CN112212616A - Production line and process of blood coagulation reagent production equipment - Google Patents
Production line and process of blood coagulation reagent production equipment Download PDFInfo
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- CN112212616A CN112212616A CN202011094608.7A CN202011094608A CN112212616A CN 112212616 A CN112212616 A CN 112212616A CN 202011094608 A CN202011094608 A CN 202011094608A CN 112212616 A CN112212616 A CN 112212616A
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0011—Heating features
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/30—Accessories for evaporators ; Constructional details thereof
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/001—Handling, e.g. loading or unloading arrangements
- F26B25/003—Handling, e.g. loading or unloading arrangements for articles
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/008—Seals, locks, e.g. gas barriers or air curtains, for drying enclosures
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B25/00—Details of general application not covered by group F26B21/00 or F26B23/00
- F26B25/06—Chambers, containers, or receptacles
- F26B25/14—Chambers, containers, receptacles of simple construction
- F26B25/18—Chambers, containers, receptacles of simple construction mainly open, e.g. dish, tray, pan, rack
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- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Basic Packing Technique (AREA)
Abstract
The invention discloses a production line of blood coagulation reagent production equipment and a process thereof, belonging to the technical field of blood coagulation reagent production, wherein the production line comprises a solution preparation device, a bottling device and a freeze-drying device, wherein the solution preparation device provides a prepared solution for the bottling device through a conveying pipeline; the freeze-drying device is characterized in that the freeze-drying device comprises a case, a heater is installed at the top of the case, a refrigerator is arranged at the bottom of the case, a vacuum cover is installed between the heater and the refrigerator, an opening at the bottom of the vacuum cover is arranged, an air suction pump for vacuum air suction is installed outside the vacuum cover, a lifting plate is installed above the refrigerator and driven by an air cylinder, a heat-conducting supporting plate is installed on the surface of the lifting plate, a plurality of reagent bottle grooves are formed in the upper surface of the heat-conducting supporting plate, a sealing bag matched with the vacuum cover in specification is installed on the upper surface of the heat-conducting supporting plate in a circle around the plurality of reagent bottle grooves.
Description
Technical Field
The invention relates to the technical field of production of a blood coagulation reagent, and particularly relates to a production line of blood coagulation reagent production equipment and a process thereof.
Background
Hemagglutination reagents are agents used to test enzymes for different kinds of functions, such as: prothrombin time assay (PT), activated partial prothrombin time Assay (APTT), thrombin time assay (TT), and fibrinogen content assay were performed. The hemagglutination reagent has two types, namely a liquid type and a freeze-drying type, and the freeze-drying type reagent is convenient to store, so that the freeze-drying type reagent is mostly adopted in the hemagglutination reagents on the market.
The blood coagulation reagent needs to be freeze-dried by a freeze dryer to discharge internal water during production, so that the storage time is prolonged, and the vacuum freeze-drying technology of the freeze dryer, which is originated in the 20 th age of the 19 th century, has been greatly developed in the last 20 years after the vacuum freeze-drying technology has been fluctuated and wandered for decades. In the 21 st century, vacuum freeze-drying technology is more and more favored by people by virtue of incomparable advantages of other drying methods, and the application scale and the application field of the vacuum freeze-drying technology are continuously expanded besides being widely applied to the fields of medicines, biological products, foods, blood products and active substances.
The basic principle of freeze-drying is based on the tristate change of water, so that the prepared solution of the traditional blood coagulation reagent needs to be frozen firstly during production, then the solution is vacuumized and heated finally, and the reagent bottle needs to be transferred without stop by manpower, so that the efficiency is low, the production cost is improved, the reagent occupies a large amount of space from preparation to freeze-drying of the whole assembly line, and the reaction condition of the reagent solution is not convenient to observe during reagent preparation, so that the supervision is not convenient.
Disclosure of Invention
The invention aims to solve the problems of inconvenient supervision of the preparation of the reagent solution, large volume of the whole production line and low efficiency in freeze-drying operation, and provides a production line of blood coagulation reagent production equipment and a process thereof.
The invention achieves the aim through the following technical scheme, and the production line of the blood coagulation reagent production equipment comprises a solution preparation device, a bottling device and a freeze-drying device, wherein the solution preparation device provides a prepared solution for the bottling device through a material conveying pipeline;
the freeze-drying device is characterized in that the freeze-drying device comprises a case, a heater is installed at the top of the case, a refrigerator is arranged at the bottom of the case, a vacuum cover is installed between the heater and the refrigerator, an opening at the bottom of the vacuum cover is arranged, an air suction pump for vacuum air suction is installed outside the vacuum cover, a lifting plate is installed above the refrigerator and driven by an air cylinder, a heat-conducting supporting plate is installed on the surface of the lifting plate, a plurality of reagent bottle grooves are formed in the upper surface of the heat-conducting supporting plate, a sealing bag matched with the vacuum cover in specification is installed on the upper surface of the heat-conducting supporting plate in a circle around the plurality of reagent bottle grooves.
Preferably, the solution preparation device includes blending tank and inlet pipe, the top one end of blending tank sets up the glass window, the internally mounted puddler of blending tank, and the top of puddler passes the outer wall of blending tank and is connected with the output of motor.
Preferably, the bottling device comprises an equipment frame and a fixing frame, a transmission track is installed on the equipment frame, a liquid storage tank is installed on the upper surface of the fixing frame, a plurality of liquid outlets are installed on the lower surface of the fixing frame, and the liquid outlets and the liquid outlet pipes are communicated through communicating pipes.
Preferably, the conveying track is of a U-shaped structure, and the liquid outlet nozzles are distributed on the fixing frame in a U shape.
Preferably, an electromagnetic valve is installed inside the liquid outlet nozzle.
Preferably, one end of the material conveying pipeline is connected to the bottom end of the solution preparation device, the other end of the material conveying pipeline is connected with the liquid storage tank, and the material conveying pipeline provides power through the conveying pump.
Preferably, the material conveying pipeline is communicated with a sampling pipe, and the sampling pipe is provided with a valve.
A preparation process of a hemagglutination reagent comprises the following steps:
s1, weighing reagent raw materials, adding the reagent raw materials and industrial water into a solution preparation device, mixing, stirring continuously through a stirring rod in the mixing process to prepare a reagent solution, pumping the reagent solution into a liquid storage tank of a bottling device through a conveying pump, and extracting a sample solution through a sampling pipe for index inspection when the reagent solution is transferred;
s2, placing the reagent bottles into a transmission rail of a bottling device after rough washing and fine washing, conveying the reagent bottles to the lower part of a liquid outlet nozzle along with the transmission rail, opening the liquid outlet nozzle through an electromagnetic valve to fill the solution into the reagent bottles, and quantitatively extracting the reagent bottles for quality inspection;
s3, taking down the reagent bottles, putting the reagent bottles on a heat-conducting supporting plate, conveying the reagent bottles onto a lifting plate in a freeze-drying device, freezing the reagent bottles, conveying the reagent bottles into a vacuum cover through an air cylinder, carrying out vacuum heating to evaporate water in the solution, and extracting the freeze-dried reagent for drying and inspection;
s4, labeling the freeze-dried reagent, filling the reagent bottle label together with an instruction into a reagent kit, sealing the reagent kit, completing the packaging of the reagent, and performing spot check on the state of accessories of the reagent kit packaging and the finished product performance index of the reagent;
and S5, transporting the finished product to a warehouse for low-temperature storage.
Preferably, the steps S1, S2 and S3 are all performed in a hundred thousand grade clean room.
Compared with the prior art, the invention has the beneficial effects that:
1. through divide into upper and lower two-layer with freeze-drying device, freezing and drying respectively, it refrigerates to the heat conduction layer board through the refrigerator to freeze reagent solution, send into the vacuum cover through the cylinder after freezing and carry out vacuum heating, the bottom opening of vacuum cover, the seal bag on the heat conduction layer board just can seal the vacuum cover, does not need artifical reagent bottle that shifts like this, and the automatic freeze-drying operation of raising the efficiency realization.
2. The conveying track setting when will bottling is the track of U type structure, can practice thrift the space like this, and the distribution of liquid outlet nozzle also is U type structure moreover, improves the efficiency of bottling.
3. Through set up a sampling pipe on the conveying pipeline, through valve control sampling pipe, can conveniently sample reagent solution, the top of blending tank also is equipped with the glass window moreover, can see through the convenient observation bucket of glass window the interior preparation condition when the raw materials mixes the preparation.
Drawings
FIG. 1 is a schematic diagram of the overall pipeline structure of the present invention.
FIG. 2 is a schematic structural diagram of a solution preparing apparatus according to the present invention.
Fig. 3 is a schematic structural view of the bottling device of the present invention.
Fig. 4 is a schematic diagram of a structure of a conveying track according to the present invention.
Fig. 5 is a schematic structural diagram of the freeze-drying device of the present invention.
Fig. 6 is a schematic structural diagram of a heat-conducting supporting plate according to the present invention.
FIG. 7 is a flow chart of the process for producing the hemagglutination reagent of the present invention.
In the figure: 1. the device comprises a solution preparation device, 11, a mixing barrel, 12, a feeding pipe, 13, a glass window, 14, a motor, 15, a stirring rod, 2, a conveying pump, 3, a conveying pipeline, 3, a sampling pipe, 4, a bottling device, 41, an equipment rack, 42, a liquid storage tank, 43, a fixing rack, 44, a liquid outlet nozzle, 45, a communicating pipe, 46, a conveying track, 5, a freeze-drying device, 51, a heater, 52, a vacuum cover, 53, an air suction pump, 54, a refrigerator, 55, a lifting plate, 56, a cylinder, 57, a heat conducting supporting plate, 58, a sealing bag, 59 and a reagent bottle groove.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, 5 and 6, a flow line of a blood coagulation reagent production apparatus includes a solution preparing device 1, a bottling device 4 and a freeze-drying device 5, wherein the solution preparing device 1 provides a prepared solution to the bottling device 4 through a delivery pipeline 3; the freeze-drying device 5 comprises a case 510, a heater 51 is arranged at the top of the case 510, a refrigerator 54 is arranged at the bottom, a vacuum cover 52 is arranged between the heater 51 and the refrigerator 54, the bottom opening of the vacuum cover 52 is arranged, an air pump 53 for vacuum air suction is arranged outside the vacuum cover, a lifting plate 55 is arranged above the refrigerator 54, the lifting plate 55 is driven by an air cylinder 56, a heat-conducting supporting plate 57 is arranged on the surface of the lifting plate 55, a plurality of reagent bottle grooves 59 are arranged on the upper surface of the heat-conducting supporting plate 57, a circle of sealing bag 58 matched with the specification of the vacuum cover 52 is arranged on the upper surface of the heat-conducting supporting plate 57, liquid is filled in the sealing bag 58, the reagent solution is frozen by the current lower layer of the heat-conducting supporting plate 57, the reagent bottles are sent into the vacuum cover 52 through the air cylinder 56 after freezing is finished, the sealing bag 58 on the, when the air pump 53 sucks air, the sealing bag 58 is sucked by suction force and deformed to tightly adhere to the inner wall of the vacuum cover 52, so that the sealing effect is achieved, a vacuum area is formed between the sealing bag and the vacuum cover 52, the heater 51 heats the vacuum reagent again, the moisture in the reagent is evaporated, and the drying effect is achieved.
As shown in fig. 2, the solution preparation device 1 includes a mixing barrel 11 and a feeding pipe 12, a glass window 13 is arranged at one end of the top of the mixing barrel 11, a stirring rod 15 is arranged inside the mixing barrel 11, the top end of the stirring rod 15 penetrates through the outer wall of the mixing barrel 11 to be connected with the output end of a motor 14, the mixing barrel 11 is used for mixing reagent raw materials and industrial water, the stirring rod 15 plays a role in accelerating mixing during mixing, the inner condition of the mixing barrel 11 can be conveniently observed through the glass window 13, and an operator can conveniently observe the reagent preparation condition.
As shown in fig. 3-4, the bottling device 4 includes a device rack 41 and a fixing frame 43, a transmission rail 46 is installed on the device rack 41, a liquid storage tank 42 is installed on the upper surface of the fixing frame 43, a plurality of liquid outlets 44 are installed on the lower surface, the liquid outlets 44 are communicated with the liquid outlet pipe 42 through a communication pipe 45, the transmission rail 46 is in a U-shaped structure, the liquid outlets 44 are distributed on the fixing frame 43 in a U-shape, electromagnetic valves are installed inside the liquid outlets 44, one end of the material delivery pipeline 3 is connected to the bottom end of the solution preparation device 1, the other end of the material delivery pipeline is connected to the liquid storage tank 42, the material delivery pipeline 3 provides power through the delivery pump 2, the material delivery pipeline 3 is communicated with the sampling pipe 3, a valve is arranged on the sampling pipe 3, the transmission rail 46 is in a U-shaped structure, so as to increase the transmission amount of reagent bottles and, when the reagent bottle is conveyed to the position below the liquid outlet nozzle 44, the electromagnetic valve is opened to discharge liquid, the reagent solution is filled into the bottle, the electromagnetic valve is closed, and the reagent bottle leaves the position below the liquid outlet nozzle 44.
As shown in FIG. 7, a process for preparing a hemagglutination reagent comprises the following steps:
s1, weighing reagent raw materials, adding the reagent raw materials and industrial water into the solution preparation device 1, mixing, continuously stirring by the stirring rod 15 in the mixing process to prepare a reagent solution, pumping the reagent solution into the liquid storage tank 42 of the bottling device 4 through the delivery pump 2, and pumping a sample solution through the sampling pipe 3 for index inspection when the reagent solution is transferred;
s2, placing the reagent bottles into the transmission rail 46 of the bottling device 4 after rough washing and fine washing, conveying the reagent bottles to the lower part of the liquid outlet nozzle 44 along with the transmission rail 46, opening the liquid outlet nozzle 44 through the electromagnetic valve to fill the solution into the reagent bottles, and quantitatively extracting the reagent bottles for quality inspection;
s3, taking down the reagent bottles, putting the reagent bottles on the heat-conducting supporting plate 57, conveying the reagent bottles onto the lifting plate 55 in the freeze-drying device 5, freezing the reagent bottles, conveying the reagent bottles into the vacuum cover 52 through the air cylinder 56, carrying out vacuum heating to evaporate water in the solution, and extracting the freeze-dried reagent for drying and inspection;
s4, labeling the freeze-dried reagent, filling the reagent bottle label together with an instruction into a reagent kit, sealing the reagent kit, completing the packaging of the reagent, and performing spot check on the state of accessories of the reagent kit packaging and the finished product performance index of the reagent;
and S5, transporting the finished product to a warehouse for low-temperature storage.
Step S1, step S2, and step S3 are all performed in a hundred thousand class clean room.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (9)
1. The utility model provides a hemagglutination reagent production facility assembly line, includes solution preparation device (1), bottling device (4) and freeze-drying device (5), its characterized in that: the solution preparation device (1) provides prepared solution for the bottling device (4) through a material conveying pipeline (3);
the freeze-drying device (5) comprises a cabinet (510) inside, a heater (51) is arranged at the top of the cabinet (510), a refrigerator (54) is arranged at the bottom of the cabinet, a vacuum cover (52) is arranged between the heater (51) and the refrigerator (54), the bottom of the vacuum cover (52) is provided with an opening, the outside of the vacuum cover is provided with an air suction pump (53) for vacuum air suction, a lifting plate (55) is arranged above the refrigerator (54), the lifting plate (55) is driven by an air cylinder (56), a heat-conducting supporting plate (57) is arranged on the surface of the lifting plate (55), a plurality of reagent bottle grooves (59) are arranged on the upper surface of the heat-conducting supporting plate (57), the upper surface of the heat conducting supporting plate (57) is provided with a circle of sealing bags (58) which surround a plurality of reagent bottle grooves (59) and are matched with the vacuum cover (52) in specification, and the sealing bags (58) are filled with liquid.
2. The flow line of claim 1, wherein: solution preparation facilities (1) includes mixing tank (11) and inlet pipe (12), the top one end of mixing tank (11) sets up glass window (13), internally mounted puddler (15) of mixing tank (11), and the outer wall that mixing tank (11) were passed on the top of puddler (15) is connected with the output of motor (14).
3. The flow line of claim 1, wherein: bottling device (4) includes equipment rack (41) and mount (43), last installation transmission track (46) of equipment rack (41), the upper surface mounting liquid storage pot (42) of mount (43), a plurality of liquid outlet nozzle (44) of lower surface mounting are linked together through communicating pipe (45) between liquid outlet nozzle (44) and liquid outlet pipe (42).
4. The assembly line of claim 3, wherein: the conveying track (46) is of a U-shaped structure, and the liquid outlets (44) are distributed on the fixing frame (43) in a U shape.
5. The assembly line of claim 3, wherein: an electromagnetic valve is arranged in the liquid outlet nozzle (44).
6. The flow line of claim 1, wherein: one end of the material conveying pipeline (3) is connected to the bottom end of the solution preparation device (1), the other end of the material conveying pipeline is connected with the liquid storage tank (42), and the material conveying pipeline (3) provides power through the delivery pump (2).
7. The assembly line of claim 6, wherein: the material conveying pipeline (3) is communicated with a sampling pipe (3), and a valve is arranged on the sampling pipe (3).
8. A reagent preparing process based on the blood coagulation reagent producing apparatus according to claims 1 to 7, characterized in that: the method comprises the following steps:
s1, weighing reagent raw materials, adding the reagent raw materials and industrial water into the solution preparation device (1) for mixing, continuously stirring the reagent raw materials and the industrial water by a stirring rod (15) in the mixing process to prepare a reagent solution, pumping the reagent solution into a liquid storage tank (42) of a bottling device (4) by a delivery pump (2), and pumping a sample solution through a sampling pipe (3) for index detection when the reagent solution is transferred;
s2, placing the reagent bottles into a transmission rail (46) of a bottling device (4) after rough washing and fine washing, conveying the reagent bottles to the lower part of a liquid outlet nozzle (44) along with the transmission rail (46), opening the liquid outlet nozzle (44) through an electromagnetic valve to fill the solution into the reagent bottles, and quantitatively extracting the reagent bottles for quality inspection;
s3, taking down the reagent bottles, putting the reagent bottles on a heat-conducting supporting plate (57), conveying the reagent bottles onto a lifting plate (55) in a freeze-drying device (5), freezing the reagent bottles, conveying the reagent bottles into a vacuum cover (52) through an air cylinder (56) for vacuum heating to evaporate water in the solution, and extracting the freeze-dried reagent for drying and inspection;
s4, labeling the freeze-dried reagent, filling the reagent bottle label together with an instruction into a reagent kit, sealing the reagent kit, completing the packaging of the reagent, and performing spot check on the state of accessories of the reagent kit packaging and the finished product performance index of the reagent;
and S5, transporting the finished product to a warehouse for low-temperature storage.
9. The process for preparing a hemagglutination reagent according to claims 1-7, wherein: the steps S1, S2 and S3 are all performed in a hundred thousand grade clean room.
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CN202011094608.7A CN112212616A (en) | 2020-10-14 | 2020-10-14 | Production line and process of blood coagulation reagent production equipment |
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CN202011094608.7A CN112212616A (en) | 2020-10-14 | 2020-10-14 | Production line and process of blood coagulation reagent production equipment |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6564471B1 (en) * | 2001-03-12 | 2003-05-20 | S. P. Industries, Inc., The Virtis Division | Method and apparatus for freeze-drying |
US20090107000A1 (en) * | 2004-02-17 | 2009-04-30 | Georg-Wilhelm Oetjen | Method and Device for Freeze-Drying Products |
CN207729934U (en) * | 2017-12-29 | 2018-08-14 | 江西乐成生物医疗有限公司 | A kind of vacuum freezing drying device |
CN207797518U (en) * | 2017-12-01 | 2018-08-31 | 曾向东 | A kind of novel vacuum freezing drying device |
CN208915934U (en) * | 2018-10-31 | 2019-05-31 | 贵阳中医学院 | A kind of higher boiling chemical reagent purification filling apparatus |
CN110615146A (en) * | 2019-10-12 | 2019-12-27 | 徐飞 | Automatic change chemical reagent liquid filling machine |
-
2020
- 2020-10-14 CN CN202011094608.7A patent/CN112212616A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6564471B1 (en) * | 2001-03-12 | 2003-05-20 | S. P. Industries, Inc., The Virtis Division | Method and apparatus for freeze-drying |
US20090107000A1 (en) * | 2004-02-17 | 2009-04-30 | Georg-Wilhelm Oetjen | Method and Device for Freeze-Drying Products |
CN207797518U (en) * | 2017-12-01 | 2018-08-31 | 曾向东 | A kind of novel vacuum freezing drying device |
CN207729934U (en) * | 2017-12-29 | 2018-08-14 | 江西乐成生物医疗有限公司 | A kind of vacuum freezing drying device |
CN208915934U (en) * | 2018-10-31 | 2019-05-31 | 贵阳中医学院 | A kind of higher boiling chemical reagent purification filling apparatus |
CN110615146A (en) * | 2019-10-12 | 2019-12-27 | 徐飞 | Automatic change chemical reagent liquid filling machine |
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Application publication date: 20210112 |