gas treatment system to be detected also greatly improves the safety factor.
Description
Technical Field
The invention relates to the field of gas analysis, in particular to a pretreatment system for gas to be detected in the production process of pharmaceutical and chemical intermediates.
Background
The pharmaceutical intermediate industry is an important link in a product chain from pharmaceutical and chemical raw materials to bulk drugs and medicines, spans two industries of chemical industry and medicine, belongs to the industries with high pollution and high environmental risk, and particularly has serious harm to the atmospheric environment and human health due to volatile organic compounds (called VOCs for short) generated in the production process of the pharmaceutical intermediate. The reaction kettle and the centrifuge are used as production equipment of the medical intermediate, and are very easy to catch fire and explode in operation, and the gas content (such as oxygen content) of the inner cavity needs to be controlled, so that danger is prevented. At present, the common solution is nitrogen charging replacement or simple gas analyzer addition. Because centrifuge, reation kettle throw the material mostly organic solvent such as benzene class, alcohols, lipids, very easily corrode the gas sensor, lead to the unable normal work of instrument, need take pretreatment systems to carry out gas concentration detection to delivering to the gas sensor after the gas purification treatment to await measuring again.
Disclosure of Invention
The invention provides a gas analysis pretreatment system in a pharmaceutical and chemical intermediate production process, which solves the problem that instruments cannot normally work due to the fact that materials fed into a centrifugal machine and a reaction kettle are mostly organic solvents such as benzene, alcohols and lipids and are very easy to corrode a gas sensor in the pharmaceutical and chemical intermediate production process.
The technical scheme adopted by the invention is as follows:
in a first aspect, the invention provides a gas analysis pretreatment system in a pharmaceutical and chemical intermediate production process, which comprises an impurity removal unit, a dehumidification unit, a separation unit, a precise filtration unit, a gas sensor and a sampling unit which are sequentially communicated through a pipeline, wherein,
the sampling unit is used for taking out gas to be detected from the pharmaceutical intermediate production equipment;
the impurity removal unit is used for removing organic solvent and dust in the gas to be detected; the impurity removal unit is communicated with a sampling port of the production equipment through a pipeline;
the dehumidification unit is used for removing gaseous water and liquid water in the gas to be detected;
the separation unit is used for separating a gaseous substance and a liquid substance;
the precise filtering unit is used for removing micro-particles and micro-droplet components in the gas to be detected;
the gas sensor is used for detecting the gas content in the gas to be detected.
According to the technology, materials fed by a centrifugal machine and a reaction kettle are mostly organic solvents such as benzene, alcohol and lipid, so that the gas sensor is easy to corrode, the instrument cannot work normally, the organic solvents and dust in the gas to be detected are removed through the impurity removal unit, and the gas to be detected is prevented from corroding the gas sensor; the system integrally carries out a series of treatments of impurity removal, dehumidification and cooling on the gas to be detected through a plurality of equipment units, provides stable and safe gas to be detected for the gas analysis instrument, ensures that the instrument runs reliably for a long time, and simultaneously, the highly reliable gas treatment system to be detected also greatly improves the safety factor.
In one possible design, the sampling unit comprises a pumping device arranged on the duct path; the sampling unit further comprises one or more of a flow meter, a pressure maintaining valve and a flow stabilizing valve arranged on the pipeline path.
In one possible design, the sampling port is provided with a shut-off valve. When stopping the sampling, the stop valve is used for closing pipeline air supply export, through the installation stop valve, conveniently controls the air supply export.
In one possible design, the impurity removal unit comprises a closed container for containing a water washing solvent, and the container is provided with a first gas inlet and a first gas outlet for leading out gas to be detected; one end of the first air inlet is arranged below the liquid level of the water washing solvent, and the first air outlet is arranged above the liquid level of the water washing solvent. The gas to be detected contacts with the water washing solvent through the first air inlet, benzene, alcohol and lipid substances and dust in the gas to be detected are removed by the water washing solvent, and the residual gas is discharged out of the container through the first air outlet, so that impurity removal of the gas to be detected is realized.
In one possible design, the impurity removing unit further comprises a liquid injection port arranged above the container and a liquid discharge port arranged at the bottom of the container; the liquid injection port is provided with a first switch device, and the liquid discharge port is provided with a second switch device; the first switch device and the second switch device are electromagnetic valves or pumps. When the switch device is an electromagnetic valve, the electromagnetic valve can be controlled to control the injection or discharge of liquid; when the switching device is a pump, the pump is used for actively injecting liquid or pumping out liquid, so that the washing solvent can be quickly replaced, and the practicability is enhanced.
In one possible design, the dehumidification unit is a condensation dehumidification device, and the condensation dehumidification device comprises a condensation cavity and a refrigerator; the refrigerator is used for reducing the temperature of the condensation cavity. Through condensation dehydrating unit, the gas that awaits measuring is in by cooling in the condensation chamber, steam is appeared from the gas that awaits measuring, realizes the dehumidification of the gas that awaits measuring.
In one possible design, the microfiltration unit is an activated carbon filter.
In a possible design, the device further comprises a back-blowing device; the back flushing device is communicated with the sampling unit through a pipeline, the back flushing device is communicated with the compressed air tank, and the pipeline in the sampling unit is cleaned through the compressed air tank. Through setting up the blowback device, utilize the compressed air jar to blow and spout the washing to the pipeline of sample connection, prevent that sample connection impurity is too much, influence the sampling, can play the gaseous impurity effect of reduction sampling, the work that reduces the edulcoration unit accords with, strengthens this system's practicality.
In one possible design, the device further comprises a calibration device; the calibration device comprises a standard gas tank, a pressure stabilizing valve and a flow valve which are sequentially communicated through a pipeline; the calibration device is communicated with the gas sensor.
In one possible design, the control device comprises a controller, and a solenoid valve and a detector which are electrically connected with the controller;
the electromagnetic valve comprises a sampling valve, a calibration valve, a back flushing valve and a refrigerating valve: wherein,
the sampling valve is connected between the sampling port and the impurity removal unit; and during sampling, opening the sampling valve, and closing the back flushing valve and the calibration valve.
The calibration valve is connected between the calibration device and the gas sensor; and during calibration, opening the calibration valve, closing the sampling valve, and introducing a standard gas tank into the gas sensor for calibration.
The blowback valve is connected to a pipeline between the compressed air tank and the sampling port; and during back flushing, opening a back flushing valve, closing the sampling valve, and purging and cleaning the sampling unit.
A refrigerating valve connected to a pipe between the refrigerator and the compressed air tank; when refrigerating, the refrigerating valve is opened, the compressed air tank is introduced into the refrigerator, and the refrigerator can be driven by the power supply to refrigerate.
The detector comprises a pressure detector, a flow detector and a temperature detector; the detector is arranged between the sampling port and the gas sensor and is used for detecting pressure, flow and temperature parameters in the pretreatment system.
The invention has the following advantages and beneficial effects:
1. according to the technology, materials fed by a centrifugal machine and a reaction kettle are mostly organic solvents such as benzene, alcohols and lipids, so that the gas sensor is easily corroded, the instrument cannot normally work, the organic solvents and dust in the gas to be detected are removed through an impurity removal unit, and the gas sensor is prevented from being corroded by the gas to be detected; the system integrally carries out a series of treatments of impurity removal, dehumidification and cooling on the gas to be detected through a plurality of equipment units, provides stable and safe gas to be detected for the gas analysis instrument, ensures that the instrument runs reliably for a long time, and greatly improves the safety factor of the highly reliable gas treatment system to be detected;
2. according to the invention, the liquid injection port and the liquid discharge port of the impurity removal unit are provided with the switch devices, and when the switch devices are electromagnetic valves, the electromagnetic valves can be controlled to control the injection of liquid or the discharge of liquid, and when the switch devices are pumps, the pumps are used for actively injecting liquid or extracting liquid, so that the washing solvent can be quickly replaced, and the practicability is enhanced;
3. according to the invention, the back blowing device is arranged, and the compressed air tank is used for blowing and cleaning the pipeline of the sampling port, so that excessive impurities at the sampling port are prevented from affecting sampling, the function of reducing the impurities of the sampled gas can be achieved, the working conformity of the impurity removal unit is reduced, and the practicability of the system is enhanced.
Drawings
The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1 is a connection block diagram of the present invention.
FIG. 2 shows an arrangement of a sampling unit according to an embodiment of the present invention.
FIG. 3 shows the arrangement of the gas-liquid separator in the embodiment of the present invention.
Fig. 4 is a block diagram of modules in an embodiment of the invention.
The reference numbers in the figures are:
the method comprises the following steps of 1-sampling unit, 2-impurity removal unit, 3-dehumidification unit, 4-separation unit, 5-precision filtration unit, 6-gas sensor, 101-sampling port, 102-pumping unit, 401-first gas-liquid separation device, and 402-second gas-liquid separation device.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention.
It should be understood that the terms first, second, etc. are used merely for distinguishing between descriptions and are not intended to indicate or imply relative importance. Although the terms first, second, etc. may be used herein to describe various elements, these elements should not be limited by these terms. These terms are only used to distinguish one element from another. For example, a first element could be termed a second element, and, similarly, a second element could be termed a first element, without departing from the scope of example embodiments of the present invention.
It will be understood that when an element is referred to as being "connected," "connected," or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may be present. In contrast, when an element is referred to as being "directly adjacent" or "directly coupled" to another element, there are no intervening elements present. Other words used to describe the relationship between elements should be interpreted in a similar manner (e.g., "between … …" versus "directly between … …", "adjacent" versus "directly adjacent", etc.).
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," and "connected" are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises," "comprising," "includes," and/or "including," when used herein, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, numbers, steps, operations, elements, components, and/or groups thereof; the term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, may mean: a exists alone, B exists alone, and A and B exist at the same time, and the term "/and" is used herein to describe another association object relationship, which means that two relationships may exist, for example, A/and B, may mean: a alone, and both a and B alone, and further, the character "/" in this document generally means that the former and latter associated objects are in an "or" relationship.
It should also be noted that, in some alternative implementations, the functions/acts noted may occur out of the order noted in the figures. For example, two figures shown in succession may, in fact, be executed substantially concurrently, or the figures may sometimes be executed in the reverse order, depending upon the functionality/acts involved.
It should be understood that specific details are provided in the following description to facilitate a thorough understanding of example embodiments. However, it will be understood by those of ordinary skill in the art that the example embodiments may be practiced without these specific details. For example, systems may be shown in block diagrams in order not to obscure the examples in unnecessary detail. In other instances, well-known processes, structures and techniques may be shown without unnecessary detail in order to avoid obscuring example embodiments.
Example 1:
as shown in fig. 1, the present embodiment provides, in a first aspect, a gas analysis pretreatment system for a pharmaceutical chemical intermediate production process, comprising an impurity removal unit 2, a dehumidification unit 3, a separation unit 4, a precise filtration unit 5, a gas sensor 6, and a sampling unit 1 disposed on a pipeline, which are sequentially connected by a pipeline, wherein,
the sampling unit is used for taking out gas to be detected from the pharmaceutical intermediate production equipment;
the impurity removal unit is used for removing organic solvent and dust in the gas to be detected; the impurity removal unit is communicated with a sampling port 101 of the production equipment;
the dehumidification unit is used for removing gaseous water and liquid water in the gas to be detected;
the separation unit is used for separating a gaseous substance and a liquid substance;
the precise filtering unit is used for removing micro-particles and micro-droplet components in the gas to be detected;
the gas sensor is used for detecting the gas content in the gas to be detected.
According to the technology, materials fed by a centrifugal machine and a reaction kettle are mostly organic solvents such as benzene, alcohol and lipid, so that the gas sensor is easy to corrode, the instrument cannot work normally, the organic solvents and dust in the gas to be detected are removed through the impurity removal unit, and the gas to be detected is prevented from corroding the gas sensor; the system integrally carries out a series of treatments of impurity removal, dehumidification and cooling on the gas to be detected through a plurality of equipment units, provides stable and safe gas to be detected for the gas analysis instrument, ensures that the instrument runs reliably for a long time, and simultaneously, the highly reliable gas treatment system to be detected also greatly improves the safety factor.
In one possible design, the sampling unit comprises a pumping device 102 disposed on the tubing path; the pumping device can be arranged at any position in the gas path of the system, for example, as shown in fig. 2 and 4, the pumping device is arranged between the dehumidification unit and the impurity removal unit; the sampling unit further comprises one or more of a flow meter, a pressure maintaining valve and a flow stabilizing valve arranged on the pipeline path. In specific implementation, the pressure stabilizing valve and the flow stabilizing valve are arranged between the gas source and the pumping device and are communicated through a pipeline for stabilizing the pressure and the flow of the gas to be detected; the flowmeter is used for detecting the flow of the gas to be detected.
In one possible design, the sampling port is provided with a shut-off valve; and when the sampling is stopped, the stop valve is used for closing the pipeline air source outlet.
In one possible design, the impurity removal unit comprises a closed container for containing a water washing solvent, and the container is provided with a first gas inlet and a first gas outlet for leading out gas to be detected; the end part of the first air inlet is arranged below the liquid level of the water washing solvent, and the first air outlet is arranged above the liquid level of the water washing solvent.
In one possible design, the impurity removing unit further comprises a liquid injection port arranged above the container and a liquid discharge port arranged at the bottom of the container; the liquid injection port is provided with a first switch device, and the liquid discharge port is provided with a second switch device; the first switch device and the second switch device are electromagnetic valves or pumps.
Preferably, the water washing solvent is purified water or tap water.
In one possible design, as shown in fig. 4, the dehumidification unit is a condensation dehumidification device, which includes a condensation chamber and a refrigerator; the refrigerator is used for reducing the temperature of the condensation cavity, the gas to be detected is cooled in the condensation cavity, water vapor is separated out from the gas to be detected, and during specific implementation, a liquid discharge pump is installed at the bottom of the condensation cavity to discharge separated water. When the refrigeration device is specifically implemented, the refrigerator comprises a condensation pipe and a compressed air tank refrigeration device, and the condensation pipe is refrigerated by the compressed air tank refrigeration device.
In specific implementation, the separation unit is a gas-liquid separation device, the condensed liquid substance is deposited at the bottom of the cavity of the separation unit, and the gaseous substance flows into the next device after passing through the separation unit. In specific implementation, in order to discharge the liquid substances in the separation unit in time, the bottom of the cavity of the separation unit is also provided with a liquid discharge port, and the liquid discharge port is provided with a third switching device; the third switching device is an electromagnetic valve or a pump.
In specific implementation, as shown in fig. 3 and 4, the separation unit may be divided into a plurality of units, for example, a first gas-liquid separation device 401 after the impurity removal unit and a second gas-liquid separation device 402 after the dehumidification unit are respectively connected in series; or may be a unit disposed before the microfiltration unit.
In one possible design, the microfiltration unit is an activated carbon filter. In specific implementation, the models of the activated carbon filter are CI-GF2600, CI-GF2800 or CI-GF 2900.
In a possible design, the device further comprises a back-blowing device; the back flushing device is communicated with the sampling unit through a pipeline, and the back flushing device utilizes a compressed air tank to clean the sampling unit.
In one possible design, as shown in fig. 4, a calibration device is further included; the calibration device comprises a standard gas tank, a pressure stabilizing valve and a flow valve which are sequentially communicated; the calibration device is communicated with the gas sensor.
In one possible design, the control device comprises a controller, and a solenoid valve and a detector which are electrically connected with the controller;
the electromagnetic valve comprises a sampling valve, a calibration valve, a back flushing valve and a refrigerating valve: wherein,
the sampling valve is connected between the sampling port and the impurity removal unit; and during sampling, opening the sampling valve, and closing the back flushing valve and the calibration valve.
The calibration valve is connected between the calibration device and the gas sensor; and during calibration, opening the calibration valve, closing the sampling valve, and introducing a standard gas tank into the gas sensor for calibration.
The blowback valve is connected to a pipeline between the compressed air tank and the sampling port; and during back flushing, opening a back flushing valve, closing the sampling valve, and purging and cleaning the sampling unit.
A refrigerating valve connected to a pipe between the refrigerator and the compressed air tank; when refrigerating, the refrigerating valve is opened, the compressed air tank is introduced into the refrigerator, and the refrigerator can be driven by the power supply to refrigerate.
The detector comprises a pressure detector, a flow detector and a temperature detector; the detector is arranged between the sampling port and the gas sensor and is used for detecting pressure, flow and temperature parameters in the pretreatment system.
When the electromagnetic pump is specifically implemented, the control device can adopt a switch control panel, and all electromagnetic valve switches or pump body switches are centralized on the switch panel, so that the control is convenient; secondly, the control device can also be controlled by a terminal with a processor, and the processor can be but is not limited to a microprocessor with the model number STM32F105 series.
In conclusion, the sampling gas processing system provided by the invention can provide the gas to be detected which meets the use conditions of the instrument for the gas analysis instrument by performing a series of treatments such as impurity removal, dehumidification, cooling and the like on the sampling gas, so that the instrument can run reliably for a long time, and meanwhile, the highly reliable sampling gas processing system also greatly improves the safety coefficient.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. A gas analysis pretreatment system in the production process of pharmaceutical and chemical intermediates is characterized by comprising an impurity removal unit, a dehumidification unit, a separation unit, a precise filtration unit, a gas sensor and a sampling unit arranged on a pipeline, wherein the impurity removal unit, the dehumidification unit, the separation unit, the precise filtration unit and the gas sensor are sequentially communicated,
the sampling unit is used for taking out gas to be detected from the pharmaceutical intermediate production equipment;
the impurity removal unit is used for removing organic solvent and dust in the gas to be detected; the impurity removal unit is communicated with a sampling port of the production equipment;
the dehumidification unit is used for removing gaseous water and liquid water in the gas to be detected;
the separation unit is used for separating a gaseous substance and a liquid substance;
the precise filtering unit is used for removing micro-particles and micro-droplet components in the gas to be detected;
the gas sensor is used for detecting the gas content in the gas to be detected.
2. The pharmaceutical chemical intermediate production process gas analysis pretreatment system of claim 1, wherein: the sampling unit comprises a pumping device arranged on the pipeline path; the sampling unit further comprises one or more of a flow meter, a pressure maintaining valve and a flow stabilizing valve arranged on the pipeline path.
3. The pharmaceutical chemical intermediate production process gas analysis pretreatment system of claim 1, wherein: the sampling port is provided with a stop valve.
4. The pharmaceutical chemical intermediate production process gas analysis pretreatment system of claim 1, wherein: the impurity removal unit comprises a closed container used for containing a washing solvent, and the container is provided with a first air inlet and a first air outlet for leading out gas to be detected; the end part of the first air inlet is arranged below the liquid level of the water washing solvent, and the first air outlet is arranged above the liquid level of the water washing solvent.
5. The system for analyzing and pretreating the gas in the pharmaceutical and chemical intermediate production process according to claim 4, wherein the impurity removing unit further comprises a liquid injection port arranged above the container and a liquid discharge port arranged at the bottom of the container; the liquid injection port is provided with a first switch device, and the liquid discharge port is provided with a second switch device; the first switch device and the second switch device are electromagnetic valves or pumps.
6. The pharmaceutical chemical intermediate production process gas analysis pretreatment system of claim 1, wherein: the dehumidification unit is a condensation dehumidification device, and the condensation dehumidification device comprises a condensation cavity and a refrigerator; the refrigerator is used for reducing the temperature of the condensation cavity.
7. The analytical pretreatment system for gases in pharmaceutical and chemical intermediate production processes as claimed in claim 1, wherein the precise filtration unit is an activated carbon filter.
8. The system for analyzing and pretreating the gas in the production process of pharmaceutical and chemical intermediates of claim 1, further comprising a back-flushing device; the back flushing device is communicated with the sampling unit through a pipeline and communicated with the compressed air tank.
9. The pharmaceutical chemical intermediate production process gas analysis pretreatment system of claim 8, wherein: the device also comprises a calibration device; the calibration device comprises a standard gas tank, a pressure stabilizing valve and a flow valve which are sequentially communicated through a pipeline; the calibration device is communicated with the gas sensor.
10. The analytical pretreatment system for pharmaceutical chemical intermediate production process gas according to claim 9, further comprising a control device, wherein the control device comprises a controller, and a solenoid valve and a detector electrically connected to the controller;
the electromagnetic valve comprises a sampling valve, a calibration valve, a back-flushing valve and a refrigerating valve, wherein
The sampling valve is connected to a pipeline between the sampling port and the impurity removal unit;
the calibration valve is connected between the calibration device and the gas sensor;
the blowback valve is connected between the compressed air tank and the sampling port;
the refrigerating valve is connected between the refrigerator and the compressed air tank;
the detector comprises a pressure detector, a flow detector and a temperature detector, and is arranged on a pipeline between the sampling port and the gas sensor and used for detecting pressure, flow and temperature parameters in the pretreatment system.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011193418.0A CN112213454A (en) | 2020-10-30 | 2020-10-30 | Pharmaceutical chemical intermediate production process gas analysis pretreatment system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011193418.0A CN112213454A (en) | 2020-10-30 | 2020-10-30 | Pharmaceutical chemical intermediate production process gas analysis pretreatment system |
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| CN112213454A true CN112213454A (en) | 2021-01-12 |
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| CN202011193418.0A Withdrawn CN112213454A (en) | 2020-10-30 | 2020-10-30 | Pharmaceutical chemical intermediate production process gas analysis pretreatment system |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112903917A (en) * | 2021-01-25 | 2021-06-04 | 上海艺旻科技有限公司 | Gas analyzer dehumidification edulcoration system |
| CN114113398A (en) * | 2021-11-29 | 2022-03-01 | 安徽泽升科技有限公司 | Pretreatment analysis system and method for medical intermediate |
| CN114942163A (en) * | 2022-04-24 | 2022-08-26 | 重庆大学 | Online gas sampling system suitable for multiple catalysis |
-
2020
- 2020-10-30 CN CN202011193418.0A patent/CN112213454A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112903917A (en) * | 2021-01-25 | 2021-06-04 | 上海艺旻科技有限公司 | Gas analyzer dehumidification edulcoration system |
| CN114113398A (en) * | 2021-11-29 | 2022-03-01 | 安徽泽升科技有限公司 | Pretreatment analysis system and method for medical intermediate |
| CN114113398B (en) * | 2021-11-29 | 2023-07-07 | 安徽泽升科技有限公司 | Pretreatment analysis system and method for medical intermediate |
| CN114942163A (en) * | 2022-04-24 | 2022-08-26 | 重庆大学 | Online gas sampling system suitable for multiple catalysis |
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